PCIDB

KNApSAcK Metabolite C00003454

Metabolite

KNApSAcK Entry

id C00003454
Name Mezerein
CAS RN 34807-41-5
Standard InChI InChI=1S/C38H38O10/c1-21(2)36-30(44-27(40)18-12-11-15-24-13-7-5-8-14-24)23(4)37-26-19-22(3)29(41)35(26,43)33(42)34(20-39)31(45-34)28(37)32(36)46-38(47-36,48-37)25-16-9-6-10-17-25/h5-19,23,26,28,30-33,39,42-43H,1,20H2,2-4H3/b15-11+,18-12+/t23-,26-,28+,30-,31+,32-,33-,34+,35-,36+,37+,38?/m1/s1
Standard InChI (Main Layer) InChI=1S/C38H38O10/c1-21(2)36-30(44-27(40)18-12-11-15-24-13-7-5-8-14-24)23(4)37-26-19-22(3)29(41)35(26,43)33(42)34(20-39)31(45-34)28(37)32(36)46-38(47-36,48-37)25-16-9-6-10-17-25/h5-19,23,26,28,30-33,39,42-43H,1,20H2,2-4H3

Cluster

Phytochemical cluster No. 41
KCF-S cluster No. 401

Link

ChEMBL

By standard InChI CHEMBL126750
By standard InChI Main Layer CHEMBL126750 CHEMBL1468786 CHEMBL2007127

KEGG

By LinkDB C09134

CTD

By CAS RN C011309

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Thymelaeaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Daphne mezereum 66680 Thymelaeaceae rosids Viridiplantae

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL1468786 CHEMBL2114784 (1)
1 / 1
P37840 Alpha-synuclein Unclassified protein CHEMBL1468786 CHEMBL2354282 (1)
4 / 2
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1468786 CHEMBL1794495 (1)
2 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL1468786 CHEMBL2114788 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1468786 CHEMBL2114810 (1)
7 / 3
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL126750 CHEMBL1468786 CHEMBL1963893 (2)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL126750 CHEMBL2114827 (1) CHEMBL2114929 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1468786 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL126750 CHEMBL1614211 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1468786 CHEMBL1738184 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL126750 CHEMBL1614364 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1468786 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL1468786 CHEMBL1963966 (1)
0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein CHEMBL1468786 CHEMBL2114913 (1)
0 / 3

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C011309 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) 3-aminobenzamide inhibits the reaction [mezerein results in increased activity of PARP1 protein] decreases reaction
/ increases activity
protein 2120135
C011309 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) mezerein results in increased activity of PARP1 protein increases activity
protein 2120135
2126186
C011309 5578 PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
protein kinase C, alpha (EC:2.7.11.13) [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein affects cotreatment
/ decreases expression
protein 8892972
C011309 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein affects cotreatment
/ decreases expression
protein 8892972
C011309 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form affects cotreatment
/ decreases expression
protein 8892972
C011309 5582 PRKCG
PKC-gamma
PKCC
PKCG
SCA14
protein kinase C, gamma (EC:2.7.11.13) [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein affects cotreatment
/ decreases expression
protein 8892972

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#127750 Dementia, lewy body; dlb P37840
#137800 Glioma susceptibility 1; glm1 O75874
#174800 Mccune-albright syndrome; mas P63092
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (11)

KEGG disease name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002471 C011309 Cell Transformation, Neoplastic marker/mechanism
8243401
D010212 C011309 Papilloma marker/mechanism
12065085
D012878 C011309 Skin Neoplasms marker/mechanism
3098411
12065085