KCF-S cluster No. 502 (16 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (16)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

---

Cumulative plant class count

class name	count
asterids	55

---

Cumulative family count

class name	count
Apocynaceae	55
Diclidophoridae	1

KEGG BRITE br08003

---

Categories (1)

br08003 Category	# of metabolite
Indole alkaloids	3

---

metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Indole alkaloids	C09035	C00001688
Indole alkaloids	C09146	C00001713
Indole alkaloids	C09149	C00001714

Metabolite list (16)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001688	Apovincamine	CHEMBL1163488	C063621
C00001713	Eburnamine / (-)-Eburnamine	CHEMBL2104946
C00001714	Eburnamonine	CHEMBL1318553 CHEMBL1553441 CHEMBL1733074 CHEMBL1892145		14 / 20 / 16
C00024535	Goniomitine / (-)-Goniomitine
C00025041	(-)-11-Methoxyeburnamonine
C00025047	Vincamenine / (-)-Eburnamenine / cis-Vincamenine	CHEMBL1097688
C00025051	O-Methyleburnamine / (-)-O-Methyleburnamine / O-Methyl-(-)-eburnamine	CHEMBL1097360 CHEMBL1164562
C00025061	(+)-Eburnamenine	CHEMBL1097688
C00025062	(+)-Isoeburnamine	CHEMBL2104946
C00025071	16-Epivincanol	CHEMBL2104946
C00025075	(+)-O-methylisoeburnamine	CHEMBL1097360 CHEMBL1164562
C00025079	20-Oxoeburnamenine
C00027619	(+)-19-Oxoeburnamine
C00027628	(+)-Vincamone / d-Eburnamonine / (+)-Eburnamonine / (+)-cis-Vincamone / (+)-cis-Eburnamonine	CHEMBL1318553 CHEMBL1553441 CHEMBL1733074 CHEMBL1892145	C016422	14 / 20 / 16	2 / 0
C00042577	Hecubine
C00047264	Kopsiyunnanine D / (-)-Kopsiyunnanine D	CHEMBL564146

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001714 C00027628	1 / 0
Q99700	Ataxin-2	Unclassified protein	C00001714 C00027628	1 / 1
P02545	Prelamin-A/C	Unclassified protein	C00001714 C00027628	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00001714 C00027628	3 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001714 C00027628	0 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00001714 C00027628	2 / 0
O75496	Geminin	Unclassified protein	C00001714 C00027628	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001714 C00027628	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00001714 C00027628	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001714 C00027628	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001714 C00027628	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001714 C00027628	0 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001714 C00027628	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00001714 C00027628	1 / 0

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1129	CHRM2, HM2	cholinergic receptor, muscarinic 2	C00027628
1132	CHRM4, HM4, M4R	cholinergic receptor, muscarinic 4	C00027628

Related Diseases

Diseases related to proteins in ChEMBL interactions