| class name | count |
|---|---|
| rosids | 17 |
| class name | count |
|---|---|
| Rutaceae | 17 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001745
|
Mahanimbine
|
CHEMBL495873
|
3 / 7 / 10 |
|
||
|
C00024680
|
7-Methoxymurrayacine
|
CHEMBL1689803
|
|
|||
|
C00024704
|
Eustifoline B
|
|
||||
|
C00024709
|
Glycomaurine
/ Eustifoline-A |
|
||||
|
C00024713
|
Isomahanine
|
CHEMBL498436
|
20 / 19 / 21 |
|
||
|
C00024719
|
Mukonicine
|
|
||||
|
C00024746
|
NSC 654283
/ Pyrayafoline B |
CHEMBL495872
|
|
|||
|
C00024747
|
Pyrayafoline C
|
|
||||
|
C00024748
|
Pyrayafoline D
|
CHEMBL498436
|
20 / 19 / 21 |
|
||
|
C00024749
|
Pyrayafoline E
|
|
||||
|
C00025171
|
NSC 94932
/ Girinimbin / Girinimbine |
CHEMBL1477760
|
C034052
|
16 / 17 / 43 |
|
|
|
C00028618
|
Murrayamine I
|
|
||||
|
C00028619
|
Murrayamine J
|
|
||||
|
C00028620
|
Murrayamine K
|
|
||||
|
C00028622
|
Murrayamine N
|
|
||||
|
C00044783
|
Glycoborinine
|
CHEMBL506671
|
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001745 C00024713 C00024748 C00025171 | 4 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001745 C00024713 C00024748 | 1 / 2 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00024713 C00024748 C00025171 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00024713 C00024748 C00025171 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00024713 C00024748 C00025171 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00024713 C00024748 C00025171 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001745 C00024713 C00024748 | 2 / 5 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00024713 C00024748 C00025171 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00024713 C00024748 C00025171 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00024713 C00024748 C00025171 | 2 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00024713 C00024748 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00024713 C00024748 | 4 / 2 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00024713 C00024748 | 1 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00024713 C00024748 | 1 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00024713 C00024748 | 1 / 1 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00024713 C00024748 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00024713 C00024748 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00024713 C00024748 | 1 / 1 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00024713 C00024748 | 0 / 3 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00024713 C00024748 | 1 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00025171 | 1 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00025171 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00025171 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00025171 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00025171 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00025171 | 0 / 0 |
| P17861 | X-box-binding protein 1 | Unclassified protein | C00025171 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00025171 | 7 / 37 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #133239 | Esophageal cancer |
P04637
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #612371 | Major affective disorder 7; mafd7 |
P17861
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
Q13315 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|