KCF-S cluster No. 5088 (2 metabolites)
Corresponding Phytochemical cluster No. 1
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| Liliopsida | 2 |
Cumulative family count
| class name | count |
|---|---|
| Arecaceae | 2 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Pyridine alkaloids | 2 |
metabolites link (2)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Pyridine alkaloids | C10128 | C00002019 |
| Pyridine alkaloids | C10149 | C00002043 |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002019
|
Arecaidine
|
CHEMBL432561
|
C015688
|
1 / 0 |
|
|
|
C00002043
|
Guvacine
|
CHEMBL76768
|
C015910
|
13 / 5 / 5 |
|
Human Protein / Gene in interactions
13 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P48066 | Sodium- and chloride-dependent GABA transporter 3 | GABA | C00002043 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002043 | 1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002043 | 0 / 0 |
| P30531 | Sodium- and chloride-dependent GABA transporter 1 | GABA | C00002043 | 0 / 0 |
| Q9NSD5 | Sodium- and chloride-dependent GABA transporter 2 | GABA | C00002043 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002043 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002043 | 0 / 1 |
| P48065 | Sodium- and chloride-dependent betaine transporter | Betaine and GABA Na-symporter | C00002043 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002043 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002043 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002043 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002043 | 0 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002043 | 0 / 0 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 7076 | TIMP1, CLGI, EPA, EPO, HCI, TIMP | TIMP metallopeptidase inhibitor 1 |
C00002019
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|