PCIDB

KNApSAcK Metabolite C00004802

Metabolite

KNApSAcK Entry

id C00004802
Name 5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
CAS RN 1176-88-1
Standard InChI InChI=1S/C21H22O9/c1-24-11-8-7-10(9-12(11)25-2)16-18(26-3)14(22)13-15(23)19(27-4)21(29-6)20(28-5)17(13)30-16/h7-9,23H,1-6H3
Standard InChI (Main Layer) InChI=1S/C21H22O9/c1-24-11-8-7-10(9-12(11)25-2)16-18(26-3)14(22)13-15(23)19(27-4)21(29-6)20(28-5)17(13)30-16/h7-9,23H,1-6H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 8

Link

ChEMBL

By standard InChI CHEMBL422237
By standard InChI Main Layer CHEMBL422237

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

26 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL422237 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL422237 CHEMBL1794585 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL422237 CHEMBL1614166 (1)
1 / 0
O75496 Geminin Unclassified protein CHEMBL422237 CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL422237 CHEMBL2114788 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL422237 CHEMBL1794401 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL422237 CHEMBL1738588 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL422237 CHEMBL1614421 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL422237 CHEMBL1738184 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL422237 CHEMBL1613914 (1)
0 / 0
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL422237 CHEMBL2354287 (1)
1 / 1
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL422237 CHEMBL818984 (1) CHEMBL820476 (1)
1 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (6)

KEGG disease name UniProt
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)