PCIDB

KNApSAcK Metabolite C00001518

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00001518
Name	L-Glutathione
CAS RN	70-18-8
Standard InChI	InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
Standard InChI (Main Layer)	InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)

Cluster

Phytochemical cluster
KCF-S cluster	No. 3357

Link

ChEMBL

By standard InChI	CHEMBL1543
By standard InChI Main Layer	CHEMBL100476 CHEMBL1543 CHEMBL1514919

KEGG

By LinkDB	C00051

CTD

By CAS RN	D005978

Species

Summary

Plant class

class name	count
rosids	2

Family

family name	count
Brassicaceae	1
Enterobacteriaceae	1
Fabaceae	1

List (3)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Arabidopsis thaliana	3702	Brassicaceae	rosids	Viridiplantae
Escherichia coli	562	Enterobacteriaceae		Bacteria
Vicia faba	3906	Fabaceae	rosids	Viridiplantae

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
P33527	Multidrug resistance-associated protein 1	drugs	CHEMBL1543	CHEMBL1004850 (1) CHEMBL957857 (1) CHEMBL2078376 (1)	0 / 0
P02545	Prelamin-A/C	Unclassified protein	CHEMBL1514919	CHEMBL1614544 (1)	11 / 10
P00918	Carbonic anhydrase 2	Lyase	CHEMBL1543	CHEMBL1220461 (1)	1 / 2
O75496	Geminin	Unclassified protein	CHEMBL100476	CHEMBL2114780 (1)	0 / 0
O15439	Multidrug resistance-associated protein 4	Unclassified protein	CHEMBL1543	CHEMBL2077907 (1)	0 / 0
Q9Y2Q3	Glutathione S-transferase kappa 1	Enzyme	CHEMBL1543	CHEMBL686166 (1)	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	CHEMBL1543	CHEMBL1006005 (1) CHEMBL2076882 (1) CHEMBL2077632 (1) CHEMBL2075113 (1)	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	CHEMBL1514919	CHEMBL1614240 (1)	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	CHEMBL1514919	CHEMBL1614250 (1) CHEMBL1614421 (1)	4 / 3
Q04760	Lactoylglutathione lyase	Enzyme	CHEMBL1543	CHEMBL684310 (1)	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	CHEMBL1514919	CHEMBL1613914 (1)	0 / 0
Q96QA9	Multidrug resistance associated protein	Unclassified protein	CHEMBL1543	CHEMBL2076877 (1)	0 / 0

CTD interaction (337)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	ABCC1 protein affects the export of Glutathione	affects export	protein	15498506
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione]	affects reaction / increases transport	protein	21856323
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]	affects cotreatment / affects transport	protein	15161912
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	ABCC1 protein affects the transport of Glutathione	affects transport	protein	11278867
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	ABCC1 protein affects the transport of Glutathione analog	affects transport	protein	20584751
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	ABCC1 protein results in increased export of Glutathione	increases export	protein	12504668
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]	increases export / increases reaction	protein	12504668
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]	decreases abundance / decreases reaction / decreases response to substance		21918036
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]	decreases abundance / decreases reaction / decreases response to substance		21918036
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]	decreases reaction / increases reaction / increases transport		21918036
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]	decreases reaction / increases export / increases reaction	protein	12504668
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione affects the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]	affects reaction / increases secretion	protein	12018890
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione affects the reaction [ABCC1 protein results in increased secretion of arsenic trioxide]	affects reaction / increases secretion	protein	12018890
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione binds to and affects the folding of and affects the activity of ABCC1 protein	affects activity / affects binding / affects folding	protein	15579473
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]	decreases reaction / increases reaction / increases transport		21918036
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]	affects export / increases reaction	protein	15766272
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]	affects transport / increases reaction	protein	15245331
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]	increases reaction / increases transport		21918036
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Glutathione results in increased stability of and results in decreased degradation of and affects the localization of ABCC1 protein mutant form	affects localization / decreases degradation / increases stability	protein	15581632
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]	affects export / increases reaction	protein	15498506
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]	affects export / increases reaction	protein	15498506
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]	affects transport / increases reaction	protein	11278867
D005978	4363	ABCC1 ABC29 ABCC GS-X MRP MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]	decreases reaction / increases reaction / increases transport		21918036
D005978	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione]	affects cotreatment / affects transport	protein	16049127
D005978	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	ABCC2 protein affects the transport of Glutathione analog	affects transport	protein	20584751
D005978	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate]	affects export / increases reaction	protein	16002050
D005978	8714	ABCC3 ABC31 EST90757 MLP2 MOAT-D MRP3 cMOAT2	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione]	affects reaction / increases transport	protein	21856323
D005978	8714	ABCC3 ABC31 EST90757 MLP2 MOAT-D MRP3 cMOAT2	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]	affects transport / increases reaction	protein	15210835
D005978	10257	ABCC4 EST170205 MOAT-B MOATB MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	ABCC4 protein affects the transport of Glutathione analog	affects transport	protein	20584751
D005978	10257	ABCC4 EST170205 MOAT-B MOATB MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM]	affects transport / increases reaction	protein	15210835
D005978	10057	ABCC5 ABC33 EST277145 MOAT-C MOATC MRP5 SMRP pABC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]	affects reaction / increases transport	protein	21856323
D005978	10057	ABCC5 ABC33 EST277145 MOAT-C MOATC MRP5 SMRP pABC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	ABCC5 protein affects the transport of Glutathione analog	affects transport	protein	20584751
D005978	368	ABCC6 ABC34 ARA EST349056 GACI2 MLP1 MOAT-E MOATE MRP6 PXE PXE1 URG7	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM]	affects transport / increases reaction	protein	15210835
D005978	128	ADH5 ADH-3 ADHX FALDH FDH GSH-FDH GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284)	Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]	decreases reaction / increases reduction	protein	19428350
D005978	231	AKR1B1 ADR ALDR1 ALR2 AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	AKR1B1 protein binds to Glutathione	affects binding	protein	11306073
D005978	231	AKR1B1 ADR ALDR1 ALR2 AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	Glutathione results in increased glutathionylation of AKR1B1 protein modified form	increases glutathionylation	protein	19061876
D005978	231	AKR1B1 ADR ALDR1 ALR2 AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	Glutathione results in increased reduction of AKR1B1 protein modified form	increases reduction	protein	19061876
D005978	8574	AKR7A2 AFAR AFAR1 AFB1-AR1 AKR7	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11)	AKR7A2 protein inhibits the reaction [Vitamin K 3 results in decreased abundance of Glutathione]	decreases abundance / decreases reaction	protein	22001351
D005978	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]	decreases reaction / increases activity / increases phosphorylation	protein	17640567
D005978	57412	AS3MT CYT19	arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137)	Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]	increases chemical synthesis / increases metabolic processing / increases reaction	protein	22868225
D005978	581	BAX BCL2L4	BCL2-associated X protein	Glutathione results in increased expression of BAX protein	increases expression	protein	10897038
D005978	581	BAX BCL2L4	BCL2-associated X protein	[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein	affects localization / decreases abundance / increases abundance	protein	21621595
D005978	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	598	BCL2L1 BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS	BCL2-like 1	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]	decreases reaction / increases expression	protein	17640567
D005978	329	BIRC2 API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1	baculoviral IAP repeat containing 2	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	330	BIRC3 AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2	baculoviral IAP repeat containing 3	Glutathione inhibits the reaction [Thimerosal results in decreased expression of BIRC3 protein]	decreases expression / decreases reaction	protein	12140745
D005978	648	BMI1 FLVI2/BMI1 PCGF4 RNF51	BMI1 polycomb ring finger oncogene	BMI1 protein results in increased abundance of Glutathione	increases abundance	protein	21445297
D005978	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]	decreases reaction / increases activity	protein	14660655
D005978	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Glutathione inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]	decreases reaction / increases activity	protein	21300145
D005978	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]	decreases reaction / increases activity	protein	17640567
D005978	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP3 protein]	decreases reaction / increases activity	protein	12140745
D005978	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein	decreases abundance / increases abundance / increases activity	protein	21621595
D005978	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]	affects activity / affects reaction	protein	18594523
D005978	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP9 protein]	decreases reaction / increases activity	protein	12140745
D005978	6364	CCL20 CKb4 LARC MIP-3-alpha MIP-3a MIP3A SCYA20 ST38	chemokine (C-C motif) ligand 20	Glutathione results in decreased expression of CCL20 mRNA	decreases expression	mRNA	22385246
D005978	595	CCND1 BCL1 D11S287E PRAD1 U21B31	cyclin D1	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]	decreases reaction / increases expression	protein	17640567
D005978	942	CD86 B7-2 B7.2 B70 CD28LG2 LAB72	CD86 molecule	Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	decreases reaction / increases expression	protein	20457211
D005978	942	CD86 B7-2 B7.2 B70 CD28LG2 LAB72	CD86 molecule	Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	decreases reaction / increases expression	protein	20457211
D005978	942	CD86 B7-2 B7.2 B70 CD28LG2 LAB72	CD86 molecule	Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	decreases reaction / increases expression	protein	20457211
D005978	994	CDC25B	cell division cycle 25B (EC:3.1.3.48)	[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate	affects cotreatment / increases reduction	protein	20025242
D005978	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate	affects cotreatment / increases reduction	protein	20025242
D005978	1080	CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]	decreases activity / decreases reaction	protein	15657297
D005978	1080	CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein]	decreases activity / decreases reaction	protein	15657297
D005978	1080	CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	Glutathione analog results in decreased activity of CFTR protein	decreases activity	protein	15657297
D005978	1080	CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	[Glutathione co-treated with Diamide] results in decreased activity of CFTR protein	affects cotreatment / decreases activity	protein	15857825
D005978	1270	CNTF HCNTF	ciliary neurotrophic factor	Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]	decreases reaction / increases phosphorylation	protein	16896058
D005978	1270	CNTF HCNTF	ciliary neurotrophic factor	Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]	decreases reaction / increases phosphorylation	protein	16896058
D005978	54205	CYCS CYC HCS THC4	cytochrome c, somatic	[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein	affects localization / decreases abundance / increases abundance	protein	21621595
D005978	1544	CYP1A2 CP12 P3-450 P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	[CYP1A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine	affects cotreatment / increases activity / increases glutathionylation	protein	20825217
D005978	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	14679015
D005978	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	14679015
D005978	1565	CYP2D6 CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	[CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine	affects cotreatment / increases activity / increases glutathionylation	protein	20825217
D005978	1571	CYP2E1 CPE1 CYP2E P450-J P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	[CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione	decreases abundance / increases metabolic processing	protein	10573527
D005978	1571	CYP2E1 CPE1 CYP2E P450-J P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]	decreases reaction / increases response to substance	protein	16872732
D005978	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	[CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine	affects cotreatment / increases activity / increases glutathionylation	protein	20825217
D005978	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol]	affects binding / affects reaction	protein	18206979
D005978	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]	affects reaction / increases oxidation	protein	18206979
D005978	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline]	affects reaction / increases oxidation	protein	18206979
D005978	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	Glutathione binds to CYP3A4 protein	affects binding	protein	18206979
D005978	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein]	decreases activity / decreases reaction	protein	15523003
D005978	1649	DDIT3 CEBPZ CHOP CHOP-10 CHOP10 GADD153	DNA-damage-inducible transcript 3	Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]	decreases reaction / increases expression	mRNA	17171638
D005978	1649	DDIT3 CEBPZ CHOP CHOP-10 CHOP10 GADD153	DNA-damage-inducible transcript 3	Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]	decreases reaction / increases expression	protein	17171638
D005978	1649	DDIT3 CEBPZ CHOP CHOP-10 CHOP10 GADD153	DNA-damage-inducible transcript 3	Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of DDIT3 mRNA]	decreases reaction / increases expression	mRNA	17171638
D005978	1649	DDIT3 CEBPZ CHOP CHOP-10 CHOP10 GADD153	DNA-damage-inducible transcript 3	Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]	decreases reaction / increases expression	mRNA	17171638
D005978	1673	DEFB4A BD-2 DEFB-2 DEFB102 DEFB2 DEFB4 HBD-2 SAP1	defensin, beta 4A	Glutathione results in decreased expression of DEFB4A mRNA	decreases expression	mRNA	22385246
D005978	1956	EGFR ERBB ERBB1 HER1 PIG61 mENA	epidermal growth factor receptor (EC:2.7.10.1)	Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein]	decreases reaction / increases phosphorylation	protein	14660655
D005978	2056	EPO EP MVCD2	erythropoietin	EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione]	decreases abundance / decreases reaction	protein	22013135
D005978	14103			FASL protein results in decreased abundance of Glutathione	decreases abundance	protein	17724027
D005978	14103			verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione]	decreases abundance / increases reaction	protein	17724027
D005978	2495	FTH1 FHC FTH FTHL6 PIG15 PLIF	ferritin, heavy polypeptide 1 (EC:1.16.3.1)	Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA]	decreases reaction / increases expression	mRNA	16631525
D005978	2534	FYN SLK SYN p59-FYN	FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)	Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	decreases reaction / increases phosphorylation	protein	14572611
D005978	2534	FYN SLK SYN p59-FYN	FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)	Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	decreases reaction / increases phosphorylation	protein	14572611
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]	affects cotreatment / decreases reaction / increases reduction	protein	15788719
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]	affects cotreatment / decreases reaction / increases reduction	protein	15788719
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]	affects binding / decreases abundance / increases reaction	protein	21827172
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]	decreases abundance / decreases activity / increases reaction	protein	21827172
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog	affects cotreatment / increases reduction	protein	15788719
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	Glutathione results in increased metabolism of and results in increased activity of GAPDH protein modified form	increases activity / increases metabolic processing	protein	21827172
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]	affects cotreatment / decreases reaction / increases reduction	protein	15788719
D005978	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]	affects cotreatment / decreases reaction / increases reduction	protein	15788719
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	GCLC polymorphism affects the chemical synthesis of Glutathione	affects chemical synthesis	polymorphism	16599007
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]	decreases reaction / increases export / increases reaction	protein	12504668
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	GCLC results in increased abundance of Glutathione	increases abundance		18556457
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	[GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride	decreases response to substance / increases abundance		18556457
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	[Ginkgo biloba extract 761 results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione	increases chemical synthesis / increases expression	protein	11673643
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	increases abundance / increases activity / increases expression	protein	21728338
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione	increases abundance / increases activity / increases expression	protein	21728338
D005978	2729	GCLC GCL GCS GLCL GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	[KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione	increases abundance / increases expression	mRNA	21833590
D005978	2730	GCLM GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	GCLM gene SNP results in decreased chemical synthesis of and results in decreased abundance of Glutathione	decreases abundance / decreases chemical synthesis	gene	12975258
D005978	2745	GLRX GRX GRX1	glutaredoxin (thioltransferase) (EC:1.8.4.1)	[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate	affects cotreatment / increases reduction	protein	20025242
D005978	2745	GLRX GRX GRX1	glutaredoxin (thioltransferase) (EC:1.8.4.1)	[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate	affects cotreatment / increases reduction	protein	20025242
D005978	2936	GSR	glutathione reductase (EC:1.8.1.7)	[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate	affects cotreatment / increases reduction	protein	20025242
D005978	2936	GSR	glutathione reductase (EC:1.8.1.7)	[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate	affects cotreatment / increases reduction	protein	20025242
D005978	2937	GSS GSHS	glutathione synthetase (EC:6.3.2.3)	[Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione	increases chemical synthesis / increases expression	protein	18487201
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]	affects cotreatment / affects metabolic processing / decreases activity	protein	11849043
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]	affects cotreatment / affects metabolic processing / decreases activity	protein	11849043
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	10437668
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	11115505
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	12516103
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	14690442
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of Glutathione	affects metabolic processing	protein	8886613 9084911
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	11368548
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	7712478
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	affects binding / affects cotreatment / affects metabolic processing	protein	12147362
D005978	2938	GSTA1 GST2 GSTA1-1 GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]	decreases abundance / decreases reaction	protein	16890185
D005978	2939	GSTA2 GST2 GSTA2-2 GTA2 GTH2	glutathione S-transferase alpha 2 (EC:2.5.1.18)	GSTA2 protein affects the metabolism of Glutathione	affects metabolic processing	protein	9084911
D005978	2940	GSTA3 GSTA3-3 GTA3	glutathione S-transferase alpha 3 (EC:2.5.1.18)	GSTA3 protein binds to and affects the metabolism of Glutathione	affects binding / affects metabolic processing	protein	15454730 15595823
D005978	2941	GSTA4 GSTA4-4 GTA4	glutathione S-transferase alpha 4 (EC:2.5.1.18)	GSTA4 protein affects the metabolism of Glutathione	affects metabolic processing	protein	14727915
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of [1,2,5,6-dibenzanthracene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	14979731
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]	affects cotreatment / affects metabolic processing / decreases activity	protein	11849043
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]	affects cotreatment / affects metabolic processing / decreases activity	protein	11849043
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of [Benzo(a)pyrene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of [chrysene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of Glutathione	affects metabolic processing	protein	7826396 8886613 9084911 9545290
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	11368548
D005978	2944	GSTM1 GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	[GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione	affects cotreatment / decreases abundance	protein	21925487
D005978	2946	GSTM2 GST4 GSTM GSTM2-2 GTHMUS	glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18)	GSTM2 protein affects the metabolism of Glutathione	affects metabolic processing	protein	10858281
D005978	2947	GSTM3 GST5 GSTB GSTM3-3 GTM3	glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)	GSTM3 protein affects the metabolism of Glutathione	affects metabolic processing	protein	9545290
D005978	2948	GSTM4 GSTM4-4 GTM4	glutathione S-transferase mu 4 (EC:2.5.1.18)	GSTM4 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	8203914
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	Glutathione analog results in decreased activity of GSTP1 protein	decreases activity	protein	13679171
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]	affects metabolic processing / affects reaction	gene	10334868
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [4-oxo-2-nonenal co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	15528046
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	12470677
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [acrylodan co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	12470677
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]	affects cotreatment / affects metabolic processing / decreases activity	protein	11849043
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]	affects cotreatment / affects metabolic processing / decreases activity	protein	11849043
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	15115887
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [benzo(c)chrysene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [benzo(c)phenanthrene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [benzo(g)chrysene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	9403173
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of Glutathione	affects metabolic processing	protein	7826396 8886613
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	11368548
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	7712478
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	[GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]	affects cotreatment / decreases reaction / increases activity	protein	11196146
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	[GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]	affects cotreatment / decreases reaction / increases abundance / increases metabolic processing	protein	11196146
D005978	2950	GSTP1 DFN7 FAEES3 GST3 GSTP PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	GSTP1 protein promotes the reaction [Glutathione binds to Atrazine]	affects binding / increases reaction	protein	18607078
D005978	2952	GSTT1	glutathione S-transferase theta 1 (EC:2.5.1.18)	GSTT1 protein affects the metabolism of Glutathione	affects metabolic processing	protein	14727918
D005978	2952	GSTT1	glutathione S-transferase theta 1 (EC:2.5.1.18)	GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]	affects cotreatment / affects metabolic processing	protein	15533900
D005978	2954	GSTZ1 GSTZ1-1 MAAI MAI	glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2)	Glutathione binds to GSTZ1 protein	affects binding	protein	9396740 11327815 15173170
D005978	2954	GSTZ1 GSTZ1-1 MAAI MAI	glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2)	GSTZ1 protein affects the metabolism of Glutathione	affects metabolic processing	protein	1846734
D005978	2954	GSTZ1 GSTZ1-1 MAAI MAI	glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2)	GSTZ1 protein binds to and affects the metabolism of Glutathione	affects binding / affects metabolic processing	protein	12852784
D005978	3091	HIF1A HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]	decreases reaction / increases expression	protein	17658243
D005978	3091	HIF1A HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Glutathione inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]	decreases reaction / increases expression	protein	11641398
D005978	3091	HIF1A HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein]	decreases reaction / increases expression	protein	16678800
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]	decreases abundance / decreases reaction / increases expression	mRNA	21971136
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	[Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]	decreases reaction / increases abundance / increases expression	mRNA	20020861
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA	decreases abundance / increases expression	mRNA	21971136
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]	decreases abundance / decreases reaction / increases expression	protein	15602829
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	[dimethyl fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein	decreases abundance / increases expression	protein	20961405
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione affects the expression of HMOX1 mRNA	affects expression	mRNA	8743975
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]	decreases reaction / increases expression	mRNA	16631525
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]	decreases reaction / increases expression	mRNA	20934533
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione inhibits the reaction [dimethyl fumarate results in increased expression of HMOX1 protein]	decreases reaction / increases expression	protein	20961405
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]	decreases reaction / increases expression	mRNA	20934533
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]	decreases reaction / increases expression	protein	20934533
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]	decreases reaction / increases expression	mRNA	18332044
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glutathione inhibits the reaction [Raloxifene results in increased expression of HMOX1 mRNA]	decreases reaction / increases expression	mRNA	20888885
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]	decreases abundance / decreases reaction / increases expression	mRNA	21971136
D005978	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]	decreases abundance / decreases reaction / increases expression	protein	15602829
D005978	3265	HRAS C-BAS/HAS C-H-RAS C-HA-RAS1 CTLO H-RASIDX HAMSV HRAS1 K-RAS N-RAS RASH1	Harvey rat sarcoma viral oncogene homolog	Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene]	affects cotreatment / increases cleavage / increases reaction	gene	9345283
D005978	3265	HRAS C-BAS/HAS C-H-RAS C-HA-RAS1 CTLO H-RASIDX HAMSV HRAS1 K-RAS N-RAS RASH1	Harvey rat sarcoma viral oncogene homolog	[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene	affects cotreatment / increases cleavage	gene	9345283
D005978	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	[Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]	affects cotreatment / decreases reaction / increases expression	protein	20351055
D005978	3458	IFNG IFG IFI	interferon, gamma	Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]	decreases reaction / increases phosphorylation	protein	16896058
D005978	3458	IFNG IFG IFI	interferon, gamma	Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]]	decreases reaction / increases secretion	protein	17079650
D005978	3458	IFNG IFG IFI	interferon, gamma	[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein	decreases abundance / decreases secretion	protein	18214930
D005978	3586	IL10 CSIF GVHDS IL-10 IL10A TGIF	interleukin 10	[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein	decreases abundance / decreases secretion	protein	18214930
D005978	3596	IL13 IL-13 P600	interleukin 13	Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein]	affects cotreatment / decreases reaction / increases secretion	protein	17079650
D005978	3596	IL13 IL-13 P600	interleukin 13	[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein	decreases abundance / decreases secretion	protein	18214930
D005978	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Glutathione results in decreased expression of IL1B mRNA	decreases expression	mRNA	22385246
D005978	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	IL1B protein results in increased abundance of Glutathione	increases abundance	protein	10802230
D005978	3565	IL4 BCGF-1 BCGF1 BSF-1 BSF1 IL-4	interleukin 4	[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein	decreases abundance / decreases secretion	protein	18214930
D005978	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Glutathione analog promotes the reaction [Ozone results in increased expression of IL6 protein]	increases expression / increases reaction	protein	15379216
D005978	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]	decreases reaction / increases secretion	protein	17079650
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione analog inhibits the reaction [Ozone results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	15379216
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	20457211
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	20457211
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [lactacystin results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [MG 262 results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [Thimerosal results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	20457211
D005978	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione results in decreased expression of IL8 mRNA	decreases expression	mRNA	22385246
D005978	3684	ITGAM CD11B CR3A MAC-1 MAC1A MO1A SLEB6	integrin, alpha M (complement component 3 receptor 3 subunit)	Glutathione inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]	decreases reaction / increases expression	mRNA	16357311
D005978	9817	KEAP1 INrf2 KLHL19	kelch-like ECH-associated protein 1	Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]	decreases reaction / increases abundance / increases activity	gene	19608619
D005978	9817	KEAP1 INrf2 KLHL19	kelch-like ECH-associated protein 1	[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione	increases abundance / increases activity	gene	19608619
D005978	9817	KEAP1 INrf2 KLHL19	kelch-like ECH-associated protein 1	[Plant Extracts results in decreased expression of KEAP1 protein] which results in increased chemical synthesis of Glutathione	decreases expression / increases chemical synthesis	protein	21972102
D005978	9314	KLF4 EZF GKLF	Kruppel-like factor 4 (gut)	KLF4 results in increased abundance of Glutathione	increases abundance		21833590
D005978	9314	KLF4 EZF GKLF	Kruppel-like factor 4 (gut)	[KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione	increases abundance / increases expression		21833590
D005978	3932	LCK LSK YT16 p56lck pp58lck	lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)	Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]	decreases reaction / increases phosphorylation	protein	14572611
D005978	3932	LCK LSK YT16 p56lck pp58lck	lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)	Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein]	decreases reaction / increases phosphorylation	protein	14572611
D005978	4067	LYN JTK8 p53Lyn p56Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2)	Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]	decreases reaction / increases phosphorylation	protein	14572611
D005978	4067	LYN JTK8 p53Lyn p56Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2)	Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]	decreases reaction / increases phosphorylation	protein	14572611
D005978	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein	decreases abundance / increases phosphorylation	protein	21971136
D005978	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]	decreases activity / decreases reaction	protein	23370007
D005978	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein	decreases abundance / increases phosphorylation	protein	21971136
D005978	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	Glutathione deficiency promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein]	increases activity / increases reaction	protein	16112521
D005978	4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin]	affects reaction / increases response to substance	protein	16039682
D005978	4313	MMP2 CLG4 CLG4A MMP-II MONA TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	Glutathione results in decreased secretion of MMP2 protein	decreases secretion	protein	15147517
D005978	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	Glutathione binds to MMP9 protein	affects binding	protein	17015178
D005978	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	Glutathione inhibits the reaction [4-aminophenylmercuriacetate results in increased activity of MMP9 protein]	decreases reaction / increases activity	protein	17015178
D005978	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]	decreases reaction / increases expression	protein	17640567
D005978	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	Glutathione results in decreased secretion of MMP9 protein	decreases secretion	protein	15147517
D005978	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein]	affects binding / decreases reaction	protein	17015178
D005978	4353	MPO	myeloperoxidase (EC:1.11.2.2)	Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]	affects cotreatment / decreases reaction / increases oxidation	protein	19462961
D005978	4353	MPO	myeloperoxidase (EC:1.11.2.2)	Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]	affects cotreatment / decreases reaction / increases oxidation	protein	19462961
D005978	4609	MYC MRTL MYCC bHLHe39 c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	MYC protein affects the abundance of Glutathione	affects abundance	protein	12226097
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]	affects localization / decreases abundance / decreases reaction	protein	21971136
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]	decreases reaction / increases abundance / increases activity		19608619
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein	affects localization / decreases abundance	protein	21971136
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein	increases abundance / increases activity	protein	21728338
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein	increases abundance / increases activity / increases expression	protein	21728338
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione	increases abundance / increases activity / increases expression	protein	21728338
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]	affects localization / decreases reaction	protein	16631525
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione	increases abundance / increases activity		19608619
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	NFE2L2 gene mutant form results in decreased abundance of Glutathione	decreases abundance	gene	19608619
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	NFE2L2 protein affects the abundance of Glutathione	affects abundance	protein	20124447
D005978	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	NFE2L2 protein affects the reaction [Silver results in increased abundance of Glutathione]	affects reaction / increases abundance	protein	22546375
D005978	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]	decreases reaction / increases activity	protein	16219905
D005978	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]	affects binding / decreases reaction / increases activity	protein	17640567
D005978	4843	NOS2 HEP-NOS INOS NOS NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	1728	NQO1 DHQU DIA4 DTD NMOR1 NMORI QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]	decreases abundance / decreases reaction / increases expression	mRNA	21971136
D005978	1728	NQO1 DHQU DIA4 DTD NMOR1 NMORI QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA	decreases abundance / increases expression	mRNA	21971136
D005978	1728	NQO1 DHQU DIA4 DTD NMOR1 NMORI QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]	decreases abundance / decreases reaction	protein	21034357
D005978	1728	NQO1 DHQU DIA4 DTD NMOR1 NMORI QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]	decreases abundance / increases reaction	protein	21034357
D005978	1728	NQO1 DHQU DIA4 DTD NMOR1 NMORI QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]	decreases abundance / decreases reaction / increases expression	mRNA	21971136
D005978	11315	PARK7 DJ-1 DJ1	parkinson protein 7	PARK7 protein results in increased abundance of Glutathione	increases abundance	protein	18331584
D005978	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	Glutathione deficiency promotes the reaction [antimony trioxide results in increased cleavage of PARP1 protein]	increases cleavage / increases reaction	protein	16112521
D005978	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased cleavage of PARP1 protein]	decreases reaction / increases cleavage	protein	14660655
D005978	5163	PDK1	pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)	Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]	decreases reaction / increases phosphorylation	protein	17171638
D005978	5444	PON1 ESA MVCD5 PON	paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	PON1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione]	decreases abundance / decreases reaction	protein	20079818
D005978	5446	PON3	paraoxonase 3 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	PON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione]	decreases abundance / decreases reaction	protein	20079818
D005978	10891	PPARGC1A LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Glutathione analog results in increased expression of PPARGC1A mRNA	increases expression	mRNA	23056435
D005978	5580	PRKCD MAY1 PKCD nPKC-delta	protein kinase C, delta (EC:2.7.10.2 2.7.11.13)	Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of PRKCD protein]	decreases reaction / increases phosphorylation	protein	15707588
D005978	5580	PRKCD MAY1 PKCD nPKC-delta	protein kinase C, delta (EC:2.7.10.2 2.7.11.13)	Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]	decreases reaction / increases phosphorylation	protein	17171638
D005978	10544	PROCR CCCA CCD41 EPCR	protein C receptor, endothelial	Glutathione inhibits the reaction [Doxorubicin results in decreased expression of PROCR protein]	decreases expression / decreases reaction	protein	17172434
D005978	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	5757	PTMA TMSA	prothymosin, alpha	PTMA protein alternative form results in increased abundance of Glutathione	increases abundance	protein	19442654
D005978	5925	RB1 OSRC RB p105-Rb pRb pp110	retinoblastoma 1	Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein]	decreases expression / decreases reaction	protein	11139434
D005978	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]	decreases abundance / decreases reaction / increases glutathionylation	protein	20351055
D005978	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	[cinnamic aldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein	increases abundance / increases glutathionylation	protein	20351055
D005978	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	[Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]	affects cotreatment / affects localization / decreases reaction	protein	20351055
D005978	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	[Glutathione co-treated with Hydrogen Peroxide] results in increased glutathionylation of RELA protein	affects cotreatment / increases glutathionylation	protein	20351055
D005978	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]	affects binding / decreases reaction / increases activity	protein	17640567
D005978	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]	decreases reaction / increases activity	protein	16219905
D005978	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glutathione results in increased glutathionylation of RELA protein	increases glutathionylation	protein	20116392 20351055
D005978	55312	RFK RIFK	riboflavin kinase (EC:2.7.1.26)	RFK protein results in increased abundance of Glutathione	increases abundance	protein	21308351
D005978	6401	SELE CD62E ELAM ELAM1 ESEL LECAM2	selectin E	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]	decreases abundance / decreases reaction / increases expression	mRNA	21971136
D005978	6415	SEPW1 selW	selenoprotein W, 1	Glutathione deficiency promotes the reaction [Methylmercury Compounds results in decreased expression of SEPW1 mRNA]	decreases expression / increases reaction	mRNA	15823556
D005978	9356	SLC22A6 HOAT1 OAT1 PAHT ROAT1	solute carrier family 22 (organic anion transporter), member 6	SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Glutathione]	affects cotreatment / increases response to substance	protein	12606766
D005978	29986	SLC39A2 6A1 ETI-1 ZIP-2 ZIP2	solute carrier family 39 (zinc transporter), member 2	[SLC39A2 protein co-treated with zinc chloride] results in increased abundance of Glutathione	affects cotreatment / increases abundance	protein	18385089
D005978	6520	SLC3A2 4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE	solute carrier family 3 (amino acid transporter heavy chain), member 2	[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione	affects cotreatment / increases abundance / increases activity / increases uptake	protein	22216172
D005978	6520	SLC3A2 4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE	solute carrier family 3 (amino acid transporter heavy chain), member 2	[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide	affects cotreatment / decreases response to substance / increases abundance / increases activity / increases uptake	protein	22216172
D005978	23657	SLC7A11 CCBR1 xCT	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione	affects cotreatment / increases abundance / increases activity / increases uptake	protein	22216172
D005978	23657	SLC7A11 CCBR1 xCT	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide	affects cotreatment / decreases response to substance / increases abundance / increases activity / increases uptake	protein	22216172
D005978	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]	decreases expression / increases reaction	mRNA	16101137
D005978	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]	affects activity / affects reaction	protein	18594523
D005978	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]	affects reaction / decreases response to substance	protein	18594523
D005978	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]	affects reaction / decreases response to substance	protein	18594523
D005978	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]	decreases expression / increases reaction	mRNA	16101137
D005978	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein results in increased abundance of Glutathione	increases abundance	protein	15130278
D005978	6667	SP1	Sp1 transcription factor	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]	decreases expression / decreases reaction	protein	20435036
D005978	6667	SP1	Sp1 transcription factor	Glutathione results in decreased expression of SP1	decreases expression		18556457
D005978	6670	SP3 SPR2	Sp3 transcription factor	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein]	decreases expression / decreases reaction	protein	20435036
D005978	6671	SP4 HF1B SPR-1	Sp4 transcription factor	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP4 protein]	decreases expression / decreases reaction	protein	20435036
D005978	6772	STAT1 CANDF7 ISGF-3 STAT91	signal transducer and activator of transcription 1, 91kDa	Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]	decreases reaction / increases phosphorylation	protein	16896058
D005978	6772	STAT1 CANDF7 ISGF-3 STAT91	signal transducer and activator of transcription 1, 91kDa	Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]	decreases reaction / increases phosphorylation	protein	16896058
D005978	6774	STAT3 APRF HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]	decreases reaction / increases phosphorylation	protein	16896058
D005978	7097	TLR2 CD282 TIL4	toll-like receptor 2	Glutathione results in decreased expression of TLR2 mRNA	decreases expression	mRNA	22385246
D005978	7099	TLR4 ARMD10 CD284 TLR-4 TOLL	toll-like receptor 4	Glutathione results in decreased expression of TLR4 mRNA	decreases expression	mRNA	22385246
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]	decreases abundance / decreases reaction / decreases response to substance	protein	21971136
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]	decreases abundance / decreases reaction / increases expression	protein	21971136
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]	decreases abundance / decreases reaction / increases expression	protein	21971136
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]	affects cotreatment / decreases abundance / decreases reaction / increases expression	protein	16271621
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein	decreases abundance / decreases response to substance	protein	21971136
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]	affects cotreatment / affects localization / decreases reaction	protein	20351055
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]	affects cotreatment / decreases reaction / increases expression	protein	20351055
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]	decreases reaction / increases activity	protein	16219905
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]	affects binding / decreases reaction / increases activity	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]	decreases reaction / increases activity	protein	16219905
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]	decreases reaction / increases expression	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]	decreases reaction / increases expression	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]	decreases reaction / increases expression	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]	decreases reaction / increases expression	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]	decreases reaction / increases activity / increases phosphorylation	protein	17640567
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]	decreases reaction / increases secretion	protein	17079650
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glutathione results in decreased expression of TNF mRNA	decreases expression	mRNA	22385246
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]	decreases abundance / decreases reaction / increases expression	protein	21971136
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]	decreases abundance / decreases reaction / increases expression	protein	21971136
D005978	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	TNF protein results in increased abundance of Glutathione	increases abundance	protein	10802230
D005978	8795	TNFRSF10B CD262 DR5 KILLER KILLER/DR5 TRAIL-R2 TRAILR2 TRICK2 TRICK2A TRICK2B TRICKB ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	Glutathione inhibits the reaction [rosiglitazone results in increased expression of TNFRSF10B protein]	decreases reaction / increases expression	protein	18164688
D005978	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]	decreases abundance / decreases reaction / increases activity	protein	12807757
D005978	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein]	decreases reaction / increases glutathionylation	protein	17555331
D005978	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]	decreases reaction / increases expression	protein	19202565
D005978	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	Glutathione results in increased expression of TP53 protein	increases expression	protein	10897038
D005978	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	Glutathione results in increased glutathionylation of TP53 protein	increases glutathionylation	protein	17555331
D005978	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	TP53 protein results in decreased abundance of Glutathione	decreases abundance	protein	12967322
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester]	decreases reaction / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]	decreases reaction / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]	decreases reaction / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione	affects abundance / affects response to substance	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione	decreases abundance / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione	decreases abundance / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein results in increased oxidation of 4-coumaric acid] which results in decreased abundance of Glutathione	decreases abundance / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione	decreases abundance / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione	decreases abundance / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione	decreases abundance / increases oxidation	protein	20685355
D005978	7299	TYR ATN CMM8 OCA1 OCA1A OCAIA SHEP3	tyrosinase (EC:1.14.18.1)	[TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione	decreases abundance / increases oxidation	protein	20685355
D005978	7412	VCAM1 CD106 INCAM-100	vascular cell adhesion molecule 1	[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]	decreases abundance / decreases reaction / increases expression	mRNA	21971136
D005978	7412	VCAM1 CD106 INCAM-100	vascular cell adhesion molecule 1	[[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]	affects cotreatment / decreases abundance / decreases reaction / increases expression	protein	16271621
D005978	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	Glutathione inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]	decreases reaction / increases expression	mRNA	11641398
D005978	331	XIAP API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3	X-linked inhibitor of apoptosis	Glutathione inhibits the reaction [Thimerosal results in decreased expression of XIAP protein]	decreases expression / decreases reaction	protein	12140745

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM	preferred title	UniProt
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#237500	Dubin-johnson syndrome; djs	Q92887
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#600274	Frontotemporal dementia; ftd	P10636
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#259730	Osteopetrosis, autosomal recessive 3; optb3	P00918
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#275210	Restrictive dermopathy, lethal	P02545
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636

KEGG DISEASE (16)

KEGG	disease name	UniProt
H00241	Combined proximal and distal renal tubular acidosis (RTA type 3)	P00918 (related)
H00436	Osteopetrosis	P00918 (related)
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00208	Hyperbilirubinemia	Q92887 (related)

Diseases related to CTD interactions

45 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D009008	D005978	Abnormalities, Severe Teratoid	therapeutic	20566340
D058186	D005978	Acute Kidney Injury	marker/mechanism	10729747
D000647	D005978	Amnesia	marker/mechanism	14643852
D001321	D005978	Autistic Disorder	marker/mechanism	16917939 18929414 19056591 19267885
D002294	D005978	Carcinoma, Squamous Cell	therapeutic	17015178
D009202	D005978	Cardiomyopathies	marker/mechanism therapeutic	1914080 2074045
D002779	D005978	Cholestasis	marker/mechanism	8377599
D003072	D005978	Cognition Disorders	marker/mechanism	11212865 18208924 18343489 19464315
D003550	D005978	Cystic Fibrosis	therapeutic	19747007
D003556	D005978	Cystitis	therapeutic	16708234
D003877	D005978	Dermatitis, Contact	therapeutic	21722719
D017719	D005978	Diabetic Foot	marker/mechanism	11983006
D056486	D005978	Drug-Induced Liver Injury	marker/mechanism therapeutic	17584759 22310181
D064420	D005978	Drug-Related Side Effects and Adverse Reactions	therapeutic	8746330
D004487	D005978	Edema	marker/mechanism	19874808
D005076	D005978	Exanthema	marker/mechanism	8377599
D005199	D005978	Fanconi Anemia	marker/mechanism	22628295
D005234	D005978	Fatty Liver	marker/mechanism	10860543
D005334	D005978	Fever	marker/mechanism	8377599
D005767	D005978	Gastrointestinal Diseases	marker/mechanism	9199886
D006331	D005978	Heart Diseases	therapeutic	10887039
D006417	D005978	Hematuria	therapeutic	2773078
D006461	D005978	Hemolysis	marker/mechanism therapeutic	7745221 18983990
D006470	D005978	Hemorrhage	therapeutic	16708234
D020138	D005978	HYPERHOMOCYSTEINEMIA	marker/mechanism	20413874
D006973	D005978	Hypertension	therapeutic	9201603 9880127
D006975	D005978	Hypertension, Portal	marker/mechanism	8377599 15962377
D006980	D005978	Hyperthyroidism	marker/mechanism	19914224
D007565	D005978	Jaundice	marker/mechanism	8377599
D007674	D005978	Kidney Diseases	therapeutic	1724173 2344991 18536492
D008105	D005978	Liver Cirrhosis, Biliary	marker/mechanism	8377599
D008106	D005978	Liver Cirrhosis, Experimental	marker/mechanism	15962377
D008113	D005978	Liver Neoplasms	therapeutic	7852184
D008569	D005978	Memory Disorders	marker/mechanism	20871768
D008630	D005978	Mercury Poisoning	therapeutic	18536492
D008708	D005978	Methemoglobinemia	therapeutic	1308751
D009069	D005978	Movement Disorders	therapeutic	20833709
D009336	D005978	Necrosis	marker/mechanism	10753958
D009422	D005978	Nervous System Diseases	therapeutic	19287306
D020258	D005978	Neurotoxicity Syndromes	therapeutic	20696200
D010051	D005978	Ovarian Neoplasms	therapeutic	1336008
D010523	D005978	Peripheral Nervous System Diseases	marker/mechanism	1336008
D012640	D005978	Seizures	marker/mechanism therapeutic	2892286 19798568 19800361 20592767 21620807
D013226	D005978	Status Epilepticus	marker/mechanism	15752349
D001745	D005978	Urinary Bladder Diseases	marker/mechanism therapeutic	2773078 7548731

KNApSAcK Metabolite C00001518

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (3)

* NCBI

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

CTD interaction (337)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

KEGG DISEASE (16)

Diseases related to CTD interactions

45 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases