KNApSAcK Metabolite C00011512
Metabolite
KNApSAcK Entry
| id | C00011512 |
|---|---|
| Name | Bilobalide |
| CAS RN | 33570-04-6 |
| Standard InChI | InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8+,11-,13-,14+,15+/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3 |
Cluster
| Phytochemical cluster | No. 44 |
|---|---|
| KCF-S cluster | No. 6166 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL133266 CHEMBL1318117 |
KEGG
| By LinkDB | C07605 |
|---|
CTD
| By CAS RN | C073710 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Spermatophyta | 1 |
Family
| family name | count |
|---|---|
| Ginkgoaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Ginkgo biloba | 3311 | Ginkgoaceae | Spermatophyta | Viridiplantae |
Human Protein / Gene in interaction
11 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL1318117 |
CHEMBL1613842
(1)
|
4 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL1318117 |
CHEMBL1613776
(1)
|
3 / 1 |
| O75496 | Geminin | Unclassified protein | CHEMBL1318117 |
CHEMBL2114843
(1)
|
0 / 0 |
| P23416 | Glycine receptor subunit alpha-2 | GLR alpha | CHEMBL133266 |
CHEMBL1629262
(1)
|
0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | CHEMBL1318117 |
CHEMBL2114817
(1)
|
7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1318117 |
CHEMBL1794401
(1)
|
0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL1318117 |
CHEMBL1614240
(1)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL1318117 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1318117 |
CHEMBL1614531
(1)
|
1 / 3 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL1318117 |
CHEMBL1613933
(2)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL1318117 |
CHEMBL1613933
(2)
|
1 / 6 |
CTD interaction (5)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C073710 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C073710 | 1385 |
CREB1
CREB |
cAMP responsive element binding protein 1 | bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C073710 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein |
affects activity
/ affects cotreatment |
protein |
21329749
|
| C073710 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|
| C073710 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (18)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (15)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |