PCIDB

KNApSAcK Metabolite C00003192

Metabolite

KNApSAcK Entry

id C00003192
Name T-2 toxin
CAS RN 21259-20-1
Standard InChI InChI=1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1
Standard InChI (Main Layer) InChI=1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3

Cluster

Phytochemical cluster
KCF-S cluster No. 539

Link

ChEMBL

By standard InChI CHEMBL152423
By standard InChI Main Layer CHEMBL152423 CHEMBL152724 CHEMBL1553023 CHEMBL1703795 CHEMBL1989781

KEGG

By LinkDB C09738

CTD

By CAS RN D013605

Species

Summary

Plant class

class name count

Family

family name count
Nectriaceae 1
Hypocreaceae 1

List (3)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Fusarium spp.
Fusarium tricinctum 61284 Nectriaceae Fungi
Trichoderma lignorum 5547 Hypocreaceae Fungi

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1553023 CHEMBL1613842 (1)
4 / 2
O75496 Geminin Unclassified protein CHEMBL1703795 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1703795 CHEMBL2114810 (1)
7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1703795 CHEMBL1794401 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1703795 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1703795 CHEMBL2354311 (1)
1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1703795 CHEMBL2354287 (1)
1 / 1

CTD interaction (60)

compound gene gene name gene description interaction interaction type form reference
pmid
D013605 2 A2M
A2MD
CPAMD5
FWP007
S863-7
alpha-2-macroglobulin Selenium inhibits the reaction [T-2 Toxin results in decreased expression of A2M mRNA] decreases expression
/ decreases reaction
mRNA 21144892
D013605 2 A2M
A2MD
CPAMD5
FWP007
S863-7
alpha-2-macroglobulin Selenium promotes the reaction [T-2 Toxin results in decreased expression of A2M protein] decreases expression
/ increases reaction
protein 21144892
D013605 2 A2M
A2MD
CPAMD5
FWP007
S863-7
alpha-2-macroglobulin T-2 Toxin results in decreased expression of A2M mRNA decreases expression
mRNA 21144892
D013605 2 A2M
A2MD
CPAMD5
FWP007
S863-7
alpha-2-macroglobulin T-2 Toxin results in decreased expression of A2M protein decreases expression
protein 21144892
D013605 176 ACAN
AGC1
AGCAN
CSPG1
CSPGCP
MSK16
SEDK
aggrecan T-2 Toxin results in decreased expression of ACAN mRNA decreases expression
mRNA 16624732
18196609
D013605 176 ACAN
AGC1
AGCAN
CSPG1
CSPGCP
MSK16
SEDK
aggrecan T-2 Toxin results in decreased expression of ACAN protein decreases expression
protein 16624732
D013605 11096 ADAMTS5
ADAM-TS_11
ADAM-TS_5
ADAM-TS5
ADAMTS-11
ADAMTS-5
ADAMTS11
ADMP-2
ADAM metallopeptidase with thrombospondin type 1 motif, 5 T-2 Toxin results in increased expression of ADAMTS5 mRNA increases expression
mRNA 18196609
D013605 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) T-2 Toxin results in increased phosphorylation of ATM protein increases phosphorylation
protein 20150440
D013605 581 BAX
BCL2L4
BCL2-associated X protein Selenium inhibits the reaction [T-2 Toxin results in increased expression of BAX mRNA] decreases reaction
/ increases expression
mRNA 16307838
D013605 581 BAX
BCL2L4
BCL2-associated X protein T-2 Toxin affects the localization of BAX protein affects localization
protein 19541794
D013605 581 BAX
BCL2L4
BCL2-associated X protein T-2 Toxin results in increased expression of BAX mRNA increases expression
mRNA 16307838
D013605 581 BAX
BCL2L4
BCL2-associated X protein T-2 Toxin results in increased expression of BAX protein increases expression
protein 19524637
D013605 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 T-2 Toxin results in increased expression of BCL2 protein increases expression
protein 19524637
D013605 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) T-2 Toxin results in increased activity of CASP3 protein increases activity
protein 19428930
19524637
19541794
21295106
D013605 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) T-2 Toxin results in increased activity of CASP7 protein increases activity
protein 19524637
D013605 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) T-2 Toxin results in increased activity of CASP9 protein increases activity
protein 19524637
D013605 960 CD44
CDW44
CSPG8
ECMR-III
HCELL
HUTCH-I
IN
LHR
MC56
MDU2
MDU3
MIC4
Pgp1
CD44 molecule (Indian blood group) Selenium inhibits the reaction [T-2 Toxin results in decreased expression of CD44 protein] decreases expression
/ decreases reaction
protein 18196609
D013605 960 CD44
CDW44
CSPG8
ECMR-III
HCELL
HUTCH-I
IN
LHR
MC56
MDU2
MDU3
MIC4
Pgp1
CD44 molecule (Indian blood group) T-2 Toxin results in decreased expression of CD44 mRNA decreases expression
mRNA 18196609
D013605 960 CD44
CDW44
CSPG8
ECMR-III
HCELL
HUTCH-I
IN
LHR
MC56
MDU2
MDU3
MIC4
Pgp1
CD44 molecule (Indian blood group) T-2 Toxin results in decreased expression of CD44 protein decreases expression
protein 18196609
D013605 11200 CHEK2
CDS1
CHK2
HuCds1
LFS2
PP1425
RAD53
hCds1
checkpoint kinase 2 (EC:2.7.11.1) 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [T-2 Toxin results in increased activity of CHEK2 protein] decreases reaction
/ increases activity
protein 20150440
D013605 11200 CHEK2
CDS1
CHK2
HuCds1
LFS2
PP1425
RAD53
hCds1
checkpoint kinase 2 (EC:2.7.11.1) T-2 Toxin results in increased activity of CHEK2 protein increases activity
protein 20150440
D013605 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic T-2 Toxin affects the localization of CYCS protein affects localization
protein 19541794
D013605 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) T-2 Toxin results in decreased expression of CYP19A1 mRNA decreases expression
mRNA 22982764
D013605 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) resveratrol inhibits the reaction [T-2 Toxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 21453744
D013605 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) T-2 Toxin promotes the reaction [IL1B protein results in increased expression of CYP1A1 mRNA] increases expression
/ increases reaction
mRNA 21453744
D013605 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) T-2 Toxin results in increased expression of CYP1A1 mRNA increases expression
mRNA 21453744
22982764
D013605 1589 CYP21A2
CA21H
CAH1
CPS1
CYP21
CYP21B
P450c21B
cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) T-2 Toxin results in increased expression of CYP21A2 mRNA increases expression
mRNA 22982764
D013605 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [T-2 Toxin results in increased activity of H2AFX protein] decreases reaction
/ increases activity
protein 20150440
D013605 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X T-2 Toxin results in increased activity of H2AFX protein increases activity
protein 20150440
D013605 3037 HAS2
hyaluronan synthase 2 (EC:2.4.1.212) T-2 Toxin results in decreased expression of HAS2 mRNA decreases expression
mRNA 18196609
D013605 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) T-2 Toxin results in decreased expression of HMGCR mRNA decreases expression
mRNA 22982764
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [T-2 Toxin promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21453744
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta SB 203580 inhibits the reaction [T-2 Toxin promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21453744
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Selenium promotes the reaction [T-2 Toxin results in increased expression of IL1B protein] increases expression
/ increases reaction
protein 18196609
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta T-2 Toxin promotes the reaction [IL1B protein results in increased expression of CYP1A1 mRNA] increases expression
/ increases reaction
protein 21453744
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta T-2 Toxin promotes the reaction [IL1B protein results in increased expression of IL8 mRNA] increases expression
/ increases reaction
protein 21453744
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta T-2 Toxin promotes the reaction [IL1B protein results in increased expression of IL8 protein] increases expression
/ increases reaction
protein 21453744
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta T-2 Toxin promotes the reaction [IL1B protein results in increased secretion of IL8 protein] increases reaction
/ increases secretion
protein 21453744
D013605 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta T-2 Toxin results in increased expression of IL1B protein increases expression
protein 18196609
D013605 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [T-2 Toxin promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21453744
D013605 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 SB 203580 inhibits the reaction [T-2 Toxin promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 21453744
D013605 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 T-2 Toxin promotes the reaction [IL1B protein results in increased expression of IL8 mRNA] increases expression
/ increases reaction
mRNA 21453744
D013605 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 T-2 Toxin promotes the reaction [IL1B protein results in increased expression of IL8 protein] increases expression
/ increases reaction
protein 21453744
D013605 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 T-2 Toxin promotes the reaction [IL1B protein results in increased secretion of IL8 protein] increases reaction
/ increases secretion
protein 21453744
D013605 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 T-2 Toxin results in increased expression of IL8 mRNA increases expression
mRNA 21453744
D013605 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 T-2 Toxin results in increased expression of IL8 protein increases expression
protein 21453744
D013605 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) T-2 Toxin results in increased expression of MMP1 protein increases expression
protein 21144892
D013605 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA] decreases reaction
/ increases expression
mRNA 21144892
D013605 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein] decreases reaction
/ increases expression
protein 21144892
D013605 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) T-2 Toxin results in increased expression of MMP13 mRNA increases expression
mRNA 21144892
D013605 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) T-2 Toxin results in increased expression of MMP13 protein increases expression
protein 21144892
D013605 190 NR0B1
AHC
AHCH
AHX
DAX-1
DAX1
DSS
GTD
HHG
NROB1
SRXY2
nuclear receptor subfamily 0, group B, member 1 T-2 Toxin results in decreased expression of NR0B1 mRNA decreases expression
mRNA 22982764
D013605 2516 NR5A1
AD4BP
ELP
FTZ1
FTZF1
POF7
SF-1
SF1
SPGF8
SRXY3
nuclear receptor subfamily 5, group A, member 1 T-2 Toxin results in decreased expression of NR5A1 mRNA decreases expression
mRNA 22982764
D013605 7076 TIMP1
CLGI
EPA
EPO
HCI
TIMP
TIMP metallopeptidase inhibitor 1 Selenium inhibits the reaction [T-2 Toxin results in decreased expression of TIMP1 protein] decreases expression
/ decreases reaction
protein 21144892
D013605 7076 TIMP1
CLGI
EPA
EPO
HCI
TIMP
TIMP metallopeptidase inhibitor 1 T-2 Toxin results in decreased expression of TIMP1 protein decreases expression
protein 21144892
D013605 7077 TIMP2
CSC-21K
DDC8
TIMP metallopeptidase inhibitor 2 Selenium inhibits the reaction [T-2 Toxin results in decreased expression of TIMP2 protein] decreases expression
/ decreases reaction
protein 21144892
D013605 7077 TIMP2
CSC-21K
DDC8
TIMP metallopeptidase inhibitor 2 T-2 Toxin results in decreased expression of TIMP2 protein decreases expression
protein 21144892
D013605 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Selenium promotes the reaction [T-2 Toxin results in increased expression of TNF protein] increases expression
/ increases reaction
protein 18196609
D013605 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor T-2 Toxin results in increased expression of TNF protein increases expression
protein 18196609
D013605 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 T-2 Toxin results in increased expression of TP53 protein increases expression
protein 19524637

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#137800 Glioma susceptibility 1; glm1 O75874
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (5)

KEGG disease name UniProt
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

9 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003967 D013605 Diarrhea marker/mechanism
22800716
D005119 D013605 Extravasation of Diagnostic and Therapeutic Materials marker/mechanism
21112371
D007022 D013605 Hypotension marker/mechanism
3590213
D007249 D013605 Inflammation marker/mechanism
22454431
D057767 D013605 Kashin-Beck Disease marker/mechanism
21144892
D009422 D013605 Nervous System Diseases marker/mechanism
22800716
D011041 D013605 Poisoning marker/mechanism
22454431
22960706
D011201 D013605 Poultry Diseases marker/mechanism
20460662
D013610 D013605 Tachycardia marker/mechanism
3590213