PCIDB

KNApSAcK Metabolite C00003936

Metabolite

KNApSAcK Entry

id C00003936
Name Demethylnobiletin / 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one
CAS RN 2174-59-6
Standard InChI InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3
Standard InChI (Main Layer) InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 8

Link

ChEMBL

By standard InChI CHEMBL75978
By standard InChI Main Layer CHEMBL75978

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL75978 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL75978 CHEMBL1614544 (1)
11 / 10
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL75978 CHEMBL1614458 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL75978 CHEMBL1613808 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL75978 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL75978 CHEMBL1614421 (1)
4 / 3
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL75978 CHEMBL818984 (1) CHEMBL820476 (1)
1 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (16)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)