KCF-S cluster No. 7732 (1 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (1)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	3

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Cumulative family count

class name	count
Malpighiaceae	1
Passifloraceae	1
Nitrariaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Indole alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Indole alkaloids	C06536	C00001735

Metabolite list (1)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001735	Harmaline	CHEMBL340807	D006246	101 / 52 / 45	6 / 4

Human Protein / Gene in interactions

101 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001735	1 / 0
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00001735	1 / 1
Q9P1W9	Serine/threonine-protein kinase pim-2	Pim	C00001735	0 / 0
Q8TDX7	Serine/threonine-protein kinase Nek7	Nek	C00001735	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001735	1 / 1
Q15759	Mitogen-activated protein kinase 11	p38	C00001735	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00001735	0 / 0
P06746	DNA polymerase beta	Enzyme	C00001735	0 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00001735	0 / 0
P41240	Tyrosine-protein kinase CSK	Csk	C00001735	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001735	1 / 1
P45984	Mitogen-activated protein kinase 9	Jnk	C00001735	0 / 0
P29466	Caspase-1	C14	C00001735	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00001735	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00001735	0 / 0
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00001735	0 / 0
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00001735	1 / 4
Q8IWQ3	Serine/threonine-protein kinase BRSK2	CAMK serine/threonine protein kinase BRSK subfamily	C00001735	0 / 0
P27448	MAP/microtubule affinity-regulating kinase 3	CAMK serine/threonine protein kinase MARK subfamily	C00001735	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001735	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00001735	3 / 2
Q05513	Protein kinase C zeta type	Iota	C00001735	0 / 0
P47898	5-hydroxytryptamine receptor 5A	Serotonin receptor	C00001735	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00001735	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00001735	0 / 0
P23443	Ribosomal protein S6 kinase beta-1	p70	C00001735	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00001735	0 / 0
Q9UQB9	Aurora kinase C	Aur	C00001735	1 / 1
Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	CAMK serine/threonine protein kinase MNK subfamily	C00001735	0 / 0
Q9NQU5	Serine/threonine-protein kinase PAK 6	STE serine/threonine protein kinase PAKB subfamily	C00001735	0 / 0
Q16644	MAP kinase-activated protein kinase 3	CAMK serine/threonine protein kinase MAPKAPK	C00001735	0 / 0
Q9H422	Homeodomain-interacting protein kinase 3	CMGC dual-specificity kinase HIPK	C00001735	0 / 0
Q14680	Maternal embryonic leucine zipper kinase	Melk	C00001735	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00001735	1 / 2
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00001735	1 / 0
Q15746	Myosin light chain kinase, smooth muscle	Mlck	C00001735	1 / 1
Q13188	Serine/threonine-protein kinase 3	STE serine/threonine protein kinase MST subfamily	C00001735	0 / 0
P31751	RAC-beta serine/threonine-protein kinase	Akt	C00001735	2 / 2
O75582	Ribosomal protein S6 kinase alpha-5	CAMK serine/threonine protein kinase MSKB subfamily	C00001735	0 / 0
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	Other serine/threonine protein kinase	C00001735	0 / 0
Q16513	Serine/threonine-protein kinase N2	Pkn	C00001735	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00001735	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001735	0 / 0
Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	META serine/threonine protein kinase subfamily	C00001735	0 / 0
Q9P286	Serine/threonine-protein kinase PAK 7	STE serine/threonine protein kinase PAKB subfamily	C00001735	0 / 0
Q96SB4	SRSF protein kinase 1	Srpk	C00001735	0 / 0
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	CMGC dual-specificity kinase DYRK2	C00001735	0 / 0
O43781	Dual specificity tyrosine-phosphorylation-regulated kinase 3	CMGC dual-specificity kinase DYRK2	C00001735	0 / 0
O96013	Serine/threonine-protein kinase PAK 4	STE serine/threonine protein kinase PAKB subfamily	C00001735	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001735	0 / 0
P42858	Huntingtin	Unclassified protein	C00001735	1 / 1
O75496	Geminin	Unclassified protein	C00001735	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00001735	0 / 0
Q15418	Ribosomal protein S6 kinase alpha-1	Rskb	C00001735	0 / 0
O15264	Mitogen-activated protein kinase 13	p38	C00001735	0 / 0
P53779	Mitogen-activated protein kinase 10	Jnk	C00001735	0 / 1
P51955	Serine/threonine-protein kinase Nek2	Nek	C00001735	0 / 0
Q96RR4	Calcium/calmodulin-dependent protein kinase kinase 2	META serine/threonine protein kinase subfamily	C00001735	0 / 0
Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	CAMK serine/threonine protein kinase MNK subfamily	C00001735	0 / 0
P48730	Casein kinase I isoform delta	Ck1	C00001735	1 / 0
P06280	Alpha-galactosidase A	Enzyme	C00001735	1 / 1
Q96GD4	Aurora kinase B	Aur	C00001735	0 / 0
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00001735	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001735	0 / 0
P45983	Mitogen-activated protein kinase 8	Jnk	C00001735	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001735	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001735	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001735	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00001735	1 / 0
P53350	Serine/threonine-protein kinase PLK1	PLK serine/threonine protein kinase subfamily	C00001735	0 / 0
Q8IW41	MAP kinase-activated protein kinase 5	CAMK serine/threonine protein kinase MAPKAPK	C00001735	0 / 0
O75116	Rho-associated protein kinase 2	Rock	C00001735	0 / 0
P55210	Caspase-7	C14	C00001735	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00001735	4 / 1
O00141	Serine/threonine-protein kinase Sgk1	AGC serine/threonine protein kinase SGK subfamily	C00001735	0 / 0
P51812	Ribosomal protein S6 kinase alpha-3	Rskb	C00001735	2 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001735	0 / 1
Q9HC98	Serine/threonine-protein kinase Nek6	Nek	C00001735	0 / 0
Q9H2X6	Homeodomain-interacting protein kinase 2	CMGC dual-specificity kinase HIPK	C00001735	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001735	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001735	4 / 3
O96017	Serine/threonine-protein kinase Chk2	Rad53	C00001735	4 / 1
Q14012	Calcium/calmodulin-dependent protein kinase type 1	Camk1	C00001735	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00001735	0 / 0
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00001735	1 / 0
P53778	Mitogen-activated protein kinase 12	p38	C00001735	0 / 0
O00418	Eukaryotic elongation factor 2 kinase	Atypical serine/threonine protein kinase alpha subfamily	C00001735	0 / 0
Q8TD08	Mitogen-activated protein kinase 15	Mapk	C00001735	0 / 0
Q86V86	Serine/threonine-protein kinase pim-3	Pim	C00001735	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001735	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001735	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001735	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001735	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001735	1 / 1
O00255	Menin	Unclassified protein	C00001735	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001735	1 / 2
P20248	Cyclin-A2	Other cytosolic protein	C00001735	0 / 0
P78396	Cyclin-A1	Other cytosolic protein	C00001735	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00001735	0 / 0
P19784	Casein kinase II subunit alpha'	Ck2	C00001735	0 / 0
P67870	Casein kinase II subunit beta	REG serine/threonine protein kinase family	C00001735	0 / 0

6 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00001735
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001735
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00001735
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001735
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00001735
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001735

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions