Plant Species


Cumulative plant class count

class name count
rosids 17

Cumulative family count

class name count
Rutaceae 17

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001745 External link 512 Mahanimbine
CHEMBL495873
3 / 7 / 10
C00024680 External link 512 7-Methoxymurrayacine
CHEMBL1689803
C00024704 External link 512 Eustifoline B
C00024709 External link 512 Glycomaurine
/ Eustifoline-A
C00024713 External link 512 Isomahanine
CHEMBL498436
20 / 19 / 21
C00024719 External link 512 Mukonicine
C00024746 External link 512 NSC 654283
/ Pyrayafoline B
CHEMBL495872
C00024747 External link 512 Pyrayafoline C
C00024748 External link 512 Pyrayafoline D
CHEMBL498436
20 / 19 / 21
C00024749 External link 512 Pyrayafoline E
C00025171 External link 512 NSC 94932
/ Girinimbin
/ Girinimbine
CHEMBL1477760
C034052
16 / 17 / 43
C00028618 External link 512 Murrayamine I
C00028619 External link 512 Murrayamine J
C00028620 External link 512 Murrayamine K
C00028622 External link 512 Murrayamine N
C00044783 External link 512 Glycoborinine
CHEMBL506671

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10636 Microtubule-associated protein tau Unclassified protein C00001745 C00024713 C00024748 C00025171 4 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001745 C00024713 C00024748 1 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00024713 C00024748 C00025171 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00024713 C00024748 C00025171 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00024713 C00024748 C00025171 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00024713 C00024748 C00025171 1 / 1
O00255 Menin Unclassified protein C00001745 C00024713 C00024748 2 / 5
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00024713 C00024748 C00025171 0 / 0
O75496 Geminin Unclassified protein C00024713 C00024748 C00025171 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00024713 C00024748 C00025171 2 / 0
P39748 Flap endonuclease 1 Enzyme C00024713 C00024748 0 / 0
P37840 Alpha-synuclein Unclassified protein C00024713 C00024748 4 / 2
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00024713 C00024748 1 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00024713 C00024748 1 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00024713 C00024748 1 / 1
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00024713 C00024748 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00024713 C00024748 0 / 0
Q99700 Ataxin-2 Unclassified protein C00024713 C00024748 1 / 1
P01215 Glycoprotein hormones alpha chain Unclassified protein C00024713 C00024748 0 / 3
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00024713 C00024748 1 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00025171 1 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00025171 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025171 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025171 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025171 0 / 0
P06746 DNA polymerase beta Enzyme C00025171 0 / 0
P17861 X-box-binding protein 1 Unclassified protein C00025171 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00025171 7 / 37

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#133239 Esophageal cancer P04637
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#612371 Major affective disorder 7; mafd7 P17861
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (59)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
Q13315 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)