Citrus tangerina
Species
KNApSAcK Entry
| Organism name | Citrus tangerina |
|---|---|
| Genus | Citrus |
| Family | Rutaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Citrus tangerina |
|---|---|
| Linked NCBI taxonomy ID | 237575 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Rutaceae |
|---|---|
| ID | 23513 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001105
|
Tangeretin
/ 4',5,6,7,8-Pentamethoxyflavone |
CHEMBL73930
|
C059006
|
12 / 11 / 11 | 2 / 0 | No. 8 | No. 15 |
|
|
C00003898
|
5-Hydroxy-6,7,3',4'-tetramethoxyflavone
/ 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL226508
|
C045324
|
No. 8 | No. 15 |
|
||
|
C00003934
|
Hymenoxin
/ 5,7-Dihydroxy-6,8,3',4'-tetramethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6,8-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL504325
|
C068785
|
No. 8 | No. 15 |
|
||
|
C00003936
|
Demethylnobiletin
/ 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL75978
|
21 / 22 / 16 | No. 8 | No. 15 |
|
||
|
C00013596
|
Sinensetin
/ Pedalitin permethyl ether / 5,6,7,3',4'-Pentamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL226507
|
C059295
|
7 / 6 / 7 | 3 / 0 | No. 8 | No. 15 |
|
Human Protein / Gene in interactions
34 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001105 C00013596 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00001105 C00013596 | 2 / 5 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001105 C00003936 | 0 / 1 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00001105 C00013596 | 2 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001105 C00003936 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00001105 C00013596 | 1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001105 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001105 | 3 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00013596 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001105 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001105 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003936 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00001105 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003936 | 11 / 10 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003936 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00013596 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003936 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00013596 | 0 / 0 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00003936 | 0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00003936 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00003936 | 1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00003936 | 2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00003936 | 0 / 0 |
| P07437 | Tubulin beta chain | Structural | C00003936 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00003936 | 1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00003936 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00003936 | 2 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001105 | 1 / 1 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00003936 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00003936 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00003936 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00003936 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00003936 | 0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00003936 | 1 / 0 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001105
C00013596
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001105
C00013596
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00013596
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (33)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (25)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|