PCIDB

KNApSAcK Metabolite C00048304

Metabolite

KNApSAcK Entry

id C00048304
Name Acetone
CAS RN 67-64-1
Standard InChI InChI=1S/C3H6O/c1-3(2)4/h1-2H3
Standard InChI (Main Layer) InChI=1S/C3H6O/c1-3(2)4/h1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5308

Link

ChEMBL

By standard InChI CHEMBL14253
By standard InChI Main Layer CHEMBL14253

KEGG

By LinkDB C00207

CTD

By CAS RN D000096

Human Protein / Gene in interaction

1 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein CHEMBL14253 CHEMBL1614544 (1)
11 / 10

CTD interaction (10)

compound gene gene name gene description interaction interaction type form reference
pmid
D000096 847 CAT
catalase (EC:1.11.1.6) Acetone results in decreased activity of CAT protein decreases activity
protein 16169704
D000096 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Acetone results in increased expression of CCND1 mRNA increases expression
mRNA 12720008
D000096 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide] increases hydroxylation
/ increases reaction
protein 10611138
D000096 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased metabolism of Acetone increases metabolic processing
protein 15576447
D000096 2263 FGFR2
BBDS
BEK
BFR-1
CD332
CEK3
CFD1
ECT1
JWS
K-SAM
KGFR
TK14
TK25
fibroblast growth factor receptor 2 (EC:2.7.10.1) Acetone results in increased expression of FGFR2 mRNA increases expression
mRNA 12720008
D000096 3596 IL13
IL-13
P600
interleukin 13 [Acetone co-treated with olive oil] results in increased expression of IL13 mRNA affects cotreatment
/ increases expression
mRNA 21252390
D000096 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 [Acetone co-treated with olive oil] results in increased expression of IL4 mRNA affects cotreatment
/ increases expression
mRNA 21252390
D000096 3567 IL5
EDF
IL-5
TRF
interleukin 5 (colony-stimulating factor, eosinophil) [Acetone co-treated with olive oil] results in increased expression of IL5 mRNA affects cotreatment
/ increases expression
mRNA 21252390
D000096 3678 ITGA5
CD49e
FNRA
VLA5A
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) Acetone results in increased expression of ITGA5 mRNA increases expression
mRNA 12720008
D000096 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor [Acetone co-treated with olive oil] results in increased expression of TNF mRNA affects cotreatment
/ increases expression
mRNA 21252390

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (10)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)

Diseases related to CTD interactions

8 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003389 D000096 Cranial Nerve Diseases marker/mechanism
12635524
D003556 D000096 Cystitis marker/mechanism
19618450
D056486 D000096 Drug-Induced Liver Injury marker/mechanism
therapeutic
1802361
6138230
D007662 D000096 Ketosis marker/mechanism
6138230
D009374 D000096 Neoplasms, Experimental marker/mechanism
9496914
D012640 D000096 Seizures therapeutic
19694724
D012878 D000096 Skin Neoplasms marker/mechanism
9496914
D014555 D000096 Urination Disorders marker/mechanism
19618450