KNApSAcK Entry

Organism name Citrus sinensis
Genus Citrus
Family Rutaceae
Kingdom Plantae

NCBI taxonomy


Linked NCBI taxonomy name Citrus sinensis
Linked NCBI taxonomy ID 2711
Linked level species


Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (33)

Species Activity
Citrus sinensis (L.) Osbeck Antibilious
Citrus sinensis (L.) Osbeck Anticancer
Citrus sinensis (L.) Osbeck Antigastric
Citrus sinensis (L.) Osbeck Antihistaminic
Citrus sinensis (L.) Osbeck Antihomocysteine
Citrus sinensis (L.) Osbeck Antiinflammatory
Citrus sinensis (L.) Osbeck Antioxidant
Citrus sinensis (L.) Osbeck Antiseptic
Citrus sinensis (L.) Osbeck Antispasmodic
Citrus sinensis (L.) Osbeck Antitussive
Citrus sinensis (L.) Osbeck Antiulcer
Citrus sinensis (L.) Osbeck Antiviral
Citrus sinensis (L.) Osbeck Cardioprotective
Citrus sinensis (L.) Osbeck Carminative
Citrus sinensis (L.) Osbeck Depurative
Citrus sinensis (L.) Osbeck Diaphoretic
Citrus sinensis (L.) Osbeck Digestive
Citrus sinensis (L.) Osbeck Gastrostimulant
Citrus sinensis (L.) Osbeck Hepatoprotective
Citrus sinensis (L.) Osbeck Hypocholesterolemic
Citrus sinensis (L.) Osbeck Hypoglycemic
Citrus sinensis (L.) Osbeck Hypolipemic
Citrus sinensis (L.) Osbeck Hypotensive
Citrus sinensis (L.) Osbeck Hypouricemic
Citrus sinensis (L.) Osbeck Immunostimulant
Citrus sinensis (L.) Osbeck Laxative
Citrus sinensis (L.) Osbeck Myorelaxant
Citrus sinensis (L.) Osbeck Orexigenic
Citrus sinensis (L.) Osbeck Respiradepressant
Citrus sinensis (L.) Osbeck Secretolytic
Citrus sinensis (L.) Osbeck Sedative
Citrus sinensis (L.) Osbeck Stomachic
Citrus sinensis (L.) Osbeck Tonic

Metabolite list (89)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00006287 External link 512 3,8-Di-C-glucopyranosyldiosmetin
No. 1 No. 15
C00006796 External link 512 Cyanidin 3-(6''-malonylglucoside)
/ Cyanidin-3-O-(6-O-malonyl-beta-D-glucopyranoside)
No. 2 No. 15
C00002374 External link 512 Chrysanthemin
/ Cyanidin 3-O-glucoside
1 / 0 / 1 No. 2 No. 15
C00006792 External link 512 Cyanidin 3-(4''-acetylglucoside)
No. 2 No. 15
C00004711 External link 512 7-Hydroxy-3,5,6,3',4'-pentamethoxyflavone
/ Quercetagetin 3,5,6,3',4'-pentamethyl ether
/ 2-(3,4-Dimethoxyphenyl)-7-hydroxy-3,5,6-trimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00004804 External link 512 3,3',4',5,6,7,8-Heptamethoxyflavone
/ 3,5,6,7,8,3',4'-Heptamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-4H-1-benzopyran-4-one
17 / 10 / 2 No. 8 No. 15
C00004802 External link 512 5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
26 / 14 / 6 No. 8 No. 15
C00013378 External link 512 7-Hydroxy-3,5,6,8,3',4'-hexamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-7-hydroxy-3,5,6,8-tetramethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00013304 External link 512 6-Demethoxytangeritin
/ 6-Demethoxytangeretin
/ 4',5,7,8-Tetramethoxyflavone
/ Tetra-O-methylisoscutellarein
/ 5,7,8-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
No. 8 No. 15
C00001105 External link 512 Tangeretin
/ 4',5,6,7,8-Pentamethoxyflavone
12 / 11 / 11 2 / 0 No. 8 No. 15
C00001076 External link 512 Nobiletin
/ 3',4',5,6,7,8-Hexamethoxyflavone
22 / 23 / 20 5 / 2 No. 8 No. 15
C00004745 External link 512 Gossypetin hexamethyl ether
/ 3,5,7,8,3',4'-Hexamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-3,5,7,8-tetramethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00004744 External link 512 Gossypetin 3,7,8,3',4'-pentamethyl ether
/ 5-Hydroxy-3,7,8,3',4'-pentamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7,8-trimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00004713 External link 512 Hexamethylquercetagetin
/ Oxyayanin B trimethyl ether
/ Quercetagetin hexamethyl ether
/ 3,5,6,7,3',4'-Hexamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-3,5,6,7-tetramethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00013596 External link 512 Sinensetin
/ Pedalitin permethyl ether
/ 5,6,7,3',4'-Pentamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
7 / 6 / 7 3 / 0 No. 8 No. 15
C00003841 External link 512 Tetramethylscutellarein
/ 5,6,7,4'-Tetramethoxyflavone
/ Scutellarein 5,6,7,4'-tetramethyl ether
/ 5,6,7-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
9 / 4 / 8 No. 8 No. 15
C00003912 External link 512 Isosinensetin
/ 6-Demethoxynobiletin
/ 5,7,8,3',4'-Pentamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00003936 External link 512 Demethylnobiletin
/ 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one
21 / 22 / 16 No. 8 No. 15
C00008683 External link 512 Dihydrokaempferide 7-rhamnoside
No. 12 No. 14
C00006861 External link 512 Peonidin 3-(6''-p-coumarylglucoside)
No. 30 No. 15
C00000081 External link 512 GA81
/ Gibberellin A81
No. 40 No. 41
C00000004 External link 512 GA4
/ Gibberellin A4
No. 40 No. 41
C00000009 External link 512 GA9
/ Gibberellin A9
No. 40 No. 41
C00000008 External link 512 GA8
/ Gibberellin A8
No. 40 No. 41
C00000044 External link 512 GA44
/ Gibberellin A44
No. 40 No. 41
C00000029 External link 512 GA29
/ Gibberellin A29
No. 40 No. 41
C00000003 External link 512 GA3
/ Gibberellin A3
10 / 18 / 17 No. 40 No. 41
C00000020 External link 512 GA20
/ Gibberellin A20
No. 40 No. 41
C00000001 External link 512 GA1
/ Gibberellin A1
No. 40 No. 41
C00007098 External link 512 Citrunobin
No. 130
C00000017 External link 512 GA17
/ Gibberellin A17
No. 187 No. 41
C00000019 External link 512 GA19
/ Gibberellin A19
No. 187 No. 41
C00003118 External link 512 Copaene
/ alpha-Copaene
/ (-)-alpha-Copaene
No. 333 No. 38
C00003131 External link 512 beta-Farnesene
/ (E)-beta-Farnesene
/ beta-trans-Farnesene
No. 404 No. 38
C00000805 External link 512 alpha-Pinene
3 / 3 / 2 0 / 1 No. 476 No. 35
C00000816 External link 512 beta-Pinene
No. 476 No. 35
C00003110 External link 512 Caryophyllene
/ (E)-Caryophyllene
/ beta-Caryophyllene
/ (-)-(E)-Caryophyllene
/ (E)-beta-Caryophyllene
2 / 3 / 7 No. 478 No. 38
C00001265 External link 512 Pentadecane
2 / 8 / 37 No. 599
C00048301 External link 512 8-Heptadecene
No. 599
C00030472 External link 512 Heptadecane
No. 599
C00007242 External link 512 beta-Bisabolene
/ l-beta-Bisabolene
/ (-)-beta-Bisabolene
No. 701 No. 38
C00000218 External link 512 Jasmonic acid
/ trans-Jasmonic acid
/ 3-Oxo-2-(2Z-pentenyl)cyclotentylacetic acid
4 / 1 / 0 No. 707 No. 70
C00003166 External link 512 Nerolidol
3 / 3 / 1 No. 726 No. 38
C00023109 External link 512 3-Hydroxysintaxanthin
No. 747
C00023107 External link 512 Sintaxanthin
/ 7',8'-Dihydro-7'-apo-beta-caroten-8'-one
No. 747
C00000823 External link 512 Limonene
7 / 21 / 48 6 / 6 No. 848 No. 35
C00048326 External link 512 Benzene acetonitrile
No. 885
C00007535 External link 512 Phenylacetaldehyde
/ Benzeneacetaldehyde
/ Phenylacetic aldehyde
3 / 0 No. 885
C00003047 External link 512 Linalool
/ (R)-linalool
/ (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol
6 / 8 / 2 35 / 4 No. 958 No. 34
C00023114 External link 512 (3S,5R,6S)-5,6-Epoxy-5,6-dihydro-3-hydroxy-8'-apo-beta,psi-carotenal
No. 1086
C00023126 External link 512 10'-Apoviolaxanthal
/ (3S,5R,6S)-5,6-Epoxy-5,6-dihydro-3-hydroxy-10'-apo-beta,psi-carotenal
No. 1086
C00003779 External link 512 Mutatochrome
/ beta-carotene 5,8-epoxide
No. 1206 No. 59
C00003767 External link 512 5,6-epoxy-beta-Carotene
/ beta-Carotene 5,6-epoxide
No. 1206 No. 59
C00000184 External link 512 alpha-Thujene
No. 1343 No. 35
C00031258 External link 512 Sabinene
/ 4(10)-Thujene
No. 1343 No. 35
C00007453 External link 512 Cyclohexane
/ beta-Elemene
No. 1400
C00000100 External link 512 IAA
/ Indole-3-acetic acid
3 / 0 / 0 2 / 1 No. 1432 No. 4
C00003035 External link 512 Geranial
/ (E)-alpha-Citral
6 / 7 / 9 No. 1575 No. 34
C00003036 External link 512 Neral
/ Citral Z
6 / 7 / 9 No. 1575 No. 34
C00000855 External link 512 Nerol
/ cis-Geraniol
96 / 41 / 41 No. 1575 No. 34
C00048310 External link 512 Allo-Ocimene
No. 1698 No. 34
C00048486 External link 512 Neo-allo-ocimene
No. 1698 No. 34
C00035823 External link 512 Citronellal
2 / 0 / 3 0 / 2 No. 1948 No. 34
C00030767 External link 512 Methyl salicylate
92 / 52 / 46 29 / 3 No. 2169
C00003040 External link 512 p-Cymene
No. 2172 No. 35
C00048315 External link 512 alpha-Myrcene
No. 2285 No. 34
C00000853 External link 512 Myrcene
3 / 3 / 3 No. 2285 No. 34
C00003060 External link 512 alpha-Terpinene
No. 2468 No. 35
C00011045 External link 512 delta-3-Carene
/ (-)-Carene(-)-3-Carene
No. 2690 No. 35
C00029353 External link 512 (Z)-Jasmone
/ cis-Jasmone
No. 3251
C00000357 External link 512 Hexanal
7 / 0 No. 3593
C00000358 External link 512 n-Hexanol
3 / 6 / 3 No. 3722
C00000861 External link 512 Terpinolene
1 / 0 No. 3725
C00048529 External link 512 Sabinene hydrate
No. 3782 No. 35
C00034600 External link 512 Methyl anthranilate
3 / 3 / 3 No. 4170
C00000101 External link 512 IAA methyl ester
/ Methyl indole-3-acetate
No. 4225
C00003188 External link 512 alpha-Sinensal
No. 4729 No. 38
C00003189 External link 512 beta-Sinensal
No. 4729 No. 38
C00048248 External link 512 (Z)-Ocimene
/ cis-Ocimene
No. 4949
C00048263 External link 512 2,6-Dimethyl-1,3,5,7-octatetraene
No. 4953
C00048276 External link 512 2-Methylfuran
3 / 7 / 37 No. 5208
C00034775 External link 512 6-Methyl-5-hepten-2-one
No. 5297
C00048304 External link 512 Acetone
1 / 11 / 10 10 / 8 No. 5308
C00034989 External link 512 (E)-Ocimene
/ trans-Ocimene
No. 6181
C00034452 External link 512 Benzaldehyde
8 / 7 / 3 3 / 1 No. 6311
C00048438 External link 512 Isopropanol
5 / 17 / 15 33 / 2 No. 6812
C00048350 External link 512 Carvyl acetate
4 / 3 / 2 No. 6846
C00048498 External link 512 n-Phenylformamide
6 / 2 / 0 No. 8296
C00019560 External link 512 Ethanol
92 / 39 / 33 199 / 193 No. 8862

Human Protein / Gene in interactions

161 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P00352 Retinal dehydrogenase 1 Enzyme C00001076 C00001105 C00003035 C00003036 C00003841 C00003936 C00019560 C00034452 C00034600 C00048438 C00048498 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000358 C00000823 C00003841 C00004802 C00034600 C00048276 C00048350 C00048438 C00048498 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000358 C00000823 C00001105 C00003035 C00003036 C00003047 C00003166 C00048438 3 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000003 C00000855 C00001076 C00001105 C00003936 C00019560 C00030767 0 / 1
P02545 Prelamin-A/C Unclassified protein C00000003 C00000823 C00003936 C00030767 C00048304 C00048438 11 / 10
O00255 Menin Unclassified protein C00000855 C00001076 C00001105 C00003110 C00003841 C00013596 2 / 5
P28482 Mitogen-activated protein kinase 1 Erk C00000805 C00000855 C00001076 C00003936 C00019560 C00030767 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000358 C00000805 C00000853 C00019560 C00030767 C00048350 3 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000855 C00001076 C00001105 C00003110 C00003841 C00013596 1 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000823 C00000855 C00019560 C00030767 C00035823 0 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000003 C00001105 C00003047 C00004802 C00048498 0 / 0
P03372 Estrogen receptor NR3A1 C00000855 C00001265 C00019560 C00030767 C00034452 1 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00001076 C00001105 C00004804 C00013596 2 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000805 C00019560 C00048276 C00048350 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000003 C00000855 C00019560 C00030767 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000855 C00003047 C00003166 C00048350 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000853 C00000855 C00019560 C00030767 0 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000823 C00000855 C00034452 C00048498 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000855 C00003841 C00019560 C00030767 0 / 0
O75496 Geminin Unclassified protein C00000003 C00001076 C00004802 C00048498 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000855 C00019560 C00030767 C00034452 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000003 C00000855 C00019560 C00030767 1 / 1
P10275 Androgen receptor NR3C4 C00000003 C00003035 C00003036 C00048438 3 / 4
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000003 C00000855 C00019560 C00030767 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000003 C00000855 C00019560 C00030767 0 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001076 C00001105 C00003841 C00004802 1 / 1
P08183 Multidrug resistance protein 1 drug C00001076 C00001105 C00004804 C00013596 1 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000855 C00019560 C00030767 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000855 C00019560 C00030767 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000855 C00019560 C00030767 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000855 C00019560 C00030767 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000855 C00019560 C00030767 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000855 C00019560 C00030767 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000855 C00019560 C00030767 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000855 C00019560 C00030767 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000855 C00019560 C00030767 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00003936 C00004802 C00004804 1 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00003936 C00004802 C00004804 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00003936 C00004802 C00004804 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000855 C00019560 C00030767 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000855 C00019560 C00030767 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000855 C00019560 C00030767 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00003936 C00004802 C00004804 0 / 0
Q13885 Tubulin beta-2A chain Structural C00003936 C00004802 C00004804 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000855 C00019560 C00030767 1 / 8
P68363 Tubulin alpha-1B chain Unclassified protein C00003936 C00004802 C00004804 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000855 C00019560 C00030767 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000855 C00019560 C00030767 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000855 C00019560 C00030767 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000855 C00019560 C00030767 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000855 C00019560 C00030767 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000855 C00019560 C00030767 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000855 C00019560 C00030767 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000855 C00019560 C00030767 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000855 C00019560 C00030767 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000855 C00019560 C00030767 1 / 0
Q13509 Tubulin beta-3 chain Structural C00003936 C00004802 C00004804 2 / 1
P68371 Tubulin beta-4B chain Structural C00003936 C00004802 C00004804 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00003936 C00004802 C00004804 1 / 1
P07437 Tubulin beta chain Structural C00003936 C00004802 C00004804 0 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00003936 C00004802 C00004804 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001076 C00003936 C00004802 4 / 3
P04350 Tubulin beta-4A chain Structural C00003936 C00004802 C00004804 2 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000855 C00019560 C00030767 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000855 C00019560 C00030767 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000855 C00019560 C00030767 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000855 C00019560 C00030767 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000855 C00019560 C00030767 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000855 C00019560 C00030767 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000855 C00019560 C00030767 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000855 C00019560 C00030767 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000855 C00019560 C00030767 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000855 C00019560 C00030767 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00003936 C00004802 C00004804 1 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000855 C00019560 C00030767 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000855 C00019560 C00030767 0 / 0
P08311 Cathepsin G S1A C00000855 C00019560 C00030767 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000855 C00019560 C00030767 1 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00003035 C00003036 C00035823 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001076 C00003841 C00004802 0 / 0
P03956 Interstitial collagenase M10A C00000855 C00019560 C00030767 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000855 C00019560 C00030767 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000855 C00019560 C00030767 2 / 2
P68366 Tubulin alpha-4A chain Structural C00003936 C00004802 C00004804 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000855 C00019560 C00030767 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000855 C00019560 C00030767 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000855 C00019560 C00030767 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00003936 C00004802 C00004804 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000855 C00019560 C00030767 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000855 C00019560 C00030767 2 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000823 C00001265 C00048276 7 / 37
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000855 C00019560 C00030767 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000855 C00019560 C00030767 1 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000855 C00019560 C00030767 0 / 0
P21452 Substance-K receptor Neurokinin receptor C00000855 C00019560 C00030767 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000855 C00019560 C00030767 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000855 C00019560 C00030767 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000855 C00019560 C00030767 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000855 C00019560 C00030767 0 / 1
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000855 C00019560 C00030767 1 / 0
P17252 Protein kinase C alpha type Alpha C00000855 C00019560 C00030767 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000855 C00019560 C00030767 2 / 1
P29466 Caspase-1 C14 C00000855 C00019560 C00030767 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000855 C00019560 C00030767 1 / 1
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000855 C00019560 C00030767 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000855 C00019560 C00030767 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000855 C00019560 C00030767 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000855 C00019560 C00030767 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001076 C00003841 C00004802 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000855 C00019560 C00030767 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000855 C00019560 C00030767 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000855 C00019560 C00030767 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000855 C00019560 C00030767 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000855 C00019560 C00030767 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000855 C00019560 C00030767 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000855 C00019560 C00030767 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000855 C00019560 C00030767 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000855 C00019560 C00030767 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000855 C00019560 C00030767 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000855 C00019560 C00030767 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000855 C00019560 C00030767 1 / 2
Q16539 Mitogen-activated protein kinase 14 p38 C00000855 C00019560 C00030767 0 / 0
P08246 Neutrophil elastase S1A C00000855 C00019560 C00030767 2 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000855 C00019560 C00030767 2 / 2
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000855 C00019560 C00030767 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000003 C00034452 C00048498 2 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00003035 C00003036 0 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00001076 C00001105 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001076 C00004802 1 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00000855 C00003047 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001076 C00001105 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000855 C00030767 2 / 3
Q92830 Histone acetyltransferase KAT2A Enzyme C00001076 C00013596 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001076 C00004802 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001105 C00003166 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001076 C00034600 3 / 3
Q96RI1 Bile acid receptor NR1H4 C00000853 C00000855 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00003035 C00003036 1 / 4
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001076 C00004802 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000218 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001076 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000218 1 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001076 5 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00013596 0 / 0
Q9HBH1 Peptide deformylase, mitochondrial Enzyme C00000100 0 / 0
P14679 Tyrosinase Oxidoreductase C00034452 4 / 2
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00000100 0 / 0
P10145 Interleukin-8 Secreted protein C00034452 0 / 0
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000218 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001076 2 / 2
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00034452 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000218 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00002374 0 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003936 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00003047 3 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00004802 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00003841 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003047 5 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000823 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00013596 0 / 0
P02768 Serum albumin Secreted protein C00000100 0 / 0

271 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC: C00000823 C00001076 C00001105 C00003047
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00007535 C00019560 C00030767 C00048304
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC: C00000823 C00019560 C00030767 C00048438
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC: C00003047 C00019560 C00030767 C00048438
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000357 C00000823 C00003047
2512 FTL, NBIA3 ferritin, light polypeptide C00019560 C00030767 C00048438
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC: C00000861 C00003047 C00019560
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC: C00001076 C00001105 C00013596
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00003047 C00019560 C00030767
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC: C00000357 C00019560 C00034452
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC: C00000357 C00030767 C00048438
2263 FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 fibroblast growth factor receptor 2 (EC: C00019560 C00048304
218 ALDH3A1, ALDH3, ALDHIII aldehyde dehydrogenase 3 family, member A1 (EC: C00000357 C00034452
221 ALDH3B1, ALDH4, ALDH7 aldehyde dehydrogenase 3 family, member B1 (EC: C00000357 C00034452
127 ADH4, ADH-2 alcohol dehydrogenase 4 (class II), pi polypeptide (EC: C00019560 C00048438
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00000357 C00003047
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC: C00003047 C00007535
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00007535 C00019560
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC: C00001076 C00013596
2688 GH1, GH, GH-N, GHN, IGHD1B, hGH-N growth hormone 1 C00019560 C00048438
126 ADH1C, ADH3 alcohol dehydrogenase 1C (class I), gamma polypeptide (EC: C00019560 C00048438
125 ADH1B, ADH2 alcohol dehydrogenase 1B (class I), beta polypeptide (EC: C00019560 C00048438
124 ADH1A, ADH1 alcohol dehydrogenase 1A (class I), alpha polypeptide (EC: C00019560 C00048438
3678 ITGA5, CD49e, FNRA, VLA5A integrin, alpha 5 (fibronectin receptor, alpha polypeptide) C00019560 C00048304
131 ADH7, ADH4 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC: C00019560 C00048438
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00019560 C00048304
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019560 C00048304
847 CAT catalase (EC: C00019560 C00048304
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC: C00030767 C00048438
140809 SRXN1, C20orf139, Npn3, SRX, SRX1 sulfiredoxin 1 (EC: C00030767 C00048438
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC: C00003047 C00019560
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00003047 C00019560
22949 PTGR1, LTB4DH, PGR1, ZADH3 prostaglandin reductase 1 (EC: C00030767 C00048438
4852 NPY, PYY4 neuropeptide Y C00000823 C00003047
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC: C00003047 C00019560
5226 PGD, 6PGD phosphogluconate dehydrogenase (EC: C00030767 C00048438
57016 AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI aldo-keto reductase family 1, member B10 (aldose reductase) (EC: C00030767 C00048438
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC: C00030767 C00048438
4097 MAFG, hMAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G C00030767 C00048438
2936 GSR glutathione reductase (EC: C00030767 C00048438
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC: C00030767 C00048438
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00003047 C00048438
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC: C00030767 C00048438
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC: C00019560 C00048438
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000823 C00019560
2235 FECH, EPP, FCE ferrochelatase (EC: C00030767 C00048438
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00019560 C00030767
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC: C00030767 C00048438
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC: C00030767 C00048438
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC: C00030767 C00048438
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000100
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000100
26118 WSB1, SWIP1, WSB-1 WD repeat and SOCS box containing 1 C00003047
7471 WNT1, BMND16, INT1, OI15 wingless-type MMTV integration site family, member 1 C00003047
1385 CREB1, CREB cAMP responsive element binding protein 1 C00030767
2010 EMD, EDMD, LEMD5, STA emerin C00030767
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00003047
100124292 C00003047
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00003047
8850 KAT2B, CAF, P, P/CAF, PCAF K(lysine) acetyltransferase 2B (EC: C00003047
9514 GAL3ST1, CST galactose-3-O-sulfotransferase 1 (EC: C00030767
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00003047
3398 ID2, GIG8, ID2A, ID2H, bHLHb26 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein C00003047
3316 HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP heat shock 27kDa protein 2 C00003047
3308 HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY heat shock 70kDa protein 4 C00003047
4883 NPR3, ANP-C, ANPR-C, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) C00030767
3320 HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 C00003047
3297 HSF1, HSTF1 heat shock transcription factor 1 C00003047
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00003047
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00003047
1509 CTSD, CLN10, CPSD cathepsin D (EC: C00003047
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC: C00030767
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC: C00030767
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC: C00030767
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC: C00030767
1447 CSN2, CASB casein beta C00003047
1030 CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) C00003047
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC: C00048304
1028 CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 cyclin-dependent kinase inhibitor 1C (p57, Kip2) C00003047
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00003047
3596 IL13, IL-13, P600 interleukin 13 C00048304
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00048304
3567 IL5, EDF, IL-5, TRF interleukin 5 (colony-stimulating factor, eosinophil) C00048304
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00003047
23536 ADAT1, HADAT1 adenosine deaminase, tRNA-specific 1 (EC: C00019560
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00003047
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00003047
1386 ATF2, CRE-BP1, CREB2, HB16, TREB7 activating transcription factor 2 (EC: C00003047
501 ALDH7A1, ATQ1, EPD, PDE aldehyde dehydrogenase 7 family, member A1 (EC: C00000357
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC: C00019560
4316 MMP7, MMP-7, MPSL1, PUMP-1 matrix metallopeptidase 7 (matrilysin, uterine) (EC: C00001076
22977 AKR7A3, AFAR2 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) C00019560
273 AMPH, AMPH1 amphiphysin C00019560
162 AP1B1, ADTB1, AP105A, BAM22, CLAPB2 adaptor-related protein complex 1, beta 1 subunit C00019560
79065 ATG9A, APG9L1, MGD3208, mATG9 autophagy related 9A C00019560
506 ATP5B, ATPMB, ATPSB ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (EC: C00019560
581 BAX, BCL2L4 BCL2-associated X protein C00019560
8678 BECN1, ATG6, VPS30, beclin1 beclin 1, autophagy related C00019560
274 BIN1, AMPH2, AMPHL, SH3P9 bridging integrator 1 C00019560
708 C1QBP, GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32 complement component 1, q subcomponent binding protein C00019560
832 CAPZB, CAPB, CAPPB, CAPZ capping protein (actin filament) muscle Z-line, beta C00019560
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC: C00019560
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC: C00019560
857 CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV caveolin 1, caveolae protein, 22kDa C00019560
83446 CCDC70 coiled-coil domain containing 70 C00019560
54535 CCHCR1, C6orf18, HCR, SBP coiled-coil alpha-helical rod protein 1 C00019560
894 CCND2, KIAK0002 cyclin D2 C00019560
994 CDC25B cell division cycle 25B (EC: C00019560
55664 CDC37L1, CDC37B, HARC cell division cycle 37-like 1 C00019560
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00019560
23552 CDK20, CCRK, CDCH, P42, PNQALRE cyclin-dependent kinase 20 (EC: C00019560
1050 CEBPA, C/EBP-alpha, CEBP CCAAT/enhancer binding protein (C/EBP), alpha C00019560
55165 CEP55, C10orf3, CT111, URCC6 centrosomal protein 55kDa C00019560
1066 CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 carboxylesterase 1 (EC: C00019560
1138 CHRNA5, LNCR2 cholinergic receptor, nicotinic, alpha 5 (neuronal) C00019560
1140 CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS cholinergic receptor, nicotinic, beta 1 (muscle) C00019560
1191 CLU, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2 clusterin C00019560
1266 CNN3 calponin 3, acidic C00019560
1278 COL1A2, OI4 collagen, type I, alpha 2 C00019560
1417 CRYBB3, CATCN2, CRYB3, CTRCT22 crystallin, beta B3 C00019560
1442 CSH1, CS-1, CSA, CSMT, PL, hCS-A chorionic somatomammotropin hormone 1 (placental lactogen) C00019560
1535 CYBA, p22-PHOX cytochrome b-245, alpha polypeptide C00019560
1536 CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX cytochrome b-245, beta polypeptide C00019560
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00019560
10591 DNPH1, C6orf108, RCL, RP3-330M21.3, dJ330M21.3 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 C00019560
1837 DTNA, D18S892E, DRP3, DTN, DTN-A, LVNC1 dystrobrevin, alpha C00019560
338599 DUPD1, DUSP27, FMDSP dual specificity phosphatase and pro isomerase domain containing 1 (EC: C00019560
2023 ENO1, ENO1L1, MPB1, NNE, PPH enolase 1, (alpha) (EC: C00019560
10961 ERP29, C12orf8, ERp28, ERp31, PDI-DB, PDIA9 endoplasmic reticulum protein 29 C00019560
2177 FANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD Fanconi anemia, complementation group D2 C00019560
84261 FBXW9, Fbw9 F-box and WD repeat domain containing 9 C00019560
2348 FOLR1, FBP, FOLR folate receptor 1 (adult) C00019560
2526 FUT4, CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (EC:2.4.1.-) C00019560
2534 FYN, SLK, SYN, p59-FYN FYN oncogene related to SRC, FGR, YES (EC: C00019560
2670 GFAP glial fibrillary acidic protein C00019560
972 CD74, DHLAG, HLADG, II, Ia-GAMMA CD74 molecule, major histocompatibility complex, class II invariant chain C00001076
51031 GLOD4, C17orf25, HC71 glyoxalase domain containing 4 C00019560
2741 GLRA1, HKPX1, STHE glycine receptor, alpha 1 C00019560
2932 GSK3B glycogen synthase kinase 3 beta (EC: C00019560
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC: C00019560
2952 GSTT1 glutathione S-transferase theta 1 (EC: C00019560
57817 HAMP, HEPC, HFE2B, LEAP1, PLTR hepcidin antimicrobial peptide C00019560
1839 HBEGF, DTR, DTS, DTSF, HEGFL heparin-binding EGF-like growth factor C00019560
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00019560
3181 HNRNPA2B1, HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1 heterogeneous nuclear ribonucleoprotein A2/B1 C00019560
3190 HNRNPK, CSBP, HNRPK, TUNP heterogeneous nuclear ribonucleoprotein K C00019560
3359 HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic C00019560
9177 HTR3B, 5-HT3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic C00019560
27429 HTRA2, OMI, PARK13, PRSS25 HtrA serine peptidase 2 (EC: C00019560
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00019560
3479 IGF1, IGF-I, IGF1A, IGFI insulin-like growth factor 1 (somatomedin C) C00019560
3486 IGFBP3, BP-53, IBP3 insulin-like growth factor binding protein 3 C00019560
3589 IL11, AGIF, IL-11 interleukin 11 C00019560
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00019560
3708 ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 inositol 1,4,5-trisphosphate receptor, type 1 C00019560
83999 KREMEN1, KREMEN, KRM1 kringle containing transmembrane protein 1 C00019560
3875 KRT18, CYK18, K18 keratin 18 C00019560
3856 KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO keratin 8 C00019560
3897 L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1 L1 cell adhesion molecule C00019560
4017 LOXL2, LOR2, WS9-14 lysyl oxidase-like 2 (EC:1.4.3.-) C00019560
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00000823
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC: C00019560
4144 MAT2A, MATA2, MATII, SAMS2 methionine adenosyltransferase II, alpha (EC: C00019560
4148 MATN3, DIPOA, EDM5, HOA, OADIP, OS2 matrilin 3 C00019560
406931 MIR139, MIR139-3p, MIRN139 microRNA 139 C00019560
406987 MIR204, MIRN204, miRNA204 microRNA 204 C00019560
100126336 MIR208B, MIRN208B microRNA 208b C00019560
407018 MIR27A, MIR27, MIRN27A microRNA 27a C00019560
442894 MIR302B, MIRN302B microRNA 302b C00019560
693120 MIR33B, MIRN33B, hsa-mir-33b microRNA 33b C00019560
407040 MIR34A, MIRN34A, miRNA34A, mir-34 microRNA 34a C00019560
442914 MIR369, MIR369-3, MIRN369, MIRN369-3, hsa-mir-369 microRNA 369 C00019560
442915 MIR370, MIRN370, hsa-mir-370 microRNA 370 C00019560
442918 MIR373, MIRN373, hsa-mir-373, miRNA373 microRNA 373 C00019560
494324 MIR375, MIRN375, hsa-mir-375, miRNA375 microRNA 375 C00019560
574451 MIR432, MIRN432, hsa-mir-432 microRNA 432 C00019560
619552 MIR483, MIRN483, hsa-mir-483 microRNA 483 C00019560
574450 MIR493, MIRN493, hsa-mir-493 microRNA 493 C00019560
574456 MIR497, MIRN497, hsa-mir-497 microRNA 497 C00019560
574472 MIR518F, MIRN518F microRNA 518f C00019560
574471 MIR523, MIRN523, hsa-mir-523 microRNA 523 C00019560
693191 MIR606, MIRN606, hsa-mir-606 microRNA 606 C00019560
724026 MIR656, MIRN656, hsa-mir-656 microRNA 656 C00019560
100126326 MIR936, MIRN936, hsa-mir-936 microRNA 936 C00019560
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC: C00019560
4548 MTR, HMAG, MS, cblG 5-methyltetrahydrofolate-homocysteine methyltransferase (EC: C00019560
4595 MUTYH, CYP2C, MYH mutY homolog (EC:3.2.2.-) C00019560
4638 MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK myosin light chain kinase (EC: C00019560
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00019560
4688 NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX neutrophil cytosolic factor 2 C00019560
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019560
4791 NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) C00019560
4830 NME1, AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1 NME/NM23 nucleoside diphosphate kinase 1 (EC: C00019560
8996 NOL3, ARC, FCM, MYP, NOP, NOP30 nucleolar protein 3 (apoptosis repressor with CARD domain) C00019560
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC: C00019560
4854 NOTCH3, CADASIL, CASIL, IMF2 notch 3 C00019560
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00019560
4897 NRCAM neuronal cell adhesion molecule C00019560
8829 NRP1, BDCA4, CD304, NP1, NRP, VEGF165R neuropilin 1 C00019560
100506658 OCLN, BLCPMG occludin (EC: C00019560
4968 OGG1, HMMH, HOGG1, MUTM, OGH1 8-oxoguanine DNA glycosylase (EC: C00019560
4986 OPRK1, K-OR-1, KOR, KOR-1, OPRK opioid receptor, kappa 1 C00019560
4988 OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM opioid receptor, mu 1 C00019560
84876 ORAI1, CRACM1, IMD9, ORAT1, TMEM142A ORAI calcium release-activated calcium modulator 1 C00019560
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC: C00019560
5142 PDE4B, DPDE4, PDE4B5, PDEIVB phosphodiesterase 4B, cAMP-specific (EC: C00019560
5173 PDYN, ADCA, PENKB, SCA23 prodynorphin C00019560
5179 PENK proenkephalin C00019560
5204 PFDN5, MM-1, MM1, PFD5 prefoldin subunit 5 C00019560
25796 PGLS, 6PGL 6-phosphogluconolactonase (EC: C00019560
5245 PHB, PHB1 prohibitin C00019560
26227 PHGDH, 3-PGDH, 3PGDH, PDG, PGAD, PGD, PGDH, SERA phosphoglycerate dehydrogenase (EC: C00019560
5335 PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1 phospholipase C, gamma 1 (EC: C00019560
5352 PLOD2, LH2, TLH procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (EC: C00019560
57048 PLSCR3 phospholipid scramblase 3 C00019560
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00019560
5395 PMS2, HNPCC4, PMS2CL, PMSL2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) C00019560
5426 POLE, CRCS12, FILS, POLE1 polymerase (DNA directed), epsilon, catalytic subunit (EC: C00019560
5443 POMC, ACTH, CLIP, LPH, MSH, NPP, POC proopiomelanocortin C00019560
5451 POU2F1, OCT1, OTF1, oct-1B POU class 2 homeobox 1 C00019560
5460 POU5F1, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4 POU class 5 homeobox 1 C00019560
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00019560
100136658 C00019560
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00019560
8497 PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 C00019560
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC: C00019560
9588 PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29 peroxiredoxin 6 (EC: C00019560
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC: C00019560
5579 PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 protein kinase C, beta (EC: C00019560
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC: C00019560
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC: C00019560
2185 PTK2B, CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK protein tyrosine kinase 2 beta (EC: C00019560
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00019560
5884 RAD17, CCYC, HRAD17, R24L, RAD17SP, RAD24 RAD17 homolog (S. pombe) C00019560
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00019560
6236 RRAD, RAD, RAD1, REM3 Ras-related associated with diabetes C00019560
6275 S100A4, 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98 S100 calcium binding protein A4 C00019560
6342 SCP2, NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX sterol carrier protein 2 (EC: C00019560
23513 SCRIB, CRIB1, SCRB1, SCRIB1, Vartul scribbled planar cell polarity protein C00019560
6573 SLC19A1, CHMD, FOLT, IFC1, REFC, RFC1 solute carrier family 19 (folate transporter), member 1 C00019560
2030 SLC29A1, ENT1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 C00019560
60682 SMAP1, SMAP-1 small ArfGAP 1 C00019560
6678 SPARC, ON secreted protein, acidic, cysteine-rich (osteonectin) C00019560
6696 SPP1, BNSP, BSPI, ETA-1, OPN secreted phosphoprotein 1 C00019560
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00019560
6723 SRM, PAPT, SPDSY, SPS1, SRML1 spermidine synthase (EC: C00019560
56910 STARD7, GTT1 StAR-related lipid transfer (START) domain containing 7 C00019560
6786 STIM1, D11S4896E, GOK, IMD10, TAM stromal interaction molecule 1 C00019560
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC: C00019560
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC: C00019560
6783 SULT1E1, EST, EST-1, ST1E1, STE sulfotransferase family 1E, estrogen-preferring, member 1 (EC: C00019560
6822 SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (EC: C00019560
9095 TBX19, TBS19, TPIT, dJ747L4.1 T-box 19 C00019560
7037 TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90 transferrin receptor C00019560
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00019560
7052 TGM2, G-ALPHA-h, GNAH, TG2, TGC transglutaminase 2 (EC: C00019560
7082 TJP1, ZO-1 tight junction protein 1 C00019560
7083 TK1, TK2 thymidine kinase 1, soluble (EC: C00019560
7167 TPI1, TIM, TPI, TPID triosephosphate isomerase 1 (EC: C00019560
10107 TRIM10, HERF1, RFB30, RNF9 tripartite motif containing 10 C00019560
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00019560
7498 XDH, XO, XOR xanthine dehydrogenase (EC: C00019560
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00019560
7515 XRCC1, RCC X-ray repair complementing defective repair in Chinese hamster cells 1 C00019560
25925 ZNF521, EHZF, Evi3 zinc finger protein 521 C00019560
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00048438
1135 CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) C00048438
1143 CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) C00048438
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00048438
3033 HADH, HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD hydroxyacyl-CoA dehydrogenase (EC: C00048438
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00048438

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (106)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 P04626
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303


KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

210 disease in interactions with metabolites

D012640 Seizures C00034452
D056486 Drug-Induced Liver Injury C00000100
D013276 Stomach Ulcer C00000823
D008114 Liver Neoplasms, Experimental C00000823
D008569 Memory Disorders C00000823
D008107 Liver Diseases C00000823
D009336 Necrosis C00030767
D009135 Muscular Diseases C00030767
D007674 Kidney Diseases C00000823
D003877 Dermatitis, Contact C00000805
D020018 Sexual Dysfunctions, Psychological C00019560
D009369 Neoplasms C00003047
D006937 Hypercholesterolemia C00003047
D017453 Dermatitis, Irritant C00003047
D011230 Precancerous Conditions C00001076
D003110 Colonic Neoplasms C00001076
D009395 Nephritis, Interstitial C00030767
D005157 Facial Pain C00035823
D003389 Cranial Nerve Diseases C00048304
D003556 Cystitis C00048304
D007662 Ketosis C00048304
D009374 Neoplasms, Experimental C00048304
D012878 Skin Neoplasms C00048304
D014555 Urination Disorders C00048304
D000014 Abnormalities, Drug-Induced C00019560
D000138 Acidosis C00019560
D000140 Acidosis, Lactic C00019560
D058186 Acute Kidney Injury C00019560
D000402 Airway Obstruction C00019560
D000435 Alcoholic Intoxication C00019560
D020751 Alcohol-Induced Disorders C00019560
D020268 Alcohol-Induced Disorders, Nervous System C00019560
D000437 Alcoholism C00019560
D019973 Alcohol-Related Disorders C00019560
D020270 Alcohol Withdrawal Seizures C00019560
D000647 Amnesia C00019560
D020236 Amnesia, Transient Global C00019560
D019969 Amphetamine-Related Disorders C00019560
D000853 Anophthalmos C00019560
D000855 Anorexia C00019560
D001008 Anxiety Disorders C00019560
D001028 Aortopulmonary Septal Defect C00019560
D001247 Asthenia C00019560
D001259 Ataxia C00019560
D050197 Atherosclerosis C00019560
D054537 Atrioventricular Block C00019560
D001284 Atrophy C00019560
D001342 Autonomic Nervous System Diseases C00019560
D001714 Bipolar Disorder C00019560
D001766 Blindness C00019560
D001835 Body Weight C00019560
D001919 Bradycardia C00019560
D001927 Brain Diseases C00019560
D001929 Brain Edema C00019560
D001930 Brain Injuries C00019560
D002545 Brain Ischemia C00019560
D001986 Bronchial Spasm C00019560
D002056 Burns C00019560
D006528 Carcinoma, Hepatocellular C00019560
D006332 Cardiomegaly C00019560
D009202 Cardiomyopathies C00019560
D002310 Cardiomyopathy, Alcoholic C00019560
D002311 Cardiomyopathy, Dilated C00019560
D002318 Cardiovascular Diseases C00019560
D020215 Carotid Artery, Internal, Dissection C00019560
D002493 Central Nervous System Diseases C00019560
D002543 Cerebral Hemorrhage C00019560
D002779 Cholestasis C00019560
D002971 Cleft Lip C00019560
D002972 Cleft Palate C00019560
D019970 Cocaine-Related Disorders C00019560
D003072 Cognition Disorders C00019560
D003128 COMA C00019560
D003221 Confusion C00019560
C535464 Conotruncal cardiac defects C00019560
D003244 Consciousness Disorders C00019560
D019465 Craniofacial Abnormalities C00019560
D003645 Death, Sudden C00019560
D016757 Death, Sudden, Cardiac C00019560
D003693 Delirium C00019560
D003731 Dental Caries C00019560
D003866 Depressive Disorder C00019560
D003865 Depressive Disorder, Major C00019560
D002658 Developmental Disabilities C00019560
D004195 Disease Models, Animal C00019560
D018450 Disease Progression C00019560
D004244 Dizziness C00019560
D056487 Drug-Induced Liver Injury, Chronic C00019560
D064420 Drug-Related Side Effects and Adverse Reactions C00019560
D020820 Dyskinesias C00019560
D004417 Dyspnea C00019560
D004487 Edema C00019560
D004830 Epilepsy, Tonic-Clonic C00019560
D004938 Esophageal Neoplasms C00019560
D020329 Essential Tremor C00019560
D005234 Fatty Liver C00019560
D005235 Fatty Liver, Alcoholic C00019560
D063647 Fetal Alcohol Spectrum Disorders C00019560
D005313 Fetal Death C00019560
D005317 Fetal Growth Retardation C00019560
D005355 Fibrosis C00019560
D005483 Flushing C00019560
D005756 Gastritis C00019560
D005767 Gastrointestinal Diseases C00019560
D006130 Growth Disorders C00019560
D006212 Hallucinations C00019560
D006323 Heart Arrest C00019560
D006330 Heart Defects, Congenital C00019560
D006331 Heart Diseases C00019560
D006344 Heart Septal Defects, Atrial C00019560
D006345 Heart Septal Defects, Ventricular C00019560
D006470 Hemorrhage C00019560
D020141 Hemostatic Disorders C00019560
D006505 Hepatitis C00019560
D006519 Hepatitis, Alcoholic C00019560
D006529 Hepatomegaly C00019560
D006869 Hydronephrosis C00019560
D006930 Hyperalgesia C00019560
D006940 Hyperemia C00019560
D006945 Hyperhidrosis C00019560
D006948 Hyperkinesis C00019560
D006965 Hyperplasia C00019560
D006973 Hypertension C00019560
D015228 Hypertriglyceridemia C00019560
D017379 Hypertrophy, Left Ventricular C00019560
D007022 Hypotension C00019560
D007035 Hypothermia C00019560
D007154 Immune System Diseases C00019560
D007249 Inflammation C00019560
D008607 Intellectual Disability C00019560
D020300 Intracranial Hemorrhages C00019560
D007511 Ischemia C00019560
D007565 Jaundice C00019560
D007569 Jaw Abnormalities C00019560
D007683 Kidney Tubular Necrosis, Acute C00019560
D007859 Learning Disorders C00019560
D017880 Limb Deformities, Congenital C00019560
D008103 Liver Cirrhosis C00019560
D008104 Liver Cirrhosis, Alcoholic C00019560
D008106 Liver Cirrhosis, Experimental C00019560
D008108 Liver Diseases, Alcoholic C00019560
D017114 Liver Failure, Acute C00019560
D008133 Long QT Syndrome C00019560
D008175 Lung Neoplasms C00019560
D008831 Microcephaly C00019560
D048629 Micronuclei, Chromosome-Defective C00019560
D008850 Microphthalmos C00019560
D009059 Mouth Diseases C00019560
D009069 Movement Disorders C00019560
D009203 Myocardial Infarction C00019560
D017202 Myocardial Ischemia C00019560
D009325 Nausea C00019560
D009361 Neoplasm Invasiveness C00019560
D009362 Neoplasm Metastasis C00019560
D009422 Nervous System Diseases C00019560
D051474 Neuralgia, Postherpetic C00019560
D009436 Neural Tube Defects C00019560
D019954 Neurobehavioral Manifestations C00019560
D020258 Neurotoxicity Syndromes C00019560
D009901 Optic Nerve Diseases C00019560
D010146 Pain C00019560
D010190 Pancreatic Neoplasms C00019560
D010195 Pancreatitis C00019560
D019512 Pancreatitis, Alcoholic C00019560
D010243 Paralysis C00019560
D010523 Peripheral Nervous System Diseases C00019560
D010538 Peritonitis C00019560
D010698 Phobic Disorders C00019560
D011041 Poisoning C00019560
D011115 Polyneuropathies C00019560
D017119 Porphyria Cutanea Tarda C00019560
D011297 Prenatal Exposure Delayed Effects C00019560
D049188 Prenatal Injuries C00019560
D015175 Prolactinoma C00019560
D011507 Proteinuria C00019560
D011596 Psychomotor Disorders C00019560
D011605 Psychoses, Substance-Induced C00019560
D011654 Pulmonary Edema C00019560
D015427 Reperfusion Injury C00019560
D012141 Respiratory Tract Infections C00019560
D012164 Retinal Diseases C00019560
D012206 Rhabdomyolysis C00019560
D018805 Sepsis C00019560
D007938 Leukemia C00003047
D013272 Stomach Diseases C00019560
D013274 Stomach Neoplasms C00019560
D020521 Stroke C00019560
D053608 Stupor C00019560
D013345 Subarachnoid Hemorrhage C00019560
D019966 Substance-Related Disorders C00019560
D013375 Substance Withdrawal Syndrome C00019560
D013610 Tachycardia C00019560
D017180 Tachycardia, Ventricular C00019560
D013683 Telangiectasia, Hereditary Hemorrhagic C00019560
D013771 Tetralogy of Fallot C00019560
D018677 Tooth Injuries C00019560
D016388 Tooth Loss C00019560
D016171 Torsades de Pointes C00019560
D014202 Tremor C00019560
D014474 Unconsciousness C00019560
D016055 Urinary Retention C00019560
D054079 Vascular Malformations C00019560
D018487 Ventricular Dysfunction, Left C00019560
D014693 Ventricular Fibrillation C00019560
D018879 Ventricular Premature Complexes C00019560
D014811 Vitamin E Deficiency C00019560
D014839 Vomiting C00019560
D015430 Weight Gain C00019560
D015431 Weight Loss C00019560
D012772 Shock, Septic C00048438