Plant Species

Cumulative plant class count

class name count
Spermatophyta 6
Magnoliophyta 2

Cumulative family count

class name count
Ginkgoaceae 6
Lauraceae 2

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Ginkgolides 6

metabolites link (6)

br08003 Category KEGG ID KNApSAcK ID
Ginkgolides C07601 C00003429
Ginkgolides C07605 C00011512
Ginkgolides C07602 C00035830
Ginkgolides C07603 C00035831
Ginkgolides C07604 C00035832
Ginkgolides C16816 C00041545

KCF-S cluster (2)

KCF-S ID # of metabolite
No. 2137 5
No. 6166 1

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00003429 External link 512 Ginkgolide B
17 / 21 / 17 No. 2137
C00041545 External link 512 Bilobalide
11 / 18 / 15 3 / 1 No. 2137
C00035830 External link 512 Ginkgolide C
8 / 1 / 1 3 / 0 No. 2137
C00035832 External link 512 Ginkgolide M
No. 2137
C00035831 External link 512 Ginkgolide A
13 / 10 / 12 No. 2137
C00011512 External link 512 Ginkgolide J
1 / 0 / 0 1 / 0 No. 6166

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P23416 Glycine receptor subunit alpha-2 GLR alpha C00003429 C00011512 C00035830 C00035831 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00003429 C00035830 C00035831 C00035832 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00011512 C00035830 C00035831 0 / 0
O75496 Geminin Unclassified protein C00011512 C00035830 C00035831 0 / 0
P23415 Glycine receptor subunit alpha-1 GLR alpha C00003429 C00035830 C00035831 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003429 C00035830 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003429 C00035830 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003429 C00035830 0 / 1
O00255 Menin Unclassified protein C00003429 C00011512 2 / 5
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00035830 C00035831 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003429 C00035830 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003429 C00035830 1 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00011512 C00035830 7 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003429 C00011512 1 / 2
Q16637 Survival motor neuron protein Unclassified protein C00003429 C00011512 4 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00011512 3 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00035831 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00003429 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00035830 3 / 3
O75311 Glycine receptor subunit alpha-3 GLR alpha C00035830 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00011512 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003429 0 / 0
P04062 Glucosylceramidase Enzyme C00035830 6 / 4
Q92830 Histone acetyltransferase KAT2A Enzyme C00035830 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00035831 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00035830 2 / 3
Q13951 Core-binding factor subunit beta Unclassified protein C00011512 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00011512 1 / 4

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC: C00011512 C00035831 C00035832
1385 CREB1, CREB cAMP responsive element binding protein 1 C00011512 C00035831
351 APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 amyloid beta (A4) precursor protein C00011512 C00035831

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#149400 Hyperekplexia, hereditary 1; hkpx1 P23415
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473


KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00769 Hyperekplexia P23415 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

D009410 Nerve Degeneration C00011512