KCF-S cluster No. 224 (27 metabolites)

Corresponding Phytochemical cluster No. 25

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (27)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	53

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Cumulative family count

class name	count
Apiaceae	51
Rubiaceae	2

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Furanocoumarins	3
Coumarins	7

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metabolites link (10)

br08003 Category	KEGG ID	KNApSAcK ID
Furanocoumarins	C09116	C00002451
Furanocoumarins	C09123	C00002452
Coumarins	C09260	C00002468
Coumarins	C09261	C00002469
Coumarins	C09262	C00002470
Coumarins	C09270	C00002478
Furanocoumarins	C09284	C00002492
Coumarins	C09307	C00002494
Coumarins	C09310	C00002497
Coumarins	C09316	C00002504

Metabolite list (27)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002451	Archangelicin	CHEMBL1426896		17 / 18 / 10
C00002452	Athamantin
C00002468	Dihydrosamidin	CHEMBL1302867		13 / 28 / 22
C00002469	Disenecionyl cis-khellactone	CHEMBL339068 CHEMBL517515
C00002470	(3'R,4'R)-3'-Epoxyangeloyloxy-4'-acetoxy-3'4'-dihydroseselin	CHEMBL69235
C00002478	Isosamidin
C00002492	Peucenidin
C00002494	Pteryxin	CHEMBL71876 CHEMBL1376728 CHEMBL1494966 CHEMBL1884860	C019546	16 / 18 / 45
C00002497	Samidin
C00002504	Visnadin	CHEMBL2104448	C067604
C00019856	(+)-trans-4'-Acetyl-3'-tigloylkhellactone	CHEMBL72191 CHEMBL1378488		6 / 5 / 3
C00019858	Edulisin IV
C00019859	Edulisin V
C00019997	Peucedanocoumarin I	CHEMBL2104448
C00019998	Peucedanocoumarin II	CHEMBL71876 CHEMBL1376728 CHEMBL1494966 CHEMBL1884860		16 / 18 / 45
C00019999	Peucedanocoumarin III	CHEMBL71876 CHEMBL1376728 CHEMBL1494966 CHEMBL1884860		16 / 18 / 45
C00024192	Decursidin
C00029642	Ad-I
C00030015	Corymbocoumarin	CHEMBL68513 CHEMBL129045
C00030937	Pd-II / (+)-Pareruptorin B	CHEMBL71951 CHEMBL1468714 CHEMBL1610853		22 / 41 / 33
C00031866	Hyuganin A / (-)-Hyuganin A	CHEMBL307863
C00031867	Hyuganin B / (-)-Hyuganin B	CHEMBL302978
C00031868	Hyuganin C / (-)-Hyuganin C	CHEMBL68513 CHEMBL129045
C00031869	Hyuganin D / (+)-Hyuganin D	CHEMBL70302
C00031899	Isoepoxypteryxin	CHEMBL69235
C00031910	Isopteryxin / (-)-Isopteryxin	CHEMBL72191 CHEMBL1378488		6 / 5 / 3
C00032263	Suksdorfin / (+)-Suksdorfin	CHEMBL68513 CHEMBL129045	C094037

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P00352	Retinal dehydrogenase 1	Enzyme	C00002451 C00002468 C00002494 C00019856 C00019998 C00019999 C00030937 C00031910	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002451 C00002468 C00002494 C00019856 C00019998 C00019999 C00030937 C00031910	2 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002451 C00002468 C00002494 C00019856 C00019998 C00019999 C00030937 C00031910	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002451 C00002468 C00002494 C00019856 C00019998 C00019999 C00031910	2 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002451 C00002468 C00002494 C00019998 C00019999 C00030937	0 / 0
O75496	Geminin	Unclassified protein	C00002451 C00002494 C00019998 C00019999 C00030937	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002451 C00002494 C00019998 C00019999 C00030937	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002451 C00002494 C00019998 C00019999 C00030937	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002494 C00019998 C00019999 C00030937	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002468 C00002494 C00019998 C00019999	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002468 C00002494 C00019998 C00019999	3 / 3
P42858	Huntingtin	Unclassified protein	C00002451 C00019856 C00030937 C00031910	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00002494 C00019998 C00019999	7 / 37
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002494 C00019998 C00019999	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00002494 C00019998 C00019999	1 / 0
P06746	DNA polymerase beta	Enzyme	C00002451 C00019856 C00031910	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00002494 C00019998 C00019999	1 / 1
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002494 C00019998 C00019999	1 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00002468 C00030937	1 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002451 C00030937	7 / 3
P02545	Prelamin-A/C	Unclassified protein	C00002468 C00030937	11 / 10
P04062	Glucosylceramidase	Enzyme	C00002468 C00030937	6 / 4
P10636	Microtubule-associated protein tau	Unclassified protein	C00002451 C00030937	4 / 3
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002451 C00030937	1 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002451 C00030937	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002451	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002468	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00002451	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002468	3 / 2
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00030937	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00002451	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00030937	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002468	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00030937	4 / 1
O00255	Menin	Unclassified protein	C00030937	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00030937	1 / 2
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00030937	0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions