PCIDB

KNApSAcK Metabolite C00029919

Metabolite

KNApSAcK Entry

id C00029919
Name Celastrol
CAS RN 34157-83-0
Standard InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
Standard InChI (Main Layer) InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)

Cluster

Phytochemical cluster No. 51
KCF-S cluster No. 403

Link

ChEMBL

By standard InChI CHEMBL301982
By standard InChI Main Layer CHEMBL301982 CHEMBL1321090 CHEMBL1712082

KEGG

By LinkDB

CTD

By CAS RN C050414

Human Protein / Gene in interaction

46 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL301982 CHEMBL1646369 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1321090 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
Q9NR96 Toll-like receptor 9 Toll-like and Il-1 receptors CHEMBL1712082 CHEMBL1794460 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1321090 CHEMBL1613842 (1)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL1712082 CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1712082 CHEMBL1794499 (1)
2 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr CHEMBL301982 CHEMBL1646367 (1)
4 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1712082 CHEMBL1794585 (1)
0 / 0
Q16543 Hsp90 co-chaperone Cdc37 Unclassified protein CHEMBL301982 CHEMBL1803258 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL1712082 CHEMBL2354282 (1)
4 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL1321090 CHEMBL1712082 CHEMBL1794311 (2)
2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL1321090 CHEMBL1613800 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL1712082 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1321090 CHEMBL1738606 (1)
0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme CHEMBL1712082 CHEMBL1737961 (1)
1 / 2
Q00613 Heat shock factor protein 1 Unclassified protein CHEMBL301982 CHEMBL1063218 (1) CHEMBL1063219 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1712082 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1712082 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL1712082 CHEMBL2114788 (1)
0 / 0
P51684 C-C chemokine receptor type 6 CC chemokine receptor CHEMBL1712082 CHEMBL1738164 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL1712082 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1712082 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1321090 CHEMBL1794467 (1)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL1321090 CHEMBL1614252 (1)
2 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr CHEMBL301982 CHEMBL1646370 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1321090 CHEMBL1614521 (1) CHEMBL1613808 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1321090 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL1321090 CHEMBL1614038 (1)
2 / 2
P08238 Heat shock protein HSP 90-beta Other cytosolic protein CHEMBL301982 CHEMBL1664651 (1) CHEMBL1664652 (1)
CHEMBL1664653 (1) CHEMBL1664660 (1)
CHEMBL1664667 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1321090 CHEMBL1614240 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1321090 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1712082 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1712082 CHEMBL1737991 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1321090 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1712082 CHEMBL1738184 (1)
0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein CHEMBL1712082 CHEMBL1794333 (1)
0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr CHEMBL301982 CHEMBL1646368 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1321090 CHEMBL1712082 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1321090 CHEMBL1613914 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1712082 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL1321090 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1321090 CHEMBL1614257 (1)
1 / 3
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL1712082 CHEMBL2114738 (1)
0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein CHEMBL1712082 CHEMBL2114913 (1)
0 / 3
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL1712082 CHEMBL2114796 (1)
2 / 1
Q06710 Paired box protein Pax-8 Unclassified protein CHEMBL1712082 CHEMBL2354301 (1)
1 / 2

CTD interaction (134)

compound gene gene name gene description interaction interaction type form reference
pmid
C050414 10598 AHSA1
AHA1
C14orf3
p38
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) tripterine results in increased expression of AHSA1 mRNA increases expression
mRNA 17010675
C050414 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) tripterine results in increased expression of AKR1C1 mRNA increases expression
mRNA 17010675
C050414 1646 AKR1C2
AKR1C-pseudo
BABP
DD
DD2
DDH2
HAKRD
HBAB
MCDR2
SRXY8
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) tripterine results in increased expression of AKR1C2 mRNA increases expression
mRNA 17010675
C050414 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) tripterine results in decreased phosphorylation of AKT1 protein decreases phosphorylation
protein 21466843
C050414 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor CAST inhibits the reaction [tripterine results in increased degradation of AR protein] decreases reaction
/ increases degradation
protein 18726991
C050414 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor N-acetylleucyl-leucyl-methioninal inhibits the reaction [tripterine results in increased degradation of AR protein] decreases reaction
/ increases degradation
protein 18726991
C050414 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor tripterine results in decreased expression of AR protein decreases expression
protein 17010675
C050414 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor tripterine results in increased degradation of AR protein increases degradation
protein 18726991
C050414 84159 ARID5B
DESRT
MRF-2
MRF2
AT rich interactive domain 5B (MRF1-like) tripterine results in decreased expression of ARID5B mRNA decreases expression
mRNA 17010675
C050414 467 ATF3
activating transcription factor 3 tripterine results in increased expression of ATF3 mRNA increases expression
mRNA 17010675
C050414 9531 BAG3
BAG-3
BIS
CAIR-1
MFM6
BCL2-associated athanogene 3 tripterine results in increased expression of BAG3 mRNA increases expression
mRNA 17010675
C050414 581 BAX
BCL2L4
BCL2-associated X protein tripterine results in increased expression of BAX protein increases expression
protein 21466843
C050414 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 tripterine results in decreased expression of BCL2 protein decreases expression
protein 21466843
C050414 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 tripterine results in decreased expression of BIRC5 mRNA decreases expression
mRNA 17010675
C050414 694 BTG1
B-cell translocation gene 1, anti-proliferative tripterine results in decreased expression of BTG1 mRNA decreases expression
mRNA 17010675
C050414 8209 C21orf33
ES1
GT335
HES1
KNPH
KNPI
chromosome 21 open reading frame 33 tripterine results in decreased expression of C21ORF33 mRNA decreases expression
mRNA 17010675
C050414 27101 CACYBP
GIG5
RP1-102G20.6
S100A6BP
SIP
calcyclin binding protein tripterine results in increased expression of CACYBP mRNA increases expression
mRNA 17010675
C050414 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [TNFSF10 protein co-treated with tripterine] results in increased cleavage of CASP3 protein affects cotreatment
/ increases cleavage
protein 20605676
C050414 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) tripterine results in increased cleavage of CASP3 protein increases cleavage
protein 21466843
C050414 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) tripterine results in increased cleavage of CASP8 protein increases cleavage
protein 21466843
C050414 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) tripterine results in increased cleavage of CASP9 protein increases cleavage
protein 21466843
C050414 831 CAST
BS-17
calpastatin CAST inhibits the reaction [tripterine results in increased degradation of AR protein] decreases reaction
/ increases degradation
18726991
C050414 874 CBR3
SDR21C2
hCBR3
carbonyl reductase 3 (EC:1.1.1.184) tripterine results in increased expression of CBR3 mRNA increases expression
mRNA 17010675
C050414 8317 CDC7
CDC7L1
HsCDC7
Hsk1
huCDC7
cell division cycle 7 (EC:2.7.11.1) tripterine results in decreased expression of CDC7 mRNA decreases expression
mRNA 17010675
C050414 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) tripterine results in decreased expression of CDK2 mRNA decreases expression
mRNA 17010675
C050414 26973 CHORDC1
CHP1
cysteine and histidine-rich domain (CHORD) containing 1 tripterine results in increased expression of CHORDC1 mRNA increases expression
mRNA 17010675
C050414 10370 CITED2
ASD8
MRG-1
MRG1
P35SRJ
VSD2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 tripterine results in decreased expression of CITED2 mRNA decreases expression
mRNA 17010675
C050414 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) tripterine results in decreased expression of CYP1A1 mRNA decreases expression
mRNA 17010675
C050414 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 tripterine results in increased expression of DDIT3 mRNA increases expression
mRNA 17010675
C050414 54541 DDIT4
Dig2
REDD-1
REDD1
DNA-damage-inducible transcript 4 tripterine results in increased expression of DDIT4 mRNA increases expression
mRNA 17010675
C050414 3301 DNAJA1
DJ-2
DjA1
HDJ2
HSDJ
HSJ2
HSPF4
NEDD7
hDJ-2
DnaJ (Hsp40) homolog, subfamily A, member 1 tripterine results in increased expression of DNAJA1 mRNA increases expression
mRNA 17010675
C050414 11080 DNAJB4
DNAJW
DjB4
HLJ1
DnaJ (Hsp40) homolog, subfamily B, member 4 tripterine results in increased expression of DNAJB4 mRNA increases expression
mRNA 17010675
C050414 1948 EFNB2
EPLG5
HTKL
Htk-L
LERK5
ephrin-B2 tripterine results in decreased expression of EFNB2 mRNA decreases expression
mRNA 17010675
C050414 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) [Sulfasalazine co-treated with tripterine] affects the expression of EGFR protein affects cotreatment
/ affects expression
protein 20007406
C050414 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) [Sulfasalazine co-treated with tripterine] results in decreased expression of EGFR protein affects cotreatment
/ decreases expression
protein 20007406
C050414 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) tripterine results in decreased expression of EGFR protein decreases expression
protein 17010675
C050414 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor tripterine results in increased expression of FAS protein increases expression
protein 21466843
C050414 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) tripterine results in increased expression of FASLG protein increases expression
protein 21466843
C050414 11153 FICD
HIP13
HYPE
UNQ3041
FIC domain containing (EC:2.7.7.n1) tripterine results in increased expression of FICD mRNA increases expression
mRNA 17010675
C050414 2322 FLT3
CD135
FLK-2
FLK2
STK1
fms-related tyrosine kinase 3 (EC:2.7.10.1) tripterine results in decreased expression of FLT3 protein decreases expression
protein 17010675
C050414 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) tripterine results in increased expression of GCLM mRNA increases expression
mRNA 17010675
C050414 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 tripterine results in increased expression of GDF15 mRNA increases expression
mRNA 17010675
C050414 54676 GTPBP2
GTP binding protein 2 tripterine results in increased expression of GTPBP2 mRNA increases expression
mRNA 17010675
C050414 29923 HILPDA
C7orf68
HIG-2
HIG2
hypoxia inducible lipid droplet-associated tripterine results in decreased expression of HILPDA mRNA decreases expression
mRNA 17010675
C050414 3157 HMGCS1
HMGCS
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10) tripterine results in increased expression of HMGCS1 mRNA increases expression
mRNA 17010675
C050414 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) tripterine results in increased expression of HMOX1 mRNA increases expression
mRNA 17010675
C050414 3320 HSP90AA1
EL52
HSP86
HSP89A
HSP90A
HSP90N
HSPC1
HSPCA
HSPCAL1
HSPCAL4
HSPN
Hsp89
Hsp90
LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1 tripterine results in decreased activity of HSP90AA1 protein decreases activity
protein 17010675
C050414 3303 HSPA1A
HSP70-1
HSP70-1A
HSP70I
HSP72
HSPA1
heat shock 70kDa protein 1A tripterine results in increased expression of HSPA1A mRNA increases expression
mRNA 17010675
C050414 3304 HSPA1B
HSP70-1B
HSP70-2
heat shock 70kDa protein 1B tripterine results in increased expression of HSPA1B mRNA increases expression
mRNA 17010675
C050414 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) tripterine results in increased expression of HSPA5 mRNA increases expression
mRNA 17010675
C050414 10808 HSPH1
HSP105
HSP105A
HSP105B
NY-CO-25
heat shock 105kDa/110kDa protein 1 tripterine results in increased expression of HSPH1 mRNA increases expression
mRNA 17010675
C050414 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 tripterine inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 tripterine inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 16769766
C050414 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 3458 IFNG
IFG
IFI
interferon, gamma tripterine inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 3458 IFNG
IFG
IFI
interferon, gamma tripterine inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta tripterine inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta tripterine inhibits the reaction [IL1B protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 16769766
C050414 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta tripterine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 3557 IL1RN
DIRA
ICIL-1RA
IL-1RN
IL-1ra
IL-1ra3
IL1F3
IL1RA
IRAP
MVCD4
interleukin 1 receptor antagonist tripterine results in decreased expression of IL1RN mRNA decreases expression
mRNA 17010675
C050414 3638 INSIG1
CL-6
CL6
insulin induced gene 1 tripterine results in increased expression of INSIG1 mRNA increases expression
mRNA 17010675
C050414 182 JAG1
AGS
AHD
AWS
CD339
HJ1
JAGL1
jagged 1 tripterine results in decreased expression of JAG1 mRNA decreases expression
mRNA 17010675
C050414 3781 KCNN2
KCa2.2
SK2
SKCA2
SKCa_2
hSK2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 tripterine results in decreased expression of KCNN2 mRNA decreases expression
mRNA 17010675
C050414 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor tripterine results in increased expression of LDLR mRNA increases expression
mRNA 17010675
C050414 23175 LPIN1
PAP1
lipin 1 (EC:3.1.3.4) tripterine results in increased expression of LPIN1 mRNA increases expression
mRNA 17010675
C050414 26046 LTN1
C21orf10
C21orf98
RNF160
ZNF294
listerin E3 ubiquitin protein ligase 1 tripterine results in decreased expression of LTN1 mRNA decreases expression
mRNA 17010675
C050414 9935 MAFB
KRML
MCTO
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B tripterine results in decreased expression of MAFB mRNA decreases expression
mRNA 17010675
C050414 4191 MDH2
M-MDH
MDH
MGC:3559
MOR1
malate dehydrogenase 2, NAD (mitochondrial) (EC:1.1.1.37) tripterine results in decreased expression of MDH2 mRNA decreases expression
mRNA 17010675
C050414 4199 ME1
HUMNDME
MES
malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) tripterine results in increased expression of ME1 mRNA increases expression
mRNA 17010675
C050414 4335 MNT
MAD6
MXD6
ROX
bHLHd3
MAX network transcriptional repressor tripterine results in increased expression of MNT mRNA increases expression
mRNA 17010675
C050414 29074 MRPL18
L18mt
MRP-L18
mitochondrial ribosomal protein L18 tripterine results in increased expression of MRPL18 mRNA increases expression
mRNA 17010675
C050414 2956 MSH6
GTBP
GTMBP
HNPCC5
HSAP
p160
mutS homolog 6 tripterine results in decreased expression of MSH6 mRNA decreases expression
mRNA 17010675
C050414 6307 MSMO1
DESP4
ERG25
SC4MOL
methylsterol monooxygenase 1 (EC:1.14.13.72) tripterine results in increased expression of MSMO1 mRNA increases expression
mRNA 17010675
C050414 23077 MYCBP2
PAM
MYC binding protein 2, E3 ubiquitin protein ligase tripterine results in decreased expression of MYCBP2 mRNA decreases expression
mRNA 17010675
C050414 55892 MYNN
OSZF
ZBTB31
ZNF902
myoneurin tripterine results in decreased expression of MYNN mRNA decreases expression
mRNA 17010675
C050414 4683 NBN
AT-V1
AT-V2
ATV
NBS
NBS1
P95
nibrin tripterine results in decreased expression of NBN mRNA decreases expression
mRNA 17010675
C050414 4824 NKX3-1
BAPX2
NKX3
NKX3.1
NKX3A
NK3 homeobox 1 tripterine results in decreased expression of NKX3-1 mRNA decreases expression
mRNA 17010675
C050414 9315 NREP
C5orf13
D4S114
P311
PRO1873
PTZ17
SEZ17
neuronal regeneration related protein tripterine results in decreased expression of NREP mRNA decreases expression
mRNA 17010675
C050414 4986 OPRK1
K-OR-1
KOR
KOR-1
OPRK
opioid receptor, kappa 1 tripterine results in decreased expression of OPRK1 mRNA decreases expression
mRNA 17010675
C050414 51526 OSER1
C20orf111
HSPC207
Osr1
Perit1
dJ1183I21.1
oxidative stress responsive serine-rich 1 tripterine results in increased expression of OSER1 mRNA increases expression
mRNA 17010675
C050414 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] affects cotreatment
/ increases cleavage
/ increases reaction
protein 20605676
C050414 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] affects cotreatment
/ increases cleavage
/ increases reaction
protein 20605676
C050414 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) [TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein affects cotreatment
/ increases cleavage
protein 20605676
C050414 5152 PDE9A
HSPDE9A2
phosphodiesterase 9A (EC:3.1.4.35) tripterine results in decreased expression of PDE9A mRNA decreases expression
mRNA 17010675
C050414 5293 PIK3CD
P110DELTA
PI3K
p110D
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (EC:2.7.1.153) tripterine results in decreased expression of PIK3CD mRNA decreases expression
mRNA 17010675
C050414 5295 PIK3R1
AGM7
GRB1
p85
p85-ALPHA
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) tripterine results in decreased expression of PIK3R1 mRNA decreases expression
mRNA 17010675
C050414 10105 PPIF
CYP3
CyP-M
Cyp-D
CypD
peptidylprolyl isomerase F (EC:5.2.1.8) tripterine results in decreased expression of PPIF mRNA decreases expression
mRNA 17010675
C050414 5813 PURA
PUR-ALPHA
PUR1
PURALPHA
purine-rich element binding protein A tripterine results in decreased expression of PURA mRNA decreases expression
mRNA 17010675
C050414 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A tripterine inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein] affects localization
/ decreases reaction
/ increases activity
protein 16769766
C050414 6241 RRM2
R2
RR2
RR2M
ribonucleotide reductase M2 (EC:1.17.4.1) tripterine results in decreased expression of RRM2 mRNA decreases expression
mRNA 17010675
C050414 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E tripterine inhibits the reaction [IL1B protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 16769766
C050414 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E tripterine inhibits the reaction [TNF protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
mRNA 16769766
C050414 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E tripterine inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 16769766
C050414 27230 SERP1
RAMP4
stress-associated endoplasmic reticulum protein 1 tripterine results in increased expression of SERP1 mRNA increases expression
mRNA 17010675
C050414 27244 SESN1
PA26
SEST1
sestrin 1 tripterine results in decreased expression of SESN1 mRNA decreases expression
mRNA 17010675
C050414 6520 SLC3A2
4F2
4F2HC
4T2HC
CD98
CD98HC
MDU1
NACAE
solute carrier family 3 (amino acid transporter heavy chain), member 2 tripterine results in increased expression of SLC3A2 mRNA increases expression
mRNA 17010675
C050414 23657 SLC7A11
CCBR1
xCT
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 SLC7A11 protein results in decreased susceptibility to tripterine decreases response to substance
protein 20007406
C050414 23657 SLC7A11
CCBR1
xCT
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 tripterine results in increased expression of SLC7A11 mRNA increases expression
mRNA 17010675
C050414 79811 SLTM
Met
SAFB-like, transcription modulator tripterine results in decreased expression of SLTM mRNA decreases expression
mRNA 17010675
C050414 6659 SOX4
EVI16
SRY (sex determining region Y)-box 4 tripterine results in decreased expression of SOX4 mRNA decreases expression
mRNA 17010675
C050414 100380807 tripterine results in increased expression of STCH mRNA increases expression
mRNA 17010675
C050414 10963 STIP1
HOP
IEF-SSP-3521
P60
STI1
STI1L
stress-induced-phosphoprotein 1 tripterine results in increased expression of STIP1 mRNA increases expression
mRNA 17010675
C050414 51347 TAOK3
DPK
JIK
MAP3K18
TAO kinase 3 (EC:2.7.11.1) tripterine results in decreased expression of TAOK3 mRNA decreases expression
mRNA 17010675
C050414 7113 TMPRSS2
PP9284
PRSS10
transmembrane protease, serine 2 (EC:3.4.21.-) tripterine results in decreased expression of TMPRSS2 mRNA decreases expression
mRNA 17010675
C050414 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tripterine inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein] affects localization
/ decreases reaction
/ increases activity
protein 16769766
C050414 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 16769766
C050414 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tripterine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tripterine inhibits the reaction [TNF protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
protein 16769766
C050414 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tripterine inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 16769766
C050414 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 16769766
C050414 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 8797 TNFRSF10A
APO2
CD261
DR4
TRAILR-1
TRAILR1
tumor necrosis factor receptor superfamily, member 10a TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] affects cotreatment
/ increases cleavage
/ increases reaction
protein 20605676
C050414 8797 TNFRSF10A
APO2
CD261
DR4
TRAILR-1
TRAILR1
tumor necrosis factor receptor superfamily, member 10a tripterine results in increased expression of and results in increased localization of TNFRSF10A protein increases expression
/ increases localization
protein 20605676
C050414 8797 TNFRSF10A
APO2
CD261
DR4
TRAILR-1
TRAILR1
tumor necrosis factor receptor superfamily, member 10a tripterine results in increased expression of TNFRSF10A mRNA increases expression
mRNA 20605676
C050414 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] affects cotreatment
/ increases cleavage
/ increases reaction
protein 20605676
C050414 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b tripterine results in increased expression of and results in increased localization of TNFRSF10B protein increases expression
/ increases localization
protein 20605676
C050414 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b tripterine results in increased expression of TNFRSF10B mRNA increases expression
mRNA 20605676
C050414 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] affects cotreatment
/ increases cleavage
/ increases reaction
protein 20605676
C050414 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein] affects cotreatment
/ increases cleavage
/ increases reaction
protein 20605676
C050414 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 [TNFSF10 protein co-treated with tripterine] results in increased cleavage of CASP3 protein affects cotreatment
/ increases cleavage
protein 20605676
C050414 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 [TNFSF10 protein co-treated with tripterine] results in increased cleavage of PARP1 protein affects cotreatment
/ increases cleavage
protein 20605676
C050414 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 tripterine results in increased susceptibility to TNFSF10 protein increases response to substance
protein 20605676
C050414 10628 TXNIP
EST01027
HHCPA78
THIF
VDUP1
thioredoxin interacting protein tripterine results in decreased expression of TXNIP mRNA decreases expression
mRNA 17010675
C050414 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) tripterine results in increased expression of TXNRD1 mRNA increases expression
mRNA 17010675
C050414 7320 UBE2B
E2-17kDa
HHR6B
HR6B
RAD6B
UBC2
ubiquitin-conjugating enzyme E2B (EC:6.3.2.19) tripterine results in increased expression of UBE2B mRNA increases expression
mRNA 17010675
C050414 7358 UGDH
GDH
UDP-GlcDH
UDPGDH
UGD
UDP-glucose 6-dehydrogenase (EC:1.1.1.22) tripterine results in increased expression of UGDH mRNA increases expression
mRNA 17010675
C050414 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 tripterine inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 tripterine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 16769766
C050414 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 tripterine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16769766
C050414 79084 WDR77
MEP-50
MEP50
Nbla10071
RP11-552M11.3
p44
p44/Mep50
WD repeat domain 77 tripterine results in decreased expression of WDR77 mRNA decreases expression
mRNA 17010675
C050414 23099 ZBTB43
ZBTB22B
ZNF-X
ZNF297B
zinc finger and BTB domain containing 43 tripterine results in decreased expression of ZBTB43 mRNA decreases expression
mRNA 17010675
C050414 80149 ZC3H12A
MCPIP
MCPIP1
RP3-423B22.1
dJ423B22.1
zinc finger CCCH-type containing 12A tripterine results in decreased expression of ZC3H12A mRNA decreases expression
mRNA 17010675

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P18054
P84022
Q14191
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#163950 Noonan syndrome 1; ns1 Q06124
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (67)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
Q06710 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
Q06710 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)