PCIDB

Penicillium sp.

Species

KNApSAcK Entry

Organism name Penicillium sp.
Genus Penicillium
Family Trichocomaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Penicillium sp.
Linked NCBI taxonomy ID 5081
Linked level species

Family

Family in NCBI taxonomy Aspergillaceae
ID 1131492

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (36)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00026934 External link 512 11'-Deoxyverticillin A
CHEMBL508052
No. 342
C00026933 External link 512 ZH 4B
/ 11,11'-Dideoxyverticillin
/ 11,11'-Dideoxyverticillin A
/ (+)-11,11'-Dideoxyverticillin A
CHEMBL2172426
2 / 0 / 0 No. 342
C00043882 External link 512 Rugulotrosin B
CHEMBL504672
No. 648
C00043881 External link 512 Rugulotrosin A
CHEMBL506738
No. 648
C00011026 External link 512 2-Methylisoborneol
/ 2-endo-Methyl-2-exo-bornanol
/ exo-1,2,7,7-Tetramethylbicyclo[2.2.1]heptan-2-ol
C005536
No. 649 No. 35
C00029607 External link 512 8'-Hydroxyzearalanone
No. 790
C00029458 External link 512 2'-Hydroxyzearalanol
No. 790
C00023739 External link 512 cis-Resorcylide
No. 871
C00016018 External link 512 Dehydrocurvularin
/ Dehydro-curvularin
/ trans-Dehydrocurvularin
/ alpha,beta-Dehydrocurvularin
CHEMBL482050
CHEMBL520014
CHEMBL1643635
C013914
21 / 19 / 20 No. 871
C00023738 External link 512 trans-Resorcylide
No. 871
C00029515 External link 512 p-Tyrosol
/ 4-(2-Hydroxyethyl)phenol
/ p-Hydroxyphenethyl alcohol
/ 2-(4-Hydroxyphenyl)ethanol
CHEMBL53566
C011867
6 / 3 / 5 No. 936 No. 6
C00023956 External link 512 Curvularin
CHEMBL482052
CHEMBL478770
C013455
No. 1108
C00023957 External link 512 11beta-Hydroxycurvularin
CHEMBL520015
CHEMBL516578
CHEMBL476690
No. 1108
C00026692 External link 512 Nomofungin
/ Communesin B
/ (+)-Communesin B
CHEMBL509067
CHEMBL1459705
6 / 4 / 1 No. 1368
C00026688 External link 512 Communesin C
/ (-)-Communesin C
CHEMBL447208
No. 1368
C00026689 External link 512 Communesin D
/ (+)-Communesin D
CHEMBL507587
No. 1368
C00016317 External link 512 NSC 624610
/ Emodic acid
/ 9,10-Dihydro-4,5,7-trihydroxy-9,10-dioxo-2-anthroic acid
CHEMBL290914
32 / 18 / 20 No. 1811 No. 62
C00029505 External link 512 3-Methoxyphenol
/ m-Methoxyphenol
CHEMBL57891
C094702
No. 2352
C00046919 External link 512 Sculezonone B
/ (+)-Sculezonone B
No. 2770
C00046918 External link 512 Sculezonone A
/ (+)-Sculezonone A
No. 2770
C00002398 External link 512 Griseofulvin
CHEMBL562
CHEMBL1356241
CHEMBL1369825
D006118
112 / 57 / 47 11 / 45 No. 3273
C00043443 External link 512 Dechlorogriseofulvin
CHEMBL1612134
5 / 7 / 3 No. 3273
C00023987 External link 512 LL-P880alpha
/ (-)-Pestalotin
No. 3287
C00047766 External link 512 Brevione G
/ (-)-Brevione G
CHEMBL560764
CHEMBL550770
No. 3410
C00047767 External link 512 Brevione H
/ (-)-Brevione H
CHEMBL562991
No. 3410
C00047765 External link 512 Brevione F
/ (+)-Brevione F
CHEMBL560764
CHEMBL550770
No. 3410
C00016956 External link 512 Benzomalvin A
/ (-)-Benzomalvin A
C088520
No. 3779
C00016957 External link 512 Benzomalvin B
C088521
No. 3779
C00016612 External link 512 Benzomalvin C
C088522
No. 3779
C00011266 External link 512 Oxaline
CHEMBL1642246
No. 3803
C00011265 External link 512 Neoxaline
/ Neooxaline
C022264
No. 3803
C00050391 External link 512 Phomopsolide A
CHEMBL508075
CHEMBL511194
No. 5512
C00050392 External link 512 Phomopsolide B
CHEMBL464205
No. 5512
C00046351 External link 512 Ravenic acid
CHEMBL484220
No. 7724
C00044483 External link 512 7-Deacetoxyyanuthone A
No. 8497
C00033776 External link 512 Dimethyl selenide
C013503
No. 8901

Human Protein / Gene in interactions

152 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00002398 C00016018 C00016317 C00026692 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002398 C00016018 C00026692 1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002398 C00016018 C00016317 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00016018 C00016317 C00043443 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00016018 C00016317 C00043443 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00016317 C00026692 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002398 C00016317 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00016317 C00029515 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00016018 C00016317 4 / 3
P08246 Neutrophil elastase S1A C00002398 C00016317 2 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00016317 C00043443 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00016317 C00026692 0 / 0
P06746 DNA polymerase beta Enzyme C00002398 C00016317 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002398 C00043443 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002398 C00016317 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002398 C00016018 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002398 C00016317 2 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00002398 C00016317 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00002398 C00016018 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00016018 C00016317 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00016018 C00026692 0 / 0
P08311 Cathepsin G S1A C00002398 C00016317 0 / 0
O75496 Geminin Unclassified protein C00002398 C00016018 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00016018 C00026692 2 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002398 C00016317 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00002398 C00029515 1 / 2
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002398 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002398 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002398 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002398 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002398 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002398 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002398 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002398 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002398 0 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 C00002398 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002398 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002398 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002398 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002398 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00016317 1 / 0
O43463 Histone-lysine N-methyltransferase SUV39H1 Enzyme C00026933 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002398 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00016018 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00002398 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002398 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002398 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002398 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002398 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002398 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002398 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002398 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002398 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002398 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002398 3 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002398 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002398 0 / 0
P39748 Flap endonuclease 1 Enzyme C00016317 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00016018 0 / 0
P42858 Huntingtin Unclassified protein C00002398 1 / 1
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00016018 1 / 4
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00016317 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00016018 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002398 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002398 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002398 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002398 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002398 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002398 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002398 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002398 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002398 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002398 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002398 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00029515 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002398 0 / 0
Q13547 Histone deacetylase 1 Hydrolase C00016317 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002398 1 / 0
P14780 Matrix metalloproteinase-9 M10A C00002398 2 / 2
P03956 Interstitial collagenase M10A C00002398 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002398 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00043443 7 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002398 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00016317 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002398 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002398 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00016317 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002398 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002398 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002398 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002398 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002398 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002398 5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002398 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002398 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002398 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002398 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002398 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002398 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00029515 2 / 3
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002398 1 / 0
P17252 Protein kinase C alpha type Alpha C00002398 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002398 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002398 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002398 3 / 3
P29466 Caspase-1 C14 C00002398 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00016018 1 / 1
O75030 Microphthalmia-associated transcription factor Unclassified protein C00016018 4 / 4
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002398 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00029515 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002398 0 / 0
P03372 Estrogen receptor NR3A1 C00002398 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002398 1 / 0
P22303 Acetylcholinesterase Hydrolase C00002398 1 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002398 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002398 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002398 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002398 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002398 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002398 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002398 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002398 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00029515 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002398 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002398 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00016018 1 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002398 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00002398 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002398 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002398 0 / 3
P10275 Androgen receptor NR3C4 C00002398 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002398 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002398 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002398 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002398 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002398 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002398 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002398 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002398 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00016317 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00016317 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026933 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002398 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002398 4 / 1
O00255 Menin Unclassified protein C00016317 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00016317 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00016317 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00016317 1 / 4
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00016317 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00016018 0 / 3
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00016317 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00016018 1 / 1

11 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002398
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002398
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002398
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00002398
2697 GJA1, AVSD3, CMDR, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD gap junction protein, alpha 1, 43kDa C00002398
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002398
3875 KRT18, CYK18, K18 keratin 18 C00002398
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00002398
6402 SELL, CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1 selectin L C00002398
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002398
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002398

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (89)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness O75030
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
Q14191
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#174800 Mccune-albright syndrome; mas P63092
#614456 Melanoma, cutaneous malignant, susceptibility to, 8; cmm8 O75030
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#103500 Tietz syndrome O75030
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#193510 Waardenburg syndrome, type 2a; ws2a O75030
#277700 Werner syndrome; wrn Q14191
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (80)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00038 Malignant melanoma O75030 (related)
O75030 (marker)
H00169 Ocular albinism O75030 (related)
H00759 Waardenburg syndrome (WS) O75030 (related)
H01187 Tietz syndrome O75030 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P08581 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P08581 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00021 Renal cell carcinoma P08581 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

45 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000740 Anemia C00002398
D006528 Carcinoma, Hepatocellular C00002398
D002493 Central Nervous System Diseases C00002398
D002779 Cholestasis C00002398
D002780 Cholestasis, Intrahepatic C00002398
D000013 Congenital Abnormalities C00002398
D003866 Depressive Disorder C00002398
D003881 Dermatomycoses C00002398
D004211 Disseminated Intravascular Coagulation C00002398
D056486 Drug-Induced Liver Injury C00002398
D064420 Drug-Related Side Effects and Adverse Reactions C00002398
D004660 Encephalitis C00002398
D004827 Epilepsy C00002398
D005334 Fever C00002398
D006261 Headache C00002398
D006417 Hematuria C00002398
D006505 Hepatitis C00002398
D006529 Hepatomegaly C00002398
D007249 Inflammation C00002398
D041781 Jaundice, Obstructive C00002398
D007674 Kidney Diseases C00002398
D008103 Liver Cirrhosis C00002398
D008113 Liver Neoplasms C00002398
D008114 Liver Neoplasms, Experimental C00002398
D008180 Lupus Erythematosus, Systemic C00002398
D009080 MUCOCUTANEOUS LYMPH NODE SYNDROME C00002398
D009135 Muscular Diseases C00002398
D009181 Mycoses C00002398
D009220 Myositis C00002398
D009304 Nasopharyngitis C00002398
D009395 Nephritis, Interstitial C00002398
D009404 Nephrotic Syndrome C00002398
D014009 Onychomycosis C00002398
D010292 Paresthesia C00002398
D017094 Porphyrias, Hepatic C00002398
D046351 Protoporphyria, Erythropoietic C00002398
D011605 Psychoses, Substance-Induced C00002398
D011776 Pyuria C00002398
D011928 Raynaud Disease C00002398
D051437 Renal Insufficiency C00002398
D012595 Scleroderma, Systemic C00002398
D013964 Thyroid Neoplasms C00002398
D014005 Tinea C00002398
D014006 Tinea Capitis C00002398
D014008 Tinea Pedis C00002398