KCF-S cluster No. 539 (8 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (8)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count

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Cumulative family count

class name	count
Nectriaceae	12
Hypocreaceae	1
Pasteurellaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (8)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003129	Diacetoxyscirpenol	CHEMBL433680 CHEMBL155721 CHEMBL2002916 CHEMBL2005379	C001809	12 / 16 / 42
C00003192	T-2 toxin	CHEMBL152423 CHEMBL152724 CHEMBL1553023 CHEMBL1703795 CHEMBL1989781	D013605	7 / 13 / 5	28 / 9
C00012613	Solaniol / Neosolaniol / Neozolaniol / (3alpha,4beta,8alpha)-12,13-Epoxy-trichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate	CHEMBL358485 CHEMBL422680 CHEMBL345149 CHEMBL156831
C00012635	Saubinin I / Nivalenol diacetate / Nivalenol 4,15-diacetate / 12,13-Epoxy-3a,4b,7a,15-tetrahydroxytrichothec-9-en-8-one 4,15-diacetate		C081797
C00012639	NT 1 / Toxin T 1 / Toxin NT 1 / Isoneosolaniol	CHEMBL152525 CHEMBL523782	C032169
C00012640	Toxin T 3 / T 2 triol / Toxin T 2 triol / Deacetyl HT 2 toxin / 12,13-Epoxy-trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol 8-isovalerate	CHEMBL152136
C00012641	(3alpha,4beta)-4,15-bis(Acetyloxy)-12,13-epoxy-3-hydroxytrichothec-9-en-8-one	CHEMBL149588 CHEMBL155135
C00012650	Sporotrichiol

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00003129 C00003192	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003129 C00003192	1 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003129 C00003192	0 / 0
O75496	Geminin	Unclassified protein	C00003129 C00003192	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00003192	7 / 3
P37840	Alpha-synuclein	Unclassified protein	C00003129	4 / 2
P51151	Ras-related protein Rab-9A	Unclassified protein	C00003129	0 / 0
P42858	Huntingtin	Unclassified protein	C00003129	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00003192	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003129	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003129	0 / 0
P17861	X-box-binding protein 1	Unclassified protein	C00003129	1 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00003129	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00003192	4 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00003129	7 / 37

28 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
2	A2M, A2MD, CPAMD5, FWP007, S863-7	alpha-2-macroglobulin	C00003192
176	ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK	aggrecan	C00003192
11096	ADAMTS5, ADAM-TS_11, ADAM-TS_5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2	ADAM metallopeptidase with thrombospondin type 1 motif, 5	C00003192
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00003192
581	BAX, BCL2L4	BCL2-associated X protein	C00003192
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003192
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003192
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00003192
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003192
960	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1	CD44 molecule (Indian blood group)	C00003192
11200	CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1	checkpoint kinase 2 (EC:2.7.11.1)	C00003192
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00003192
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003192
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003192
1589	CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B	cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10)	C00003192
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00003192
3037	HAS2	hyaluronan synthase 2 (EC:2.4.1.212)	C00003192
3156	HMGCR, LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)	C00003192
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00003192
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00003192
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00003192
4322	MMP13, CLG3, MANDP1	matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-)	C00003192
190	NR0B1, AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2	nuclear receptor subfamily 0, group B, member 1	C00003192
2516	NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3	nuclear receptor subfamily 5, group A, member 1	C00003192
7076	TIMP1, CLGI, EPA, EPO, HCI, TIMP	TIMP metallopeptidase inhibitor 1	C00003192
7077	TIMP2, CSC-21K, DDC8	TIMP metallopeptidase inhibitor 2	C00003192
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003192
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00003192

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions