Plant Species


Cumulative plant class count

class name count
Liliopsida 2

Cumulative family count

class name count
Amaryllidaceae 2

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001243 External link 512 Diallyl disulfide
CHEMBL366603
C028009
11 / 10 / 9 33 / 5

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11473 Vitamin D3 receptor NR1I1 C00001243 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00001243 0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00001243 1 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001243 2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00001243 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001243 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001243 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001243 0 / 0
P37088 Amiloride-sensitive sodium channel subunit alpha NA C00001243 2 / 2
P51168 Amiloride-sensitive sodium channel subunit beta Unclassified protein C00001243 3 / 3
P51170 Amiloride-sensitive sodium channel subunit gamma Unclassified protein C00001243 2 / 3

33 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00001243
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001243
8714 ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 C00001243
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00001243
368 ABCC6, ABC34, ARA, EST349056, GACI2, MLP1, MOAT-E, MOATE, MRP6, PXE, PXE1, URG7 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 C00001243
467 ATF3 activating transcription factor 3 C00001243
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001243
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001243
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001243
857 CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV caveolin 1, caveolae protein, 22kDa C00001243
891 CCNB1, CCNB cyclin B1 C00001243
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00001243
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00001243
9075 CLDN2 claudin 2 C00001243
1365 CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 claudin 3 C00001243
1364 CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R claudin 4 C00001243
7122 CLDN5, AWAL, BEC1, CPETRL1, TMVCF claudin 5 C00001243
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00001243
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001243
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00001243
24300 C00001243
361523 C00001243
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00001243
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00001243
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00001243
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001243
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001243
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00001243
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00001243
6615 SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 snail family zinc finger 1 C00001243
7076 TIMP1, CLGI, EPA, EPO, HCI, TIMP TIMP metallopeptidase inhibitor 1 C00001243
7077 TIMP2, CSC-21K, DDC8 TIMP metallopeptidase inhibitor 2 C00001243
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001243

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#211400 Bronchiectasis with or without elevated sweat chloride 1; besc1 P51168
#613021 Bronchiectasis with or without elevated sweat chloride 2; besc2 P37088
#613071 Bronchiectasis with or without elevated sweat chloride 3; besc3 P51170
#119900 Digital clubbing, isolated congenital P15428
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#177200 Liddle syndrome P51168
P51170
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#264350 Pseudohypoaldosteronism, type i, autosomal recessive; pha1b P37088
P51168
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (9)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4) P37088 (related)
P51168 (related)
P51170 (related)
H00892 Bronchiectasis with or without elevated sweat chloride P37088 (related)
P51168 (related)
P51170 (related)
H00242 Liddle syndrome P51168 (related)
P51170 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000230 Adenocarcinoma C00001243
D003110 Colonic Neoplasms C00001243
D007674 Kidney Diseases C00001243
D009369 Neoplasms C00001243
D011471 Prostatic Neoplasms C00001243