PCIDB

KNApSAcK Metabolite C00001432

Metabolite

KNApSAcK Entry

id C00001432
Name Spermine
CAS RN 71-44-3
Standard InChI InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
Standard InChI (Main Layer) InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2

Cluster

Phytochemical cluster
KCF-S cluster No. 7197

Link

ChEMBL

By standard InChI CHEMBL23194
By standard InChI Main Layer CHEMBL23194

KEGG

By LinkDB C00750

CTD

By CAS RN D013096

Human Protein / Gene in interaction

35 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL23194 CHEMBL1741321 (2)
1 / 0
Q9NZQ8 Transient receptor potential cation channel subfamily M member 5 Unclassified protein CHEMBL23194 CHEMBL1629100 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL23194 CHEMBL2114744 (1)
0 / 0
P61073 C-X-C chemokine receptor type 4 CXC chemokine receptor CHEMBL23194 CHEMBL2350745 (1) CHEMBL2351016 (1)
CHEMBL2351017 (1) CHEMBL2351018 (1)
CHEMBL2351021 (1) CHEMBL2351022 (1)
1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL23194 CHEMBL1217099 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL23194 CHEMBL1217098 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL23194 CHEMBL1217101 (1)
0 / 0
Q8TD43 Transient receptor potential cation channel subfamily M member 4 Unclassified protein CHEMBL23194 CHEMBL1629243 (1)
1 / 1
P42574 Caspase-3 C14 CHEMBL23194 CHEMBL933497 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL23194 CHEMBL1217095 (1) CHEMBL1670882 (1)
1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL23194 CHEMBL1741325 (2)
0 / 1
Q05586 Glutamate receptor ionotropic, NMDA 1 NS CHEMBL23194 CHEMBL1105657 (1) CHEMBL1105661 (1)
1 / 0
Q12879 Glutamate receptor ionotropic, NMDA 2A NS CHEMBL23194 CHEMBL1105657 (1) CHEMBL1105661 (1)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL23194 CHEMBL1217100 (1)
0 / 0
P42575 Caspase-2 C14 CHEMBL23194 CHEMBL933486 (2)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL23194 CHEMBL1613800 (2)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL23194 CHEMBL1217105 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL23194 CHEMBL1217103 (1) CHEMBL1670884 (1)
1 / 2
P00915 Carbonic anhydrase 1 Lyase CHEMBL23194 CHEMBL1217094 (1) CHEMBL1670881 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL23194 CHEMBL1741322 (2)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL23194 CHEMBL1217102 (1) CHEMBL1670883 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL23194 CHEMBL1613910 (1)
3 / 3
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL23194 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL23194 CHEMBL1613777 (1) CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL23194 CHEMBL1741324 (2)
0 / 1
P07451 Carbonic anhydrase 3 Lyase CHEMBL23194 CHEMBL1217096 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL23194 CHEMBL1217097 (1)
1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL23194 CHEMBL1613829 (1)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL23194 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL23194 CHEMBL1738442 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL23194 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL23194 CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL23194 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL23194 CHEMBL1613933 (1)
1 / 6
Q9H015 Solute carrier family 22 member 4 Unclassified protein CHEMBL23194 CHEMBL2076017 (1)
1 / 1

CTD interaction (13)

compound gene gene name gene description interaction interaction type form reference
pmid
D013096 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 Spermine binds to ADRB1 protein affects binding
protein 20885010
D013096 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Spermine binds to ADRB2 protein affects binding
protein 20885010
D013096 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Spermine results in decreased expression of BCL2 protein decreases expression
protein 16151648
D013096 846 CASR
CAR
EIG8
FHH
FIH
GPRC2A
HHC
HHC1
HYPOC1
NSHPT
PCAR1
calcium-sensing receptor 2-aminoethoxydiphenyl borate inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] affects binding
/ decreases reaction
/ increases activity
protein 17041782
D013096 846 CASR
CAR
EIG8
FHH
FIH
GPRC2A
HHC
HHC1
HYPOC1
NSHPT
PCAR1
calcium-sensing receptor Lanthanum inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] affects binding
/ decreases reaction
/ increases activity
protein 17041782
D013096 846 CASR
CAR
EIG8
FHH
FIH
GPRC2A
HHC
HHC1
HYPOC1
NSHPT
PCAR1
calcium-sensing receptor Spermine binds to and results in increased activity of CASR protein affects binding
/ increases activity
protein 17041782
D013096 846 CASR
CAR
EIG8
FHH
FIH
GPRC2A
HHC
HHC1
HYPOC1
NSHPT
PCAR1
calcium-sensing receptor [Spermine binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium affects binding
/ increases activity
/ increases uptake
protein 17041782
D013096 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Spermine affects the localization of DIABLO protein affects localization
protein 16151648
D013096 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Acetylcysteine inhibits the reaction [Spermine results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
protein 20121705
D013096 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Selenomethionine inhibits the reaction [Spermine results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
protein 20121705
D013096 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Spermine results in increased activity of MAPK8 protein increases activity
protein 20121705
D013096 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Selenomethionine inhibits the reaction [Spermine results in increased activity of NOS2 protein] decreases reaction
/ increases activity
protein 20121705
D013096 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Spermine results in increased activity of NOS2 protein increases activity
protein 20121705

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#614254 Mental retardation, autosomal dominant 8; mrd8 Q05586
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604559 Progressive familial heart block, type ib; pfhb1b Q8TD43
#600852 Retinitis pigmentosa 17; rp17 P22748
#180300 Rheumatoid arthritis; ra Q9H015
#187950 Thrombocythemia 1; thcyt1 P40225
#193670 Whim syndrome P61073

KEGG DISEASE (25)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00097 Chemokine receptor defect P61073 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01263 Progressive cardiac conduction defect (PCCD) Q8TD43 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00286 Crohn's disease Q9H015 (related)

Diseases related to CTD interactions

11 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000740 D013096 Anemia marker/mechanism
6534823
D001930 D013096 Brain Injuries marker/mechanism
21307247
D002545 D013096 Brain Ischemia marker/mechanism
21307247
D006331 D013096 Heart Diseases therapeutic
1841040
D006948 D013096 Hyperkinesis therapeutic
1228250
2819921
D007859 D013096 Learning Disorders marker/mechanism
9685571
D008569 D013096 Memory Disorders marker/mechanism
9685571
D009336 D013096 Necrosis marker/mechanism
10942576
D009410 D013096 Nerve Degeneration marker/mechanism
9685571
D012640 D013096 Seizures marker/mechanism
therapeutic
1228250
9641557
12675852
D014202 D013096 Tremor marker/mechanism
9641557