PCIDB

Passiflora incarnata

Species

KNApSAcK Entry

Organism name Passiflora incarnata
Genus Passiflora
Family Passifloraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Passiflora incarnata
Linked NCBI taxonomy ID 159425
Linked level species

Family

Family in NCBI taxonomy Passifloraceae
ID 3683

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (62)

Species Activity
Passiflora incarnata L. Adaptogenic
Passiflora incarnata L. Analgesic
Passiflora incarnata L. Analgesic
Passiflora incarnata L. Antiaging
Passiflora incarnata L. Antiaromatase
Passiflora incarnata L. Antibacterial
Passiflora incarnata L. Antiinflammatory
Passiflora incarnata L. Antiinflammatory
Passiflora incarnata L. Antiseptic
Passiflora incarnata L. Antiseptic
Passiflora incarnata L. Antispasmodic
Passiflora incarnata L. Antispasmodic
Passiflora incarnata L. Antistress
Passiflora incarnata L. Antitussive
Passiflora incarnata L. Anxiolytic
Passiflora incarnata L. Anxiolytic
Passiflora incarnata L. Aphrodisiac
Passiflora incarnata L. Bactericide
Passiflora incarnata L. Candidicide
Passiflora incarnata L. Candidicide
Passiflora incarnata L. Cardiotonic
Passiflora incarnata L. Cardiotonic
Passiflora incarnata L. CNS-Depressant
Passiflora incarnata L. CNS-Depressant
Passiflora incarnata L. CNS-Stimulant
Passiflora incarnata L. CNS-Stimulant
Passiflora incarnata L. Cyanogenic
Passiflora incarnata L. Cyanogenic
Passiflora incarnata L. Digestive
Passiflora incarnata L. Digestive
Passiflora incarnata L. Emetic
Passiflora incarnata L. Emetic
Passiflora incarnata L. Fungicide
Passiflora incarnata L. Fungicide
Passiflora incarnata L. Gram(-)-icide
Passiflora incarnata L. Hematinic
Passiflora incarnata L. Hematinic
Passiflora incarnata L. Hypnotic
Passiflora incarnata L. Hypnotic
Passiflora incarnata L. Hypotensive
Passiflora incarnata L. Hypotensive
Passiflora incarnata L. MAOI
Passiflora incarnata L. MAOI
Passiflora incarnata L. Myorelaxant
Passiflora incarnata L. Myorelaxant
Passiflora incarnata L. Narcotic
Passiflora incarnata L. Narcotic
Passiflora incarnata L. Nervine
Passiflora incarnata L. Respirastimulant
Passiflora incarnata L. Respirostimulant
Passiflora incarnata L. Sedative
Passiflora incarnata L. Sedative
Passiflora incarnata L. Soporific
Passiflora incarnata L. Soporific
Passiflora incarnata L. Spermatogenic
Passiflora incarnata L. Tonic
Passiflora incarnata L. Tranquilizer
Passiflora incarnata L. Tranquilizer
Passiflora incarnata L. Uterorelaxant
Passiflora incarnata L. Uterorelaxant
Passiflora incarnata L. Uterotonic
Passiflora incarnata L. Uterotonic

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00006224 External link 512 Saponarin
C457771
No. 1 No. 15
C00006223 External link 512 Meloside A
/ Isovitexin 2''-O-glucoside
No. 1 No. 15
C00006210 External link 512 Meloside L
/ Isoorientin 2''-O-glucopyranoside
No. 1 No. 15
C00001737 External link 512 Harmine
CHEMBL269538
D006247
150 / 45 / 26 3 / 5 No. 1889 No. 4
C00001736 External link 512 Harman
/ Harmane
/ Indoter
/ Locuturin
/ Zygofabagine
CHEMBL12014
C005010
109 / 46 / 33 2 / 2 No. 1889 No. 4
C00001735 External link 512 Harmaline
CHEMBL340807
D006246
101 / 52 / 45 6 / 4 No. 7732 No. 4

Human Protein / Gene in interactions

191 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001735 C00001736 C00001737 1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00001735 C00001736 C00001737 1 / 1
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family C00001735 C00001736 C00001737 0 / 0
P19784 Casein kinase II subunit alpha' Ck2 C00001735 C00001736 C00001737 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00001735 C00001736 C00001737 0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek C00001735 C00001736 C00001737 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00001735 C00001736 C00001737 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00001735 C00001736 C00001737 0 / 0
P78396 Cyclin-A1 Other cytosolic protein C00001735 C00001736 C00001737 0 / 0
P20248 Cyclin-A2 Other cytosolic protein C00001735 C00001736 C00001737 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001735 C00001736 C00001737 0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00001735 C00001736 C00001737 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001735 C00001736 C00001737 0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00001735 C00001736 C00001737 0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00001735 C00001736 C00001737 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00001735 C00001736 C00001737 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001735 C00001736 C00001737 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00001735 C00001736 C00001737 0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim C00001735 C00001736 C00001737 0 / 0
P17252 Protein kinase C alpha type Alpha C00001735 C00001736 C00001737 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001735 C00001736 C00001737 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00001735 C00001736 C00001737 0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk C00001735 C00001736 C00001737 0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily C00001735 C00001736 C00001737 0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily C00001735 C00001736 C00001737 0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily C00001735 C00001736 C00001737 0 / 0
Q96GD4 Aurora kinase B Aur C00001735 C00001736 C00001737 0 / 0
P53778 Mitogen-activated protein kinase 12 p38 C00001735 C00001736 C00001737 0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00001735 C00001736 C00001737 1 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00001735 C00001736 C00001737 0 / 0
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 C00001735 C00001736 C00001737 0 / 0
O96017 Serine/threonine-protein kinase Chk2 Rad53 C00001735 C00001736 C00001737 4 / 1
Q05513 Protein kinase C zeta type Iota C00001735 C00001736 C00001737 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001735 C00001736 C00001737 3 / 3
P11309 Serine/threonine-protein kinase pim-1 Pim C00001735 C00001736 C00001737 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001735 C00001736 C00001737 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00001735 C00001736 C00001737 1 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001735 C00001736 C00001737 2 / 2
P23443 Ribosomal protein S6 kinase beta-1 p70 C00001735 C00001736 C00001737 0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 C00001735 C00001736 C00001737 0 / 0
Q9UQB9 Aurora kinase C Aur C00001735 C00001736 C00001737 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001735 C00001736 C00001737 0 / 0
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily C00001735 C00001736 C00001737 0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily C00001735 C00001736 C00001737 0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK C00001735 C00001736 C00001737 0 / 0
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK C00001735 C00001736 C00001737 0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk C00001735 C00001736 C00001737 0 / 0
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK C00001735 C00001736 C00001737 0 / 0
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily C00001735 C00001736 C00001737 0 / 0
Q9HC98 Serine/threonine-protein kinase Nek6 Nek C00001735 C00001736 C00001737 0 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck C00001735 C00001736 C00001737 1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily C00001735 C00001736 C00001737 0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00001735 C00001736 C00001737 2 / 2
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00001735 C00001736 C00001737 0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00001735 C00001736 C00001737 0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn C00001735 C00001736 C00001737 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00001735 C00001736 C00001737 0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily C00001735 C00001736 C00001737 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001735 C00001736 C00001737 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001735 C00001736 C00001737 0 / 1
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily C00001735 C00001736 C00001737 0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily C00001735 C00001736 C00001737 0 / 0
P51955 Serine/threonine-protein kinase Nek2 Nek C00001735 C00001736 C00001737 0 / 0
Q96SB4 SRSF protein kinase 1 Srpk C00001735 C00001736 C00001737 0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 C00001735 C00001736 C00001737 0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 C00001735 C00001736 C00001737 0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily C00001735 C00001736 C00001737 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00001735 C00001736 C00001737 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00001735 C00001736 C00001737 0 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00001735 C00001736 C00001737 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00001735 C00001736 C00001737 4 / 1
O75116 Rho-associated protein kinase 2 Rock C00001735 C00001736 C00001737 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00001735 C00001736 C00001737 0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily C00001735 C00001736 C00001737 0 / 0
P22303 Acetylcholinesterase Hydrolase C00001735 C00001736 C00001737 1 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00001735 C00001736 C00001737 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00001735 C00001736 C00001737 0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb C00001735 C00001736 C00001737 2 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00001735 C00001737 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001736 C00001737 1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001736 C00001737 0 / 0
P54132 Bloom syndrome protein Enzyme C00001735 C00001736 1 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001735 C00001736 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001736 C00001737 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001735 C00001736 4 / 3
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00001735 C00001737 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001736 C00001737 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001735 C00001736 3 / 2
O00255 Menin Unclassified protein C00001735 C00001736 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001735 C00001736 1 / 2
Q99700 Ataxin-2 Unclassified protein C00001735 C00001737 1 / 1
Q02156 Protein kinase C epsilon type Eta C00001737 0 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001737 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001737 2 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001737 0 / 0
Q8TF76 Serine/threonine-protein kinase haspin Haspin C00001737 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001737 1 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00001737 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001737 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001737 0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk C00001737 0 / 0
O75496 Geminin Unclassified protein C00001735 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001737 2 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001736 0 / 0
P07948 Tyrosine-protein kinase Lyn Src C00001737 0 / 0
P55210 Caspase-7 C14 C00001735 0 / 0
P42858 Huntingtin Unclassified protein C00001735 1 / 1
Q9Y463 Dual specificity tyrosine-phosphorylation-regulated kinase 1B CMGC dual-specificity kinase DYRK1 C00001737 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001737 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001737 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001737 2 / 2
Q9HAZ1 Dual specificity protein kinase CLK4 Clk C00001737 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001735 1 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00001737 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001736 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00001736 1 / 0
P49761 Dual specificity protein kinase CLK3 Clk C00001737 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001737 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001737 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00001737 1 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001737 1 / 1
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor C00001737 0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00001737 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001737 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00001737 0 / 1
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00001737 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001737 0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor C00001737 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001737 1 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001737 0 / 1
P02545 Prelamin-A/C Unclassified protein C00001735 11 / 10
P49760 Dual specificity protein kinase CLK2 Clk C00001737 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00001735 1 / 4
P29466 Caspase-1 C14 C00001735 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001735 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001735 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001735 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001735 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001735 1 / 1
P06746 DNA polymerase beta Enzyme C00001735 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001737 0 / 0
Q04759 Protein kinase C theta type Delta C00001737 0 / 1
P06280 Alpha-galactosidase A Enzyme C00001735 1 / 1
O94806 Serine/threonine-protein kinase D3 Pkd C00001737 0 / 0
Q05655 Protein kinase C delta type Delta C00001737 0 / 0
P05129 Protein kinase C gamma type Alpha C00001737 1 / 1
P05771 Protein kinase C beta type Alpha C00001737 0 / 0
P24723 Protein kinase C eta type Eta C00001737 1 / 0
P41743 Protein kinase C iota type Iota C00001737 0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001736 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001736 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001736 1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001736 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001736 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001736 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001736 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001736 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001736 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001736 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001736 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001736 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001736 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001736 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001736 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001736 1 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001737 2 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001737 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001737 0 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001737 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001737 0 / 0
P51946 Cyclin-H Other cytosolic protein C00001737 0 / 0
P50613 Cyclin-dependent kinase 7 Cdk7 C00001737 0 / 0
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00001737 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00001737 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00001737 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00001737 0 / 0
Q9NR20 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Enzyme C00001737 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001736 2 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001737 4 / 1
P49759 Dual specificity protein kinase CLK1 Clk C00001737 0 / 0
Q9Y2I1 Nischarin Other cytosolic protein C00001737 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001737 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001737 0 / 0
P21918 D(1B) dopamine receptor Dopamine receptor C00001737 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001737 2 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001737 1 / 0
P46098 5-hydroxytryptamine receptor 3A NS C00001737 0 / 0
O95264 5-hydroxytryptamine receptor 3B NS C00001737 0 / 0
O60563 Cyclin-T1 Other cytosolic protein C00001737 0 / 0
P50750 Cyclin-dependent kinase 9 Cdk9 C00001737 0 / 0
Q92698 DNA repair and recombination protein RAD54-like Enzyme C00001736 0 / 0

9 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001735 C00001736 C00001737
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001735
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001735
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001735
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001736
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00001735
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001735
1859 DYRK1A, DYRK, DYRK1, HP86, MNB, MNBH, MRD7 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (EC:2.7.12.1) C00001737
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00001737

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (83)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#103780 Alcohol dependence P08172
P14416
P31645
P47869
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#606798 Blepharospasm, benign essential P21918
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer O96017
P31749
#300615 Brunner syndrome P21397
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259500 Osteogenic sarcoma O96017
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#176807 Prostate cancer O96017
#176920 Proteus syndrome P31749
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#112100 Yt blood group antigen P22303

KEGG DISEASE (57)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
Q9NUW8 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00027 Ovarian cancer P31751 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
Q99714 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01282 Spermatogenic failure Q9UQB9 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D014202 Tremor C00001736
C00001735
C00001737
D006212 Hallucinations C00001735
C00001737
D056486 Drug-Induced Liver Injury C00001735
C00001737
D020329 Essential Tremor C00001735
D012640 Seizures C00001736
D004409 Dyskinesia, Drug-Induced C00001737
D010243 Paralysis C00001737