PCIDB

KNApSAcK Metabolite C00001735

Metabolite

KNApSAcK Entry

id C00001735
Name Harmaline
CAS RN 304-21-2
Standard InChI InChI=1S/C13H14N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7,15H,5-6H2,1-2H3
Standard InChI (Main Layer) InChI=1S/C13H14N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7,15H,5-6H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 7732

Link

ChEMBL

By standard InChI CHEMBL340807
By standard InChI Main Layer CHEMBL340807

KEGG

By LinkDB C06536

CTD

By CAS RN D006246

Human Protein / Gene in interaction

101 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL340807 CHEMBL1614110 (1)
1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 CHEMBL340807 CHEMBL1062820 (1)
1 / 1
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim CHEMBL340807 CHEMBL1061086 (1)
0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek CHEMBL340807 CHEMBL1060151 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL340807 CHEMBL2114784 (1)
1 / 1
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL340807 CHEMBL1052111 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL340807 CHEMBL1063767 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL340807 CHEMBL1614079 (1)
0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 CHEMBL340807 CHEMBL1063811 (1)
0 / 0
P41240 Tyrosine-protein kinase CSK Csk CHEMBL340807 CHEMBL1061954 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL340807 CHEMBL1614103 (1) CHEMBL1614031 (1)
1 / 1
P45984 Mitogen-activated protein kinase 9 Jnk CHEMBL340807 CHEMBL1060122 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL340807 CHEMBL1614158 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL340807 CHEMBL1062776 (1)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL340807 CHEMBL1061959 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL340807 CHEMBL1051374 (1)
0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily CHEMBL340807 CHEMBL1614153 (1)
1 / 4
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily CHEMBL340807 CHEMBL1051367 (1)
0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily CHEMBL340807 CHEMBL1063734 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL340807 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL340807 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
Q05513 Protein kinase C zeta type Iota CHEMBL340807 CHEMBL1052114 (1)
0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor CHEMBL340807 CHEMBL618086 (1)
0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL340807 CHEMBL1063736 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL340807 CHEMBL666137 (1) CHEMBL1056886 (1)
0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL340807 CHEMBL1052119 (1)
0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 CHEMBL340807 CHEMBL666138 (1)
0 / 0
Q9UQB9 Aurora kinase C Aur CHEMBL340807 CHEMBL1062797 (1)
1 / 1
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily CHEMBL340807 CHEMBL1060126 (1)
0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily CHEMBL340807 CHEMBL1063719 (1)
0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK CHEMBL340807 CHEMBL1061148 (1)
0 / 0
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK CHEMBL340807 CHEMBL1061964 (1)
0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk CHEMBL340807 CHEMBL1052104 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL340807 CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL340807 CHEMBL1614166 (1)
1 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck CHEMBL340807 CHEMBL1062028 (1)
1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily CHEMBL340807 CHEMBL1060209 (1)
0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt CHEMBL340807 CHEMBL1061917 (1)
2 / 2
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily CHEMBL340807 CHEMBL1062767 (1)
0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase CHEMBL340807 CHEMBL1062809 (1)
0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn CHEMBL340807 CHEMBL1060217 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL340807 CHEMBL1062021 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL340807 CHEMBL1614458 (4)
0 / 0
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily CHEMBL340807 CHEMBL1061198 (1)
0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily CHEMBL340807 CHEMBL1061163 (1)
0 / 0
Q96SB4 SRSF protein kinase 1 Srpk CHEMBL340807 CHEMBL1060225 (1)
0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 CHEMBL340807 CHEMBL1062802 (1)
0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 CHEMBL340807 CHEMBL1061956 (1)
0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily CHEMBL340807 CHEMBL1061162 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL340807 CHEMBL1738606 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL340807 CHEMBL1613918 (1)
1 / 1
O75496 Geminin Unclassified protein CHEMBL340807 CHEMBL2114780 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL340807 CHEMBL1060118 (1)
0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb CHEMBL340807 CHEMBL1052116 (1)
0 / 0
O15264 Mitogen-activated protein kinase 13 p38 CHEMBL340807 CHEMBL1060132 (1)
0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk CHEMBL340807 CHEMBL1060123 (1)
0 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek CHEMBL340807 CHEMBL1062822 (1)
0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily CHEMBL340807 CHEMBL1052080 (1)
0 / 0
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily CHEMBL340807 CHEMBL1063759 (1)
0 / 0
P48730 Casein kinase I isoform delta Ck1 CHEMBL340807 CHEMBL1062001 (1)
1 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL340807 CHEMBL1614217 (1)
1 / 1
Q96GD4 Aurora kinase B Aur CHEMBL340807 CHEMBL1051365 (1)
0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK CHEMBL340807 CHEMBL1051342 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL340807 CHEMBL1052091 (1)
0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL340807 CHEMBL1061969 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL340807 CHEMBL1613910 (2) CHEMBL1614227 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL340807 CHEMBL1614038 (3)
2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL340807 CHEMBL1738588 (1)
0 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL340807 CHEMBL2020014 (1) CHEMBL2020015 (1)
1 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL340807 CHEMBL1052115 (1)
0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL340807 CHEMBL1061101 (1)
0 / 0
O75116 Rho-associated protein kinase 2 Rock CHEMBL340807 CHEMBL1063671 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL340807 CHEMBL1613779 (2)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL340807 CHEMBL1061172 (1)
4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL340807 CHEMBL1063673 (1)
0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb CHEMBL340807 CHEMBL1063683 (1)
2 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL340807 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
Q9HC98 Serine/threonine-protein kinase Nek6 Nek CHEMBL340807 CHEMBL1060128 (1)
0 / 0
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK CHEMBL340807 CHEMBL1062015 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL340807 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL340807 CHEMBL1614421 (3) CHEMBL1614502 (1)
4 / 3
O96017 Serine/threonine-protein kinase Chk2 Rad53 CHEMBL340807 CHEMBL1062000 (1)
4 / 1
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 CHEMBL340807 CHEMBL1051272 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL340807 CHEMBL1062854 (1)
0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 CHEMBL340807 CHEMBL1062005 (1)
1 / 0
P53778 Mitogen-activated protein kinase 12 p38 CHEMBL340807 CHEMBL1062773 (1)
0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily CHEMBL340807 CHEMBL1060113 (1)
0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk CHEMBL340807 CHEMBL1062012 (1)
0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim CHEMBL340807 CHEMBL1061912 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL340807 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL340807 CHEMBL1613914 (3)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL340807 CHEMBL1613829 (2) CHEMBL1794433 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL340807 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL340807 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL340807 CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL340807 CHEMBL1614531 (2)
1 / 3
P20248 Cyclin-A2 Other cytosolic protein CHEMBL340807 CHEMBL1056886 (1)
0 / 0
P78396 Cyclin-A1 Other cytosolic protein CHEMBL340807 CHEMBL1056886 (1)
0 / 0
P68400 Casein kinase II subunit alpha Ck2 CHEMBL340807 CHEMBL1061205 (1)
0 / 0
P19784 Casein kinase II subunit alpha' Ck2 CHEMBL340807 CHEMBL1061205 (1)
0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family CHEMBL340807 CHEMBL1061205 (1)
0 / 0

CTD interaction (16)

compound gene gene name gene description interaction interaction type form reference
pmid
D006246 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] decreases reaction
/ increases expression
protein 12107048
D006246 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein] affects cotreatment
/ decreases expression
/ decreases reaction
protein 22037238
D006246 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein affects cotreatment
/ decreases expression
protein 22037238
D006246 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 22037238
D006246 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
/ increases expression
protein 22037238
D006246 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 22037238
D006246 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Harmaline results in decreased activity of CYP1A1 protein decreases activity
protein 22037238
D006246 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Harmaline results in decreased stability of CYP1A1 protein decreases stability
protein 22037238
D006246 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]] affects binding
/ decreases reaction
/ increases activity
protein 12065299
D006246 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Harmaline inhibits the reaction [IL1B protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 12065299
D006246 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Harmaline inhibits the reaction [IL1B protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 12065299
D006246 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 12107048
D006246 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]] affects binding
/ decreases reaction
/ increases activity
protein 12065299
D006246 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] affects localization
/ decreases reaction
/ increases activity
protein 12107048
D006246 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]] affects binding
/ decreases reaction
/ increases activity
protein 12065299
D006246 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] affects localization
/ decreases reaction
/ increases activity
protein 12107048

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (52)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#208900 Ataxia-telangiectasia; at Q13315
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer O96017
P31749
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P31749
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#119900 Digital clubbing, isolated congenital P15428
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#259500 Osteogenic sarcoma O96017
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#176807 Prostate cancer O96017
#176920 Proteus syndrome P31749
#275210 Restrictive dermopathy, lethal P02545
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#112100 Yt blood group antigen P22303

KEGG DISEASE (45)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00027 Ovarian cancer P31751 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
Q99714 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01282 Spermatogenic failure Q9UQB9 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D056486 D006246 Drug-Induced Liver Injury marker/mechanism
20833158
D020329 D006246 Essential Tremor marker/mechanism
19497322
D006212 D006246 Hallucinations marker/mechanism
20833158
D014202 D006246 Tremor marker/mechanism
181685
986992
12044659
15894058
17587636