KCF-S cluster No. 2137 (5 metabolites)

Corresponding Phytochemical cluster No. 44

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (5)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	5
Magnoliophyta	2

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Cumulative family count

class name	count
Ginkgoaceae	5
Lauraceae	2

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Ginkgolides	5

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Ginkgolides	C07601	C00003429
Ginkgolides	C07602	C00035830
Ginkgolides	C07603	C00035831
Ginkgolides	C07604	C00035832
Ginkgolides	C16816	C00041545

Metabolite list (5)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003429	Ginkgolide A	CHEMBL465161 CHEMBL1370614 CHEMBL1408113 CHEMBL1472160 CHEMBL1712596 CHEMBL1741996 CHEMBL2112174		13 / 10 / 12
C00035830	Ginkgolide B	CHEMBL514432 CHEMBL1434825 CHEMBL1515002 CHEMBL1898434		17 / 21 / 17
C00035831	Ginkgolide C	CHEMBL156251 CHEMBL347488 CHEMBL375821 CHEMBL1299408 CHEMBL1596335 CHEMBL1868593 CHEMBL2112173	C058295	8 / 1 / 1	3 / 0
C00035832	Ginkgolide J	CHEMBL2112172	C075228	1 / 0 / 0	1 / 0
C00041545	Ginkgolide M

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P25105	Platelet-activating factor receptor	PAF receptor	C00003429 C00035830 C00035831 C00035832	0 / 0
P23415	Glycine receptor subunit alpha-1	GLR alpha	C00003429 C00035830 C00035831	1 / 1
P23416	Glycine receptor subunit alpha-2	GLR alpha	C00003429 C00035830 C00035831	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003429 C00035830	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003429 C00035830	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00035830 C00035831	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003429 C00035830	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003429 C00035830	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00035830 C00035831	0 / 0
O75496	Geminin	Unclassified protein	C00035830 C00035831	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003429 C00035830	1 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003429	1 / 2
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00035830	7 / 3
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00035830	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00003429	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00035831	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00035830	2 / 3
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00035830	3 / 3
O75311	Glycine receptor subunit alpha-3	GLR alpha	C00035830	0 / 0
P04062	Glucosylceramidase	Enzyme	C00035830	6 / 4
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00003429	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00003429	4 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00035831	0 / 0
O00255	Menin	Unclassified protein	C00003429	2 / 5

3 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00035831 C00035832
1385	CREB1, CREB	cAMP responsive element binding protein 1	C00035831
351	APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2	amyloid beta (A4) precursor protein	C00035831

Related Diseases

Diseases related to proteins in ChEMBL interactions