KCF-S cluster No. 6812 (1 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 6 |
Cumulative family count
| class name | count |
|---|---|
| Rutaceae | 6 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00048438
|
Isopropanol
|
CHEMBL582
|
D019840
|
5 / 17 / 15 | 33 / 2 |
|
Human Protein / Gene in interactions
5 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | C00048438 | 11 / 10 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00048438 | 3 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00048438 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00048438 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00048438 | 3 / 4 |
33 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 124 | ADH1A, ADH1 | alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) |
C00048438
|
| 125 | ADH1B, ADH2 | alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) |
C00048438
|
| 126 | ADH1C, ADH3 | alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) |
C00048438
|
| 127 | ADH4, ADH-2 | alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) |
C00048438
|
| 131 | ADH7, ADH4 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) |
C00048438
|
| 231 | AKR1B1, ADR, ALDR1, ALR2, AR | aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) |
C00048438
|
| 57016 | AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI | aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) |
C00048438
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00048438
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00048438
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00048438
|
| 1135 | CHRNA2 | cholinergic receptor, nicotinic, alpha 2 (neuronal) |
C00048438
|
| 1143 | CHRNB4 | cholinergic receptor, nicotinic, beta 4 (neuronal) |
C00048438
|
| 2235 | FECH, EPP, FCE | ferrochelatase (EC:4.99.1.1) |
C00048438
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00048438
|
| 2512 | FTL, NBIA3 | ferritin, light polypeptide |
C00048438
|
| 2539 | G6PD, G6PD1 | glucose-6-phosphate dehydrogenase (EC:1.1.1.49) |
C00048438
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00048438
|
| 2730 | GCLM, GLCLR | glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) |
C00048438
|
| 2688 | GH1, GH, GH-N, GHN, IGHD1B, hGH-N | growth hormone 1 |
C00048438
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00048438
|
| 3033 | HADH, HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD | hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35) |
C00048438
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00048438
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00048438
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00048438
|
| 4097 | MAFG, hMAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G |
C00048438
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00048438
|
| 4199 | ME1, HUMNDME, MES | malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) |
C00048438
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00048438
|
| 5226 | PGD, 6PGD | phosphogluconate dehydrogenase (EC:1.1.1.44) |
C00048438
|
| 22949 | PTGR1, LTB4DH, PGR1, ZADH3 | prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) |
C00048438
|
| 140809 | SRXN1, C20orf139, Npn3, SRX, SRX1 | sulfiredoxin 1 (EC:1.8.98.2) |
C00048438
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00048438
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00048438
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (15)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|