Daphne mezereum

• Index
• Plant Species
• Natural Activity
• Metabolite list (6)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Daphne mezereum
Genus	Daphne
Family	Thymelaeaceae
Kingdom	Plantae

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Daphne mezereum
Linked NCBI taxonomy ID	66680
Linked level	species

Family

Family in NCBI taxonomy	Thymelaeaceae
ID	39987

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Natural Activity

List (12)

Species	Activity
Daphne mezereum L.	Abortifacient
Daphne mezereum L.	Alterative
Daphne mezereum L.	Antiaggregant
Daphne mezereum L.	Antitumor
Daphne mezereum L.	Diaphoretic
Daphne mezereum L.	Diuretic
Daphne mezereum L.	Hallucinogen
Daphne mezereum L.	Immunostimulant
Daphne mezereum L.	Laxative
Daphne mezereum L.	Rubefacient
Daphne mezereum L.	Stimulant
Daphne mezereum L.	toxic

Metabolite list (6)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00007190	(+)-Pinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862	C103298	7 / 5 / 6		No. 38	No. 21
C00002631	(+)-Lirioresinol B / (+)-Syringaresinol	CHEMBL361362 CHEMBL402653	C042192	1 / 0 / 0		No. 38	No. 21
C00003454	Mezerein	CHEMBL126750 CHEMBL1468786 CHEMBL2007127	C011309	14 / 16 / 11	4 / 3	No. 401	No. 41
C00000602	(+)-Lariciresinol	CHEMBL518421		2 / 1 / 1		No. 700	No. 21
C00002463	Daphnoretin	CHEMBL508494	C035316	14 / 11 / 10		No. 1906	No. 25
C00003420	Daphnetoxin	CHEMBL2023369	C452759			No. 5420	No. 41

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003454 C00007190	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002463 C00003454	1 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002463 C00003454	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000602 C00002463	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002463	3 / 3
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00007190	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002463	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00003454	4 / 2
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00002463	1 / 0
P11387	DNA topoisomerase 1	Isomerase	C00002631	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002463	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00003454	2 / 2
O75496	Geminin	Unclassified protein	C00002463	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003454	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00003454	7 / 3
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00003454	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00007190	5 / 3
P06746	DNA polymerase beta	Enzyme	C00002463	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002463	2 / 2
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000602	1 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00007190	0 / 3
Q9UNA4	DNA polymerase iota	Enzyme	C00002463	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00003454	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00007190	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002463	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003454	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00007190	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002463	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002463	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00003454	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003454	1 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00003454	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00003454	0 / 3
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00007190	0 / 0

4 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00003454
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00003454
5579	PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2	protein kinase C, beta (EC:2.7.11.13)	C00003454
5582	PRKCG, PKC-gamma, PKCC, PKCG, SCA14	protein kinase C, gamma (EC:2.7.11.13)	C00003454

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions