PCIDB

Canavalia ensiformis

Species

KNApSAcK Entry

Organism name Canavalia ensiformis
Genus Canavalia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Canavalia ensiformis
Linked NCBI taxonomy ID 3823
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (41)

Species Activity
Canavalia ensiformis (L.) DC. Allelochemic
Canavalia ensiformis (L.) DC. Amyolitic
Canavalia ensiformis (L.) DC. Amyolytic
Canavalia ensiformis (L.) DC. Analgesic
Canavalia ensiformis (L.) DC. Antiadhesive
Canavalia ensiformis (L.) DC. Antiaggregant
Canavalia ensiformis (L.) DC. Antiaggregant
Canavalia ensiformis (L.) DC. Antiallergic
Canavalia ensiformis (L.) DC. Antiallergic
Canavalia ensiformis (L.) DC. Antibilious
Canavalia ensiformis (L.) DC. Anticapillary Fragility
Canavalia ensiformis (L.) DC. Antiherpetic
Canavalia ensiformis (L.) DC. Antiherpetic
Canavalia ensiformis (L.) DC. Antihistaminic
Canavalia ensiformis (L.) DC. Antihistaminic
Canavalia ensiformis (L.) DC. Antiinflammatory
Canavalia ensiformis (L.) DC. Antiinflammatory
Canavalia ensiformis (L.) DC. Antimetabolic
Canavalia ensiformis (L.) DC. Antimetabolic
Canavalia ensiformis (L.) DC. Antioxidant
Canavalia ensiformis (L.) DC. Antioxidant
Canavalia ensiformis (L.) DC. Antiseptic
Canavalia ensiformis (L.) DC. Antiviral
Canavalia ensiformis (L.) DC. Antiviral
Canavalia ensiformis (L.) DC. Bactericide
Canavalia ensiformis (L.) DC. Bechic
Canavalia ensiformis (L.) DC. Capillariprotective
Canavalia ensiformis (L.) DC. Demulcent
Canavalia ensiformis (L.) DC. Fungicide
Canavalia ensiformis (L.) DC. Fungicide
Canavalia ensiformis (L.) DC. Hemolytic
Canavalia ensiformis (L.) DC. Hemolytic
Canavalia ensiformis (L.) DC. Hypocholesterolemic
Canavalia ensiformis (L.) DC. Hypocholesterolemic
Canavalia ensiformis (L.) DC. Hypotensive
Canavalia ensiformis (L.) DC. Hypotensive
Canavalia ensiformis (L.) DC. Insecticide
Canavalia ensiformis (L.) DC. Mitogenic
Canavalia ensiformis (L.) DC. Mitogenic
Canavalia ensiformis (L.) DC. Stomachic
Canavalia ensiformis (L.) DC. Tonic

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002512 External link 512 Cajanin
/ 5,2',4'-Trihydroxy-7-methoxyisoflavone
CHEMBL469630
No. 3 No. 15
C00020647 External link 512 Malvidin
CHEMBL255753
1 / 0 / 1 No. 210 No. 15
C00001346 External link 512 L-Canaline
CHEMBL1231652
C001926
No. 3420
C00001555 External link 512 Trigonelline
CHEMBL350675
C009560
3 / 1 / 0 No. 3681 No. 1
C00001431 External link 512 Spermidine
CHEMBL19612
D013095
26 / 10 / 12 5 / 5 No. 5867
C00001432 External link 512 Spermine
CHEMBL23194
D013096
35 / 17 / 25 7 / 11 No. 7197
C00001347 External link 512 L-Canavanine
CHEMBL182461
CHEMBL443732
19 / 26 / 27 No. 8219

Human Protein / Gene in interactions

51 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001347 C00001431 C00001432 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001347 C00001431 C00001432 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001347 C00001431 C00001432 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001347 C00001431 C00001432 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00001347 C00001431 C00001432 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001347 C00001431 C00001432 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001347 C00001431 C00001432 0 / 1
O43570 Carbonic anhydrase 12 Lyase C00001431 C00001432 1 / 2
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001431 C00001432 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00001431 C00001432 0 / 0
Q9H015 Solute carrier family 22 member 4 Unclassified protein C00001431 C00001432 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001347 C00001432 1 / 2
O00255 Menin Unclassified protein C00001347 C00001432 2 / 5
P40225 Thrombopoietin Unclassified protein C00001431 C00001432 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00001347 C00001431 3 / 2
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001347 C00001432 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00001431 C00001432 1 / 2
P22748 Carbonic anhydrase 4 Lyase C00001431 C00001432 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00001431 C00001432 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00001431 C00001432 0 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001431 C00001432 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00001431 C00001432 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00001431 C00001432 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001431 C00001432 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00001431 C00001432 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001347 C00001555 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001431 0 / 0
P42575 Caspase-2 C14 C00001432 0 / 0
Q6QHF9 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase Enzyme C00001431 0 / 0
P54132 Bloom syndrome protein Enzyme C00001347 1 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001347 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001432 0 / 0
Q12879 Glutamate receptor ionotropic, NMDA 2A NS C00001432 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001432 3 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001431 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001347 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001347 1 / 1
P35228 Nitric oxide synthase, inducible Enzyme C00001347 1 / 1
Q9NZQ8 Transient receptor potential cation channel subfamily M member 5 Unclassified protein C00001432 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001347 4 / 1
Q05586 Glutamate receptor ionotropic, NMDA 1 NS C00001432 1 / 0
P61073 C-X-C chemokine receptor type 4 CXC chemokine receptor C00001432 1 / 1
P42574 Caspase-3 C14 C00001432 0 / 0
Q8TD43 Transient receptor potential cation channel subfamily M member 4 Unclassified protein C00001432 1 / 1
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001431 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001555 1 / 0
P02545 Prelamin-A/C Unclassified protein C00001347 11 / 10
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001555 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001432 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001432 1 / 4
P28907 ADP-ribosyl cyclase 1 Enzyme C00020647 0 / 1

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
153 ADRB1, ADRB1R, B1AR, BETA1AR, RHR adrenoceptor beta 1 C00001431 C00001432
154 ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR adrenoceptor beta 2, surface C00001431 C00001432
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001432
486 FXYD2, ATP1G1, HOMG2 FXYD domain containing ion transport regulator 2 C00001431
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00001431
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001431
846 CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1 calcium-sensing receptor C00001432
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00001432
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001432
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00001432

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614254 Mental retardation, autosomal dominant 8; mrd8 Q05586
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604559 Progressive familial heart block, type ib; pfhb1b Q8TD43
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#180300 Rheumatoid arthritis; ra Q9H015
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#187950 Thrombocythemia 1; thcyt1 P40225
#193670 Whim syndrome P61073

KEGG DISEASE (43)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00005 Chronic lymphocytic leukemia (CLL) P28907 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35228 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00097 Chemokine receptor defect P61073 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H01263 Progressive cardiac conduction defect (PCCD) Q8TD43 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00286 Crohn's disease Q9H015 (related)

Diseases related to CTD interactions

14 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006948 Hyperkinesis C00001431
C00001432
D012640 Seizures C00001431
C00001432
D002545 Brain Ischemia C00001432
D011041 Poisoning C00001431
D056486 Drug-Induced Liver Injury C00001431
D000740 Anemia C00001432
D001930 Brain Injuries C00001432
D006332 Cardiomegaly C00001431
D006331 Heart Diseases C00001432
D007859 Learning Disorders C00001432
D008569 Memory Disorders C00001432
D009336 Necrosis C00001432
D009410 Nerve Degeneration C00001432
D014202 Tremor C00001432