Fusarium spp.
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003192
|
T-2 toxin
|
CHEMBL152423
CHEMBL152724 CHEMBL1553023 CHEMBL1703795 CHEMBL1989781 |
D013605
|
7 / 13 / 5 | 28 / 9 | No. 539 |
|
|
|
C00012613
|
Solaniol
/ Neosolaniol / Neozolaniol / (3alpha,4beta,8alpha)-12,13-Epoxy-trichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate |
CHEMBL358485
CHEMBL422680 CHEMBL345149 CHEMBL156831 |
No. 539 |
|
||||
|
C00012614
|
8-Acetylneosolaniol
/ Neosoloaniol monoacetate |
CHEMBL152165
CHEMBL489963 |
C016009
|
1 / 0 | No. 539 |
|
||
|
C00012633
|
(3alpha,4beta,7alpha,8alpha)-12,13-Epoxytrichothec-9-ene-3,4,7,8,15-pentol 4,15-diacetate
|
No. 539 |
|
|||||
|
C00012634
|
Fusarenone X
|
CHEMBL1079719
CHEMBL1485708 |
C002469
|
3 / 1 | No. 539 |
|
||
|
C00012636
|
(3alpha,4beta,7alpha)12,13-Epoxy-trichothec-9-ene-3,4,7,15-tetrol 4,15-diacetate
|
No. 539 |
|
|||||
|
C00012651
|
Toxin HT 2
|
CHEMBL440357
CHEMBL1996430 |
C012351
|
9 / 0 | No. 539 |
|
||
|
C00012656
|
12,13-Epoxy-trichothec-9-ene-3a,4b,8,15-tetrol 4,15-diacetate 8-isovalerate
|
CHEMBL152423
CHEMBL152724 CHEMBL1553023 CHEMBL1703795 CHEMBL1989781 |
7 / 13 / 5 | No. 539 |
|
Human Protein / Gene in interactions
7 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003192 C00012656 | 4 / 1 |
| O75496 | Geminin | Unclassified protein | C00003192 C00012656 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00003192 C00012656 | 7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003192 C00012656 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003192 C00012656 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003192 C00012656 | 1 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00003192 C00012656 | 1 / 1 |
35 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003192
C00012614
C00012651
|
| 1589 | CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B | cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) |
C00003192
C00012651
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003192
C00012651
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003192
C00012651
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003192
C00012651
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003192
|
| 100313513 |
C00012651
|
||
| 22926 | ATF6, ATF6A | activating transcription factor 6 |
C00012634
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00012634
|
| 2052 | EPHX1, EPHX, EPOX, HYL1, MEH | epoxide hydrolase 1, microsomal (xenobiotic) (EC:3.3.2.9) |
C00012651
|
| 83939 | EIF2A, EIF-2A, MST089, MSTP004, MSTP089 | eukaryotic translation initiation factor 2A, 65kDa |
C00012634
|
| 3292 | HSD17B1, EDH17B2, EDHB17, HSD17, SDR28C1 | hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) |
C00012651
|
| 2 | A2M, A2MD, CPAMD5, FWP007, S863-7 | alpha-2-macroglobulin |
C00003192
|
| 176 | ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK | aggrecan |
C00003192
|
| 11096 | ADAMTS5, ADAM-TS_11, ADAM-TS_5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
C00003192
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00003192
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003192
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00012651
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00003192
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003192
|
| 960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00003192
|
| 11200 | CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 | checkpoint kinase 2 (EC:2.7.11.1) |
C00003192
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00003192
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00003192
|
| 3037 | HAS2 | hyaluronan synthase 2 (EC:2.4.1.212) |
C00003192
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00003192
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00003192
|
| 4312 | MMP1, CLG, CLGN | matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) |
C00003192
|
| 4322 | MMP13, CLG3, MANDP1 | matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) |
C00003192
|
| 190 | NR0B1, AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2 | nuclear receptor subfamily 0, group B, member 1 |
C00003192
|
| 2516 | NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 | nuclear receptor subfamily 5, group A, member 1 |
C00003192
|
| 7076 | TIMP1, CLGI, EPA, EPO, HCI, TIMP | TIMP metallopeptidase inhibitor 1 |
C00003192
|
| 7077 | TIMP2, CSC-21K, DDC8 | TIMP metallopeptidase inhibitor 2 |
C00003192
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00003192
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003192
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (13)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
KEGG DISEASE (5)
| KEGG | name | UniProt |
|---|---|---|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D014839 | Vomiting |
C00012634
|
| D003967 | Diarrhea |
C00003192
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00003192
|
| D007022 | Hypotension |
C00003192
|
| D007249 | Inflammation |
C00003192
|
| D057767 | Kashin-Beck Disease |
C00003192
|
| D009422 | Nervous System Diseases |
C00003192
|
| D011041 | Poisoning |
C00003192
|
| D011201 | Poultry Diseases |
C00003192
|
| D013610 | Tachycardia |
C00003192
|