Mentha spicata
Species
KNApSAcK Entry
| Organism name | Mentha spicata |
|---|---|
| Genus | Mentha |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Mentha spicata |
|---|---|
| Linked NCBI taxonomy ID | 29719 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (20)
| Species | Activity |
|---|---|
| Mentha spicata L. | Allergenic |
| Mentha spicata L. | Analgesic |
| Mentha spicata L. | Antipyretic |
| Mentha spicata L. | Antiseptic |
| Mentha spicata L. | Antispasmodic |
| Mentha spicata L. | Carminative |
| Mentha spicata L. | Decongestant |
| Mentha spicata L. | Deodorant |
| Mentha spicata L. | Dermatitigenic |
| Mentha spicata L. | Diaphoretic |
| Mentha spicata L. | Digestive |
| Mentha spicata L. | Diuretic |
| Mentha spicata L. | Emetic |
| Mentha spicata L. | Expectorant |
| Mentha spicata L. | Insecticide |
| Mentha spicata L. | Neurodepressant |
| Mentha spicata L. | Sedative |
| Mentha spicata L. | Stimulant |
| Mentha spicata L. | Stomachic |
| Mentha spicata L. | Vermifuge |
Metabolite list (13)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003892
|
6-Hydroxyluteolin 7,3'-dimethyl ether
/ 5,6,4'-Trihydroxy-7,3'-dimethoxyflavone / 5,6-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one |
No. 3 | No. 15 |
|
||||
|
C00003927
|
Sideritiflavone
/ 5,3',4'-Trihydroxy-6,7,8-trimethoxyflavone / 2-(3,4-Dihydroxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL312790
|
No. 3 | No. 15 |
|
|||
|
C00001036
|
Diosmetin
/ 4'-Methylluteolin / 5,7,3'-Trihydroxy-4'-methoxyflavone |
CHEMBL90568
|
C039602
|
11 / 12 / 8 | 5 / 0 | No. 3 | No. 15 |
|
|
C00003931
|
Thymonin
/ Majoranin / Mucroflavone B / 5,6,4'-Trihydroxy-7,8,3'-trimethoxyflavone / 5,6-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL478416
|
No. 3 | No. 15 |
|
|||
|
C00003936
|
Demethylnobiletin
/ 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL75978
|
21 / 22 / 16 | No. 8 | No. 15 |
|
||
|
C00013339
|
Pebrellin
/ 5,6-Dihydroxy-7,8,3',4'-tetramethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5,6-dihydroxy-7,8-dimethoxy-4H-1-benzopyran-4-one |
No. 8 | No. 15 |
|
||||
|
C00029346
|
(Z)-3-Hexenyl beta-D-glucopyranoside
/ (-)-(Z)-3-Hexenyl-beta-glucopyranoside / (Z)-3-Hexen-1-ol-beta-D-glucopyranoside |
CHEMBL2152486
|
C058860
|
No. 258 | No. 73 |
|
||
|
C00000803
|
(-)-Limonene
|
CHEMBL15799
CHEMBL449062 |
7 / 21 / 48 | No. 848 | No. 35 |
|
||
|
C00000814
|
(-)-trans-Carveol
|
CHEMBL1385229
CHEMBL1907992 CHEMBL1908058 |
6 / 15 / 40 | No. 1555 | No. 35 |
|
||
|
C00000807
|
(R)-(-)-Carvone
|
CHEMBL15676
CHEMBL501949 |
8 / 9 / 9 | No. 1740 | No. 35 |
|
||
|
C00003058
|
(+)-Rotundifolone
|
No. 5079 | No. 35 |
|
||||
|
C00000146
|
(+)-Bottrospicatol
|
No. 5341 |
|
|||||
|
C00010936
|
(-)-cis-Pulegol
/ p-Menth-4(8)-en-3-ol |
No. 5592 |
|
Human Protein / Gene in interactions
47 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000803 C00000814 | 7 / 37 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000803 C00000807 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000807 C00003936 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000803 C00000807 | 3 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000803 C00003936 | 11 / 10 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000803 C00001036 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003936 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000803 | 0 / 3 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000814 | 3 / 2 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00000807 | 2 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00000803 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00001036 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00001036 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000814 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00000814 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001036 | 5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00001036 | 4 / 4 |
| P04745 | Alpha-amylase 1 | Enzyme | C00001036 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003936 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001036 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00001036 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001036 | 1 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000807 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003936 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001036 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000814 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003936 | 4 / 3 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000814 | 3 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001036 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000807 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000807 | 1 / 2 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00003936 | 0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00003936 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00003936 | 1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00003936 | 2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00003936 | 0 / 0 |
| P07437 | Tubulin beta chain | Structural | C00003936 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00003936 | 1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00003936 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00003936 | 2 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000807 | 1 / 1 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00003936 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00003936 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00003936 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00003936 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00003936 | 0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00003936 | 1 / 0 |
5 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00001036
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001036
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001036
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001036
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00001036
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (58)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #211980 | Lung cancer |
P04637
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601665 | Obesity |
P37231
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
KEGG DISEASE (67)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|