KCF-S cluster No. 401 (19 metabolites)

Corresponding Phytochemical cluster No. 41

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (19)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	24

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Cumulative family count

class name	count
Thymelaeaceae	19
Euphorbiaceae	5

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Daphnanes	8
Others	1

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metabolites link (9)

br08003 Category	KEGG ID	KNApSAcK ID
Daphnanes	C09095	C00003430
Daphnanes	C09096	C00003431
Daphnanes	C09101	C00003432
Daphnanes	C09102	C00003433
Daphnanes	C09108	C00003435
Daphnanes	C09134	C00003454
Others	C09135	C00003455
Daphnanes	C09185	C00003482
Daphnanes	C09198	C00003490

Metabolite list (19)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003430	Gnidicin	CHEMBL49689 CHEMBL2023370	C010459
C00003431	Gnididin		C010460
C00003432	Gnididilatin	CHEMBL454006
C00003433	Gniditrin	CHEMBL1159653	C010461
C00003435	Huratoxin	CHEMBL470375 CHEMBL1978920	C044222
C00003454	Mezerein	CHEMBL126750 CHEMBL1468786 CHEMBL2007127	C011309	14 / 16 / 11	4 / 3
C00003455	Montanin	CHEMBL451572	C024716
C00003482	Simplexin	CHEMBL444290	C011110
C00003490	Terpenoid EA-I	CHEMBL453030 CHEMBL447856
C00039258	Genkwadaphnin / (+)-Genkwadaphnin		C036412
C00039283	Gnidilatidin	CHEMBL504425	C048261
C00044232	Mellerin B / (+)-Mellerin B
C00047057	Kirkinine / (+)-Kirkinine	CHEMBL502037
C00047922	Hirsein A / (+)-Hirsein A	CHEMBL553900
C00047923	Hirsein B	CHEMBL562784
C00049027	Wikstroelide A / (+)-Wikstroelide A	CHEMBL499462
C00049028	Wikstroelide B / (+)-Wikstroelide B
C00049032	Wikstroelide H / (+)-Wikstroelide H
C00049035	Wikstroelide L / (+)-Wikstroelide L	CHEMBL499462

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q99700	Ataxin-2	Unclassified protein	C00003454	1 / 1
P37840	Alpha-synuclein	Unclassified protein	C00003454	4 / 2
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00003454	2 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003454	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00003454	7 / 3
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00003454	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003454	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00003454	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00003454	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003454	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003454	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003454	1 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00003454	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00003454	0 / 3

4 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00003454
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00003454
5579	PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2	protein kinase C, beta (EC:2.7.11.13)	C00003454
5582	PRKCG, PKC-gamma, PKCC, PKCG, SCA14	protein kinase C, gamma (EC:2.7.11.13)	C00003454

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions