Plant Species


Cumulative plant class count

class name count
rosids 18
eudicotyledons 1

Cumulative family count

class name count
Fabaceae 17
Brassicaceae 1
Montiaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001432 External link 512 Spermine
CHEMBL23194
D013096
35 / 17 / 25 7 / 11

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001432 1 / 0
Q9NZQ8 Transient receptor potential cation channel subfamily M member 5 Unclassified protein C00001432 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001432 0 / 0
P61073 C-X-C chemokine receptor type 4 CXC chemokine receptor C00001432 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001432 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001432 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00001432 0 / 0
Q8TD43 Transient receptor potential cation channel subfamily M member 4 Unclassified protein C00001432 1 / 1
P42574 Caspase-3 C14 C00001432 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00001432 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001432 0 / 1
Q05586 Glutamate receptor ionotropic, NMDA 1 NS C00001432 1 / 0
Q12879 Glutamate receptor ionotropic, NMDA 2A NS C00001432 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00001432 0 / 0
P42575 Caspase-2 C14 C00001432 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001432 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00001432 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00001432 1 / 2
P00915 Carbonic anhydrase 1 Lyase C00001432 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001432 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00001432 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001432 3 / 3
P16050 Arachidonate 15-lipoxygenase Enzyme C00001432 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001432 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001432 0 / 1
P07451 Carbonic anhydrase 3 Lyase C00001432 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00001432 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001432 0 / 0
P40225 Thrombopoietin Unclassified protein C00001432 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001432 0 / 0
O00255 Menin Unclassified protein C00001432 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001432 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001432 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001432 1 / 4
Q9H015 Solute carrier family 22 member 4 Unclassified protein C00001432 1 / 1

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
153 ADRB1, ADRB1R, B1AR, BETA1AR, RHR adrenoceptor beta 1 C00001432
154 ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR adrenoceptor beta 2, surface C00001432
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001432
846 CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1 calcium-sensing receptor C00001432
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00001432
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001432
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00001432

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#614254 Mental retardation, autosomal dominant 8; mrd8 Q05586
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604559 Progressive familial heart block, type ib; pfhb1b Q8TD43
#600852 Retinitis pigmentosa 17; rp17 P22748
#180300 Rheumatoid arthritis; ra Q9H015
#187950 Thrombocythemia 1; thcyt1 P40225
#193670 Whim syndrome P61073

KEGG DISEASE (25)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00097 Chemokine receptor defect P61073 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01263 Progressive cardiac conduction defect (PCCD) Q8TD43 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00286 Crohn's disease Q9H015 (related)

Diseases related to CTD interactions

11 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000740 Anemia C00001432
D001930 Brain Injuries C00001432
D002545 Brain Ischemia C00001432
D006331 Heart Diseases C00001432
D006948 Hyperkinesis C00001432
D007859 Learning Disorders C00001432
D008569 Memory Disorders C00001432
D009336 Necrosis C00001432
D009410 Nerve Degeneration C00001432
D012640 Seizures C00001432
D014202 Tremor C00001432