KCF-S cluster No. 450 (17 metabolites)

Corresponding Phytochemical cluster No. 13

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (17)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	25
Liliopsida	16
asterids	13
eudicotyledons	2
Euphyllophyta	1
Embryophyta	1

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Cumulative family count

class name	count
Anacardiaceae	17
Cyperaceae	15
Asteraceae	11
Fabaceae	5
Plantaginaceae	2
Plumbaginaceae	2
Simaroubaceae	1
Asparagaceae	1
Passifloraceae	1
Aspleniaceae	1
Funariaceae	1
Moraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Aurones	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Aurones	C08644	C00008024
Aurones	C08720	C00008029
Aurones	C08577	C00008031

Metabolite list (17)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00008024	Hispidol	CHEMBL426110 CHEMBL502446		2 / 4 / 2
C00008025	4,6,4'-Trihydroxyaurone	CHEMBL201626 CHEMBL466981		2 / 4 / 2
C00008026	Sulfuretin / Sulphuretin / 6,3',4'-Trihydroxyaurone	CHEMBL490355 CHEMBL513487	C054989	42 / 37 / 34
C00008027	Aureusidin	CHEMBL593229
C00008028	Rengasin
C00008029	Maritimetin
C00008030	Leptosidin
C00008031	Bracteatin
C00008032	6,3',4'-Trihydroxy-4-methoxy-5-methylaurone
C00014649	Broussoaurone A / 2-[(3,4-Dihydroxyphenyl)methylene]-6-hydroxy-5-(3-methyl-2-butenyl)-3(2H)-benzofuranone	CHEMBL463019
C00014650	Licoagroaurone / (2Z)-2-[(3,4-Dihydroxyphenyl)methylene]-6-hydroxy-7-(3-methyl-2-butenyl)-3(2H)-benzofuranone
C00014652	Helmon / 4,7,4',6-Tetrahydroxyaurone
C00014653	4,6,3',4'-Tetrahydroxy-5-methylaurone
C00014654	4,6,3',4'-Tetrahydroxy-7-methylaurone
C00014655	6,3',4'-Trihydroxy-4-methoxy-7-methylaurone
C00014656	6,3'-Dihydroxy-4,4'-dimethoxy-5-methylaurone
C00044469	6,4'-Dihydroxy-3'-methoxyaurone	CHEMBL446827		28 / 32 / 55

Human Protein / Gene in interactions

52 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00008026 C00044469	2 / 1
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00008026 C00044469	0 / 0
O00255	Menin	Unclassified protein	C00008026 C00044469	2 / 5
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00008026 C00044469	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00008026 C00044469	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00008026 C00044469	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00008026 C00044469	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00008026 C00044469	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00008026 C00044469	4 / 3
P15559	NAD(P)H dehydrogenase [quinone] 1	Enzyme	C00008024 C00008025	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00008026 C00044469	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00008026 C00044469	1 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00008026 C00044469	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00008026 C00044469	1 / 1
P39748	Flap endonuclease 1	Enzyme	C00008026 C00044469	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00008026 C00044469	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00008024 C00008025	4 / 2
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00008026 C00044469	7 / 3
P11308	Transcriptional regulator ERG	Unclassified protein	C00008026 C00044469	1 / 2
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00008026 C00044469	4 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00008026 C00044469	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00008026 C00044469	1 / 2
Q9Y253	DNA polymerase eta	Enzyme	C00008026	1 / 1
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00008026	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00008026	3 / 1
P51151	Ras-related protein Rab-9A	Unclassified protein	C00044469	0 / 0
O75496	Geminin	Unclassified protein	C00044469	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00044469	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00008026	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00008026	0 / 0
Q99816	Tumor susceptibility gene 101 protein	Unclassified protein	C00044469	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00008026	2 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00008026	0 / 1
P08253	72 kDa type IV collagenase	M10A	C00008026	1 / 3
P47901	Vasopressin V1b receptor	Vasopressin and oxytocin receptor	C00008026	0 / 0
Q8WXD0	Relaxin receptor 2	Relaxin receptor	C00008026	1 / 1
P11473	Vitamin D3 receptor	NR1I1	C00008026	2 / 3
Q9HBX9	Relaxin receptor 1	Relaxin receptor	C00008026	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00008026	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00008026	3 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00008026	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00044469	0 / 0
P06746	DNA polymerase beta	Enzyme	C00044469	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00008026	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00044469	1 / 1
O00487	26S proteasome non-ATPase regulatory subunit 14	Enzyme	C00008026	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00008026	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00008026	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00008026	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00008026	0 / 0
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00008026	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00044469	7 / 37

Related Diseases

Diseases related to proteins in ChEMBL interactions