KNApSAcK Metabolite C00001243
Metabolite
KNApSAcK Entry
| id | C00001243 |
|---|---|
| Name | Diallyl disulfide |
| CAS RN | 2179-57-9 |
| Standard InChI | InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2 |
| Standard InChI (Main Layer) | InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 6073 |
Link
ChEMBL
| By standard InChI | CHEMBL366603 |
|---|---|
| By standard InChI Main Layer | CHEMBL366603 |
KEGG
| By LinkDB | C08369 |
|---|
CTD
| By CAS RN | C028009 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Liliopsida | 2 |
Family
| family name | count |
|---|---|
| Amaryllidaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Allium cepa | 4679 | Amaryllidaceae | Liliopsida | Viridiplantae |
| Allium sativum | 4682 | Amaryllidaceae | Liliopsida | Viridiplantae |
Human Protein / Gene in interaction
11 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL366603 |
CHEMBL1794311
(1)
|
2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL366603 |
CHEMBL1614458
(1)
|
0 / 0 |
| O75762 | Transient receptor potential cation channel subfamily A member 1 | Unclassified protein | CHEMBL366603 |
CHEMBL1118238
(1)
CHEMBL1118242
(1)
|
1 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL366603 |
CHEMBL1614038
(1)
|
2 / 2 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL366603 |
CHEMBL1614240
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL366603 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | CHEMBL366603 |
CHEMBL1743280
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL366603 |
CHEMBL1614211
(1)
|
0 / 0 |
| P37088 | Amiloride-sensitive sodium channel subunit alpha | NA | CHEMBL366603 |
CHEMBL2051232
(1)
|
2 / 2 |
| P51168 | Amiloride-sensitive sodium channel subunit beta | Unclassified protein | CHEMBL366603 |
CHEMBL2051232
(1)
|
3 / 3 |
| P51170 | Amiloride-sensitive sodium channel subunit gamma | Unclassified protein | CHEMBL366603 |
CHEMBL2051232
(1)
|
2 / 3 |
CTD interaction (55)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C028009 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | diallyl disulfide results in increased expression of ABCB1 mRNA |
increases expression
|
mRNA |
22397993
|
| C028009 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | diallyl disulfide results in decreased expression of ABCC1 mRNA |
decreases expression
|
mRNA |
22397993
|
| C028009 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | diallyl disulfide results in increased expression of ABCC1 mRNA |
increases expression
|
mRNA |
22397993
|
| C028009 | 8714 |
ABCC3
ABC31 EST90757 MLP2 MOAT-D MRP3 cMOAT2 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | diallyl disulfide affects the expression of ABCC3 mRNA |
affects expression
|
mRNA |
22397993
|
| C028009 | 8714 |
ABCC3
ABC31 EST90757 MLP2 MOAT-D MRP3 cMOAT2 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | diallyl disulfide results in increased expression of ABCC3 mRNA |
increases expression
|
mRNA |
22397993
|
| C028009 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | diallyl disulfide results in decreased expression of ABCC4 mRNA |
decreases expression
|
mRNA |
22397993
|
| C028009 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | diallyl disulfide results in increased expression of ABCC4 mRNA |
increases expression
|
mRNA |
22397993
|
| C028009 | 368 |
ABCC6
ABC34 ARA EST349056 GACI2 MLP1 MOAT-E MOATE MRP6 PXE PXE1 URG7 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | diallyl disulfide results in decreased expression of ABCC6 mRNA |
decreases expression
|
mRNA |
22397993
|
| C028009 | 368 |
ABCC6
ABC34 ARA EST349056 GACI2 MLP1 MOAT-E MOATE MRP6 PXE PXE1 URG7 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | diallyl disulfide results in increased expression of ABCC6 mRNA |
increases expression
|
mRNA |
22397993
|
| C028009 | 467 |
ATF3
|
activating transcription factor 3 | diallyl disulfide results in increased expression of ATF3 protein |
increases expression
|
protein |
15897233
|
| C028009 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | diallyl disulfide results in decreased expression of BCL2 protein |
decreases expression
|
protein |
14522920
|
| C028009 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | diallyl disulfide results in increased activity of CASP3 protein |
increases activity
|
protein |
14522920
|
| C028009 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | diallyl disulfide results in increased activity of CASP9 protein |
increases activity
|
protein |
14522920
|
| C028009 | 857 |
CAV1
BSCL3 CGL3 MSTP085 PPH3 VIP21 CAV |
caveolin 1, caveolae protein, 22kDa | diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein] |
affects binding
/ increases reaction |
protein |
20229525
|
| C028009 | 891 |
CCNB1
CCNB |
cyclin B1 | diallyl disulfide results in decreased expression of CCNB1 protein |
decreases expression
|
protein |
16691315
|
| C028009 | 891 |
CCNB1
CCNB |
cyclin B1 | diallyl disulfide results in increased expression of CCNB1 protein |
increases expression
|
protein |
19202565
|
| C028009 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | diallyl disulfide results in decreased expression of CDH1 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | diallyl disulfide results in decreased expression of CDH1 protein |
decreases expression
|
protein |
20600798
|
| C028009 | 983 |
CDK1
CDC2 CDC28A P34CDC2 |
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) | diallyl disulfide results in decreased expression of CDK1 protein |
decreases expression
|
protein |
16691315
|
| C028009 | 9075 |
CLDN2
|
claudin 2 | diallyl disulfide results in decreased expression of CLDN2 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 9075 |
CLDN2
|
claudin 2 | diallyl disulfide results in decreased expression of CLDN2 protein |
decreases expression
|
protein |
20600798
|
| C028009 | 1365 |
CLDN3
C7orf1 CPE-R2 CPETR2 HRVP1 RVP1 |
claudin 3 | diallyl disulfide results in decreased expression of CLDN3 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 1365 |
CLDN3
C7orf1 CPE-R2 CPETR2 HRVP1 RVP1 |
claudin 3 | diallyl disulfide results in decreased expression of CLDN3 protein |
decreases expression
|
protein |
20600798
|
| C028009 | 1364 |
CLDN4
CPE-R CPER CPETR CPETR1 WBSCR8 hCPE-R |
claudin 4 | diallyl disulfide results in decreased expression of CLDN4 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 1364 |
CLDN4
CPE-R CPER CPETR CPETR1 WBSCR8 hCPE-R |
claudin 4 | diallyl disulfide results in decreased expression of CLDN4 protein |
decreases expression
|
protein |
20600798
|
| C028009 | 7122 |
CLDN5
AWAL BEC1 CPETRL1 TMVCF |
claudin 5 | diallyl disulfide results in decreased expression of CLDN5 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 7122 |
CLDN5
AWAL BEC1 CPETRL1 TMVCF |
claudin 5 | diallyl disulfide results in decreased expression of CLDN5 protein |
decreases expression
|
protein |
20600798
|
| C028009 | 1499 |
CTNNB1
CTNNB MRD19 armadillo |
catenin (cadherin-associated protein), beta 1, 88kDa | diallyl disulfide results in increased expression of CTNNB1 mRNA |
increases expression
|
mRNA |
20600798
|
| C028009 | 1499 |
CTNNB1
CTNNB MRD19 armadillo |
catenin (cadherin-associated protein), beta 1, 88kDa | diallyl disulfide results in increased expression of CTNNB1 protein |
increases expression
|
protein |
20600798
|
| C028009 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | diallyl disulfide results in decreased activity of CYP1A1 protein |
decreases activity
|
protein |
18339364
|
| C028009 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | diallyl disulfide results in decreased activity of CYP2A6 protein |
decreases activity
|
protein |
18339364
|
| C028009 | 24300 | diallyl disulfide results in increased expression of CYP2B1 mRNA |
increases expression
|
mRNA |
17353348
|
||
| C028009 | 361523 | diallyl disulfide results in increased expression of CYP2B2 mRNA |
increases expression
|
mRNA |
17353348
|
||
| C028009 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | diallyl disulfide results in decreased activity of CYP2E1 protein |
decreases activity
|
protein |
18339364
|
| C028009 | 9518 |
GDF15
GDF-15 MIC-1 MIC1 NAG-1 PLAB PTGFB |
growth differentiation factor 15 | diallyl disulfide results in increased expression of GDF15 protein |
increases expression
|
protein |
11925476
|
| C028009 | 9518 |
GDF15
GDF-15 MIC-1 MIC1 NAG-1 PLAB PTGFB |
growth differentiation factor 15 | TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein] |
affects reaction
/ increases expression |
protein |
11925476
|
| C028009 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | diallyl disulfide results in increased phosphorylation of JUN protein |
increases phosphorylation
|
protein |
14522920
|
| C028009 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | diallyl disulfide results in increased phosphorylation of MAPK8 protein |
increases phosphorylation
|
protein |
14522920
|
| C028009 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | diallyl disulfide results in decreased expression of and results in decreased activity of MMP2 protein |
decreases activity
/ decreases expression |
protein |
20600798
|
| C028009 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | diallyl disulfide results in decreased expression of MMP2 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | diallyl disulfide results in decreased expression of and results in decreased activity of MMP9 protein |
decreases activity
/ decreases expression |
protein |
20600798
|
| C028009 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | diallyl disulfide results in decreased expression of MMP9 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein] |
affects binding
/ increases reaction |
protein |
20229525
|
| C028009 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | diallyl disulfide results in decreased degradation of NOS3 protein |
decreases degradation
|
protein |
20229525
|
| C028009 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | diallyl disulfide results in increased expression of NOS3 protein |
increases expression
|
protein |
20229525
|
| C028009 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | diallyl disulfide results in increased phosphorylation of NOS3 protein |
increases phosphorylation
|
protein |
20229525
|
| C028009 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
20229525
|
| C028009 | 6615 |
SNAI1
SLUGH2 SNA SNAH SNAIL SNAIL1 dJ710H13.1 |
snail family zinc finger 1 | diallyl disulfide results in decreased expression of SNAI1 mRNA |
decreases expression
|
mRNA |
20600798
|
| C028009 | 6615 |
SNAI1
SLUGH2 SNA SNAH SNAIL SNAIL1 dJ710H13.1 |
snail family zinc finger 1 | diallyl disulfide results in decreased expression of SNAI1 protein |
decreases expression
|
protein |
20600798
|
| C028009 | 7076 |
TIMP1
CLGI EPA EPO HCI TIMP |
TIMP metallopeptidase inhibitor 1 | diallyl disulfide results in increased expression of TIMP1 mRNA |
increases expression
|
mRNA |
20600798
|
| C028009 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | diallyl disulfide results in increased expression of TIMP2 mRNA |
increases expression
|
mRNA |
20600798
|
| C028009 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Acetylcysteine inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein] |
decreases reaction
/ increases expression |
protein |
19202565
|
| C028009 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | diallyl disulfide results in increased expression of TP53 protein |
increases expression
|
protein |
11925476
19202565 |
| C028009 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein] |
decreases reaction
/ increases expression |
protein |
19202565
|
| C028009 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein] |
affects reaction
/ increases expression |
protein |
11925476
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (10)
| OMIM | preferred title | UniProt |
|---|---|---|
| #211400 | Bronchiectasis with or without elevated sweat chloride 1; besc1 |
P51168
|
| #613021 | Bronchiectasis with or without elevated sweat chloride 2; besc2 |
P37088
|
| #613071 | Bronchiectasis with or without elevated sweat chloride 3; besc3 |
P51170
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #615040 | Episodic pain syndrome, familial, 1; feps1 |
O75762
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #177200 | Liddle syndrome |
P51168
P51170 |
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #264350 | Pseudohypoaldosteronism, type i, autosomal recessive; pha1b |
P37088
P51168 |
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (9)
| KEGG | disease name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00243 | Hyperkalemic distal renal tubular acidosis (RTA type 4) |
P37088
(related)
P51168 (related) P51170 (related) |
| H00892 | Bronchiectasis with or without elevated sweat chloride |
P37088
(related)
P51168 (related) P51170 (related) |
| H00242 | Liddle syndrome |
P51168
(related)
P51170 (related) |
Diseases related to CTD interactions
5 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000230 | C028009 | Adenocarcinoma |
therapeutic
|
8339252
|
|
| D003110 | C028009 | Colonic Neoplasms |
therapeutic
|
8339252
|
|
| D007674 | C028009 | Kidney Diseases |
therapeutic
|
12877940
|
|
| D009369 | C028009 | Neoplasms |
therapeutic
|
22397993
|
|
| D011471 | C028009 | Prostatic Neoplasms |
therapeutic
|
16691315
|