PCIDB

KNApSAcK Metabolite C00048438

Metabolite

KNApSAcK Entry

id C00048438
Name Isopropanol
CAS RN 67-63-0
Standard InChI InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3
Standard InChI (Main Layer) InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 6812

Link

ChEMBL

By standard InChI CHEMBL582
By standard InChI Main Layer CHEMBL582

KEGG

By LinkDB C01845

CTD

By CAS RN D019840

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein CHEMBL582 CHEMBL1614544 (1)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL582 CHEMBL1794561 (1)
3 / 1
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL582 CHEMBL1614458 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL582 CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL582 CHEMBL1794560 (1)
3 / 4

CTD interaction (35)

compound gene gene name gene description interaction interaction type form reference
pmid
D019840 124 ADH1A
ADH1
alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) ADH1A protein results in increased oxidation of 2-Propanol increases oxidation
protein 21167143
D019840 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) ADH1B protein results in increased oxidation of 2-Propanol increases oxidation
protein 21167143
D019840 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) ADH1C protein results in increased oxidation of 2-Propanol increases oxidation
protein 21167143
D019840 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) ADH4 protein results in increased oxidation of 2-Propanol increases oxidation
protein 21167143
D019840 131 ADH7
ADH4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) ADH7 protein results in increased oxidation of 2-Propanol increases oxidation
protein 21167143
D019840 231 AKR1B1
ADR
ALDR1
ALR2
AR
aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) 2-Propanol results in increased expression of AKR1B1 mRNA increases expression
mRNA 20566472
D019840 57016 AKR1B10
AKR1B11
AKR1B12
ALDRLn
ARL-1
ARL1
HIS
HSI
aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) 2-Propanol results in increased expression of AKR1B10 mRNA increases expression
mRNA 20566472
D019840 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) 2-Propanol results in increased expression of AKR1C1 mRNA increases expression
mRNA 20566472
D019840 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) 2-Propanol results in increased expression of AKR1C3 mRNA increases expression
mRNA 20566472
D019840 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 22020770
D019840 1135 CHRNA2
cholinergic receptor, nicotinic, alpha 2 (neuronal) 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] affects binding
/ increases reaction
/ increases transport
protein 11821649
D019840 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] affects binding
/ increases reaction
/ increases transport
protein 11821649
D019840 2235 FECH
EPP
FCE
ferrochelatase (EC:4.99.1.1) 2-Propanol results in increased expression of FECH mRNA increases expression
mRNA 20566472
D019840 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog 2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 affects the localization of FOS protein] affects localization
/ decreases reaction
protein 22020770
D019840 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog 2-Propanol results in decreased activity of FOS protein decreases activity
protein 22020770
D019840 2512 FTL
NBIA3
ferritin, light polypeptide 2-Propanol results in increased expression of FTL mRNA increases expression
mRNA 20566472
D019840 2539 G6PD
G6PD1
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) 2-Propanol results in increased expression of G6PD mRNA increases expression
mRNA 20566472
D019840 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) 2-Propanol results in increased expression of GCLC mRNA increases expression
mRNA 20566472
D019840 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) 2-Propanol results in increased expression of GCLM mRNA increases expression
mRNA 20566472
D019840 2688 GH1
GH
GH-N
GHN
IGHD1B
hGH-N
growth hormone 1 2-Propanol affects the folding of GH1 protein affects folding
protein 11064379
D019840 2936 GSR
glutathione reductase (EC:1.8.1.7) 2-Propanol results in increased expression of GSR mRNA increases expression
mRNA 20566472
D019840 3033 HADH
HAD
HADH1
HADHSC
HCDH
HHF4
MSCHAD
SCHAD
hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35) HADH protein results in increased metabolism of 2-Propanol increases metabolic processing
protein 10600649
D019840 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) 2-Propanol results in increased expression of HMOX1 mRNA increases expression
mRNA 20566472
D019840 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) 2-Propanol promotes the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased secretion of IL6 protein] increases reaction
/ increases secretion
protein 22020770
D019840 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene 2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 affects the localization of JUN protein] affects localization
/ decreases reaction
protein 22020770
D019840 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene 2-Propanol results in decreased activity of JUN protein decreases activity
protein 22020770
D019840 4097 MAFG
hMAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2-Propanol results in increased expression of MAFG mRNA increases expression
mRNA 20566472
D019840 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22020770
D019840 4199 ME1
HUMNDME
MES
malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) 2-Propanol results in increased expression of ME1 mRNA increases expression
mRNA 20566472
D019840 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) 2-Propanol results in increased expression of NQO1 mRNA increases expression
mRNA 20566472
D019840 5226 PGD
6PGD
phosphogluconate dehydrogenase (EC:1.1.1.44) 2-Propanol results in increased expression of PGD mRNA increases expression
mRNA 20566472
D019840 22949 PTGR1
LTB4DH
PGR1
ZADH3
prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) 2-Propanol results in increased expression of PTGR1 mRNA increases expression
mRNA 20566472
D019840 140809 SRXN1
C20orf139
Npn3
SRX
SRX1
sulfiredoxin 1 (EC:1.8.98.2) 2-Propanol results in increased expression of SRXN1 mRNA increases expression
mRNA 20566472
D019840 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor 2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased secretion of TNF protein] decreases reaction
/ increases secretion
protein 22020770
D019840 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) 2-Propanol results in increased expression of TXNRD1 mRNA increases expression
mRNA 20566472

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (15)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007674 D019840 Kidney Diseases marker/mechanism
23159986
D012772 D019840 Shock, Septic therapeutic
22020770