KNApSAcK Metabolite C00003133
Metabolite
KNApSAcK Entry
| id | C00003133 |
|---|---|
| Name | Fumidil / Fugillin / Fumadil B / Amebacilin / Fumagillin / Fumagillin DCH / (-)-Fumagillin |
| CAS RN | 23110-15-8 |
| Standard InChI | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2065 |
Link
ChEMBL
| By standard InChI | CHEMBL32838 |
|---|---|
| By standard InChI Main Layer | CHEMBL32838 CHEMBL117603 CHEMBL1396346 CHEMBL1522710 CHEMBL1992691 |
KEGG
| By LinkDB | C09668 |
|---|
CTD
| By CAS RN | C026211 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Aspergillaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Aspergillus fumigatus | 746128 | Aspergillaceae | Fungi | |
| Penicillium janczewskii | 121612 | Aspergillaceae | Fungi |
Human Protein / Gene in interaction
13 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL32838 |
CHEMBL1794552
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL1396346 |
CHEMBL1614544
(1)
|
11 / 10 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL1396346 CHEMBL1522710 |
CHEMBL1794311
(2)
|
2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1522710 |
CHEMBL1614458
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL1396346 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P53582 | Methionine aminopeptidase 1 | M24A | CHEMBL32838 |
CHEMBL1027136
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL1522710 |
CHEMBL1614250
(1)
CHEMBL1614421
(1)
|
4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL32838 |
CHEMBL2114890
(1)
|
0 / 0 |
| P50579 | Methionine aminopeptidase 2 | M24A | CHEMBL32838 CHEMBL117603 |
CHEMBL709685
(1)
CHEMBL716777
(1)
CHEMBL881950 (1) CHEMBL1027137 (1) CHEMBL1048165 (1) |
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL1522710 |
CHEMBL1794536
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1396346 CHEMBL1522710 |
CHEMBL1738442
(2)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL1522710 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1522710 |
CHEMBL1614531
(1)
|
1 / 3 |
CTD interaction (5)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C026211 | 23173 |
METAP1
MAP1A MetAP1A |
methionyl aminopeptidase 1 (EC:3.4.11.18) | fumagillin results in decreased activity of METAP1 protein |
decreases activity
|
protein |
14534293
|
| C026211 | 23173 |
METAP1
MAP1A MetAP1A |
methionyl aminopeptidase 1 (EC:3.4.11.18) | [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein |
affects cotreatment
/ decreases activity / decreases metabolic processing |
protein |
14534293
|
| C026211 | 10988 |
METAP2
MAP2 MNPEP p67 p67eIF2 |
methionyl aminopeptidase 2 (EC:3.4.11.18) | [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein |
affects cotreatment
/ decreases activity / decreases metabolic processing |
protein |
14534293
|
| C026211 | 10988 |
METAP2
MAP2 MNPEP p67 p67eIF2 |
methionyl aminopeptidase 2 (EC:3.4.11.18) | fumagillin results in decreased activity of METAP2 protein |
decreases activity
|
protein |
14534293
15516829 |
| C026211 | 7532 |
YWHAG
14-3-3GAMMA |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein |
affects cotreatment
/ decreases activity / decreases metabolic processing |
protein |
14534293
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (20)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (23)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|