KCF-S cluster No. 3357 (3 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	2

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Cumulative family count

class name	count
Aspergillaceae	2
Enterobacteriaceae	2
Streptomycetaceae	1
Flavobacteriaceae	1
Pseudonocardiaceae	1
Brassicaceae	1
Xanthomonadaceae	1
Fabaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000779	delta-(L-a-Aminoadipyl)-L-cysteinyl-D-valine	CHEMBL418100 CHEMBL70421 CHEMBL2115474
C00001518	L-Glutathione	CHEMBL100476 CHEMBL1543 CHEMBL1514919	D005978	12 / 17 / 16	119 / 45
C00019550	S-Lactoylglutathione / (R)-S-Lactoylglutathione	CHEMBL1966820	C013585

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P33527	Multidrug resistance-associated protein 1	drugs	C00001518	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001518	11 / 10
P00918	Carbonic anhydrase 2	Lyase	C00001518	1 / 2
O75496	Geminin	Unclassified protein	C00001518	0 / 0
O15439	Multidrug resistance-associated protein 4	Unclassified protein	C00001518	0 / 0
Q9Y2Q3	Glutathione S-transferase kappa 1	Enzyme	C00001518	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00001518	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001518	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001518	4 / 3
Q04760	Lactoylglutathione lyase	Enzyme	C00001518	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001518	0 / 0
Q96QA9	Multidrug resistance associated protein	Unclassified protein	C00001518	0 / 0

119 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00001518
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00001518
8714	ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	C00001518
10257	ABCC4, EST170205, MOAT-B, MOATB, MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	C00001518
10057	ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	C00001518
368	ABCC6, ABC34, ARA, EST349056, GACI2, MLP1, MOAT-E, MOATE, MRP6, PXE, PXE1, URG7	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	C00001518
128	ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284)	C00001518
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00001518
8574	AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11)	C00001518
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00001518
57412	AS3MT, CYT19	arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137)	C00001518
581	BAX, BCL2L4	BCL2-associated X protein	C00001518
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00001518
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00001518
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00001518
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00001518
648	BMI1, FLVI2/BMI1, PCGF4, RNF51	BMI1 polycomb ring finger oncogene	C00001518
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001518
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00001518
6364	CCL20, CKb4, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38	chemokine (C-C motif) ligand 20	C00001518
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00001518
942	CD86, B7-2, B7.2, B70, CD28LG2, LAB72	CD86 molecule	C00001518
994	CDC25B	cell division cycle 25B (EC:3.1.3.48)	C00001518
995	CDC25C, CDC25, PPP1R60	cell division cycle 25C (EC:3.1.3.48)	C00001518
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00001518
1270	CNTF, HCNTF	ciliary neurotrophic factor	C00001518
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00001518
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00001518
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00001518
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00001518
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00001518
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00001518
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00001518
1673	DEFB4A, BD-2, DEFB-2, DEFB102, DEFB2, DEFB4, HBD-2, SAP1	defensin, beta 4A	C00001518
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00001518
2056	EPO, EP, MVCD2	erythropoietin	C00001518
14103			C00001518
2495	FTH1, FHC, FTH, FTHL6, PIG15, PLIF	ferritin, heavy polypeptide 1 (EC:1.16.3.1)	C00001518
2534	FYN, SLK, SYN, p59-FYN	FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)	C00001518
2597	GAPDH, G3PD, GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	C00001518
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00001518
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00001518
2745	GLRX, GRX, GRX1	glutaredoxin (thioltransferase) (EC:1.8.4.1)	C00001518
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00001518
2937	GSS, GSHS	glutathione synthetase (EC:6.3.2.3)	C00001518
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00001518
2939	GSTA2, GST2, GSTA2-2, GTA2, GTH2	glutathione S-transferase alpha 2 (EC:2.5.1.18)	C00001518
2940	GSTA3, GSTA3-3, GTA3	glutathione S-transferase alpha 3 (EC:2.5.1.18)	C00001518
2941	GSTA4, GSTA4-4, GTA4	glutathione S-transferase alpha 4 (EC:2.5.1.18)	C00001518
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00001518
2946	GSTM2, GST4, GSTM, GSTM2-2, GTHMUS	glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18)	C00001518
2947	GSTM3, GST5, GSTB, GSTM3-3, GTM3	glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)	C00001518
2948	GSTM4, GSTM4-4, GTM4	glutathione S-transferase mu 4 (EC:2.5.1.18)	C00001518
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00001518
2952	GSTT1	glutathione S-transferase theta 1 (EC:2.5.1.18)	C00001518
2954	GSTZ1, GSTZ1-1, MAAI, MAI	glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2)	C00001518
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00001518
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00001518
3265	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1	Harvey rat sarcoma viral oncogene homolog	C00001518
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00001518
3458	IFNG, IFG, IFI	interferon, gamma	C00001518
3586	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF	interleukin 10	C00001518
3596	IL13, IL-13, P600	interleukin 13	C00001518
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00001518
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00001518
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00001518
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001518
3684	ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6	integrin, alpha M (complement component 3 receptor 3 subunit)	C00001518
9817	KEAP1, INrf2, KLHL19	kelch-like ECH-associated protein 1	C00001518
9314	KLF4, EZF, GKLF	Kruppel-like factor 4 (gut)	C00001518
3932	LCK, LSK, YT16, p56lck, pp58lck	lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)	C00001518
4067	LYN, JTK8, p53Lyn, p56Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2)	C00001518
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001518
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001518
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00001518
4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	C00001518
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00001518
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00001518
4353	MPO	myeloperoxidase (EC:1.11.2.2)	C00001518
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00001518
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00001518
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00001518
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00001518
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00001518
11315	PARK7, DJ-1, DJ1	parkinson protein 7	C00001518
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00001518
5163	PDK1	pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)	C00001518
5444	PON1, ESA, MVCD5, PON	paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	C00001518
5446	PON3	paraoxonase 3 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	C00001518
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00001518
5580	PRKCD, MAY1, PKCD, nPKC-delta	protein kinase C, delta (EC:2.7.10.2 2.7.11.13)	C00001518
10544	PROCR, CCCA, CCD41, EPCR	protein C receptor, endothelial	C00001518
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00001518
5757	PTMA, TMSA	prothymosin, alpha	C00001518
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00001518
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001518
55312	RFK, RIFK	riboflavin kinase (EC:2.7.1.26)	C00001518
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00001518
6415	SEPW1, selW	selenoprotein W, 1	C00001518
9356	SLC22A6, HOAT1, OAT1, PAHT, ROAT1	solute carrier family 22 (organic anion transporter), member 6	C00001518
29986	SLC39A2, 6A1, ETI-1, ZIP-2, ZIP2	solute carrier family 39 (zinc transporter), member 2	C00001518
6520	SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE	solute carrier family 3 (amino acid transporter heavy chain), member 2	C00001518
23657	SLC7A11, CCBR1, xCT	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	C00001518
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00001518
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00001518
6667	SP1	Sp1 transcription factor	C00001518
6670	SP3, SPR2	Sp3 transcription factor	C00001518
6671	SP4, HF1B, SPR-1	Sp4 transcription factor	C00001518
6772	STAT1, CANDF7, ISGF-3, STAT91	signal transducer and activator of transcription 1, 91kDa	C00001518
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00001518
7097	TLR2, CD282, TIL4	toll-like receptor 2	C00001518
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00001518
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001518
8795	TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	C00001518
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001518
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00001518
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00001518
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00001518
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00001518

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions