Satureja montana
Species
KNApSAcK Entry
| Organism name | Satureja montana |
|---|---|
| Genus | Satureja |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Satureja montana |
|---|---|
| Linked NCBI taxonomy ID | 49988 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003879
|
Xanthomicrol
/ 5-Hydroxy-2-(4-hydroxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL476121
|
C462036
|
No. 3 | No. 15 |
|
||
|
C00003883
|
Gardenin B
/ Demethyltangeretin / 5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL226512
|
7 / 10 / 4 | No. 8 | No. 15 |
|
||
|
C00003936
|
Demethylnobiletin
/ 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL75978
|
21 / 22 / 16 | No. 8 | No. 15 |
|
||
|
C00019064
|
Oleanolic acid
/ Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid |
CHEMBL56615
CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454 |
D009828
|
30 / 8 / 12 | 21 / 15 | No. 13 | No. 51 |
|
Human Protein / Gene in interactions
54 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003936 C00019064 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003883 C00003936 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003883 C00019064 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003883 C00003936 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00019064 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00019064 | 4 / 2 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00019064 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00019064 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00019064 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003936 | 11 / 10 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00019064 | 0 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | Enzyme | C00003883 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00019064 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00019064 | 0 / 3 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00019064 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00003883 | 2 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00019064 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00019064 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00019064 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00003883 | 7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00019064 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00019064 | 2 / 2 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00019064 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00019064 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003883 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00019064 | 0 / 0 |
| P35228 | Nitric oxide synthase, inducible | Enzyme | C00019064 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003936 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00019064 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00019064 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003936 | 4 / 3 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00019064 | 0 / 1 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00019064 | 0 / 0 |
| P04054 | Phospholipase A2 | Enzyme | C00019064 | 0 / 0 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00019064 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00019064 | 1 / 4 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00003936 | 0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00003936 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00003936 | 1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00003936 | 2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00003936 | 0 / 0 |
| P07437 | Tubulin beta chain | Structural | C00003936 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00003936 | 1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00003936 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00003936 | 2 / 1 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00003936 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00003936 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00003936 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00003936 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00003936 | 0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00003936 | 1 / 0 |
21 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00019064
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00019064
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00019064
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00019064
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00019064
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00019064
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00019064
|
| 3065 | HDAC1, GON-10, HD1, RPD3, RPD3L1 | histone deacetylase 1 (EC:3.5.1.98) |
C00019064
|
| 3146 | HMGB1, HMG1, HMG3, SBP-1 | high mobility group box 1 |
C00019064
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00019064
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00019064
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00019064
|
| 4233 | MET, AUTS9, HGFR, RCCP2, c-Met | met proto-oncogene (EC:2.7.10.1) |
C00019064
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00019064
|
| 5052 | PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 | peroxiredoxin 1 (EC:1.11.1.15) |
C00019064
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00019064
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00019064
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00019064
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00019064
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00019064
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00019064
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (40)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #611162 | Malaria, susceptibility to |
P35228
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (32)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H00017 | Esophageal cancer |
P35228
(related)
P35354 (related) |
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
Diseases related to CTD interactions
15 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002252 | Carbon Tetrachloride Poisoning |
C00019064
|
| D056486 | Drug-Induced Liver Injury |
C00019064
|
| D050171 | Dyslipidemias |
C00019064
|
| D018149 | Glucose Intolerance |
C00019064
|
| D006949 | Hyperlipidemias |
C00019064
|
| D007249 | Inflammation |
C00019064
|
| D007674 | Kidney Diseases |
C00019064
|
| D008103 | Liver Cirrhosis |
C00019064
|
| D008106 | Liver Cirrhosis, Experimental |
C00019064
|
| D008107 | Liver Diseases |
C00019064
|
| D017202 | Myocardial Ischemia |
C00019064
|
| D009369 | Neoplasms |
C00019064
|
| D009765 | Obesity |
C00019064
|
| D011041 | Poisoning |
C00019064
|
| D011230 | Precancerous Conditions |
C00019064
|