KNApSAcK Metabolite C00012651
Metabolite
KNApSAcK Entry
| id | C00012651 |
|---|---|
| Name | Toxin HT 2 |
| CAS RN | 26934-87-2 |
| Standard InChI | InChI=1S/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3/t14-,15+,17+,18+,19+,20?,21+,22?/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 539 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL440357 CHEMBL1996430 |
KEGG
| By LinkDB | C19952 |
|---|
CTD
| By CAS RN | C012351 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Fusarium spp. |
Human Protein / Gene in interaction
CTD interaction (9)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C012351 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | HT-2 toxin results in increased activity of CASP3 protein |
increases activity
|
protein |
19428930
|
| C012351 | 100313513 | HT-2 toxin results in decreased expression of CYP11A mRNA |
decreases expression
|
mRNA |
22982764
|
||
| C012351 | 1586 |
CYP17A1
CPT7 CYP17 P450C17 S17AH |
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) | HT-2 toxin results in decreased expression of CYP17A1 mRNA |
decreases expression
|
mRNA |
22982764
|
| C012351 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | HT-2 toxin results in decreased expression of CYP19A1 mRNA |
decreases expression
|
mRNA |
22982764
|
| C012351 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | HT-2 toxin results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
22982764
|
| C012351 | 1589 |
CYP21A2
CA21H CAH1 CPS1 CYP21 CYP21B P450c21B |
cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) | HT-2 toxin results in increased expression of CYP21A2 mRNA |
increases expression
|
mRNA |
22982764
|
| C012351 | 2052 |
EPHX1
EPHX EPOX HYL1 MEH |
epoxide hydrolase 1, microsomal (xenobiotic) (EC:3.3.2.9) | HT-2 toxin results in increased expression of EPHX1 mRNA |
increases expression
|
mRNA |
22982764
|
| C012351 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | HT-2 toxin results in decreased expression of HMGCR mRNA |
decreases expression
|
mRNA |
22982764
|
| C012351 | 3292 |
HSD17B1
EDH17B2 EDHB17 HSD17 SDR28C1 |
hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) | HT-2 toxin results in increased expression of HSD17B1 mRNA |
increases expression
|
mRNA |
22982764
|