KCF-S cluster No. 260 (26 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (26)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	60

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Cumulative family count

class name	count
Apocynaceae	52
Gelsemiaceae	7
Loganiaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Indole alkaloids	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Indole alkaloids	C09107	C00001704
Indole alkaloids	C11691	C00026041

Metabolite list (26)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001681	Akuammidine	CHEMBL454572 CHEMBL498115
C00001704	Catharanthine	CHEMBL1187281 CHEMBL1418171 CHEMBL1988908 CHEMBL2163793	C017836	5 / 6 / 11
C00025136	16-Epivoacarpine
C00025197	Polyneuridine / Normacusine A / (-)-Polyneuridine	CHEMBL454572 CHEMBL498115
C00025226	Voacarpine
C00025720	Epiisositsirikine / 16-Epiisositsirikine / 16-epi-Isositsirikine / 16-epi-19E-Isositsirikine	CHEMBL453018
C00025725	19,20-Dehydro-alpha-yohimbine / (+/-)-19,20-Dehydro-a-yohimbine
C00025912	Isositsirikine / 16R,19E-Isositsirikine	CHEMBL453018	C038932
C00025979	O-Acetylvallesamine / Vallesamine acetate
C00026009	Pericyclivine / (+)-Pericyclivine / Deformoakuammidine		C031498
C00026041	Stemmadenine	CHEMBL486212	C046117
C00026073	Vallesamine / (+)-Vallesamine / 19,20-(E)-Vallesamine
C00026662	Polyneuridine-N-oxide
C00027077	Sitsirikine
C00029414	19Z-16-epi-Voacarpine
C00030371	Gelsempervine A
C00030372	Gelsempervine B
C00030373	Gelsempervine C
C00030374	Gelsempervine D
C00035211	19,20-E-Vallesamine / 19,20-(E)-Vallesamine / (+)-19,20-(E)-Vallesamine
C00038183	19,20-Didehydroervatamine
C00040643	Voachalotine	CHEMBL1368524		3 / 7 / 3
C00041252	19(Z)-Akuammidine	CHEMBL454572 CHEMBL498115
C00041686	N(4)-Methylakuammidine
C00047662	3-Epivobasinol / (-)-3-Epivobasinol
C00047664	3-O-Methylepivobasinol / (-)-3-O-Methylepivobasinol

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11473	Vitamin D3 receptor	NR1I1	C00001704	2 / 3
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00040643	7 / 3
P06276	Cholinesterase	Hydrolase	C00001704	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00040643	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00040643	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001704	1 / 1
O00255	Menin	Unclassified protein	C00001704	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001704	1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions