Canavalia bonariensis
Species
KNApSAcK Entry
| Organism name | Canavalia bonariensis |
|---|---|
| Genus | Canavalia |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Canavalia bonariensis |
|---|---|
| Linked NCBI taxonomy ID | 192414 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002547
|
(-)-Medicarpin
/ 3-Hydroxy-9-methoxypterocarpan |
CHEMBL238845
CHEMBL413297 |
C047353
|
3 / 1 / 1 | No. 66 | No. 15 |
|
|
|
C00002546
|
Inermin
/ Maackiain / (-)-Maackiain / Demethylpterocarpin / 3-Hydroxy-8,9-methylenedioxypterocarpan |
CHEMBL334918
CHEMBL239047 CHEMBL445279 |
3 / 2 / 3 | No. 66 | No. 15 |
|
||
|
C00001431
|
Spermidine
|
CHEMBL19612
|
D013095
|
26 / 10 / 12 | 5 / 5 | No. 5867 |
|
|
|
C00001432
|
Spermine
|
CHEMBL23194
|
D013096
|
35 / 17 / 25 | 7 / 11 | No. 7197 |
|
Human Protein / Gene in interactions
45 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001431 C00001432 C00002546 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001431 C00001432 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001431 C00001432 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00001431 C00001432 | 1 / 1 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00001431 C00001432 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00001431 C00001432 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001431 C00001432 | 1 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00001431 C00001432 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00001431 C00001432 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00001431 C00001432 | 0 / 0 |
| Q9H015 | Solute carrier family 22 member 4 | Unclassified protein | C00001431 C00001432 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001431 C00001432 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00001431 C00001432 | 0 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001431 C00001432 | 1 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001431 C00001432 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001431 C00001432 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001431 C00001432 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00001431 C00001432 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00001431 C00001432 | 1 / 2 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001431 C00001432 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00001431 C00001432 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001431 | 0 / 0 |
| P42575 | Caspase-2 | C14 | C00001432 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002547 | 0 / 0 |
| Q12879 | Glutamate receptor ionotropic, NMDA 2A | NS | C00001432 | 0 / 0 |
| Q6QHF9 | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Enzyme | C00001431 | 0 / 0 |
| Q05586 | Glutamate receptor ionotropic, NMDA 1 | NS | C00001432 | 1 / 0 |
| P42574 | Caspase-3 | C14 | C00001432 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001432 | 3 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001431 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001431 | 3 / 2 |
| Q8TD43 | Transient receptor potential cation channel subfamily M member 4 | Unclassified protein | C00001432 | 1 / 1 |
| P61073 | C-X-C chemokine receptor type 4 | CXC chemokine receptor | C00001432 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002547 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001432 | 0 / 0 |
| Q9NZQ8 | Transient receptor potential cation channel subfamily M member 5 | Unclassified protein | C00001432 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001432 | 0 / 0 |
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00002546 | 1 / 1 |
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00002546 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001432 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001432 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001432 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001432 | 1 / 4 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00001431 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002547 | 1 / 1 |
10 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 153 | ADRB1, ADRB1R, B1AR, BETA1AR, RHR | adrenoceptor beta 1 |
C00001431
C00001432
|
| 154 | ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR | adrenoceptor beta 2, surface |
C00001431
C00001432
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001432
|
| 486 | FXYD2, ATP1G1, HOMG2 | FXYD domain containing ion transport regulator 2 |
C00001431
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00001431
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001431
|
| 846 | CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1 | calcium-sensing receptor |
C00001432
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00001432
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001432
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00001432
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (23)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #614254 | Mental retardation, autosomal dominant 8; mrd8 |
Q05586
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #604559 | Progressive familial heart block, type ib; pfhb1b |
Q8TD43
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #180300 | Rheumatoid arthritis; ra |
Q9H015
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #193670 | Whim syndrome |
P61073
|
KEGG DISEASE (30)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00097 | Chemokine receptor defect |
P61073
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H01263 | Progressive cardiac conduction defect (PCCD) |
Q8TD43
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00286 | Crohn's disease |
Q9H015
(related)
|
Diseases related to CTD interactions
14 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006948 | Hyperkinesis |
C00001431
C00001432 |
| D012640 | Seizures |
C00001431
C00001432 |
| D002545 | Brain Ischemia |
C00001432
|
| D011041 | Poisoning |
C00001431
|
| D056486 | Drug-Induced Liver Injury |
C00001431
|
| D000740 | Anemia |
C00001432
|
| D001930 | Brain Injuries |
C00001432
|
| D006332 | Cardiomegaly |
C00001431
|
| D006331 | Heart Diseases |
C00001432
|
| D007859 | Learning Disorders |
C00001432
|
| D008569 | Memory Disorders |
C00001432
|
| D009336 | Necrosis |
C00001432
|
| D009410 | Nerve Degeneration |
C00001432
|
| D014202 | Tremor |
C00001432
|