Plant Species


Cumulative plant class count

class name count
rosids 8

Cumulative family count

class name count
Rutaceae 8
Enterobacteriaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00019560 External link 512 Ethanol
CHEMBL545
D000431
92 / 39 / 33 199 / 193

Human Protein / Gene in interactions

92 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00019560 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00019560 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019560 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00019560 2 / 2
P08246 Neutrophil elastase S1A C00019560 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00019560 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00019560 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00019560 0 / 0
P29466 Caspase-1 C14 C00019560 0 / 0
P17252 Protein kinase C alpha type Alpha C00019560 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00019560 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00019560 2 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00019560 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00019560 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00019560 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00019560 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00019560 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00019560 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00019560 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00019560 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00019560 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00019560 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00019560 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00019560 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00019560 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00019560 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00019560 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00019560 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00019560 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00019560 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00019560 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00019560 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00019560 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00019560 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00019560 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00019560 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00019560 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00019560 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00019560 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00019560 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00019560 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00019560 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00019560 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00019560 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00019560 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00019560 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00019560 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00019560 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00019560 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00019560 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00019560 0 / 0
P08311 Cathepsin G S1A C00019560 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00019560 1 / 0
P03956 Interstitial collagenase M10A C00019560 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00019560 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00019560 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00019560 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00019560 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00019560 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00019560 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00019560 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00019560 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00019560 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00019560 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00019560 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00019560 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00019560 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00019560 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00019560 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00019560 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00019560 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00019560 0 / 0
P03372 Estrogen receptor NR3A1 C00019560 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00019560 1 / 0
P22303 Acetylcholinesterase Hydrolase C00019560 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00019560 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00019560 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00019560 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00019560 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00019560 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00019560 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00019560 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00019560 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00019560 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00019560 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00019560 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00019560 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00019560 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00019560 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00019560 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00019560 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00019560 0 / 0

199 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
23536 ADAT1, HADAT1 adenosine deaminase, tRNA-specific 1 (EC:3.5.4.34) C00019560
124 ADH1A, ADH1 alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) C00019560
125 ADH1B, ADH2 alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) C00019560
126 ADH1C, ADH3 alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) C00019560
127 ADH4, ADH-2 alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) C00019560
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) C00019560
131 ADH7, ADH4 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) C00019560
22977 AKR7A3, AFAR2 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) C00019560
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00019560
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) C00019560
273 AMPH, AMPH1 amphiphysin C00019560
162 AP1B1, ADTB1, AP105A, BAM22, CLAPB2 adaptor-related protein complex 1, beta 1 subunit C00019560
79065 ATG9A, APG9L1, MGD3208, mATG9 autophagy related 9A C00019560
506 ATP5B, ATPMB, ATPSB ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (EC:3.6.3.14) C00019560
581 BAX, BCL2L4 BCL2-associated X protein C00019560
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00019560
8678 BECN1, ATG6, VPS30, beclin1 beclin 1, autophagy related C00019560
274 BIN1, AMPH2, AMPHL, SH3P9 bridging integrator 1 C00019560
708 C1QBP, GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32 complement component 1, q subcomponent binding protein C00019560
832 CAPZB, CAPB, CAPPB, CAPZ capping protein (actin filament) muscle Z-line, beta C00019560
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00019560
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00019560
847 CAT catalase (EC:1.11.1.6) C00019560
857 CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV caveolin 1, caveolae protein, 22kDa C00019560
83446 CCDC70 coiled-coil domain containing 70 C00019560
54535 CCHCR1, C6orf18, HCR, SBP coiled-coil alpha-helical rod protein 1 C00019560
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019560
894 CCND2, KIAK0002 cyclin D2 C00019560
994 CDC25B cell division cycle 25B (EC:3.1.3.48) C00019560
55664 CDC37L1, CDC37B, HARC cell division cycle 37-like 1 C00019560
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00019560
23552 CDK20, CCRK, CDCH, P42, PNQALRE cyclin-dependent kinase 20 (EC:2.7.11.22) C00019560
1050 CEBPA, C/EBP-alpha, CEBP CCAAT/enhancer binding protein (C/EBP), alpha C00019560
55165 CEP55, C10orf3, CT111, URCC6 centrosomal protein 55kDa C00019560
1066 CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) C00019560
1138 CHRNA5, LNCR2 cholinergic receptor, nicotinic, alpha 5 (neuronal) C00019560
1140 CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS cholinergic receptor, nicotinic, beta 1 (muscle) C00019560
1191 CLU, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2 clusterin C00019560
1266 CNN3 calponin 3, acidic C00019560
1278 COL1A2, OI4 collagen, type I, alpha 2 C00019560
1417 CRYBB3, CATCN2, CRYB3, CTRCT22 crystallin, beta B3 C00019560
1442 CSH1, CS-1, CSA, CSMT, PL, hCS-A chorionic somatomammotropin hormone 1 (placental lactogen) C00019560
1535 CYBA, p22-PHOX cytochrome b-245, alpha polypeptide C00019560
1536 CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX cytochrome b-245, beta polypeptide C00019560
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00019560
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00019560
10591 DNPH1, C6orf108, RCL, RP3-330M21.3, dJ330M21.3 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 C00019560
1837 DTNA, D18S892E, DRP3, DTN, DTN-A, LVNC1 dystrobrevin, alpha C00019560
338599 DUPD1, DUSP27, FMDSP dual specificity phosphatase and pro isomerase domain containing 1 (EC:3.1.3.16 3.1.3.48) C00019560
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00019560
2023 ENO1, ENO1L1, MPB1, NNE, PPH enolase 1, (alpha) (EC:4.2.1.11) C00019560
10961 ERP29, C12orf8, ERp28, ERp31, PDI-DB, PDIA9 endoplasmic reticulum protein 29 C00019560
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00019560
2177 FANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD Fanconi anemia, complementation group D2 C00019560
84261 FBXW9, Fbw9 F-box and WD repeat domain containing 9 C00019560
2263 FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 fibroblast growth factor receptor 2 (EC:2.7.10.1) C00019560
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00019560
2348 FOLR1, FBP, FOLR folate receptor 1 (adult) C00019560
2512 FTL, NBIA3 ferritin, light polypeptide C00019560
2526 FUT4, CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (EC:2.4.1.-) C00019560
2534 FYN, SLK, SYN, p59-FYN FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) C00019560
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00019560
2670 GFAP glial fibrillary acidic protein C00019560
2688 GH1, GH, GH-N, GHN, IGHD1B, hGH-N growth hormone 1 C00019560
51031 GLOD4, C17orf25, HC71 glyoxalase domain containing 4 C00019560
2741 GLRA1, HKPX1, STHE glycine receptor, alpha 1 C00019560
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00019560
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00019560
2952 GSTT1 glutathione S-transferase theta 1 (EC:2.5.1.18) C00019560
57817 HAMP, HEPC, HFE2B, LEAP1, PLTR hepcidin antimicrobial peptide C00019560
1839 HBEGF, DTR, DTS, DTSF, HEGFL heparin-binding EGF-like growth factor C00019560
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00019560
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00019560
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00019560
3181 HNRNPA2B1, HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1 heterogeneous nuclear ribonucleoprotein A2/B1 C00019560
3190 HNRNPK, CSBP, HNRPK, TUNP heterogeneous nuclear ribonucleoprotein K C00019560
3359 HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic C00019560
9177 HTR3B, 5-HT3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic C00019560
27429 HTRA2, OMI, PARK13, PRSS25 HtrA serine peptidase 2 (EC:3.4.21.108) C00019560
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00019560
3479 IGF1, IGF-I, IGF1A, IGFI insulin-like growth factor 1 (somatomedin C) C00019560
3486 IGFBP3, BP-53, IBP3 insulin-like growth factor binding protein 3 C00019560
3589 IL11, AGIF, IL-11 interleukin 11 C00019560
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00019560
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00019560
3678 ITGA5, CD49e, FNRA, VLA5A integrin, alpha 5 (fibronectin receptor, alpha polypeptide) C00019560
3708 ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 inositol 1,4,5-trisphosphate receptor, type 1 C00019560
83999 KREMEN1, KREMEN, KRM1 kringle containing transmembrane protein 1 C00019560
3875 KRT18, CYK18, K18 keratin 18 C00019560
3856 KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO keratin 8 C00019560
3897 L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1 L1 cell adhesion molecule C00019560
4017 LOXL2, LOR2, WS9-14 lysyl oxidase-like 2 (EC:1.4.3.-) C00019560
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00019560
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00019560
4144 MAT2A, MATA2, MATII, SAMS2 methionine adenosyltransferase II, alpha (EC:2.5.1.6) C00019560
4148 MATN3, DIPOA, EDM5, HOA, OADIP, OS2 matrilin 3 C00019560
406931 MIR139, MIR139-3p, MIRN139 microRNA 139 C00019560
406987 MIR204, MIRN204, miRNA204 microRNA 204 C00019560
100126336 MIR208B, MIRN208B microRNA 208b C00019560
407018 MIR27A, MIR27, MIRN27A microRNA 27a C00019560
442894 MIR302B, MIRN302B microRNA 302b C00019560
693120 MIR33B, MIRN33B, hsa-mir-33b microRNA 33b C00019560
407040 MIR34A, MIRN34A, miRNA34A, mir-34 microRNA 34a C00019560
442914 MIR369, MIR369-3, MIRN369, MIRN369-3, hsa-mir-369 microRNA 369 C00019560
442915 MIR370, MIRN370, hsa-mir-370 microRNA 370 C00019560
442918 MIR373, MIRN373, hsa-mir-373, miRNA373 microRNA 373 C00019560
494324 MIR375, MIRN375, hsa-mir-375, miRNA375 microRNA 375 C00019560
574451 MIR432, MIRN432, hsa-mir-432 microRNA 432 C00019560
619552 MIR483, MIRN483, hsa-mir-483 microRNA 483 C00019560
574450 MIR493, MIRN493, hsa-mir-493 microRNA 493 C00019560
574456 MIR497, MIRN497, hsa-mir-497 microRNA 497 C00019560
574472 MIR518F, MIRN518F microRNA 518f C00019560
574471 MIR523, MIRN523, hsa-mir-523 microRNA 523 C00019560
693191 MIR606, MIRN606, hsa-mir-606 microRNA 606 C00019560
724026 MIR656, MIRN656, hsa-mir-656 microRNA 656 C00019560
100126326 MIR936, MIRN936, hsa-mir-936 microRNA 936 C00019560
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00019560
4548 MTR, HMAG, MS, cblG 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) C00019560
4595 MUTYH, CYP2C, MYH mutY homolog (EC:3.2.2.-) C00019560
4638 MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK myosin light chain kinase (EC:2.7.11.18) C00019560
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00019560
4688 NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX neutrophil cytosolic factor 2 C00019560
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019560
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00019560
4791 NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) C00019560
4830 NME1, AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1 NME/NM23 nucleoside diphosphate kinase 1 (EC:2.7.4.6) C00019560
8996 NOL3, ARC, FCM, MYP, NOP, NOP30 nucleolar protein 3 (apoptosis repressor with CARD domain) C00019560
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00019560
4854 NOTCH3, CADASIL, CASIL, IMF2 notch 3 C00019560
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00019560
4897 NRCAM neuronal cell adhesion molecule C00019560
8829 NRP1, BDCA4, CD304, NP1, NRP, VEGF165R neuropilin 1 C00019560
100506658 OCLN, BLCPMG occludin (EC:2.1.1.67) C00019560
4968 OGG1, HMMH, HOGG1, MUTM, OGH1 8-oxoguanine DNA glycosylase (EC:4.2.99.18) C00019560
4986 OPRK1, K-OR-1, KOR, KOR-1, OPRK opioid receptor, kappa 1 C00019560
4988 OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM opioid receptor, mu 1 C00019560
84876 ORAI1, CRACM1, IMD9, ORAT1, TMEM142A ORAI calcium release-activated calcium modulator 1 C00019560
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00019560
5142 PDE4B, DPDE4, PDE4B5, PDEIVB phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) C00019560
5173 PDYN, ADCA, PENKB, SCA23 prodynorphin C00019560
5179 PENK proenkephalin C00019560
5204 PFDN5, MM-1, MM1, PFD5 prefoldin subunit 5 C00019560
25796 PGLS, 6PGL 6-phosphogluconolactonase (EC:3.1.1.31) C00019560
5245 PHB, PHB1 prohibitin C00019560
26227 PHGDH, 3-PGDH, 3PGDH, PDG, PGAD, PGD, PGDH, SERA phosphoglycerate dehydrogenase (EC:1.1.1.95) C00019560
5335 PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1 phospholipase C, gamma 1 (EC:3.1.4.11) C00019560
5352 PLOD2, LH2, TLH procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (EC:1.14.11.4) C00019560
57048 PLSCR3 phospholipid scramblase 3 C00019560
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00019560
5395 PMS2, HNPCC4, PMS2CL, PMSL2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) C00019560
5426 POLE, CRCS12, FILS, POLE1 polymerase (DNA directed), epsilon, catalytic subunit (EC:2.7.7.7) C00019560
5443 POMC, ACTH, CLIP, LPH, MSH, NPP, POC proopiomelanocortin C00019560
5451 POU2F1, OCT1, OTF1, oct-1B POU class 2 homeobox 1 C00019560
5460 POU5F1, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4 POU class 5 homeobox 1 C00019560
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00019560
100136658 C00019560
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00019560
8497 PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 C00019560
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019560
9588 PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29 peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) C00019560
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00019560
5579 PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 protein kinase C, beta (EC:2.7.11.13) C00019560
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00019560
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00019560
2185 PTK2B, CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK protein tyrosine kinase 2 beta (EC:2.7.10.2) C00019560
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00019560
5884 RAD17, CCYC, HRAD17, R24L, RAD17SP, RAD24 RAD17 homolog (S. pombe) C00019560
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00019560
6236 RRAD, RAD, RAD1, REM3 Ras-related associated with diabetes C00019560
6275 S100A4, 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98 S100 calcium binding protein A4 C00019560
6342 SCP2, NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX sterol carrier protein 2 (EC:2.3.1.176) C00019560
23513 SCRIB, CRIB1, SCRB1, SCRIB1, Vartul scribbled planar cell polarity protein C00019560
6573 SLC19A1, CHMD, FOLT, IFC1, REFC, RFC1 solute carrier family 19 (folate transporter), member 1 C00019560
2030 SLC29A1, ENT1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 C00019560
60682 SMAP1, SMAP-1 small ArfGAP 1 C00019560
6678 SPARC, ON secreted protein, acidic, cysteine-rich (osteonectin) C00019560
6696 SPP1, BNSP, BSPI, ETA-1, OPN secreted phosphoprotein 1 C00019560
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00019560
6723 SRM, PAPT, SPDSY, SPS1, SRML1 spermidine synthase (EC:2.5.1.16) C00019560
56910 STARD7, GTT1 StAR-related lipid transfer (START) domain containing 7 C00019560
6786 STIM1, D11S4896E, GOK, IMD10, TAM stromal interaction molecule 1 C00019560
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00019560
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00019560
6783 SULT1E1, EST, EST-1, ST1E1, STE sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) C00019560
6822 SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (EC:2.8.2.14) C00019560
9095 TBX19, TBS19, TPIT, dJ747L4.1 T-box 19 C00019560
7037 TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90 transferrin receptor C00019560
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00019560
7052 TGM2, G-ALPHA-h, GNAH, TG2, TGC transglutaminase 2 (EC:2.3.2.13) C00019560
7082 TJP1, ZO-1 tight junction protein 1 C00019560
7083 TK1, TK2 thymidine kinase 1, soluble (EC:2.7.1.21) C00019560
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00019560
7167 TPI1, TIM, TPI, TPID triosephosphate isomerase 1 (EC:5.3.1.1) C00019560
10107 TRIM10, HERF1, RFB30, RNF9 tripartite motif containing 10 C00019560
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00019560
7498 XDH, XO, XOR xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) C00019560
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00019560
7515 XRCC1, RCC X-ray repair complementing defective repair in Chinese hamster cells 1 C00019560
25925 ZNF521, EHZF, Evi3 zinc finger protein 521 C00019560

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (33)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

193 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000014 Abnormalities, Drug-Induced C00019560
D000138 Acidosis C00019560
D000140 Acidosis, Lactic C00019560
D058186 Acute Kidney Injury C00019560
D000402 Airway Obstruction C00019560
D000435 Alcoholic Intoxication C00019560
D020751 Alcohol-Induced Disorders C00019560
D020268 Alcohol-Induced Disorders, Nervous System C00019560
D000437 Alcoholism C00019560
D019973 Alcohol-Related Disorders C00019560
D020270 Alcohol Withdrawal Seizures C00019560
D000647 Amnesia C00019560
D020236 Amnesia, Transient Global C00019560
D019969 Amphetamine-Related Disorders C00019560
D000853 Anophthalmos C00019560
D000855 Anorexia C00019560
D001008 Anxiety Disorders C00019560
D001028 Aortopulmonary Septal Defect C00019560
D001247 Asthenia C00019560
D001259 Ataxia C00019560
D050197 Atherosclerosis C00019560
D054537 Atrioventricular Block C00019560
D001284 Atrophy C00019560
D001342 Autonomic Nervous System Diseases C00019560
D001714 Bipolar Disorder C00019560
D001766 Blindness C00019560
D001835 Body Weight C00019560
D001919 Bradycardia C00019560
D001927 Brain Diseases C00019560
D001929 Brain Edema C00019560
D001930 Brain Injuries C00019560
D002545 Brain Ischemia C00019560
D001986 Bronchial Spasm C00019560
D002056 Burns C00019560
D006528 Carcinoma, Hepatocellular C00019560
D006332 Cardiomegaly C00019560
D009202 Cardiomyopathies C00019560
D002310 Cardiomyopathy, Alcoholic C00019560
D002311 Cardiomyopathy, Dilated C00019560
D002318 Cardiovascular Diseases C00019560
D020215 Carotid Artery, Internal, Dissection C00019560
D002493 Central Nervous System Diseases C00019560
D002543 Cerebral Hemorrhage C00019560
D002779 Cholestasis C00019560
D002971 Cleft Lip C00019560
D002972 Cleft Palate C00019560
D019970 Cocaine-Related Disorders C00019560
D003072 Cognition Disorders C00019560
D003128 COMA C00019560
D003221 Confusion C00019560
C535464 Conotruncal cardiac defects C00019560
D003244 Consciousness Disorders C00019560
D019465 Craniofacial Abnormalities C00019560
D003645 Death, Sudden C00019560
D016757 Death, Sudden, Cardiac C00019560
D003693 Delirium C00019560
D003731 Dental Caries C00019560
D003866 Depressive Disorder C00019560
D003865 Depressive Disorder, Major C00019560
D002658 Developmental Disabilities C00019560
D004195 Disease Models, Animal C00019560
D018450 Disease Progression C00019560
D004244 Dizziness C00019560
D056486 Drug-Induced Liver Injury C00019560
D056487 Drug-Induced Liver Injury, Chronic C00019560
D064420 Drug-Related Side Effects and Adverse Reactions C00019560
D020820 Dyskinesias C00019560
D004417 Dyspnea C00019560
D004487 Edema C00019560
D004830 Epilepsy, Tonic-Clonic C00019560
D004938 Esophageal Neoplasms C00019560
D020329 Essential Tremor C00019560
D005234 Fatty Liver C00019560
D005235 Fatty Liver, Alcoholic C00019560
D063647 Fetal Alcohol Spectrum Disorders C00019560
D005313 Fetal Death C00019560
D005317 Fetal Growth Retardation C00019560
D005355 Fibrosis C00019560
D005483 Flushing C00019560
D005756 Gastritis C00019560
D005767 Gastrointestinal Diseases C00019560
D006130 Growth Disorders C00019560
D006212 Hallucinations C00019560
D006323 Heart Arrest C00019560
D006330 Heart Defects, Congenital C00019560
D006331 Heart Diseases C00019560
D006344 Heart Septal Defects, Atrial C00019560
D006345 Heart Septal Defects, Ventricular C00019560
D006470 Hemorrhage C00019560
D020141 Hemostatic Disorders C00019560
D006505 Hepatitis C00019560
D006519 Hepatitis, Alcoholic C00019560
D006529 Hepatomegaly C00019560
D006869 Hydronephrosis C00019560
D006930 Hyperalgesia C00019560
D006940 Hyperemia C00019560
D006945 Hyperhidrosis C00019560
D006948 Hyperkinesis C00019560
D006965 Hyperplasia C00019560
D006973 Hypertension C00019560
D015228 Hypertriglyceridemia C00019560
D017379 Hypertrophy, Left Ventricular C00019560
D007022 Hypotension C00019560
D007035 Hypothermia C00019560
D007154 Immune System Diseases C00019560
D007249 Inflammation C00019560
D008607 Intellectual Disability C00019560
D020300 Intracranial Hemorrhages C00019560
D007511 Ischemia C00019560
D007565 Jaundice C00019560
D007569 Jaw Abnormalities C00019560
D007683 Kidney Tubular Necrosis, Acute C00019560
D007859 Learning Disorders C00019560
D017880 Limb Deformities, Congenital C00019560
D008103 Liver Cirrhosis C00019560
D008104 Liver Cirrhosis, Alcoholic C00019560
D008106 Liver Cirrhosis, Experimental C00019560
D008107 Liver Diseases C00019560
D008108 Liver Diseases, Alcoholic C00019560
D017114 Liver Failure, Acute C00019560
D008114 Liver Neoplasms, Experimental C00019560
D008133 Long QT Syndrome C00019560
D008175 Lung Neoplasms C00019560
D008569 Memory Disorders C00019560
D008831 Microcephaly C00019560
D048629 Micronuclei, Chromosome-Defective C00019560
D008850 Microphthalmos C00019560
D009059 Mouth Diseases C00019560
D009069 Movement Disorders C00019560
D009135 Muscular Diseases C00019560
D009203 Myocardial Infarction C00019560
D017202 Myocardial Ischemia C00019560
D009325 Nausea C00019560
D009336 Necrosis C00019560
D009361 Neoplasm Invasiveness C00019560
D009362 Neoplasm Metastasis C00019560
D009422 Nervous System Diseases C00019560
D051474 Neuralgia, Postherpetic C00019560
D009436 Neural Tube Defects C00019560
D019954 Neurobehavioral Manifestations C00019560
D020258 Neurotoxicity Syndromes C00019560
D009901 Optic Nerve Diseases C00019560
D010146 Pain C00019560
D010190 Pancreatic Neoplasms C00019560
D010195 Pancreatitis C00019560
D019512 Pancreatitis, Alcoholic C00019560
D010243 Paralysis C00019560
D010523 Peripheral Nervous System Diseases C00019560
D010538 Peritonitis C00019560
D010698 Phobic Disorders C00019560
D011041 Poisoning C00019560
D011115 Polyneuropathies C00019560
D017119 Porphyria Cutanea Tarda C00019560
D011297 Prenatal Exposure Delayed Effects C00019560
D049188 Prenatal Injuries C00019560
D015175 Prolactinoma C00019560
D011507 Proteinuria C00019560
D011596 Psychomotor Disorders C00019560
D011605 Psychoses, Substance-Induced C00019560
D011654 Pulmonary Edema C00019560
D015427 Reperfusion Injury C00019560
D012141 Respiratory Tract Infections C00019560
D012164 Retinal Diseases C00019560
D012206 Rhabdomyolysis C00019560
D012640 Seizures C00019560
D018805 Sepsis C00019560
D020018 Sexual Dysfunctions, Psychological C00019560
D013272 Stomach Diseases C00019560
D013274 Stomach Neoplasms C00019560
D013276 Stomach Ulcer C00019560
D020521 Stroke C00019560
D053608 Stupor C00019560
D013345 Subarachnoid Hemorrhage C00019560
D019966 Substance-Related Disorders C00019560
D013375 Substance Withdrawal Syndrome C00019560
D013610 Tachycardia C00019560
D017180 Tachycardia, Ventricular C00019560
D013683 Telangiectasia, Hereditary Hemorrhagic C00019560
D013771 Tetralogy of Fallot C00019560
D018677 Tooth Injuries C00019560
D016388 Tooth Loss C00019560
D016171 Torsades de Pointes C00019560
D014202 Tremor C00019560
D014474 Unconsciousness C00019560
D016055 Urinary Retention C00019560
D054079 Vascular Malformations C00019560
D018487 Ventricular Dysfunction, Left C00019560
D014693 Ventricular Fibrillation C00019560
D018879 Ventricular Premature Complexes C00019560
D014811 Vitamin E Deficiency C00019560
D014839 Vomiting C00019560
D015430 Weight Gain C00019560
D015431 Weight Loss C00019560