PCIDB

KNApSAcK Metabolite C00019560

Metabolite

KNApSAcK Entry

id C00019560
Name Ethanol
CAS RN 64-17-5
Standard InChI InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
Standard InChI (Main Layer) InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 8862

Link

ChEMBL

By standard InChI CHEMBL545
By standard InChI Main Layer CHEMBL545

KEGG

By LinkDB C00469

CTD

By CAS RN D000431

Human Protein / Gene in interaction

92 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL545 CHEMBL1909136 (2)
1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL545 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL545 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL545 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL545 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL545 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL545 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL545 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL545 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL545 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL545 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL545 CHEMBL1909197 (2)
2 / 2
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL545 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL545 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL545 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL545 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL545 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL545 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL545 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL545 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL545 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL545 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL545 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL545 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL545 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL545 CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL545 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL545 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL545 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL545 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL545 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL545 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL545 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL545 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL545 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL545 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL545 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL545 CHEMBL1614458 (1)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL545 CHEMBL1909133 (2)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL545 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL545 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL545 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL545 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL545 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL545 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL545 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL545 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL545 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL545 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL545 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL545 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL545 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL545 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL545 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL545 CHEMBL1909119 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL545 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL545 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL545 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL545 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL545 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL545 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL545 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL545 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL545 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL545 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL545 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL545 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL545 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL545 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL545 CHEMBL1909132 (2)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL545 CHEMBL2114842 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL545 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL545 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL545 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL545 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL545 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL545 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL545 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL545 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL545 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL545 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL545 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL545 CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL545 CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL545 CHEMBL1743289 (1) CHEMBL1909137 (2)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL545 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL545 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL545 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL545 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL545 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL545 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL545 CHEMBL1909128 (2)
0 / 0

CTD interaction (416)

compound gene gene name gene description interaction interaction type form reference
pmid
D000431 23536 ADAT1
HADAT1
adenosine deaminase, tRNA-specific 1 (EC:3.5.4.34) Ethanol results in decreased expression of ADAT1 mRNA decreases expression
mRNA 15963989
D000431 124 ADH1A
ADH1
alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) ADH1A protein results in increased oxidation of Ethanol increases oxidation
protein 21167143
D000431 124 ADH1A
ADH1
alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) Ethanol results in increased expression of ADH1A mRNA increases expression
mRNA 23300006
D000431 124 ADH1A
ADH1
alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) Ethanol results in increased expression of ADH1A protein increases expression
protein 23300006
D000431 124 ADH1A
ADH1
alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) fomepizole inhibits the reaction [ADH1A protein results in increased oxidation of Ethanol] decreases reaction
/ increases oxidation
protein 21167143
D000431 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) ADH1B gene polymorphism affects the susceptibility to Ethanol affects response to substance
gene 20171022
22960999
D000431 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) ADH1B protein results in increased metabolism of Ethanol increases metabolic processing
protein 15499379
D000431 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) [ADH1B protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde increases chemical synthesis
/ increases metabolic processing
protein 15499379
D000431 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) ADH1B protein results in increased oxidation of Ethanol increases oxidation
protein 21167143
D000431 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) Ethanol results in increased expression of ADH1B mRNA increases expression
mRNA 22056336
D000431 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) fomepizole inhibits the reaction [ADH1B protein results in increased oxidation of Ethanol] decreases reaction
/ increases oxidation
protein 21167143
D000431 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) resveratrol inhibits the reaction [Ethanol results in increased expression of ADH1B mRNA] decreases reaction
/ increases expression
mRNA 22056336
D000431 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) ADH1C gene polymorphism affects the susceptibility to Ethanol affects response to substance
gene 20171022
D000431 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) ADH1C protein results in increased metabolism of Ethanol increases metabolic processing
protein 15138216
19822198
D000431 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) [ADH1C protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde increases chemical synthesis
/ increases metabolic processing
protein 15138216
D000431 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) ADH1C protein results in increased oxidation of Ethanol increases oxidation
protein 21167143
D000431 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) Ethanol results in increased expression of ADH1C mRNA increases expression
mRNA 23300006
D000431 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) fomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol] decreases reaction
/ increases oxidation
protein 21167143
D000431 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) Pentachlorophenol inhibits the reaction [ADH1C protein results in increased metabolism of Ethanol] decreases reaction
/ increases metabolic processing
protein 19822198
D000431 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) 2,6-dichloro-4-nitrophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol] decreases reaction
/ increases metabolic processing
protein 19822198
D000431 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) ADH4 promoter polymorphism affects the oxidation of Ethanol affects oxidation
promoter 19182438
D000431 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) ADH4 protein results in increased metabolism of Ethanol increases metabolic processing
protein 19822198
D000431 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) ADH4 protein results in increased oxidation of Ethanol increases oxidation
protein 19182438
21167143
D000431 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] decreases reaction
/ increases oxidation
protein 21167143
D000431 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) Pentachlorophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol] decreases reaction
/ increases metabolic processing
protein 19822198
D000431 128 ADH5
ADH-3
ADHX
FALDH
FDH
GSH-FDH
GSNOR
alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) ADH5 protein results in increased oxidation of Ethanol increases oxidation
protein 19038239
D000431 128 ADH5
ADH-3
ADHX
FALDH
FDH
GSH-FDH
GSNOR
alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol] increases oxidation
/ increases reaction
protein 19038239
D000431 131 ADH7
ADH4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) 2,6-dichloro-4-nitrophenol inhibits the reaction [ADH7 protein results in increased metabolism of Ethanol] decreases reaction
/ increases metabolic processing
protein 19822198
D000431 131 ADH7
ADH4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) ADH7 protein results in increased metabolism of Ethanol increases metabolic processing
protein 19822198
D000431 131 ADH7
ADH4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) ADH7 protein results in increased oxidation of Ethanol increases oxidation
protein 21167143
D000431 131 ADH7
ADH4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) fomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] decreases reaction
/ increases oxidation
protein 21167143
D000431 131 ADH7
ADH4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) Pentachlorophenol inhibits the reaction [ADH7 protein results in increased metabolism of Ethanol] decreases reaction
/ increases metabolic processing
protein 19822198
D000431 22977 AKR7A3
AFAR2
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) Ethanol results in decreased expression of AKR7A3 protein decreases expression
protein 20621659
D000431 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Ethanol promotes the reaction [sodium arsenite results in increased activity of AKT1 protein] increases activity
/ increases reaction
protein 22872060
D000431 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Ethanol results in increased phosphorylation of and results in increased activity of AKT1 protein increases activity
/ increases phosphorylation
protein 18295389
D000431 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) [sodium arsenite co-treated with Ethanol] results in increased phosphorylation of AKT1 protein affects cotreatment
/ increases phosphorylation
protein 22872060
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 gene polymorphism affects the susceptibility to Ethanol affects response to substance
gene 15840430
22960999
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein affects the susceptibility to Ethanol affects response to substance
protein 10780266
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in decreased expression of NOL3 protein] decreases expression
/ decreases reaction
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein] decreases phosphorylation
/ decreases reaction
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in increased expression of BAX protein] decreases reaction
/ increases expression
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein] decreases reaction
/ increases expression
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in increased expression of HTRA2 protein] decreases reaction
/ increases expression
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein inhibits the reaction [Ethanol results in increased expression of XIAP protein] decreases reaction
/ increases expression
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in decreased susceptibility to Ethanol decreases response to substance
protein 19429258
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in increased metabolism of Ethanol increases metabolic processing
protein 10064379
10826103
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in increased susceptibility to Ethanol increases response to substance
protein 15840430
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) Ethanol results in increased expression of ALDH2 mRNA increases expression
mRNA 22056336
D000431 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) resveratrol promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA] increases expression
/ increases reaction
mRNA 22056336
D000431 273 AMPH
AMPH1
amphiphysin Ethanol results in decreased expression of AMPH protein decreases expression
protein 20621659
D000431 162 AP1B1
ADTB1
AP105A
BAM22
CLAPB2
adaptor-related protein complex 1, beta 1 subunit Ethanol results in increased expression of AP1B1 protein increases expression
protein 20621659
D000431 79065 ATG9A
APG9L1
MGD3208
mATG9
autophagy related 9A Ethanol results in decreased expression of ATG9A protein decreases expression
protein 20621659
D000431 506 ATP5B
ATPMB
ATPSB
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (EC:3.6.3.14) Ethanol results in increased expression of ATP5B protein increases expression
protein 20621659
D000431 581 BAX
BCL2L4
BCL2-associated X protein ALDH2 protein inhibits the reaction [Ethanol results in increased expression of BAX protein] decreases reaction
/ increases expression
protein 19429258
D000431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Ethanol results in decreased expression of BCL2 mRNA] decreases expression
/ decreases reaction
mRNA 21878650
D000431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 ALDH2 protein inhibits the reaction [Ethanol results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19429258
D000431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Ethanol results in decreased expression of BCL2 mRNA decreases expression
mRNA 21878650
D000431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Ethanol results in increased expression of BCL2 protein increases expression
protein 21410490
D000431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Lithium inhibits the reaction [Ethanol results in decreased expression of BCL2 mRNA] decreases expression
/ decreases reaction
mRNA 21878650
D000431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Sirolimus promotes the reaction [Ethanol results in increased expression of BCL2 protein] increases expression
/ increases reaction
protein 21410490
D000431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein] decreases reaction
/ increases expression
protein 21410490
D000431 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related Ethanol results in decreased expression of BECN1 protein decreases expression
protein 21410490
D000431 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related Ethanol results in increased degradation of BECN1 protein increases degradation
protein 21410490
D000431 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related Sirolimus inhibits the reaction [Ethanol results in increased degradation of BECN1 protein] decreases reaction
/ increases degradation
protein 21410490
D000431 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related wortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein] increases degradation
/ increases reaction
protein 21410490
D000431 274 BIN1
AMPH2
AMPHL
SH3P9
bridging integrator 1 Ethanol results in increased expression of BIN1 protein increases expression
protein 20621659
D000431 708 C1QBP
GC1QBP
HABP1
SF2p32
gC1Q-R
gC1qR
p32
complement component 1, q subcomponent binding protein Ethanol results in decreased expression of C1QBP protein decreases expression
protein 20621659
D000431 832 CAPZB
CAPB
CAPPB
CAPZ
capping protein (actin filament) muscle Z-line, beta Ethanol results in increased expression of CAPZB protein increases expression
protein 20621659
D000431 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) ALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 19429258
D000431 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Ethanol results in increased activity of CASP3 protein increases activity
protein 17869084
19919524
D000431 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Ethanol results in increased cleavage of CASP3 protein increases cleavage
protein 21410490
D000431 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) HBEGF protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 19919524
D000431 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17869084
D000431 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Sirolimus inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 21410490
D000431 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) ALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein] decreases reaction
/ increases expression
protein 19429258
D000431 847 CAT
catalase (EC:1.11.1.6) Ethanol results in decreased activity of CAT protein decreases activity
protein 11344824
D000431 847 CAT
catalase (EC:1.11.1.6) Ethanol results in decreased expression of CAT protein decreases expression
protein 1937386
D000431 857 CAV1
BSCL3
CGL3
MSTP085
PPH3
VIP21
CAV
caveolin 1, caveolae protein, 22kDa Ethanol results in increased expression of CAV1 mRNA increases expression
mRNA 15963989
D000431 83446 CCDC70
coiled-coil domain containing 70 Ethanol results in decreased expression of CCDC70 protein decreases expression
protein 20621659
D000431 54535 CCHCR1
C6orf18
HCR
SBP
coiled-coil alpha-helical rod protein 1 Ethanol results in decreased expression of CCHCR1 protein decreases expression
protein 20621659
D000431 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Ethanol results in increased expression of CCND1 mRNA increases expression
mRNA 12720008
D000431 894 CCND2
KIAK0002
cyclin D2 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Ethanol results in decreased expression of CCND2 mRNA] decreases expression
/ decreases reaction
mRNA 21878650
D000431 894 CCND2
KIAK0002
cyclin D2 Ethanol results in decreased expression of CCND2 mRNA decreases expression
mRNA 21878650
D000431 894 CCND2
KIAK0002
cyclin D2 Lithium inhibits the reaction [Ethanol results in decreased expression of CCND2 mRNA] decreases expression
/ decreases reaction
mRNA 21878650
D000431 994 CDC25B
cell division cycle 25B (EC:3.1.3.48) Ethanol results in increased expression of CDC25B protein increases expression
protein 20621659
D000431 55664 CDC37L1
CDC37B
HARC
cell division cycle 37-like 1 Ethanol results in decreased expression of CDC37L1 mRNA decreases expression
mRNA 15963989
D000431 1003 CDH5
7B4
CD144
cadherin 5, type 2 (vascular endothelium) Ethanol affects the localization of CDH5 protein affects localization
protein 22331491
D000431 1003 CDH5
7B4
CD144
cadherin 5, type 2 (vascular endothelium) Ethanol results in increased uptake of CDH5 protein increases uptake
protein 22331491
D000431 1003 CDH5
7B4
CD144
cadherin 5, type 2 (vascular endothelium) jasplakinolide inhibits the reaction [Ethanol results in increased uptake of CDH5 protein] decreases reaction
/ increases uptake
protein 22331491
D000431 23552 CDK20
CCRK
CDCH
P42
PNQALRE
cyclin-dependent kinase 20 (EC:2.7.11.22) CDK20 gene SNP affects the susceptibility to Ethanol affects response to substance
gene 18438686
D000431 1050 CEBPA
C/EBP-alpha
CEBP
CCAAT/enhancer binding protein (C/EBP), alpha Ethanol results in decreased expression of CEBPA protein decreases expression
protein 16737972
D000431 55165 CEP55
C10orf3
CT111
URCC6
centrosomal protein 55kDa Ethanol results in decreased expression of CEP55 protein decreases expression
protein 20621659
D000431 1066 CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) CES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol] affects cotreatment
/ increases metabolic processing
protein 9311626
12773168
D000431 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) Ethanol affects the expression of CHRNA5 mRNA affects expression
mRNA 20438829
D000431 1140 CHRNB1
ACHRB
CHRNB
CMS1D
CMS2A
SCCMS
cholinergic receptor, nicotinic, beta 1 (muscle) Ethanol results in decreased expression of CHRNB1 protein decreases expression
protein 20621659
D000431 1191 CLU
APO-J
APOJ
CLI
CLU1
CLU2
KUB1
NA1/NA2
SGP-2
SGP2
SP-40
TRPM-2
TRPM2
clusterin Ethanol results in increased expression of CLU mRNA increases expression
mRNA 15963989
D000431 1266 CNN3
calponin 3, acidic Ethanol results in decreased expression of CNN3 protein decreases expression
protein 20621659
D000431 1278 COL1A2
OI4
collagen, type I, alpha 2 Ethanol inhibits the reaction [sodium arsenite results in increased expression of COL1A2 mRNA] decreases reaction
/ increases expression
mRNA 18182400
D000431 1417 CRYBB3
CATCN2
CRYB3
CTRCT22
crystallin, beta B3 Ethanol results in decreased expression of CRYBB3 mRNA decreases expression
mRNA 11566570
D000431 1442 CSH1
CS-1
CSA
CSMT
PL
hCS-A
chorionic somatomammotropin hormone 1 (placental lactogen) Ethanol results in decreased expression of CSH1 protein decreases expression
protein 20621659
D000431 1535 CYBA
p22-PHOX
cytochrome b-245, alpha polypeptide Ethanol results in increased expression of CYBA protein increases expression
protein 22872060
D000431 1535 CYBA
p22-PHOX
cytochrome b-245, alpha polypeptide [sodium arsenite co-treated with Ethanol] results in increased expression of CYBA protein affects cotreatment
/ increases expression
protein 22872060
D000431 1535 CYBA
p22-PHOX
cytochrome b-245, alpha polypeptide sodium arsenite promotes the reaction [Ethanol results in increased expression of CYBA protein] increases expression
/ increases reaction
protein 22872060
D000431 1536 CYBB
AMCBX2
CGD
GP91-1
GP91-PHOX
GP91PHOX
NOX2
p91-PHOX
cytochrome b-245, beta polypeptide Ethanol results in increased expression of CYBB mRNA increases expression
mRNA 18845238
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) allyl sulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein] decreases reaction
/ increases expression
protein 22138249
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein affects cotreatment
/ increases expression
protein 17034788
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein affects cotreatment
/ increases expression
protein 17034788
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein affects cotreatment
/ increases expression
protein 17034788
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 gene polymorphism affects the susceptibility to Ethanol affects response to substance
gene 20171022
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA] increases expression
/ increases reaction
protein 19133322
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased metabolism of Ethanol increases metabolic processing
protein 10573527
10826103
12464242
18845238
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione decreases abundance
/ increases metabolic processing
protein 10573527
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Acetaldehyde increases abundance
/ increases metabolic processing
protein 18845238
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Nitric Oxide increases abundance
/ increases metabolic processing
protein 18845238
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species increases abundance
/ increases metabolic processing
protein 18845238
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased susceptibility to Ethanol increases response to substance
protein 8798623
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine] affects reaction
/ increases metabolic processing
protein 16235733
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol affects the reaction [CYP2E1 protein results in increased susceptibility to Acetaminophen] affects reaction
/ increases response to substance
protein 11212141
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [Ethanol co-treated with CYP2E1 protein] results in increased abundance of Reactive Oxygen Species affects cotreatment
/ increases abundance
protein 22222162
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [Ethanol co-treated with CYP2E1 protein] results in increased phosphorylation of EGFR protein affects cotreatment
/ increases phosphorylation
protein 22222162
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]] decreases reaction
/ increases oxidation
protein 8531136
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] decreases reaction
/ increases degradation
protein 9143349
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol] increases oxidation
/ increases reaction
protein 8074729
8531136
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of aniline] increases oxidation
/ increases reaction
protein 8074729
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Dimethylnitrosamine] increases oxidation
/ increases reaction
protein 8074729
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol results in increased activity of CYP2E1 protein increases activity
protein 8074729
11212141
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol results in increased expression of and results in increased activity of CYP2E1 protein increases activity
/ increases expression
protein 15802389
18845238
22552773
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol results in increased expression of CYP2E1 mRNA increases expression
mRNA 23300006
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ethanol results in increased expression of CYP2E1 protein increases expression
protein 3782137
8074729
17590308
22138249
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
/ increases metabolic processing
protein 18845238
D000431 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased susceptibility to Ethanol] increases reaction
/ increases response to substance
protein 8798623
D000431 54541 DDIT4
Dig2
REDD-1
REDD1
DNA-damage-inducible transcript 4 [sodium arsenite co-treated with Ethanol] results in increased expression of DDIT4 protein affects cotreatment
/ increases expression
protein 22872060
D000431 10591 DNPH1
C6orf108
RCL
RP3-330M21.3
dJ330M21.3
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Ethanol results in decreased expression of DNPH1 mRNA decreases expression
mRNA 11566570
D000431 1837 DTNA
D18S892E
DRP3
DTN
DTN-A
LVNC1
dystrobrevin, alpha Ethanol results in increased expression of DTNA protein increases expression
protein 20621659
D000431 338599 DUPD1
DUSP27
FMDSP
dual specificity phosphatase and pro isomerase domain containing 1 (EC:3.1.3.16 3.1.3.48) Ethanol results in increased expression of DUPD1 protein increases expression
protein 20621659
D000431 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) [Ethanol co-treated with CYP2E1 protein] results in increased phosphorylation of EGFR protein affects cotreatment
/ increases phosphorylation
protein 22222162
D000431 2023 ENO1
ENO1L1
MPB1
NNE
PPH
enolase 1, (alpha) (EC:4.2.1.11) Ethanol results in decreased expression of ENO1 protein decreases expression
protein 20621659
D000431 2023 ENO1
ENO1L1
MPB1
NNE
PPH
enolase 1, (alpha) (EC:4.2.1.11) Ethanol results in increased expression of ENO1 protein increases expression
protein 20621659
D000431 10961 ERP29
C12orf8
ERp28
ERp31
PDI-DB
PDIA9
endoplasmic reticulum protein 29 Ethanol results in increased expression of ERP29 protein increases expression
protein 20621659
D000431 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Ethanol results in increased expression of ESR1 protein increases expression
protein 15659783
D000431 2177 FANCD2
FA-D2
FA4
FACD
FAD
FAD2
FANCD
Fanconi anemia, complementation group D2 Ethanol results in increased expression of FANCD2 mRNA increases expression
mRNA 18482162
D000431 2177 FANCD2
FA-D2
FA4
FACD
FAD
FAD2
FANCD
Fanconi anemia, complementation group D2 Ethanol results in increased expression of FANCD2 protein increases expression
protein 18482162
D000431 84261 FBXW9
Fbw9
F-box and WD repeat domain containing 9 Ethanol results in decreased expression of FBXW9 protein decreases expression
protein 20621659
D000431 2263 FGFR2
BBDS
BEK
BFR-1
CD332
CEK3
CFD1
ECT1
JWS
K-SAM
KGFR
TK14
TK25
fibroblast growth factor receptor 2 (EC:2.7.10.1) Ethanol results in increased expression of FGFR2 mRNA increases expression
mRNA 12720008
D000431 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Ethanol results in increased expression of FN1 mRNA increases expression
mRNA 15963989
D000431 2348 FOLR1
FBP
FOLR
folate receptor 1 (adult) Ethanol results in decreased expression of FOLR1 mRNA decreases expression
mRNA 17531458
D000431 2348 FOLR1
FBP
FOLR
folate receptor 1 (adult) Ethanol results in increased expression of FOLR1 mRNA increases expression
mRNA 19616087
D000431 2512 FTL
NBIA3
ferritin, light polypeptide Ethanol results in increased expression of FTL mRNA increases expression
mRNA 15963989
D000431 2526 FUT4
CD15
ELFT
FCT3A
FUC-TIV
FUTIV
LeX
SSEA-1
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (EC:2.4.1.-) Ethanol results in increased expression of FUT4 protein increases expression
protein 19919524
D000431 2526 FUT4
CD15
ELFT
FCT3A
FUC-TIV
FUTIV
LeX
SSEA-1
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (EC:2.4.1.-) HBEGF protein inhibits the reaction [Ethanol results in increased expression of FUT4 protein] decreases reaction
/ increases expression
protein 19919524
D000431 2534 FYN
SLK
SYN
p59-FYN
FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) Ethanol results in increased phosphorylation of FYN protein increases phosphorylation
protein 18182400
D000431 2534 FYN
SLK
SYN
p59-FYN
FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of FYN protein] increases phosphorylation
/ increases reaction
protein 18182400
D000431 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA] increases expression
/ increases reaction
mRNA 19133322
D000431 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) Ethanol results in increased expression of GCLC mRNA increases expression
mRNA 19133322
D000431 2670 GFAP
glial fibrillary acidic protein Ethanol results in increased expression of GFAP protein increases expression
protein 20621659
D000431 2688 GH1
GH
GH-N
GHN
IGHD1B
hGH-N
growth hormone 1 Ethanol affects the folding of GH1 protein affects folding
protein 11064379
D000431 51031 GLOD4
C17orf25
HC71
glyoxalase domain containing 4 Ethanol results in decreased expression of GLOD4 protein decreases expression
protein 20621659
D000431 2741 GLRA1
HKPX1
STHE
glycine receptor, alpha 1 Ethanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] increases activity
/ increases reaction
protein 10825391
D000431 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) ALDH2 protein inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein] decreases phosphorylation
/ decreases reaction
protein 19429258
D000431 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) [sodium arsenite co-treated with Ethanol] results in increased phosphorylation of GSK3B protein affects cotreatment
/ increases phosphorylation
protein 22872060
D000431 2944 GSTM1
GST1
GSTM1-1
GSTM1a-1a
GSTM1b-1b
GTH4
GTM1
H-B
MU
MU-1
glutathione S-transferase mu 1 (EC:2.5.1.18) GSTM1 gene mutant form affects the susceptibility to Ethanol affects response to substance
gene 20171022
D000431 2944 GSTM1
GST1
GSTM1-1
GSTM1a-1a
GSTM1b-1b
GTH4
GTM1
H-B
MU
MU-1
glutathione S-transferase mu 1 (EC:2.5.1.18) GSTM1 gene polymorphism affects the susceptibility to Ethanol affects response to substance
gene 15932176
D000431 2952 GSTT1
glutathione S-transferase theta 1 (EC:2.5.1.18) GSTT1 gene polymorphism affects the susceptibility to Ethanol affects response to substance
gene 15932176
D000431 57817 HAMP
HEPC
HFE2B
LEAP1
PLTR
hepcidin antimicrobial peptide Acetaldehyde inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] decreases expression
/ decreases reaction
mRNA 16737972
D000431 57817 HAMP
HEPC
HFE2B
LEAP1
PLTR
hepcidin antimicrobial peptide Ethanol results in decreased expression of HAMP mRNA decreases expression
mRNA 16737972
D000431 57817 HAMP
HEPC
HFE2B
LEAP1
PLTR
hepcidin antimicrobial peptide Ethanol results in decreased expression of HAMP protein decreases expression
protein 16737972
D000431 57817 HAMP
HEPC
HFE2B
LEAP1
PLTR
hepcidin antimicrobial peptide fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] decreases expression
/ decreases reaction
mRNA 16737972
D000431 1839 HBEGF
DTR
DTS
DTSF
HEGFL
heparin-binding EGF-like growth factor HBEGF protein inhibits the reaction [Ethanol results in decreased expression of POU5F1 protein] decreases expression
/ decreases reaction
protein 19919524
D000431 1839 HBEGF
DTR
DTS
DTSF
HEGFL
heparin-binding EGF-like growth factor HBEGF protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 19919524
D000431 1839 HBEGF
DTR
DTS
DTSF
HEGFL
heparin-binding EGF-like growth factor HBEGF protein inhibits the reaction [Ethanol results in increased expression of FUT4 protein] decreases reaction
/ increases expression
protein 19919524
D000431 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [sodium arsenite co-treated with Ethanol] affects the localization of HIF1A protein affects cotreatment
/ affects localization
protein 22872060
D000431 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) Ethanol results in decreased activity of HMGCR protein decreases activity
protein 22841563
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione] decreases abundance
/ decreases reaction
/ increases expression
protein 15602829
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde] decreases reaction
/ increases abundance
/ increases expression
protein 15602829
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol decreases response to substance
/ increases expression
protein 15602829
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Ethanol results in decreased expression of HMOX1 mRNA decreases expression
mRNA 22484158
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Ethanol results in decreased expression of HMOX1 protein decreases expression
protein 22484158
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Ethanol results in increased expression of HMOX1 mRNA increases expression
mRNA 15602829
17295091
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Ethanol results in increased expression of HMOX1 protein increases expression
protein 15602829
17295091
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin increases abundance
/ increases expression
protein 15602829
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Iron increases abundance
/ increases expression
protein 15602829
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA] decreases expression
/ decreases reaction
mRNA 22484158
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein] decreases expression
/ decreases reaction
protein 22484158
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]] decreases abundance
/ decreases reaction
/ increases expression
protein 15602829
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]] decreases reaction
/ increases abundance
/ increases expression
protein 15602829
D000431 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol] decreases reaction
/ decreases response to substance
/ increases expression
protein 15602829
D000431 3181 HNRNPA2B1
HNRNPA2
HNRNPB1
HNRPA2
HNRPA2B1
HNRPB1
IBMPFD2
RNPA2
SNRPB1
heterogeneous nuclear ribonucleoprotein A2/B1 Ethanol results in increased expression of HNRNPA2B1 protein increases expression
protein 20621659
D000431 3190 HNRNPK
CSBP
HNRPK
TUNP
heterogeneous nuclear ribonucleoprotein K Ethanol results in increased expression of HNRNPK protein increases expression
protein 20621659
D000431 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D000431 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D000431 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D000431 27429 HTRA2
OMI
PARK13
PRSS25
HtrA serine peptidase 2 (EC:3.4.21.108) ALDH2 protein inhibits the reaction [Ethanol results in increased expression of HTRA2 protein] decreases reaction
/ increases expression
protein 19429258
D000431 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Ethanol results in increased expression of ICAM1 mRNA increases expression
mRNA 23300006
D000431 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Ethanol results in increased expression of ICAM1 protein increases expression
protein 23300006
D000431 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Ethanol results in increased secretion of ICAM1 protein increases secretion
protein 23300006
D000431 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) [Ethanol co-treated with sodium arsenite] results in increased expression of IGF1 mRNA affects cotreatment
/ increases expression
mRNA 18182400
D000431 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) Ethanol inhibits the reaction [IGF1 protein results in increased activity of MTR protein] decreases reaction
/ increases activity
protein 14745455
D000431 3486 IGFBP3
BP-53
IBP3
insulin-like growth factor binding protein 3 Ethanol results in increased expression of IGFBP3 mRNA increases expression
mRNA 15963989
D000431 3589 IL11
AGIF
IL-11
interleukin 11 Ethanol results in increased expression of IL11 mRNA increases expression
mRNA 17295091
D000431 3589 IL11
AGIF
IL-11
interleukin 11 Ethanol results in increased expression of IL11 protein increases expression
protein 17295091
D000431 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Ethanol results in increased expression of IL1B protein increases expression
protein 11344824
D000431 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Ethanol inhibits the reaction [sodium arsenite results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 18182400
D000431 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Ethanol results in increased secretion of IL8 protein increases secretion
protein 23300006
D000431 3678 ITGA5
CD49e
FNRA
VLA5A
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) Ethanol results in increased expression of ITGA5 mRNA increases expression
mRNA 12720008
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 Cycloheximide inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA] decreases reaction
/ increases expression
mRNA 17241155
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 Dactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA] decreases reaction
/ increases expression
mRNA 17241155
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 Ethanol results in increased expression of and affects the localization of ITPR1 protein affects localization
/ increases expression
protein 17241155
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 Ethanol results in increased expression of ITPR1 mRNA increases expression
mRNA 17241155
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] affects localization
/ decreases reaction
/ increases expression
protein 17241155
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 ITPR1 protein promotes the reaction [Ethanol metabolite results in increased abundance of Calcium] increases abundance
/ increases reaction
protein 17241155
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] affects localization
/ decreases reaction
/ increases expression
protein 17241155
D000431 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 xestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] affects localization
/ decreases reaction
/ increases expression
protein 17241155
D000431 83999 KREMEN1
KREMEN
KRM1
kringle containing transmembrane protein 1 Ethanol results in decreased expression of KREMEN1 protein decreases expression
protein 20621659
D000431 3875 KRT18
CYK18
K18
keratin 18 [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein affects cotreatment
/ increases expression
protein 17034788
D000431 3875 KRT18
CYK18
K18
keratin 18 Ethanol results in increased expression of KRT18 protein increases expression
protein 20621659
D000431 3856 KRT8
CARD2
CK-8
CK8
CYK8
K2C8
K8
KO
keratin 8 [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein affects cotreatment
/ increases expression
protein 17034788
D000431 3897 L1CAM
CAML1
CD171
HSAS
HSAS1
MASA
MIC5
N-CAM-L1
N-CAML1
NCAM-L1
S10
SPG1
L1 cell adhesion molecule Ethanol binds to and results in decreased activity of L1CAM protein affects binding
/ decreases activity
protein 18165316
D000431 3897 L1CAM
CAML1
CD171
HSAS
HSAS1
MASA
MIC5
N-CAM-L1
N-CAML1
NCAM-L1
S10
SPG1
L1 cell adhesion molecule Ethanol results in decreased activity of L1CAM protein decreases activity
protein 8609170
D000431 3897 L1CAM
CAML1
CD171
HSAS
HSAS1
MASA
MIC5
N-CAM-L1
N-CAML1
NCAM-L1
S10
SPG1
L1 cell adhesion molecule Octanols analog inhibits the reaction [Ethanol binds to and results in decreased activity of L1CAM protein] affects binding
/ decreases activity
/ decreases reaction
protein 18165316
D000431 4017 LOXL2
LOR2
WS9-14
lysyl oxidase-like 2 (EC:1.4.3.-) Ethanol results in increased expression of LOXL2 mRNA increases expression
mRNA 15963989
D000431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Ethanol results in increased phosphorylation of and results in increased activity of MAPK1 protein increases activity
/ increases phosphorylation
protein 18295389
D000431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Propolis inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Ethanol results in decreased expression of MAPK3 mRNA decreases expression
mRNA 11566570
D000431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Ethanol results in increased phosphorylation of and results in increased activity of MAPK3 protein increases activity
/ increases phosphorylation
protein 18295389
D000431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Propolis inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 18295389
D000431 4144 MAT2A
MATA2
MATII
SAMS2
methionine adenosyltransferase II, alpha (EC:2.5.1.6) Ethanol results in decreased expression of MAT2A mRNA decreases expression
mRNA 17869084
D000431 4148 MATN3
DIPOA
EDM5
HOA
OADIP
OS2
matrilin 3 Ethanol results in decreased expression of MATN3 protein decreases expression
protein 20621659
D000431 406931 MIR139
MIR139-3p
MIRN139
microRNA 139 Ethanol results in increased expression of MIR139 increases expression
21878650
D000431 406987 MIR204
MIRN204
miRNA204
microRNA 204 Ethanol results in increased expression of MIR204 increases expression
21878650
D000431 100126336 MIR208B
MIRN208B
microRNA 208b Ethanol results in increased expression of MIR208B increases expression
21878650
D000431 407018 MIR27A
MIR27
MIRN27A
microRNA 27a Ethanol results in decreased expression of MIR27A decreases expression
21878650
D000431 442894 MIR302B
MIRN302B
microRNA 302b 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Ethanol results in increased expression of MIR302B] decreases reaction
/ increases expression
21878650
D000431 442894 MIR302B
MIRN302B
microRNA 302b Ethanol results in increased expression of MIR302B increases expression
21878650
D000431 442894 MIR302B
MIRN302B
microRNA 302b Lithium inhibits the reaction [Ethanol results in increased expression of MIR302B] decreases reaction
/ increases expression
21878650
D000431 693120 MIR33B
MIRN33B
hsa-mir-33b
microRNA 33b Ethanol results in decreased expression of MIR33B decreases expression
21878650
D000431 407040 MIR34A
MIRN34A
miRNA34A
mir-34
microRNA 34a Ethanol results in increased expression of MIR34A increases expression
21878650
D000431 442914 MIR369
MIR369-3
MIRN369
MIRN369-3
hsa-mir-369
microRNA 369 Ethanol results in increased expression of MIR369 increases expression
21878650
D000431 442915 MIR370
MIRN370
hsa-mir-370
microRNA 370 Ethanol results in increased expression of MIR370 increases expression
21878650
D000431 442918 MIR373
MIRN373
hsa-mir-373
miRNA373
microRNA 373 Ethanol results in increased expression of MIR373 increases expression
21878650
D000431 494324 MIR375
MIRN375
hsa-mir-375
miRNA375
microRNA 375 Ethanol results in increased expression of MIR375 increases expression
21878650
D000431 574451 MIR432
MIRN432
hsa-mir-432
microRNA 432 Ethanol results in increased expression of MIR432 increases expression
21878650
D000431 619552 MIR483
MIRN483
hsa-mir-483
microRNA 483 Ethanol results in increased expression of MIR483 increases expression
21878650
D000431 574450 MIR493
MIRN493
hsa-mir-493
microRNA 493 Ethanol results in increased expression of MIR493 increases expression
21878650
D000431 574456 MIR497
MIRN497
hsa-mir-497
microRNA 497 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Ethanol results in increased expression of MIR497] decreases reaction
/ increases expression
21878650
D000431 574456 MIR497
MIRN497
hsa-mir-497
microRNA 497 Ethanol results in increased expression of MIR497 increases expression
21878650
D000431 574456 MIR497
MIRN497
hsa-mir-497
microRNA 497 Lithium inhibits the reaction [Ethanol results in increased expression of MIR497] decreases reaction
/ increases expression
21878650
D000431 574472 MIR518F
MIRN518F
microRNA 518f Ethanol results in increased expression of MIR518F increases expression
21878650
D000431 574471 MIR523
MIRN523
hsa-mir-523
microRNA 523 Ethanol results in increased expression of MIR523 increases expression
21878650
D000431 693191 MIR606
MIRN606
hsa-mir-606
microRNA 606 Ethanol results in decreased expression of MIR606 decreases expression
21878650
D000431 724026 MIR656
MIRN656
hsa-mir-656
microRNA 656 Ethanol results in decreased expression of MIR656 decreases expression
21878650
D000431 100126326 MIR936
MIRN936
hsa-mir-936
microRNA 936 Ethanol results in increased expression of MIR936 increases expression
21878650
D000431 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) [sodium arsenite co-treated with Ethanol] results in increased expression of MMP2 protein affects cotreatment
/ increases expression
protein 22872060
D000431 4548 MTR
HMAG
MS
cblG
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) Ethanol inhibits the reaction [IGF1 protein results in increased activity of MTR protein] decreases reaction
/ increases activity
protein 14745455
D000431 4548 MTR
HMAG
MS
cblG
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) Ethanol promotes the reaction [Dopamine results in increased activity of MTR protein] increases activity
/ increases reaction
protein 14745455
D000431 4595 MUTYH
CYP2C
MYH
mutY homolog (EC:3.2.2.-) Ethanol results in decreased expression of MUTYH mRNA decreases expression
mRNA 11566570
D000431 4638 MYLK
AAT7
KRP
MLCK
MLCK1
MLCK108
MLCK210
MSTP083
MYLK1
smMLCK
myosin light chain kinase (EC:2.7.11.18) Ethanol results in increased activity of MYLK protein increases activity
protein 10198341
D000431 4638 MYLK
AAT7
KRP
MLCK
MLCK1
MLCK108
MLCK210
MSTP083
MYLK1
smMLCK
myosin light chain kinase (EC:2.7.11.18) ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein] decreases reaction
/ increases activity
protein 10198341
D000431 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 Ethanol results in increased expression of NCF1 protein increases expression
protein 22872060
D000431 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 [sodium arsenite co-treated with Ethanol] results in increased expression of NCF1 protein affects cotreatment
/ increases expression
protein 22872060
D000431 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 sodium arsenite promotes the reaction [Ethanol results in increased expression of NCF1 protein] increases expression
/ increases reaction
protein 22872060
D000431 4688 NCF2
NCF-2
NOXA2
P67-PHOX
P67PHOX
neutrophil cytosolic factor 2 Ethanol results in increased expression of NCF2 protein increases expression
protein 22872060
D000431 4688 NCF2
NCF-2
NOXA2
P67-PHOX
P67PHOX
neutrophil cytosolic factor 2 [sodium arsenite co-treated with Ethanol] results in increased expression of NCF2 protein affects cotreatment
/ increases expression
protein 22872060
D000431 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 [lucidone co-treated with Ethanol] results in increased expression of NFE2L2 mRNA affects cotreatment
/ increases expression
mRNA 22484158
D000431 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Ethanol results in increased activity of [NFKB2 protein binds to NFKB1 protein] affects binding
/ increases activity
protein 10573527
D000431 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Ethanol results in increased activity of [RELA protein binds to NFKB1 protein] affects binding
/ increases activity
protein 10573527
D000431 4791 NFKB2
H2TF1
LYT-10
LYT10
NF-kB2
p105
p52
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Ethanol results in increased activity of [NFKB2 protein binds to NFKB1 protein] affects binding
/ increases activity
protein 10573527
D000431 4830 NME1
AWD
GAAD
NB
NBS
NDKA
NDPK-A
NDPKA
NM23
NM23-H1
NME/NM23 nucleoside diphosphate kinase 1 (EC:2.7.4.6) Ethanol results in increased expression of NME1 protein increases expression
protein 20621659
D000431 8996 NOL3
ARC
FCM
MYP
NOP
NOP30
nucleolar protein 3 (apoptosis repressor with CARD domain) ALDH2 protein inhibits the reaction [Ethanol results in decreased expression of NOL3 protein] decreases expression
/ decreases reaction
protein 19429258
D000431 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Ethanol results in increased expression of NOS2 protein increases expression
protein 18845238
D000431 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) [Ethanol results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide increases abundance
/ increases expression
protein 18845238
D000431 4854 NOTCH3
CADASIL
CASIL
IMF2
notch 3 Ethanol results in increased expression of NOTCH3 mRNA increases expression
mRNA 20713136
D000431 27035 NOX1
GP91-2
MOX1
NOH-1
NOH1
NADPH oxidase 1 Ethanol results in increased expression of NOX1 protein increases expression
protein 22872060
D000431 27035 NOX1
GP91-2
MOX1
NOH-1
NOH1
NADPH oxidase 1 [sodium arsenite co-treated with Ethanol] results in increased expression of NOX1 protein affects cotreatment
/ increases expression
protein 22872060
D000431 27035 NOX1
GP91-2
MOX1
NOH-1
NOH1
NADPH oxidase 1 sodium arsenite promotes the reaction [Ethanol results in increased expression of NOX1 protein] increases expression
/ increases reaction
protein 22872060
D000431 4897 NRCAM
neuronal cell adhesion molecule NRCAM mRNA SNP results in increased susceptibility to Ethanol increases response to substance
mRNA 16123759
D000431 8829 NRP1
BDCA4
CD304
NP1
NRP
VEGF165R
neuropilin 1 Ethanol results in decreased expression of NRP1 protein decreases expression
protein 20621659
D000431 100506658 OCLN
BLCPMG
occludin (EC:2.1.1.67) Ethanol affects the localization of OCLN protein affects localization
protein 22563376
D000431 4968 OGG1
HMMH
HOGG1
MUTM
OGH1
8-oxoguanine DNA glycosylase (EC:4.2.99.18) Ethanol results in increased expression of OGG1 mRNA increases expression
mRNA 22056336
D000431 4968 OGG1
HMMH
HOGG1
MUTM
OGH1
8-oxoguanine DNA glycosylase (EC:4.2.99.18) Ethanol results in increased expression of OGG1 protein increases expression
protein 22056336
D000431 4986 OPRK1
K-OR-1
KOR
KOR-1
OPRK
opioid receptor, kappa 1 Ethanol results in decreased expression of OPRK1 mRNA decreases expression
mRNA 17934066
D000431 4986 OPRK1
K-OR-1
KOR
KOR-1
OPRK
opioid receptor, kappa 1 fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] decreases expression
/ decreases reaction
mRNA 17934066
D000431 4988 OPRM1
LMOR
M-OR-1
MOP
MOR
MOR1
OPRM
opioid receptor, mu 1 OPRM1 gene SNP results in increased susceptibility to Ethanol increases response to substance
gene 12815747
D000431 84876 ORAI1
CRACM1
IMD9
ORAT1
TMEM142A
ORAI calcium release-activated calcium modulator 1 Ethanol results in increased expression of ORAI1 mRNA increases expression
mRNA 22119170
D000431 84876 ORAI1
CRACM1
IMD9
ORAT1
TMEM142A
ORAI calcium release-activated calcium modulator 1 Ethanol results in increased expression of ORAI1 protein increases expression
protein 22119170
D000431 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Ethanol results in increased cleavage of PARP1 protein increases cleavage
protein 21410490
D000431 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Sirolimus inhibits the reaction [Ethanol results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 21410490
D000431 5142 PDE4B
DPDE4
PDE4B5
PDEIVB
phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) PDE4B gene SNP affects the susceptibility to Ethanol affects response to substance
gene 18438686
D000431 5173 PDYN
ADCA
PENKB
SCA23
prodynorphin Ethanol results in decreased expression of PDYN mRNA decreases expression
mRNA 17934066
D000431 5173 PDYN
ADCA
PENKB
SCA23
prodynorphin fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA] decreases expression
/ decreases reaction
mRNA 17934066
D000431 5173 PDYN
ADCA
PENKB
SCA23
prodynorphin PDYN gene SNP affects the susceptibility to Ethanol affects response to substance
gene 18923396
D000431 5179 PENK
proenkephalin Ethanol results in decreased expression of PENK mRNA decreases expression
mRNA 17934066
D000431 5179 PENK
proenkephalin Ethanol results in decreased expression of PENK protein decreases expression
protein 20621659
D000431 5179 PENK
proenkephalin fomepizole inhibits the reaction [Ethanol results in decreased expression of PENK mRNA] decreases expression
/ decreases reaction
mRNA 17934066
D000431 5204 PFDN5
MM-1
MM1
PFD5
prefoldin subunit 5 Ethanol results in decreased expression of PFDN5 mRNA decreases expression
mRNA 11566570
D000431 25796 PGLS
6PGL
6-phosphogluconolactonase (EC:3.1.1.31) Ethanol results in increased expression of PGLS protein increases expression
protein 20621659
D000431 5245 PHB
PHB1
prohibitin Ethanol results in increased expression of PHB protein increases expression
protein 20621659
D000431 26227 PHGDH
3-PGDH
3PGDH
PDG
PGAD
PGD
PGDH
SERA
phosphoglycerate dehydrogenase (EC:1.1.1.95) Ethanol results in increased expression of PHGDH protein increases expression
protein 20621659
D000431 5335 PLCG1
NCKAP3
PLC-II
PLC1
PLC148
PLCgamma1
phospholipase C, gamma 1 (EC:3.1.4.11) [Ethanol co-treated with sodium arsenite] results in increased localization of PLCG1 protein affects cotreatment
/ increases localization
protein 18182400
D000431 5352 PLOD2
LH2
TLH
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (EC:1.14.11.4) Ethanol results in increased expression of PLOD2 mRNA increases expression
mRNA 15997088
D000431 57048 PLSCR3
phospholipid scramblase 3 Ethanol results in increased expression of PLSCR3 protein increases expression
protein 20621659
D000431 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Ethanol results in increased expression of PMAIP1 mRNA increases expression
mRNA 20713136
D000431 5395 PMS2
HNPCC4
PMS2CL
PMSL2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae) Ethanol results in decreased expression of PMS2 mRNA decreases expression
mRNA 11566570
D000431 5426 POLE
CRCS12
FILS
POLE1
polymerase (DNA directed), epsilon, catalytic subunit (EC:2.7.7.7) Ethanol results in decreased expression of POLE protein decreases expression
protein 20621659
D000431 5443 POMC
ACTH
CLIP
LPH
MSH
NPP
POC
proopiomelanocortin Ethanol results in decreased expression of POMC mRNA decreases expression
mRNA 17934066
D000431 5443 POMC
ACTH
CLIP
LPH
MSH
NPP
POC
proopiomelanocortin fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] decreases expression
/ decreases reaction
mRNA 17934066
D000431 5451 POU2F1
OCT1
OTF1
oct-1B
POU class 2 homeobox 1 Ethanol results in decreased expression of POU2F1 mRNA decreases expression
mRNA 11566570
D000431 5460 POU5F1
OCT3
OCT4
OTF-3
OTF3
OTF4
Oct-3
Oct-4
POU class 5 homeobox 1 Ethanol results in decreased expression of POU5F1 protein decreases expression
protein 19919524
D000431 5460 POU5F1
OCT3
OCT4
OTF-3
OTF3
OTF4
Oct-3
Oct-4
POU class 5 homeobox 1 HBEGF protein inhibits the reaction [Ethanol results in decreased expression of POU5F1 protein] decreases expression
/ decreases reaction
protein 19919524
D000431 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha allyl sulfide inhibits the reaction [Ethanol results in decreased expression of PPARA protein] decreases expression
/ decreases reaction
protein 22138249
D000431 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Ethanol inhibits the reaction [GW 7647 results in increased activity of PPARA protein] decreases reaction
/ increases activity
protein 18003597
D000431 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Ethanol results in decreased expression of PPARA protein decreases expression
protein 22138249
D000431 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Ethanol results in increased expression of PPARA mRNA increases expression
mRNA 18003597
D000431 100136658 Ethanol inhibits the reaction [GW0742 results in increased activity of PPARB protein] decreases reaction
/ increases activity
protein 18003597
D000431 100136658 Ethanol results in increased expression of PPARB mRNA increases expression
mRNA 18003597
D000431 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Cyanamide inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] decreases reaction
/ increases activity
protein 17030193
D000431 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Ethanol inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased activity of PPARG protein] decreases reaction
/ increases activity
protein 17030193
D000431 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Ethanol inhibits the reaction [pioglitazone results in increased activity of PPARG protein] decreases reaction
/ increases activity
protein 17030193
D000431 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein] decreases reaction
/ increases activity
protein 17030193
D000431 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma fomepizole inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] decreases reaction
/ increases activity
protein 17030193
D000431 8497 PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Ethanol results in decreased expression of PPFIA4 protein decreases expression
protein 20621659
D000431 5052 PRDX1
MSP23
NKEF-A
NKEFA
PAG
PAGA
PAGB
PRX1
PRXI
TDPX2
peroxiredoxin 1 (EC:1.11.1.15) Ethanol results in increased expression of PRDX1 protein increases expression
protein 20621659
D000431 9588 PRDX6
1-Cys
AOP2
NSGPx
PRX
aiPLA2
p29
peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) Ethanol results in decreased expression of PRDX6 protein decreases expression
protein 20621659
D000431 5578 PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
protein kinase C, alpha (EC:2.7.11.13) [Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] increases abundance
/ increases activity
/ increases localization
/ increases reaction
protein 10651808
D000431 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] increases abundance
/ increases activity
/ increases localization
/ increases reaction
protein 10651808
D000431 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) Ethanol results in increased phosphorylation of PRKCD protein increases phosphorylation
protein 18182400
D000431 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PRKCD protein] increases phosphorylation
/ increases reaction
protein 18182400
D000431 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [sodium arsenite co-treated with Ethanol] results in increased expression of PTGS2 protein affects cotreatment
/ increases expression
protein 22872060
D000431 2185 PTK2B
CADTK
CAKB
FADK2
FAK2
PKB
PTK
PYK2
RAFTK
protein tyrosine kinase 2 beta (EC:2.7.10.2) Ethanol results in increased phosphorylation of PTK2B protein increases phosphorylation
protein 18182400
D000431 2185 PTK2B
CADTK
CAKB
FADK2
FAK2
PKB
PTK
PYK2
RAFTK
protein tyrosine kinase 2 beta (EC:2.7.10.2) sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PTK2B protein] increases phosphorylation
/ increases reaction
protein 18182400
D000431 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [Ethanol co-treated with sodium arsenite] results in increased localization of RAC1 protein affects cotreatment
/ increases localization
protein 18182400
D000431 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Ethanol results in increased localization of RAC1 protein increases localization
protein 18182400
D000431 5884 RAD17
CCYC
HRAD17
R24L
RAD17SP
RAD24
RAD17 homolog (S. pombe) Ethanol results in decreased expression of RAD17 protein decreases expression
protein 20621659
D000431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ethanol affects the localization of and results in increased activity of RELA protein] affects localization
/ decreases reaction
/ increases activity
protein 18295389
D000431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol affects the localization of and results in increased activity of RELA protein] affects localization
/ decreases reaction
/ increases activity
protein 18295389
D000431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Ethanol affects the localization of and results in increased activity of RELA protein affects localization
/ increases activity
protein 18295389
D000431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Ethanol promotes the reaction [RELA protein binds to TGM2 promoter] affects binding
/ increases reaction
protein 18295389
D000431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Ethanol results in increased activity of [RELA protein binds to NFKB1 protein] affects binding
/ increases activity
protein 10573527
D000431 6236 RRAD
RAD
RAD1
REM3
Ras-related associated with diabetes Ethanol results in decreased expression of RRAD mRNA decreases expression
mRNA 11566570
D000431 6275 S100A4
18A2
42A
CAPL
FSP1
MTS1
P9KA
PEL98
S100 calcium binding protein A4 Ethanol results in increased expression of S100A4 mRNA increases expression
mRNA 15963989
D000431 6342 SCP2
NLTP
NSL-TP
SCP-2
SCP-CHI
SCP-X
SCPX
sterol carrier protein 2 (EC:2.3.1.176) Ethanol results in decreased expression of SCP2 protein decreases expression
protein 20621659
D000431 23513 SCRIB
CRIB1
SCRB1
SCRIB1
Vartul
scribbled planar cell polarity protein Ethanol results in decreased expression of SCRIB protein decreases expression
protein 20621659
D000431 6573 SLC19A1
CHMD
FOLT
IFC1
REFC
RFC1
solute carrier family 19 (folate transporter), member 1 Ethanol results in decreased expression of SLC19A1 mRNA decreases expression
mRNA 19616087
D000431 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 Ethanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine] increases reaction
/ increases uptake
protein 21283641
D000431 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 Ethanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine] increases reaction
/ increases uptake
protein 21283641
D000431 60682 SMAP1
SMAP-1
small ArfGAP 1 Ethanol results in increased expression of SMAP1 protein increases expression
protein 20621659
D000431 6678 SPARC
ON
secreted protein, acidic, cysteine-rich (osteonectin) Ethanol results in increased expression of SPARC mRNA increases expression
mRNA 15963989
D000431 6696 SPP1
BNSP
BSPI
ETA-1
OPN
secreted phosphoprotein 1 Ethanol results in increased expression of SPP1 protein increases expression
protein 18703563
D000431 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 allyl sulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein] decreases reaction
/ increases expression
protein 22138249
D000431 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 Ethanol results in increased expression of SREBF1 protein increases expression
protein 22138249
D000431 6723 SRM
PAPT
SPDSY
SPS1
SRML1
spermidine synthase (EC:2.5.1.16) Ethanol results in decreased expression of SRM protein decreases expression
protein 20621659
D000431 56910 STARD7
GTT1
StAR-related lipid transfer (START) domain containing 7 Ethanol results in decreased expression of STARD7 protein decreases expression
protein 20621659
D000431 56910 STARD7
GTT1
StAR-related lipid transfer (START) domain containing 7 Ethanol results in increased expression of STARD7 protein increases expression
protein 20621659
D000431 6786 STIM1
D11S4896E
GOK
IMD10
TAM
stromal interaction molecule 1 Ethanol results in increased expression of STIM1 mRNA increases expression
mRNA 22119170
D000431 6786 STIM1
D11S4896E
GOK
IMD10
TAM
stromal interaction molecule 1 Ethanol results in increased expression of STIM1 protein increases expression
protein 22119170
D000431 6786 STIM1
D11S4896E
GOK
IMD10
TAM
stromal interaction molecule 1 STIM1 affects the susceptibility to Ethanol affects response to substance
22119170
D000431 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) Ethanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene] decreases reaction
/ increases sulfation
protein 14570759
D000431 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) Ethanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] decreases reaction
/ increases sulfation
protein 14570759
D000431 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A1 protein] decreases activity
/ increases reaction
protein 14570759
D000431 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) Ethanol results in decreased activity of SULT1A1 protein decreases activity
protein 14570759
D000431 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) Ethanol inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene] decreases reaction
/ increases sulfation
protein 14570759
D000431 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) Ethanol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine] decreases reaction
/ increases sulfation
protein 14570759
D000431 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A3 protein] decreases activity
/ increases reaction
protein 14570759
D000431 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) Ethanol results in decreased activity of SULT1A3 protein decreases activity
protein 14570759
D000431 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Ethanol inhibits the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene] decreases reaction
/ increases sulfation
protein 14570759
D000431 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Ethanol inhibits the reaction [SULT1E1 protein results in increased sulfation of Ethinyl Estradiol] decreases reaction
/ increases sulfation
protein 14570759
D000431 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1E1 protein] decreases activity
/ increases reaction
protein 14570759
D000431 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Ethanol results in decreased activity of SULT1E1 protein decreases activity
protein 14570759
D000431 6822 SULT2A1
DHEA-ST
DHEAS
HST
ST2
ST2A1
ST2A3
STD
hSTa
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (EC:2.8.2.14) Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene] decreases reaction
/ increases sulfation
protein 14570759
D000431 6822 SULT2A1
DHEA-ST
DHEAS
HST
ST2
ST2A1
ST2A3
STD
hSTa
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (EC:2.8.2.14) Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone] decreases reaction
/ increases sulfation
protein 14570759
D000431 6822 SULT2A1
DHEA-ST
DHEAS
HST
ST2
ST2A1
ST2A3
STD
hSTa
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (EC:2.8.2.14) Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein] decreases activity
/ increases reaction
protein 14570759
D000431 6822 SULT2A1
DHEA-ST
DHEAS
HST
ST2
ST2A1
ST2A3
STD
hSTa
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (EC:2.8.2.14) Ethanol results in decreased activity of SULT2A1 protein decreases activity
protein 14570759
D000431 9095 TBX19
TBS19
TPIT
dJ747L4.1
T-box 19 TBX19 gene SNP affects the susceptibility to Ethanol affects response to substance
gene 18438686
D000431 7037 TFRC
CD71
T9
TFR
TFR1
TR
TRFR
p90
transferrin receptor Ethanol results in increased expression of TFRC mRNA increases expression
mRNA 15963989
D000431 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Ethanol results in increased expression of TGFB1 mRNA increases expression
mRNA 11344824
15963989
D000431 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Ethanol results in increased expression of TGFB1 protein increases expression
protein 11344824
15147944
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein] decreases reaction
/ increases activity
protein 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein] decreases reaction
/ increases activity
protein 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Ethanol promotes the reaction [RELA protein binds to TGM2 promoter] affects binding
/ increases reaction
promoter 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Ethanol results in increased activity of TGM2 protein increases activity
protein 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Ethanol results in increased expression of TGM2 mRNA increases expression
mRNA 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) pinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein] decreases reaction
/ increases activity
protein 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) pinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA] decreases reaction
/ increases expression
mRNA 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Propolis inhibits the reaction [Ethanol results in increased activity of TGM2 protein] decreases reaction
/ increases activity
protein 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Propolis inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA] decreases reaction
/ increases expression
mRNA 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Tosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased activity of TGM2 protein] decreases reaction
/ increases activity
protein 18295389
D000431 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Tosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA] decreases reaction
/ increases expression
mRNA 18295389
D000431 7082 TJP1
ZO-1
tight junction protein 1 Ethanol affects the localization of TJP1 protein affects localization
protein 10198341
22563376
D000431 7083 TK1
TK2
thymidine kinase 1, soluble (EC:2.7.1.21) Ethanol inhibits the reaction [Zidovudine results in increased activity of TK1 protein] decreases reaction
/ increases activity
protein 11923581
D000431 7083 TK1
TK2
thymidine kinase 1, soluble (EC:2.7.1.21) Ethanol results in decreased activity of TK1 protein decreases activity
protein 11923581
D000431 7083 TK1
TK2
thymidine kinase 1, soluble (EC:2.7.1.21) Zidovudine inhibits the reaction [Ethanol results in decreased activity of TK1 protein] decreases activity
/ decreases reaction
protein 11923581
D000431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Ethanol results in increased expression of TNF increases expression
22484158
D000431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Ethanol results in increased expression of TNF mRNA increases expression
mRNA 11344824
D000431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Ethanol results in increased secretion of TNF protein increases secretion
protein 22841563
D000431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor lucidone inhibits the reaction [Ethanol results in increased expression of TNF] decreases reaction
/ increases expression
22484158
D000431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Vitamin E inhibits the reaction [Ethanol results in increased secretion of TNF protein] decreases reaction
/ increases secretion
protein 22841563
D000431 7167 TPI1
TIM
TPI
TPID
triosephosphate isomerase 1 (EC:5.3.1.1) Ethanol results in increased expression of TPI1 protein increases expression
protein 20621659
D000431 10107 TRIM10
HERF1
RFB30
RNF9
tripartite motif containing 10 Ethanol results in increased expression of TRIM10 protein increases expression
protein 20621659
D000431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A bisindolylmaleimide I inhibits the reaction [[Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 18210215
D000431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A [Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA affects cotreatment
/ increases expression
mRNA 18182400
D000431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Ethanol inhibits the reaction [sodium arsenite results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 22872060
D000431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Go 6976 inhibits the reaction [[Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 18210215
D000431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A [sodium arsenite co-treated with Ethanol] results in increased expression of VEGFA protein affects cotreatment
/ increases expression
protein 22872060
D000431 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) Ethanol results in increased expression of XDH mRNA increases expression
mRNA 18845238
D000431 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) Ethanol results in increased expression of XDH protein increases expression
protein 18845238
D000431 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis ALDH2 protein inhibits the reaction [Ethanol results in increased expression of XIAP protein] decreases reaction
/ increases expression
protein 19429258
D000431 7515 XRCC1
RCC
X-ray repair complementing defective repair in Chinese hamster cells 1 Ethanol results in increased expression of XRCC1 mRNA increases expression
mRNA 22056336
D000431 7515 XRCC1
RCC
X-ray repair complementing defective repair in Chinese hamster cells 1 Ethanol results in increased expression of XRCC1 protein increases expression
protein 22056336
D000431 25925 ZNF521
EHZF
Evi3
zinc finger protein 521 Ethanol results in decreased expression of ZNF521 protein decreases expression
protein 20621659

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (33)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

193 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000014 D000431 Abnormalities, Drug-Induced marker/mechanism
10560774
17676605
18926900
22298809
D000138 D000431 Acidosis therapeutic
11192467
D000140 D000431 Acidosis, Lactic marker/mechanism
404836
2054009
D058186 D000431 Acute Kidney Injury marker/mechanism
3747662
D000402 D000431 Airway Obstruction marker/mechanism
12166551
D000435 D000431 Alcoholic Intoxication marker/mechanism
7617798
8115696
8723618
16402636
D020751 D000431 Alcohol-Induced Disorders marker/mechanism
123503
22298809
D020268 D000431 Alcohol-Induced Disorders, Nervous System marker/mechanism
15451039
15451040
D000437 D000431 Alcoholism marker/mechanism
2866286
6142366
6542488
6685307
7885422
10708326
15542752
16923153
19968830
D019973 D000431 Alcohol-Related Disorders marker/mechanism
4062453
9164573
21360948
D020270 D000431 Alcohol Withdrawal Seizures marker/mechanism
7573789
16923153
D000647 D000431 Amnesia marker/mechanism
15671690
15832823
19345205
D020236 D000431 Amnesia, Transient Global marker/mechanism
3613025
D019969 D000431 Amphetamine-Related Disorders marker/mechanism
20636664
D000853 D000431 Anophthalmos marker/mechanism
15513904
D000855 D000431 Anorexia marker/mechanism
6663657
D001008 D000431 Anxiety Disorders marker/mechanism
therapeutic
7617798
11141031
12783153
D001028 D000431 Aortopulmonary Septal Defect marker/mechanism
20374213
D001247 D000431 Asthenia therapeutic
8590611
D001259 D000431 Ataxia marker/mechanism
1621360
2556616
6663657
7193248
7965752
8731063
9972844
D050197 D000431 Atherosclerosis marker/mechanism
9601935
D054537 D000431 Atrioventricular Block marker/mechanism
1444808
19918387
D001284 D000431 Atrophy marker/mechanism
14594753
18801475
D001342 D000431 Autonomic Nervous System Diseases therapeutic
8590611
D001714 D000431 Bipolar Disorder marker/mechanism
3711369
D001766 D000431 Blindness marker/mechanism
404836
4367894
D001835 D000431 Body Weight marker/mechanism
19100286
D001919 D000431 Bradycardia therapeutic
7672010
8113962
9309312
11486246
D001927 D000431 Brain Diseases marker/mechanism
6857682
18801475
20487539
D001929 D000431 Brain Edema therapeutic
17645627
D001930 D000431 Brain Injuries marker/mechanism
22960445
D002545 D000431 Brain Ischemia marker/mechanism
3764016
D001986 D000431 Bronchial Spasm marker/mechanism
1422404
D002056 D000431 Burns therapeutic
16374292
D006528 D000431 Carcinoma, Hepatocellular marker/mechanism
1679055
8025892
12637151
15289165
15763234
18788625
D006332 D000431 Cardiomegaly marker/mechanism
19332462
D009202 D000431 Cardiomyopathies marker/mechanism
5387726
16227066
21945864
D002310 D000431 Cardiomyopathy, Alcoholic marker/mechanism
20109599
22497828
D002311 D000431 Cardiomyopathy, Dilated therapeutic
12198386
D002318 D000431 Cardiovascular Diseases marker/mechanism
12186111
D020215 D000431 Carotid Artery, Internal, Dissection marker/mechanism
19655286
D002493 D000431 Central Nervous System Diseases marker/mechanism
22298809
D002543 D000431 Cerebral Hemorrhage marker/mechanism
therapeutic
12507409
17645627
D002779 D000431 Cholestasis marker/mechanism
6872919
D002971 D000431 Cleft Lip marker/mechanism
15513904
D002972 D000431 Cleft Palate marker/mechanism
15513904
D019970 D000431 Cocaine-Related Disorders marker/mechanism
therapeutic
10708326
12186111
19631491
D003072 D000431 Cognition Disorders marker/mechanism
9589271
10881254
12151022
16019965
18571546
D003128 D000431 COMA marker/mechanism
6862465
8115696
8693299
D003221 D000431 Confusion marker/mechanism
2068441
C535464 D000431 Conotruncal cardiac defects marker/mechanism
20374213
D003244 D000431 Consciousness Disorders marker/mechanism
18418024
D019465 D000431 Craniofacial Abnormalities marker/mechanism
10194807
11198716
11873399
15451039
15451040
15513904
19302082
22298809
D003645 D000431 Death, Sudden marker/mechanism
6082192
D016757 D000431 Death, Sudden, Cardiac marker/mechanism
11789664
D003693 D000431 Delirium marker/mechanism
2054009
D003731 D000431 Dental Caries marker/mechanism
17687962
D003866 D000431 Depressive Disorder marker/mechanism
18625256
D003865 D000431 Depressive Disorder, Major marker/mechanism
6663657
D002658 D000431 Developmental Disabilities marker/mechanism
18381539
D004195 D000431 Disease Models, Animal marker/mechanism
9314248
D018450 D000431 Disease Progression marker/mechanism
22331491
D004244 D000431 Dizziness marker/mechanism
18418024
D056486 D000431 Drug-Induced Liver Injury marker/mechanism
920871
1828327
3511825
5581500
6681608
7130740
11032766
11331107
11566570
12508366
14871588
18304714
20116195
20637825
20923693
21414402
22056766
22484158
22627062
D056487 D000431 Drug-Induced Liver Injury, Chronic marker/mechanism
22525864
D064420 D000431 Drug-Related Side Effects and Adverse Reactions marker/mechanism
21172400
D020820 D000431 Dyskinesias marker/mechanism
2054009
D004417 D000431 Dyspnea marker/mechanism
19657887
D004487 D000431 Edema marker/mechanism
17559993
D004830 D000431 Epilepsy, Tonic-Clonic marker/mechanism
3420461
D004938 D000431 Esophageal Neoplasms marker/mechanism
16704527
D020329 D000431 Essential Tremor therapeutic
15765150
D005234 D000431 Fatty Liver marker/mechanism
844254
6681608
11032766
16317704
16409862
18620774
18718457
18755807
19167417
19236843
19371623
19588123
20637825
21051528
21736892
22459179
D005235 D000431 Fatty Liver, Alcoholic marker/mechanism
4735055
15016835
17920746
18703563
19951287
20007851
20116195
20118189
21449565
22019745
22138249
22413959
D063647 D000431 Fetal Alcohol Spectrum Disorders marker/mechanism
9314248
10194807
10518076
15451040
15513904
16946407
18992320
20374213
20438829
21658441
22666445
D005313 D000431 Fetal Death marker/mechanism
1370119
8563186
D005317 D000431 Fetal Growth Retardation marker/mechanism
8563186
22298809
D005355 D000431 Fibrosis marker/mechanism
6681608
D005483 D000431 Flushing marker/mechanism
8903321
17220694
19657887
21053676
D005756 D000431 Gastritis marker/mechanism
6663657
15046732
D005767 D000431 Gastrointestinal Diseases marker/mechanism
7481522
17709257
D006130 D000431 Growth Disorders marker/mechanism
16634859
D006212 D000431 Hallucinations marker/mechanism
7859199
D006323 D000431 Heart Arrest marker/mechanism
3718622
D006330 D000431 Heart Defects, Congenital marker/mechanism
3719451
20374213
D006331 D000431 Heart Diseases marker/mechanism
6645200
D006344 D000431 Heart Septal Defects, Atrial marker/mechanism
20374213
D006345 D000431 Heart Septal Defects, Ventricular marker/mechanism
20374213
D006470 D000431 Hemorrhage marker/mechanism
7411781
D020141 D000431 Hemostatic Disorders marker/mechanism
6547757
D006505 D000431 Hepatitis marker/mechanism
1937386
D006519 D000431 Hepatitis, Alcoholic marker/mechanism
920871
D006529 D000431 Hepatomegaly marker/mechanism
19637192
D006869 D000431 Hydronephrosis marker/mechanism
9314248
D006930 D000431 Hyperalgesia marker/mechanism
9239313
10323274
17319957
18234883
20726883
D006940 D000431 Hyperemia marker/mechanism
15314997
D006945 D000431 Hyperhidrosis marker/mechanism
21053676
D006948 D000431 Hyperkinesis marker/mechanism
7546334
8447966
D006965 D000431 Hyperplasia marker/mechanism
20116195
D006973 D000431 Hypertension marker/mechanism
1422404
4732960
9330917
D015228 D000431 Hypertriglyceridemia marker/mechanism
6663657
D017379 D000431 Hypertrophy, Left Ventricular marker/mechanism
22497828
D007022 D000431 Hypotension marker/mechanism
therapeutic
2402817
3718622
9309312
9756044
11486246
15196476
17220694
17620917
19657887
21053676
22613216
D007035 D000431 Hypothermia marker/mechanism
2556616
3718622
D007154 D000431 Immune System Diseases marker/mechanism
11789664
D007249 D000431 Inflammation marker/mechanism
6681608
15016835
20116195
D008607 D000431 Intellectual Disability marker/mechanism
22298809
D020300 D000431 Intracranial Hemorrhages marker/mechanism
2190362
5008389
16227066
D007511 D000431 Ischemia marker/mechanism
4367894
D007565 D000431 Jaundice marker/mechanism
3511825
D007569 D000431 Jaw Abnormalities marker/mechanism
15513904
D007683 D000431 Kidney Tubular Necrosis, Acute marker/mechanism
9297132
D007859 D000431 Learning Disorders marker/mechanism
7637548
7796719
15451040
D017880 D000431 Limb Deformities, Congenital marker/mechanism
17676605
D008103 D000431 Liver Cirrhosis marker/mechanism
52258
920871
2920047
5581500
7130740
15289165
22149461
D008104 D000431 Liver Cirrhosis, Alcoholic marker/mechanism
18295389
19731237
22446813
23274713
D008106 D000431 Liver Cirrhosis, Experimental marker/mechanism
18166357
21863215
D008107 D000431 Liver Diseases marker/mechanism
6685305
16865776
D008108 D000431 Liver Diseases, Alcoholic marker/mechanism
6732388
17207112
17347304
21086752
22525864
D017114 D000431 Liver Failure, Acute marker/mechanism
1602296
3747662
7364436
15811896
D008114 D000431 Liver Neoplasms, Experimental marker/mechanism
2867966
3957177
D008133 D000431 Long QT Syndrome marker/mechanism
23155471
D008175 D000431 Lung Neoplasms marker/mechanism
19933698
D008569 D000431 Memory Disorders marker/mechanism
7796719
15451040
16125021
18411066
D008831 D000431 Microcephaly marker/mechanism
19442832
D048629 D000431 Micronuclei, Chromosome-Defective marker/mechanism
22535522
D008850 D000431 Microphthalmos marker/mechanism
21658441
D009059 D000431 Mouth Diseases marker/mechanism
17559993
D009069 D000431 Movement Disorders marker/mechanism
10802025
D009135 D000431 Muscular Diseases marker/mechanism
20442652
D009203 D000431 Myocardial Infarction marker/mechanism
3764016
19225254
D017202 D000431 Myocardial Ischemia marker/mechanism
17620917
D009325 D000431 Nausea marker/mechanism
21053676
D009336 D000431 Necrosis marker/mechanism
2524618
3865005
6645200
6681608
15016835
19167417
20116195
20442652
21051528
21410490
D009361 D000431 Neoplasm Invasiveness marker/mechanism
22331491
D009362 D000431 Neoplasm Metastasis marker/mechanism
22331491
D009422 D000431 Nervous System Diseases marker/mechanism
therapeutic
1665979
2554183
12486488
21783534
D051474 D000431 Neuralgia, Postherpetic therapeutic
15220798
D009436 D000431 Neural Tube Defects marker/mechanism
8563186
D019954 D000431 Neurobehavioral Manifestations marker/mechanism
23227189
D020258 D000431 Neurotoxicity Syndromes marker/mechanism
19442832
D009901 D000431 Optic Nerve Diseases marker/mechanism
17262233
D010146 D000431 Pain marker/mechanism
therapeutic
2587434
7473002
D010190 D000431 Pancreatic Neoplasms marker/mechanism
12384795
D010195 D000431 Pancreatitis marker/mechanism
12713032
D019512 D000431 Pancreatitis, Alcoholic marker/mechanism
15056978
D010243 D000431 Paralysis marker/mechanism
4367894
D010523 D000431 Peripheral Nervous System Diseases marker/mechanism
7552481
17319957
20726883
D010538 D000431 Peritonitis marker/mechanism
20624996
D010698 D000431 Phobic Disorders marker/mechanism
7769598
D011041 D000431 Poisoning marker/mechanism
1665979
D011115 D000431 Polyneuropathies marker/mechanism
6538276
D017119 D000431 Porphyria Cutanea Tarda therapeutic
11586030
D011297 D000431 Prenatal Exposure Delayed Effects marker/mechanism
123503
12456917
18571546
21382472
D049188 D000431 Prenatal Injuries marker/mechanism
8563186
D015175 D000431 Prolactinoma marker/mechanism
1472301
D011507 D000431 Proteinuria therapeutic
7748275
8194094
D011596 D000431 Psychomotor Disorders marker/mechanism
2050169
D011605 D000431 Psychoses, Substance-Induced marker/mechanism
7859199
D011654 D000431 Pulmonary Edema marker/mechanism
4732960
D015427 D000431 Reperfusion Injury therapeutic
22022451
D012141 D000431 Respiratory Tract Infections marker/mechanism
12166551
D012164 D000431 Retinal Diseases marker/mechanism
4367894
D012206 D000431 Rhabdomyolysis marker/mechanism
10863119
D012640 D000431 Seizures marker/mechanism
therapeutic
123503
2406529
2734334
2827698
3010161
4732960
6353625
7870991
9754883
11812504
16769170
17364644
17418694
D018805 D000431 Sepsis marker/mechanism
20624996
D020018 D000431 Sexual Dysfunctions, Psychological marker/mechanism
6520658
D013272 D000431 Stomach Diseases marker/mechanism
12438555
18237473
20678495
23516624
D013274 D000431 Stomach Neoplasms marker/mechanism
18456281
D013276 D000431 Stomach Ulcer marker/mechanism
3865005
8405073
8913705
9055195
9211565
9324159
9562338
9872509
10422768
10674923
11025360
11390426
11787760
11906479
12123631
14504662
15177919
16015682
16259727
16425415
16425418
16755016
17139445
17189318
17409556
17603938
17918041
18385449
19088804
19410566
19497430
19570992
19783516
19853593
20805684
20934418
22178775
22465177
D020521 D000431 Stroke marker/mechanism
19655286
21053676
D053608 D000431 Stupor marker/mechanism
4367894
7172122
D013345 D000431 Subarachnoid Hemorrhage marker/mechanism
3696399
12507409
D019966 D000431 Substance-Related Disorders marker/mechanism
21360948
D013375 D000431 Substance Withdrawal Syndrome marker/mechanism
1557510
2587434
2742726
2866286
3365642
3395463
4048228
6142366
6542488
6687130
7862907
8174503
8279662
8590611
9754883
10823403
12500104
15542752
18004067
D013610 D000431 Tachycardia marker/mechanism
9309312
19657887
21053676
22613216
D017180 D000431 Tachycardia, Ventricular marker/mechanism
11229942
D013683 D000431 Telangiectasia, Hereditary Hemorrhagic marker/mechanism
1251813
D013771 D000431 Tetralogy of Fallot marker/mechanism
20374213
D018677 D000431 Tooth Injuries marker/mechanism
17687962
D016388 D000431 Tooth Loss marker/mechanism
17687962
D016171 D000431 Torsades de Pointes marker/mechanism
19114159
19655286
D014202 D000431 Tremor marker/mechanism
17220694
21053676
D014474 D000431 Unconsciousness marker/mechanism
6281507
D016055 D000431 Urinary Retention marker/mechanism
16263650
D054079 D000431 Vascular Malformations therapeutic
20442652
D018487 D000431 Ventricular Dysfunction, Left marker/mechanism
20109599
22497828
D014693 D000431 Ventricular Fibrillation marker/mechanism
2465450
19114159
D018879 D000431 Ventricular Premature Complexes marker/mechanism
4185489
D014811 D000431 Vitamin E Deficiency therapeutic
4735055
D014839 D000431 Vomiting marker/mechanism
6663657
21053676
D015430 D000431 Weight Gain marker/mechanism
therapeutic
18755807
21051528
D015431 D000431 Weight Loss marker/mechanism
6685307