Plant Species


Cumulative plant class count

class name count

Cumulative family count

class name count
Aspergillaceae 4

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00002398 External link 512 Griseofulvin
CHEMBL562
CHEMBL1356241
CHEMBL1369825
D006118
112 / 57 / 47 11 / 45
C00018860 External link 512 (+)-5'-Hydroxygriseofulvin
C00043443 External link 512 Dechlorogriseofulvin
CHEMBL1612134
5 / 7 / 3

Human Protein / Gene in interactions

116 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002398 C00043443 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002398 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002398 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00002398 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002398 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002398 2 / 2
P08246 Neutrophil elastase S1A C00002398 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00002398 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002398 0 / 0
P06746 DNA polymerase beta Enzyme C00002398 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002398 0 / 0
P29466 Caspase-1 C14 C00002398 0 / 0
P17252 Protein kinase C alpha type Alpha C00002398 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002398 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002398 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002398 2 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00002398 3 / 2
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002398 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00002398 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002398 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002398 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002398 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002398 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002398 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002398 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002398 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002398 0 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 C00002398 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002398 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002398 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002398 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002398 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002398 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00002398 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002398 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002398 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002398 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002398 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002398 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002398 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002398 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002398 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002398 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002398 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002398 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002398 0 / 0
P42858 Huntingtin Unclassified protein C00002398 1 / 1
O75496 Geminin Unclassified protein C00002398 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002398 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002398 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002398 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002398 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002398 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002398 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002398 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002398 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002398 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002398 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002398 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002398 0 / 0
P08311 Cathepsin G S1A C00002398 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002398 1 / 0
P03956 Interstitial collagenase M10A C00002398 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002398 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00043443 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00002398 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00002398 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002398 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002398 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002398 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002398 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002398 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002398 5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002398 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002398 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002398 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002398 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002398 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002398 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002398 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002398 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002398 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002398 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002398 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002398 2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002398 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002398 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002398 4 / 1
P03372 Estrogen receptor NR3A1 C00002398 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002398 1 / 0
P22303 Acetylcholinesterase Hydrolase C00002398 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002398 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002398 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002398 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002398 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002398 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002398 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002398 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002398 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002398 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002398 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00043443 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00043443 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002398 0 / 0
P10275 Androgen receptor NR3C4 C00002398 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002398 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002398 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002398 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002398 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002398 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002398 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002398 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00043443 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002398 1 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002398 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002398 1 / 0

11 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002398
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002398
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002398
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00002398
2697 GJA1, AVSD3, CMDR, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD gap junction protein, alpha 1, 43kDa C00002398
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002398
3875 KRT18, CYK18, K18 keratin 18 C00002398
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00002398
6402 SELL, CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1 selectin L C00002398
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002398
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002398

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (64)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#609338 Carotid intimal medial thickness 1 P37231
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (50)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

45 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000740 Anemia C00002398
D006528 Carcinoma, Hepatocellular C00002398
D002493 Central Nervous System Diseases C00002398
D002779 Cholestasis C00002398
D002780 Cholestasis, Intrahepatic C00002398
D000013 Congenital Abnormalities C00002398
D003866 Depressive Disorder C00002398
D003881 Dermatomycoses C00002398
D004211 Disseminated Intravascular Coagulation C00002398
D056486 Drug-Induced Liver Injury C00002398
D064420 Drug-Related Side Effects and Adverse Reactions C00002398
D004660 Encephalitis C00002398
D004827 Epilepsy C00002398
D005334 Fever C00002398
D006261 Headache C00002398
D006417 Hematuria C00002398
D006505 Hepatitis C00002398
D006529 Hepatomegaly C00002398
D007249 Inflammation C00002398
D041781 Jaundice, Obstructive C00002398
D007674 Kidney Diseases C00002398
D008103 Liver Cirrhosis C00002398
D008113 Liver Neoplasms C00002398
D008114 Liver Neoplasms, Experimental C00002398
D008180 Lupus Erythematosus, Systemic C00002398
D009080 MUCOCUTANEOUS LYMPH NODE SYNDROME C00002398
D009135 Muscular Diseases C00002398
D009181 Mycoses C00002398
D009220 Myositis C00002398
D009304 Nasopharyngitis C00002398
D009395 Nephritis, Interstitial C00002398
D009404 Nephrotic Syndrome C00002398
D014009 Onychomycosis C00002398
D010292 Paresthesia C00002398
D017094 Porphyrias, Hepatic C00002398
D046351 Protoporphyria, Erythropoietic C00002398
D011605 Psychoses, Substance-Induced C00002398
D011776 Pyuria C00002398
D011928 Raynaud Disease C00002398
D051437 Renal Insufficiency C00002398
D012595 Scleroderma, Systemic C00002398
D013964 Thyroid Neoplasms C00002398
D014005 Tinea C00002398
D014006 Tinea Capitis C00002398
D014008 Tinea Pedis C00002398