Psophocarpus tetragonolobus
Species
KNApSAcK Entry
| Organism name | Psophocarpus tetragonolobus |
|---|---|
| Genus | Psophocarpus |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Psophocarpus tetragonolobus |
|---|---|
| Linked NCBI taxonomy ID | 3891 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (19)
| Species | Activity |
|---|---|
| Psophocarpus tetragonolobus (L.) DC. | Anthelminthic |
| Psophocarpus tetragonolobus (L.) DC. | Anti-HIV |
| Psophocarpus tetragonolobus (L.) DC. | Antibacterial |
| Psophocarpus tetragonolobus (L.) DC. | Anticancer |
| Psophocarpus tetragonolobus (L.) DC. | Antiedemic |
| Psophocarpus tetragonolobus (L.) DC. | Antiinflammatory |
| Psophocarpus tetragonolobus (L.) DC. | Antileukemic |
| Psophocarpus tetragonolobus (L.) DC. | Antimalarial |
| Psophocarpus tetragonolobus (L.) DC. | Antimelanomic |
| Psophocarpus tetragonolobus (L.) DC. | Antinociceptive |
| Psophocarpus tetragonolobus (L.) DC. | Antiplasmodial |
| Psophocarpus tetragonolobus (L.) DC. | Antiseptic |
| Psophocarpus tetragonolobus (L.) DC. | Antitumor |
| Psophocarpus tetragonolobus (L.) DC. | Antiviral |
| Psophocarpus tetragonolobus (L.) DC. | Aphrodisiac |
| Psophocarpus tetragonolobus (L.) DC. | Apoptotic |
| Psophocarpus tetragonolobus (L.) DC. | Cytotoxic |
| Psophocarpus tetragonolobus (L.) DC. | Depurative |
| Psophocarpus tetragonolobus (L.) DC. | Phospholipase-A2 Inhibitor |
Metabolite list (10)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001059
|
Isovitexin
/ Saponaretin / Homovitexin / 6-C-beta-D-Glucopyranosylapigenin / 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL465360
CHEMBL1601394 |
C049772
|
28 / 20 / 19 | No. 22 | No. 15 |
|
|
|
C00000001
|
GA1
/ Gibberellin A1 |
C422660
|
No. 40 | No. 41 |
|
|||
|
C00009611
|
Isomedicarpin
/ 9-Hydroxy-3-methoxypterocarpan |
No. 66 | No. 15 |
|
||||
|
C00009610
|
Demethylmedicarpin
/ 3,9-Dihydroxypterocarpan |
CHEMBL238823
CHEMBL1098413 |
C042060
|
No. 66 | No. 15 |
|
||
|
C00020091
|
Delphinidine
|
CHEMBL276780
|
1 / 0 / 1 | No. 71 | No. 15 |
|
||
|
C00009654
|
1-Methoxyphaseollidin
/ 3,9-Dihydroxy-1-methoxy-10-prenylpterocarpan |
CHEMBL1726462
|
5 / 4 / 2 | No. 188 | No. 15 |
|
||
|
C00002515
|
Cristacarpin
/ Erythrabyssin I |
CHEMBL454849
|
C085157
|
2 / 1 / 1 | No. 325 | No. 15 |
|
|
|
C00001431
|
Spermidine
|
CHEMBL19612
|
D013095
|
26 / 10 / 12 | 5 / 5 | No. 5867 |
|
|
|
C00001432
|
Spermine
|
CHEMBL23194
|
D013096
|
35 / 17 / 25 | 7 / 11 | No. 7197 |
|
|
|
C00001400
|
Agmatine
|
CHEMBL58343
|
D000376
|
11 / 2 / 3 | 0 / 9 | No. 7327 | No. 78 |
|
Human Protein / Gene in interactions
72 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001400 C00001431 C00001432 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001400 C00001431 C00001432 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001400 C00001431 C00001432 | 0 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001400 C00001431 C00001432 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001400 C00001431 C00001432 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001400 C00001431 C00001432 | 0 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001400 C00001431 C00001432 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001059 C00009654 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001059 C00001432 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00001431 C00001432 | 1 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00001431 C00001432 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00001431 C00001432 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00001431 C00001432 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00001431 C00001432 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00001431 C00001432 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001059 C00001432 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001059 C00001432 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001059 C00001432 | 0 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001059 C00001431 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001431 C00001432 | 1 / 2 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001059 C00001432 | 1 / 4 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00001431 C00001432 | 0 / 1 |
| Q9H015 | Solute carrier family 22 member 4 | Unclassified protein | C00001431 C00001432 | 1 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001059 C00009654 | 1 / 1 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00001431 C00001432 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001431 C00001432 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001431 C00001432 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00001431 C00001432 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00001431 C00001432 | 1 / 2 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001059 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001059 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001059 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001431 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00009654 | 2 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002515 | 0 / 1 |
| P42575 | Caspase-2 | C14 | C00001432 | 0 / 0 |
| Q6QHF9 | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Enzyme | C00001431 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00009654 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001059 | 7 / 3 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001059 | 1 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001059 | 0 / 0 |
| Q12879 | Glutamate receptor ionotropic, NMDA 2A | NS | C00001432 | 0 / 0 |
| Q05586 | Glutamate receptor ionotropic, NMDA 1 | NS | C00001432 | 1 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001432 | 3 / 3 |
| P42574 | Caspase-3 | C14 | C00001432 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002515 | 1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001400 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001431 | 3 / 2 |
| P30989 | Neurotensin receptor type 1 | Neurotensin receptor | C00001059 | 0 / 0 |
| Q8TD43 | Transient receptor potential cation channel subfamily M member 4 | Unclassified protein | C00001432 | 1 / 1 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00001400 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001059 | 0 / 0 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00020091 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001059 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001059 | 2 / 2 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001059 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001059 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001059 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001059 | 0 / 0 |
| P61073 | C-X-C chemokine receptor type 4 | CXC chemokine receptor | C00001432 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00001059 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001432 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001059 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001059 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00009654 | 1 / 1 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00001400 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001059 | 0 / 0 |
| Q9NZQ8 | Transient receptor potential cation channel subfamily M member 5 | Unclassified protein | C00001432 | 0 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00001431 | 0 / 0 |
| O75751 | Solute carrier family 22 member 3 | Unclassified protein | C00001400 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001059 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001059 | 2 / 1 |
10 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 153 | ADRB1, ADRB1R, B1AR, BETA1AR, RHR | adrenoceptor beta 1 |
C00001431
C00001432
|
| 154 | ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR | adrenoceptor beta 2, surface |
C00001431
C00001432
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001432
|
| 486 | FXYD2, ATP1G1, HOMG2 | FXYD domain containing ion transport regulator 2 |
C00001431
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00001431
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001431
|
| 846 | CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1 | calcium-sensing receptor |
C00001432
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00001432
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001432
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00001432
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (39)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #614254 | Mental retardation, autosomal dominant 8; mrd8 |
Q05586
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #604559 | Progressive familial heart block, type ib; pfhb1b |
Q8TD43
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #180300 | Rheumatoid arthritis; ra |
Q9H015
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #193670 | Whim syndrome |
P61073
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (38)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P28907
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00097 | Chemokine receptor defect |
P61073
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H01263 | Progressive cardiac conduction defect (PCCD) |
Q8TD43
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00286 | Crohn's disease |
Q9H015
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
23 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006948 | Hyperkinesis |
C00001431
C00001432 |
| D012640 | Seizures |
C00001431
C00001432 |
| D001919 | Bradycardia |
C00001400
|
| D007022 | Hypotension |
C00001400
|
| D009021 | Morphine Dependence |
C00001400
|
| D009293 | Opioid-Related Disorders |
C00001400
|
| D010146 | Pain |
C00001400
|
| D013375 | Substance Withdrawal Syndrome |
C00001400
|
| D013610 | Tachycardia |
C00001400
|
| D006332 | Cardiomegaly |
C00001431
|
| D056486 | Drug-Induced Liver Injury |
C00001431
|
| D006973 | Hypertension |
C00001400
|
| D011041 | Poisoning |
C00001431
|
| D006930 | Hyperalgesia |
C00001400
|
| D000740 | Anemia |
C00001432
|
| D001930 | Brain Injuries |
C00001432
|
| D002545 | Brain Ischemia |
C00001432
|
| D006331 | Heart Diseases |
C00001432
|
| D007859 | Learning Disorders |
C00001432
|
| D008569 | Memory Disorders |
C00001432
|
| D009336 | Necrosis |
C00001432
|
| D009410 | Nerve Degeneration |
C00001432
|
| D014202 | Tremor |
C00001432
|