KCF-S cluster No. 403 (19 metabolites)

Corresponding Phytochemical cluster No. 51

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (19)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	45

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Cumulative family count

class name	count
Celastraceae	45

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Dammarenes	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Dammarenes	C08633	C00003753
Dammarenes	C08638	C00003759

Metabolite list (19)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003753	Pristimerin	CHEMBL54804 CHEMBL227090 CHEMBL1486063	C009043	13 / 21 / 47
C00003759	Maytenin / Tingenone	CHEMBL432519	C009492	1 / 4 / 2	0 / 1
C00024086	15alpha,22beta-Dihydroxytingenone
C00024088	Salaciquinone
C00029919	Celastrol	CHEMBL301982 CHEMBL1321090 CHEMBL1712082	C050414	46 / 43 / 67	100 / 0
C00035476	22beta-Hydroxymaytenin	CHEMBL402975 CHEMBL454076 CHEMBL1651343 CHEMBL1999709	C066185
C00040072	Pristimerine	CHEMBL494862
C00040796	20,21alpha-Dihydroxy-22-oxo-21-desoxotingenone
C00040797	20,22beta-Dihydroxytingenone / (-)-20,22beta-Dihydroxytingenone
C00040798	20-Hydroxy-22-oxo-20-epi-tingenone / (-)-20-Hydroxy-22-oxo-20-epi-tingenone
C00040799	20-Hydroxy-22-oxotingenone
C00040800	20-Hydroxytingenone	CHEMBL487800 CHEMBL1651342
C00040801	20-Oxo-20,21-seco-tingen-21-oic acid
C00040802	20-Oxo-21-nor-20,21-seco-tingen-22-al
C00042072	20-epi-Isoiguesterinol	CHEMBL480292 CHEMBL495863
C00042632	Isoiguesterin	CHEMBL454064
C00045054	Salaquinone A / (+)-Salaquinone A
C00049109	Amazoquinone / (-)-Amazoquinone	CHEMBL517612		1 / 0 / 0
C00050124	Isoiguesterol

Human Protein / Gene in interactions

48 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00003753 C00029919	2 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00003753 C00029919	7 / 37
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00003753 C00029919	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00003753 C00029919	4 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00003753 C00029919	4 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003753 C00029919	0 / 1
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00003759 C00029919	4 / 2
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00003753 C00029919	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00003753 C00029919	2 / 2
P28482	Mitogen-activated protein kinase 1	Erk	C00003753 C00029919	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003753 C00029919	2 / 3
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00003753 C00029919	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003753 C00029919	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00029919	0 / 0
P11413	Glucose-6-phosphate 1-dehydrogenase	Enzyme	C00029919	1 / 2
Q00613	Heat shock factor protein 1	Unclassified protein	C00029919	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00029919	2 / 0
O75496	Geminin	Unclassified protein	C00029919	0 / 0
P15121	Aldose reductase	Enzyme	C00049109	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00029919	0 / 0
P51684	C-C chemokine receptor type 6	CC chemokine receptor	C00029919	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00029919	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00029919	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00029919	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00029919	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00029919	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00029919	4 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00029919	3 / 3
Q16543	Hsp90 co-chaperone Cdc37	Unclassified protein	C00029919	0 / 0
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00029919	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00029919	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00029919	2 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00029919	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00029919	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00029919	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00029919	0 / 0
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00029919	0 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00029919	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00029919	0 / 0
Q9NR96	Toll-like receptor 9	Toll-like and Il-1 receptors	C00029919	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003753	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00029919	1 / 0
O00255	Menin	Unclassified protein	C00029919	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00029919	1 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00029919	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00029919	0 / 3
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00029919	2 / 1
Q06710	Paired box protein Pax-8	Unclassified protein	C00029919	1 / 2

100 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
10598	AHSA1, AHA1, C14orf3, p38	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	C00029919
1645	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	C00029919
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00029919
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00029919
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00029919
84159	ARID5B, DESRT, MRF-2, MRF2	AT rich interactive domain 5B (MRF1-like)	C00029919
467	ATF3	activating transcription factor 3	C00029919
9531	BAG3, BAG-3, BIS, CAIR-1, MFM6	BCL2-associated athanogene 3	C00029919
581	BAX, BCL2L4	BCL2-associated X protein	C00029919
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00029919
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00029919
694	BTG1	B-cell translocation gene 1, anti-proliferative	C00029919
8209	C21orf33, ES1, GT335, HES1, KNPH, KNPI	chromosome 21 open reading frame 33	C00029919
27101	CACYBP, GIG5, RP1-102G20.6, S100A6BP, SIP	calcyclin binding protein	C00029919
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00029919
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00029919
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00029919
831	CAST, BS-17	calpastatin	C00029919
874	CBR3, SDR21C2, hCBR3	carbonyl reductase 3 (EC:1.1.1.184)	C00029919
8317	CDC7, CDC7L1, HsCDC7, Hsk1, huCDC7	cell division cycle 7 (EC:2.7.11.1)	C00029919
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00029919
26973	CHORDC1, CHP1	cysteine and histidine-rich domain (CHORD) containing 1	C00029919
10370	CITED2, ASD8, MRG-1, MRG1, P35SRJ, VSD2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	C00029919
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00029919
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00029919
54541	DDIT4, Dig2, REDD-1, REDD1	DNA-damage-inducible transcript 4	C00029919
3301	DNAJA1, DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2	DnaJ (Hsp40) homolog, subfamily A, member 1	C00029919
11080	DNAJB4, DNAJW, DjB4, HLJ1	DnaJ (Hsp40) homolog, subfamily B, member 4	C00029919
1948	EFNB2, EPLG5, HTKL, Htk-L, LERK5	ephrin-B2	C00029919
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00029919
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00029919
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00029919
11153	FICD, HIP13, HYPE, UNQ3041	FIC domain containing (EC:2.7.7.n1)	C00029919
2322	FLT3, CD135, FLK-2, FLK2, STK1	fms-related tyrosine kinase 3 (EC:2.7.10.1)	C00029919
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00029919
9518	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB	growth differentiation factor 15	C00029919
54676	GTPBP2	GTP binding protein 2	C00029919
29923	HILPDA, C7orf68, HIG-2, HIG2	hypoxia inducible lipid droplet-associated	C00029919
3157	HMGCS1, HMGCS	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10)	C00029919
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00029919
3320	HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	C00029919
3303	HSPA1A, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1	heat shock 70kDa protein 1A	C00029919
3304	HSPA1B, HSP70-1B, HSP70-2	heat shock 70kDa protein 1B	C00029919
3309	HSPA5, BIP, GRP78, MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	C00029919
10808	HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25	heat shock 105kDa/110kDa protein 1	C00029919
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00029919
3458	IFNG, IFG, IFI	interferon, gamma	C00029919
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00029919
3557	IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4	interleukin 1 receptor antagonist	C00029919
3638	INSIG1, CL-6, CL6	insulin induced gene 1	C00029919
182	JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1	jagged 1	C00029919
3781	KCNN2, KCa2.2, SK2, SKCA2, SKCa_2, hSK2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	C00029919
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00029919
23175	LPIN1, PAP1	lipin 1 (EC:3.1.3.4)	C00029919
26046	LTN1, C21orf10, C21orf98, RNF160, ZNF294	listerin E3 ubiquitin protein ligase 1	C00029919
9935	MAFB, KRML, MCTO	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B	C00029919
4191	MDH2, M-MDH, MDH, MGC:3559, MOR1	malate dehydrogenase 2, NAD (mitochondrial) (EC:1.1.1.37)	C00029919
4199	ME1, HUMNDME, MES	malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40)	C00029919
4335	MNT, MAD6, MXD6, ROX, bHLHd3	MAX network transcriptional repressor	C00029919
29074	MRPL18, L18mt, MRP-L18	mitochondrial ribosomal protein L18	C00029919
2956	MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160	mutS homolog 6	C00029919
6307	MSMO1, DESP4, ERG25, SC4MOL	methylsterol monooxygenase 1 (EC:1.14.13.72)	C00029919
23077	MYCBP2, PAM	MYC binding protein 2, E3 ubiquitin protein ligase	C00029919
55892	MYNN, OSZF, ZBTB31, ZNF902	myoneurin	C00029919
4683	NBN, AT-V1, AT-V2, ATV, NBS, NBS1, P95	nibrin	C00029919
4824	NKX3-1, BAPX2, NKX3, NKX3.1, NKX3A	NK3 homeobox 1	C00029919
9315	NREP, C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17	neuronal regeneration related protein	C00029919
4986	OPRK1, K-OR-1, KOR, KOR-1, OPRK	opioid receptor, kappa 1	C00029919
51526	OSER1, C20orf111, HSPC207, Osr1, Perit1, dJ1183I21.1	oxidative stress responsive serine-rich 1	C00029919
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00029919
5152	PDE9A, HSPDE9A2	phosphodiesterase 9A (EC:3.1.4.35)	C00029919
5293	PIK3CD, P110DELTA, PI3K, p110D	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (EC:2.7.1.153)	C00029919
5295	PIK3R1, AGM7, GRB1, p85, p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	C00029919
10105	PPIF, CYP3, CyP-M, Cyp-D, CypD	peptidylprolyl isomerase F (EC:5.2.1.8)	C00029919
5813	PURA, PUR-ALPHA, PUR1, PURALPHA	purine-rich element binding protein A	C00029919
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00029919
6241	RRM2, R2, RR2, RR2M	ribonucleotide reductase M2 (EC:1.17.4.1)	C00029919
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00029919
27230	SERP1, RAMP4	stress-associated endoplasmic reticulum protein 1	C00029919
27244	SESN1, PA26, SEST1	sestrin 1	C00029919
6520	SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE	solute carrier family 3 (amino acid transporter heavy chain), member 2	C00029919
23657	SLC7A11, CCBR1, xCT	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	C00029919
79811	SLTM, Met	SAFB-like, transcription modulator	C00029919
6659	SOX4, EVI16	SRY (sex determining region Y)-box 4	C00029919
100380807			C00029919
10963	STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L	stress-induced-phosphoprotein 1	C00029919
51347	TAOK3, DPK, JIK, MAP3K18	TAO kinase 3 (EC:2.7.11.1)	C00029919
7113	TMPRSS2, PP9284, PRSS10	transmembrane protease, serine 2 (EC:3.4.21.-)	C00029919
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00029919
8797	TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1	tumor necrosis factor receptor superfamily, member 10a	C00029919
8795	TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	C00029919
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00029919
10628	TXNIP, EST01027, HHCPA78, THIF, VDUP1	thioredoxin interacting protein	C00029919
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00029919
7320	UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2	ubiquitin-conjugating enzyme E2B (EC:6.3.2.19)	C00029919
7358	UGDH, GDH, UDP-GlcDH, UDPGDH, UGD	UDP-glucose 6-dehydrogenase (EC:1.1.1.22)	C00029919
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00029919
79084	WDR77, MEP-50, MEP50, Nbla10071, RP11-552M11.3, p44, p44/Mep50	WD repeat domain 77	C00029919
23099	ZBTB43, ZBTB22B, ZNF-X, ZNF297B	zinc finger and BTB domain containing 43	C00029919
80149	ZC3H12A, MCPIP, MCPIP1, RP3-423B22.1, dJ423B22.1	zinc finger CCCH-type containing 12A	C00029919

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions