PCIDB

KNApSAcK Metabolite C00001105

Metabolite

KNApSAcK Entry

id C00001105
Name Tangeretin / 4',5,6,7,8-Pentamethoxyflavone
CAS RN 481-53-8
Standard InChI InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
Standard InChI (Main Layer) InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 8

Link

ChEMBL

By standard InChI CHEMBL73930
By standard InChI Main Layer CHEMBL73930

KEGG

By LinkDB C10190

CTD

By CAS RN C059006

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL73930 CHEMBL2076048 (1) CHEMBL2076049 (1)
0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL73930 CHEMBL1023248 (1)
1 / 1
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL73930 CHEMBL1613776 (1)
3 / 1
P08183 Multidrug resistance protein 1 drug CHEMBL73930 CHEMBL1687396 (1) CHEMBL2075209 (1)
CHEMBL2077299 (1) CHEMBL2077304 (1)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL73930 CHEMBL1614458 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL73930 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL73930 CHEMBL1794467 (1)
0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL73930 CHEMBL1687393 (1) CHEMBL1687394 (1)
2 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL73930 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
O00255 Menin Unclassified protein CHEMBL73930 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL73930 CHEMBL1614257 (1)
1 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL73930 CHEMBL2354287 (1)
1 / 1

CTD interaction (3)

compound gene gene name gene description interaction interaction type form reference
pmid
C059006 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 17090139
C059006 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] decreases reaction
/ increases expression
protein 17090139
C059006 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] decreases reaction
/ increases expression
mRNA 17090139

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614490 Blood group, junior system; jr Q9UNQ0
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989

KEGG DISEASE (11)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)