PCIDB

KNApSAcK Metabolite C00002398

Metabolite

KNApSAcK Entry

id C00002398
Name Griseofulvin
CAS RN 126-07-8
Standard InChI InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
Standard InChI (Main Layer) InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3

Cluster

Phytochemical cluster
KCF-S cluster No. 3273

Link

ChEMBL

By standard InChI CHEMBL562
By standard InChI Main Layer CHEMBL562 CHEMBL1356241 CHEMBL1369825

KEGG

By LinkDB C06686

CTD

By CAS RN D006118

Human Protein / Gene in interaction

112 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL562 CHEMBL1909136 (2)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL562 CHEMBL1613842 (1)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL562 CHEMBL2114784 (1)
1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL562 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL562 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL562 CHEMBL1794573 (1) CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL562 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL562 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL562 CHEMBL1909201 (2)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL1369825 CHEMBL1614079 (1)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL562 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL562 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL562 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL562 CHEMBL1909199 (2)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL562 CHEMBL1794552 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL562 CHEMBL1909197 (2)
2 / 2
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL562 CHEMBL1356241 CHEMBL1614281 (1) CHEMBL1614361 (2)
3 / 2
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL562 CHEMBL1794371 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL562 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL562 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL562 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL562 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL562 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL562 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL562 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL562 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL562 CHEMBL1909093 (2)
0 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 CHEMBL562 CHEMBL934981 (1)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL562 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL562 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL562 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL562 CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL562 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL562 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL562 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL562 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL562 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL562 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL562 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL562 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL562 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL562 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL562 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL562 CHEMBL1369825 CHEMBL1614458 (4)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL562 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1369825 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL1369825 CHEMBL1613918 (1)
1 / 1
O75496 Geminin Unclassified protein CHEMBL562 CHEMBL1369825 CHEMBL2114843 (4) CHEMBL2114780 (4)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL562 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL562 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL562 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL562 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL562 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL562 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL562 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL562 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL562 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL562 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL562 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL562 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL562 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL562 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL562 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL562 CHEMBL1909119 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1369825 CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL562 CHEMBL1963863 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL562 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL562 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL562 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL562 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL562 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL562 CHEMBL1794510 (1)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL562 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL562 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL562 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL562 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL562 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL562 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL562 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL562 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL562 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL562 CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL562 CHEMBL1369825 CHEMBL1613910 (2) CHEMBL1614227 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL562 CHEMBL1369825 CHEMBL1614038 (3)
2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL562 CHEMBL2114842 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL562 CHEMBL1369825 CHEMBL1738317 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL562 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL562 CHEMBL1794542 (1) CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL562 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL562 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL562 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL562 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL562 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL562 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL562 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL562 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL562 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL562 CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL562 CHEMBL1369825 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL562 CHEMBL1909137 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL562 CHEMBL1369825 CHEMBL1738184 (2) CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL562 CHEMBL1794560 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL562 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL562 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL562 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL562 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL562 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL562 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL562 CHEMBL1909128 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL562 CHEMBL1369825 CHEMBL1613914 (3)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL1369825 CHEMBL1614364 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL562 CHEMBL1369825 CHEMBL2354311 (2)
1 / 0

CTD interaction (23)

compound gene gene name gene description interaction interaction type form reference
pmid
D006118 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Griseofulvin results in increased activity of CASP3 protein increases activity
protein 23329179
D006118 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Griseofulvin results in increased activity of CASP9 protein increases activity
protein 23329179
D006118 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline] affects metabolic processing
/ increases reaction
protein 9029748
D006118 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Griseofulvin results in increased expression of CYP3A4 mRNA increases expression
mRNA 18505790
D006118 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Griseofulvin results in increased expression of CYP3A4 protein increases expression
protein 18505790
D006118 2697 GJA1
AVSD3
CMDR
CX43
DFNB38
GJAL
HLHS1
HSS
ODDD
gap junction protein, alpha 1, 43kDa Griseofulvin results in increased expression of and results in increased localization of GJA1 protein increases expression
/ increases localization
protein 23329179
D006118 2697 GJA1
AVSD3
CMDR
CX43
DFNB38
GJAL
HLHS1
HSS
ODDD
gap junction protein, alpha 1, 43kDa Griseofulvin results in increased expression of GJA1 mRNA increases expression
mRNA 23329179
D006118 3552 IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
interleukin 1, alpha Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11367519
D006118 3875 KRT18
CYK18
K18
keratin 18 Griseofulvin promotes the reaction [KRT18 protein binds to KRT18 protein] affects binding
/ increases reaction
protein 12388748
D006118 3875 KRT18
CYK18
K18
keratin 18 Griseofulvin results in increased expression of KRT18 mRNA increases expression
mRNA 12388748
D006118 3875 KRT18
CYK18
K18
keratin 18 KRT18 protein results in decreased susceptibility to Griseofulvin decreases response to substance
protein 8770877
D006118 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 11367519
D006118 6402 SELL
CD62L
LAM1
LECAM1
LEU8
LNHR
LSEL
LYAM1
PLNHR
TQ1
selectin L Griseofulvin results in decreased expression of SELL protein decreases expression
protein 11367519
D006118 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 11367519
D006118 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 11367519
D006118 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11154858
11367519
D006118 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
protein 11154858
D006118 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] decreases reaction
/ increases expression
protein 11154858
D006118 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11367519
D006118 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 11367519
D006118 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11154858
11367519
D006118 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
mRNA 11154858
D006118 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] decreases reaction
/ increases expression
protein 11154858

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (57)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#609338 Carotid intimal medial thickness 1 P37231
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (47)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

45 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000740 D006118 Anemia marker/mechanism
2237566
D006528 D006118 Carcinoma, Hepatocellular marker/mechanism
4294321
6138303
7285200
D002493 D006118 Central Nervous System Diseases marker/mechanism
4424881
D002779 D006118 Cholestasis marker/mechanism
1751019
6679936
12735108
19043281
D002780 D006118 Cholestasis, Intrahepatic marker/mechanism
131731
D000013 D006118 Congenital Abnormalities marker/mechanism
5768794
D003866 D006118 Depressive Disorder marker/mechanism
19043281
D003881 D006118 Dermatomycoses therapeutic
1967699
D004211 D006118 Disseminated Intravascular Coagulation marker/mechanism
2084866
D056486 D006118 Drug-Induced Liver Injury marker/mechanism
8707270
8770877
10952237
11434612
20643122
D064420 D006118 Drug-Related Side Effects and Adverse Reactions marker/mechanism
8010556
D004660 D006118 Encephalitis marker/mechanism
2084866
D004827 D006118 Epilepsy marker/mechanism
595848
D005334 D006118 Fever marker/mechanism
18378354
D006261 D006118 Headache marker/mechanism
4408278
18378354
D006417 D006118 Hematuria marker/mechanism
2237566
D006505 D006118 Hepatitis marker/mechanism
15446108
D006529 D006118 Hepatomegaly marker/mechanism
15446108
D007249 D006118 Inflammation marker/mechanism
12735108
D041781 D006118 Jaundice, Obstructive marker/mechanism
131731
D007674 D006118 Kidney Diseases marker/mechanism
8323253
D008103 D006118 Liver Cirrhosis marker/mechanism
12735108
D008113 D006118 Liver Neoplasms marker/mechanism
698038
2445643
D008114 D006118 Liver Neoplasms, Experimental marker/mechanism
7214331
11746257
D008180 D006118 Lupus Erythematosus, Systemic marker/mechanism
7577414
D009080 D006118 MUCOCUTANEOUS LYMPH NODE SYNDROME marker/mechanism
8403486
D009135 D006118 Muscular Diseases marker/mechanism
7836265
D009181 D006118 Mycoses therapeutic
1751019
4424881
D009220 D006118 Myositis marker/mechanism
7572547
D009304 D006118 Nasopharyngitis marker/mechanism
18378354
D009395 D006118 Nephritis, Interstitial marker/mechanism
2237566
D009404 D006118 Nephrotic Syndrome marker/mechanism
7577414
D014009 D006118 Onychomycosis therapeutic
8985273
D010292 D006118 Paresthesia marker/mechanism
1967699
D017094 D006118 Porphyrias, Hepatic marker/mechanism
1751019
6679936
19043281
D046351 D006118 Protoporphyria, Erythropoietic marker/mechanism
10215191
11826402
15793285
19267999
D011605 D006118 Psychoses, Substance-Induced marker/mechanism
4408278
D011776 D006118 Pyuria marker/mechanism
2237566
D011928 D006118 Raynaud Disease therapeutic
5414890
D051437 D006118 Renal Insufficiency marker/mechanism
2237566
D012595 D006118 Scleroderma, Systemic therapeutic
4579328
D013964 D006118 Thyroid Neoplasms marker/mechanism
698038
D014005 D006118 Tinea therapeutic
698038
D014006 D006118 Tinea Capitis therapeutic
18378354
D014008 D006118 Tinea Pedis therapeutic
8145958