KNApSAcK Metabolite C00001737
Metabolite
KNApSAcK Entry
| id | C00001737 |
|---|---|
| Name | Harmine |
| CAS RN | 442-51-3 |
| Standard InChI | InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 |
| Standard InChI (Main Layer) | InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 1889 |
Link
ChEMBL
| By standard InChI | CHEMBL269538 |
|---|---|
| By standard InChI Main Layer | CHEMBL269538 |
KEGG
| By LinkDB | C06538 |
|---|
CTD
| By CAS RN | D006247 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 5 |
| Liliopsida | 1 |
Family
| family name | count |
|---|---|
| Nitrariaceae | 2 |
| Malpighiaceae | 2 |
| Passifloraceae | 1 |
| Cyperaceae | 1 |
List (6)
* NCBI
Human Protein / Gene in interaction
150 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL269538 |
CHEMBL729206
(1)
CHEMBL1614110
(1)
CHEMBL1741321 (1) |
1 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | CHEMBL269538 |
CHEMBL1062820
(1)
|
1 / 1 |
| Q9Y2I1 | Nischarin | Other cytosolic protein | CHEMBL269538 |
CHEMBL841854
(1)
CHEMBL841867
(1)
|
0 / 0 |
| P49759 | Dual specificity protein kinase CLK1 | Clk | CHEMBL269538 |
CHEMBL1794519
(2)
CHEMBL1805398
(1)
CHEMBL2186708 (1) CHEMBL2320044 (1) |
0 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | CHEMBL269538 |
CHEMBL1061086
(1)
|
0 / 0 |
| Q8TDX7 | Serine/threonine-protein kinase Nek7 | Nek | CHEMBL269538 |
CHEMBL1060151
(1)
|
0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL269538 |
CHEMBL1613842
(2)
|
4 / 2 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL269538 |
CHEMBL2114784
(1)
|
1 / 1 |
| Q9NR20 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 | Enzyme | CHEMBL269538 |
CHEMBL2187130
(1)
|
0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | CHEMBL269538 |
CHEMBL1648261
(1)
|
0 / 0 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | CHEMBL269538 |
CHEMBL1052111
(1)
|
0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | CHEMBL269538 |
CHEMBL1063767
(1)
|
0 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | CHEMBL269538 |
CHEMBL1063811
(1)
|
0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | CHEMBL269538 |
CHEMBL1061954
(1)
|
0 / 0 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | CHEMBL269538 |
CHEMBL1060122
(1)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL269538 |
CHEMBL767447
(1)
CHEMBL1062776
(1)
|
0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | CHEMBL269538 |
CHEMBL1061959
(1)
|
0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | CHEMBL269538 |
CHEMBL1051374
(1)
|
0 / 0 |
| Q8IWQ3 | Serine/threonine-protein kinase BRSK2 | CAMK serine/threonine protein kinase BRSK subfamily | CHEMBL269538 |
CHEMBL1051367
(1)
|
0 / 0 |
| P27448 | MAP/microtubule affinity-regulating kinase 3 | CAMK serine/threonine protein kinase MARK subfamily | CHEMBL269538 |
CHEMBL1063734
(1)
|
0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | CHEMBL269538 |
CHEMBL652499
(1)
|
0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | CHEMBL269538 |
CHEMBL1074724
(1)
CHEMBL1648260
(1)
CHEMBL1817453 (1) |
1 / 1 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | CHEMBL269538 |
CHEMBL616533
(1)
|
0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | CHEMBL269538 |
CHEMBL648620
(1)
|
0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | CHEMBL269538 |
CHEMBL620826
(1)
|
0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | CHEMBL269538 |
CHEMBL767447
(1)
CHEMBL1052114
(1)
|
0 / 0 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | CHEMBL269538 |
CHEMBL620716
(1)
CHEMBL618086
(1)
|
0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | CHEMBL269538 |
CHEMBL1063736
(1)
CHEMBL2187125
(1)
|
0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | CHEMBL269538 |
CHEMBL657267
(1)
CHEMBL666137
(1)
CHEMBL1056886 (1) CHEMBL2182305 (1) |
0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | CHEMBL269538 |
CHEMBL680963
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL269538 |
CHEMBL1741325
(1)
|
0 / 1 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | CHEMBL269538 |
CHEMBL1052119
(1)
|
0 / 0 |
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | CHEMBL269538 |
CHEMBL663604
(1)
CHEMBL666138
(1)
CHEMBL2182304 (1) CHEMBL2320288 (1) |
0 / 0 |
| Q9UQB9 | Aurora kinase C | Aur | CHEMBL269538 |
CHEMBL1062797
(1)
|
1 / 1 |
| P49761 | Dual specificity protein kinase CLK3 | Clk | CHEMBL269538 |
CHEMBL2186706
(1)
|
0 / 0 |
| Q9HBH9 | MAP kinase-interacting serine/threonine-protein kinase 2 | CAMK serine/threonine protein kinase MNK subfamily | CHEMBL269538 |
CHEMBL1060126
(1)
|
0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL269538 |
CHEMBL1063719
(1)
|
0 / 0 |
| Q16644 | MAP kinase-activated protein kinase 3 | CAMK serine/threonine protein kinase MAPKAPK | CHEMBL269538 |
CHEMBL1061148
(1)
|
0 / 0 |
| Q9H422 | Homeodomain-interacting protein kinase 3 | CMGC dual-specificity kinase HIPK | CHEMBL269538 |
CHEMBL1061964
(1)
|
0 / 0 |
| Q14680 | Maternal embryonic leucine zipper kinase | Melk | CHEMBL269538 |
CHEMBL1052104
(1)
|
0 / 0 |
| Q15078 | Cyclin-dependent kinase 5 activator 1 | REG serine/threonine protein kinase family | CHEMBL269538 |
CHEMBL663604
(1)
CHEMBL2182304
(1)
CHEMBL2320288 (1) |
0 / 0 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | CHEMBL269538 |
CHEMBL1062028
(1)
|
1 / 1 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | CHEMBL269538 |
CHEMBL1060209
(1)
|
0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | CHEMBL269538 |
CHEMBL1061917
(1)
|
2 / 2 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | CHEMBL269538 |
CHEMBL1062767
(1)
|
0 / 0 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | CHEMBL269538 |
CHEMBL1062809
(1)
|
0 / 0 |
| Q16513 | Serine/threonine-protein kinase N2 | Pkn | CHEMBL269538 |
CHEMBL1060217
(1)
|
0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | CHEMBL269538 |
CHEMBL767447
(1)
CHEMBL1062021
(1)
|
0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | CHEMBL269538 |
CHEMBL1613800
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL269538 |
CHEMBL1614458
(5)
|
0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | CHEMBL269538 |
CHEMBL943086
(1)
|
2 / 2 |
| Q8N5S9 | Calcium/calmodulin-dependent protein kinase kinase 1 | META serine/threonine protein kinase subfamily | CHEMBL269538 |
CHEMBL1061198
(1)
|
0 / 0 |
| Q9P286 | Serine/threonine-protein kinase PAK 7 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL269538 |
CHEMBL1061163
(1)
|
0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL269538 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| Q96SB4 | SRSF protein kinase 1 | Srpk | CHEMBL269538 |
CHEMBL1060225
(1)
|
0 / 0 |
| Q92630 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | CMGC dual-specificity kinase DYRK2 | CHEMBL269538 |
CHEMBL1062881
(1)
CHEMBL1062802
(1)
CHEMBL2015537 (1) CHEMBL2186709 (1) CHEMBL2187132 (1) CHEMBL2320042 (1) |
0 / 0 |
| O43781 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | CMGC dual-specificity kinase DYRK2 | CHEMBL269538 |
CHEMBL1061956
(1)
CHEMBL1051268
(1)
CHEMBL2187131 (1) CHEMBL2320041 (1) |
0 / 0 |
| O96013 | Serine/threonine-protein kinase PAK 4 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL269538 |
CHEMBL1061162
(1)
|
0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL269538 |
CHEMBL1794486
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL269538 |
CHEMBL1738606
(1)
|
0 / 0 |
| Q9Y463 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | CMGC dual-specificity kinase DYRK1 | CHEMBL269538 |
CHEMBL2186702
(1)
CHEMBL2187133
(1)
|
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL269538 |
CHEMBL1794584
(1)
|
2 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | CHEMBL269538 |
CHEMBL647969
(1)
|
0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | CHEMBL269538 |
CHEMBL648861
(1)
|
0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | CHEMBL269538 |
CHEMBL1060118
(1)
CHEMBL2187127
(1)
|
0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | CHEMBL269538 |
CHEMBL1052116
(1)
|
0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | CHEMBL269538 |
CHEMBL1060132
(1)
|
0 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | CHEMBL269538 |
CHEMBL1060123
(1)
|
0 / 1 |
| P51955 | Serine/threonine-protein kinase Nek2 | Nek | CHEMBL269538 |
CHEMBL1062822
(1)
|
0 / 0 |
| Q96RR4 | Calcium/calmodulin-dependent protein kinase kinase 2 | META serine/threonine protein kinase subfamily | CHEMBL269538 |
CHEMBL1052080
(1)
|
0 / 0 |
| Q9BUB5 | MAP kinase-interacting serine/threonine-protein kinase 1 | CAMK serine/threonine protein kinase MNK subfamily | CHEMBL269538 |
CHEMBL1063759
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL269538 |
CHEMBL1794401
(1)
|
0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | CHEMBL269538 |
CHEMBL805517
(1)
|
2 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | CHEMBL269538 |
CHEMBL1061194
(1)
CHEMBL1062001
(1)
|
1 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | CHEMBL269538 |
CHEMBL618121
(1)
|
0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | CHEMBL269538 |
CHEMBL1051365
(1)
|
0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | CHEMBL269538 |
CHEMBL1051342
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL269538 |
CHEMBL1052091
(1)
|
0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | CHEMBL269538 |
CHEMBL1061969
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL269538 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL269538 |
CHEMBL1613910
(3)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL269538 |
CHEMBL1614038
(4)
|
2 / 2 |
| Q8TF76 | Serine/threonine-protein kinase haspin | Haspin | CHEMBL269538 |
CHEMBL2014113
(1)
|
0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | CHEMBL269538 |
CHEMBL649668
(1)
|
1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL269538 |
CHEMBL2020014
(1)
CHEMBL2020015
(1)
|
1 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | CHEMBL269538 |
CHEMBL617276
(1)
|
0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | CHEMBL269538 |
CHEMBL1052115
(1)
|
0 / 0 |
| P49840 | Glycogen synthase kinase-3 alpha | Gsk | CHEMBL269538 |
CHEMBL2187128
(1)
|
0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | CHEMBL269538 |
CHEMBL1061101
(1)
|
0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | CHEMBL269538 |
CHEMBL1063671
(1)
|
0 / 0 |
| P07948 | Tyrosine-protein kinase Lyn | Src | CHEMBL269538 |
CHEMBL841385
(1)
|
0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | CHEMBL269538 |
CHEMBL1061172
(1)
|
4 / 1 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | CHEMBL269538 |
CHEMBL1063673
(1)
|
0 / 0 |
| P51812 | Ribosomal protein S6 kinase alpha-3 | Rskb | CHEMBL269538 |
CHEMBL1063683
(1)
|
2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL269538 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL269538 |
CHEMBL1614108
(3)
CHEMBL1613886
(3)
CHEMBL1741324 (1) |
0 / 1 |
| Q9HAZ1 | Dual specificity protein kinase CLK4 | Clk | CHEMBL269538 |
CHEMBL1614024
(1)
CHEMBL2186711
(1)
|
0 / 0 |
| Q9HC98 | Serine/threonine-protein kinase Nek6 | Nek | CHEMBL269538 |
CHEMBL1060128
(1)
|
0 / 0 |
| Q9H2X6 | Homeodomain-interacting protein kinase 2 | CMGC dual-specificity kinase HIPK | CHEMBL269538 |
CHEMBL1062015
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL269538 |
CHEMBL1614211
(5)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL269538 |
CHEMBL1738184
(1)
|
0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | CHEMBL269538 |
CHEMBL615773
(1)
|
1 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | CHEMBL269538 |
CHEMBL872666
(1)
|
1 / 1 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | CHEMBL269538 |
CHEMBL616923
(1)
|
0 / 0 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | CHEMBL269538 |
CHEMBL649150
(1)
|
0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | CHEMBL269538 |
CHEMBL646281
(1)
|
0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | CHEMBL269538 |
CHEMBL872814
(1)
|
0 / 1 |
| O96017 | Serine/threonine-protein kinase Chk2 | Rad53 | CHEMBL269538 |
CHEMBL1062000
(1)
|
4 / 1 |
| Q14012 | Calcium/calmodulin-dependent protein kinase type 1 | Camk1 | CHEMBL269538 |
CHEMBL1051272
(1)
|
0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | CHEMBL269538 |
CHEMBL1062854
(1)
|
0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | CHEMBL269538 |
CHEMBL1062880
(1)
CHEMBL1062005
(1)
CHEMBL2015535 (1) CHEMBL2166480 (1) CHEMBL2186710 (1) CHEMBL2187134 (1) CHEMBL2182293 (1) CHEMBL2320043 (1) |
1 / 0 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | CHEMBL269538 |
CHEMBL1062773
(1)
|
0 / 0 |
| O00418 | Eukaryotic elongation factor 2 kinase | Atypical serine/threonine protein kinase alpha subfamily | CHEMBL269538 |
CHEMBL1060113
(1)
|
0 / 0 |
| P49760 | Dual specificity protein kinase CLK2 | Clk | CHEMBL269538 |
CHEMBL2186703
(1)
|
0 / 0 |
| Q8TD08 | Mitogen-activated protein kinase 15 | Mapk | CHEMBL269538 |
CHEMBL1062012
(1)
|
0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | CHEMBL269538 |
CHEMBL1062887
(1)
CHEMBL1061912
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL269538 |
CHEMBL1613914
(4)
|
0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | CHEMBL269538 |
CHEMBL767447
(1)
|
0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | CHEMBL269538 |
CHEMBL767447
(1)
|
0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | CHEMBL269538 |
CHEMBL767447
(1)
|
0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | CHEMBL269538 |
CHEMBL767447
(1)
|
0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | CHEMBL269538 |
CHEMBL767447
(1)
|
1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | CHEMBL269538 |
CHEMBL767447
(1)
|
0 / 0 |
| P24723 | Protein kinase C eta type | Eta | CHEMBL269538 |
CHEMBL767447
(1)
|
1 / 0 |
| P41743 | Protein kinase C iota type | Iota | CHEMBL269538 |
CHEMBL767447
(1)
|
0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | CHEMBL269538 |
CHEMBL749189
(1)
|
2 / 0 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | CHEMBL269538 |
CHEMBL749189
(1)
|
1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | CHEMBL269538 |
CHEMBL749189
(1)
|
0 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | CHEMBL269538 |
CHEMBL749189
(1)
|
0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | CHEMBL269538 |
CHEMBL749189
(1)
|
0 / 0 |
| P51946 | Cyclin-H | Other cytosolic protein | CHEMBL269538 |
CHEMBL2182303
(1)
|
0 / 0 |
| P50613 | Cyclin-dependent kinase 7 | Cdk7 | CHEMBL269538 |
CHEMBL2182303
(1)
|
0 / 0 |
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | CHEMBL269538 |
CHEMBL661324
(1)
|
0 / 0 |
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | CHEMBL269538 |
CHEMBL661324
(1)
|
0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | CHEMBL269538 |
CHEMBL661324
(1)
|
0 / 0 |
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | CHEMBL269538 |
CHEMBL661324
(1)
|
0 / 0 |
| P20248 | Cyclin-A2 | Other cytosolic protein | CHEMBL269538 |
CHEMBL657267
(1)
CHEMBL1056886
(1)
CHEMBL2182305 (1) |
0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | CHEMBL269538 |
CHEMBL657267
(1)
CHEMBL1056886
(1)
CHEMBL2182305 (1) |
0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | CHEMBL269538 |
CHEMBL1061205
(1)
|
0 / 0 |
| P19784 | Casein kinase II subunit alpha' | Ck2 | CHEMBL269538 |
CHEMBL1061205
(1)
|
0 / 0 |
| P67870 | Casein kinase II subunit beta | REG serine/threonine protein kinase family | CHEMBL269538 |
CHEMBL1061205
(1)
|
0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | CHEMBL269538 |
CHEMBL675880
(1)
|
0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | CHEMBL269538 |
CHEMBL675880
(1)
|
0 / 0 |
| P21918 | D(1B) dopamine receptor | Dopamine receptor | CHEMBL269538 |
CHEMBL675880
(1)
|
1 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | CHEMBL269538 |
CHEMBL675880
(1)
|
2 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | CHEMBL269538 |
CHEMBL675880
(1)
|
1 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | CHEMBL269538 |
CHEMBL617836
(1)
|
0 / 0 |
| O95264 | 5-hydroxytryptamine receptor 3B | NS | CHEMBL269538 |
CHEMBL617836
(1)
|
0 / 0 |
| O60563 | Cyclin-T1 | Other cytosolic protein | CHEMBL269538 |
CHEMBL2182302
(1)
|
0 / 0 |
| P50750 | Cyclin-dependent kinase 9 | Cdk9 | CHEMBL269538 |
CHEMBL2182302
(1)
|
0 / 0 |
CTD interaction (8)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D006247 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein] |
decreases reaction
/ decreases stability |
protein |
22001777
|
| D006247 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22001777
|
| D006247 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] |
decreases reaction
/ increases expression |
protein |
22001777
|
| D006247 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Harmine results in decreased activity of CYP1A1 protein |
decreases activity
|
protein |
22001777
|
| D006247 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Harmine results in decreased stability of CYP1A1 protein |
decreases stability
|
protein |
22001777
|
| D006247 | 1859 |
DYRK1A
DYRK DYRK1 HP86 MNB MNBH MRD7 |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (EC:2.7.12.1) | Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] |
decreases reaction
/ increases phosphorylation |
protein |
21573099
|
| D006247 | 1859 |
DYRK1A
DYRK DYRK1 HP86 MNB MNBH MRD7 |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (EC:2.7.12.1) | Harmine results in decreased activity of DYRK1A protein |
decreases activity
|
protein |
21573099
|
| D006247 | 4137 |
MAPT
DDPAC FTDP-17 MAPTL MSTD MTBT1 MTBT2 PPND TAU |
microtubule-associated protein tau | Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] |
decreases reaction
/ increases phosphorylation |
protein |
21573099
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (45)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #606798 | Blepharospasm, benign essential |
P21918
|
| #114480 | Breast cancer |
O96017
P31749 |
| #300615 | Brunner syndrome |
P21397
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #303600 | Coffin-lowry syndrome; cls |
P51812
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #609265 | Li-fraumeni syndrome 2; lfs2 |
O96017
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300844 | Mental retardation, x-linked 19; mrx19 |
P51812
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #159900 | Myoclonic dystonia |
P14416
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259500 | Osteogenic sarcoma |
O96017
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #176807 | Prostate cancer |
O96017
|
| #176920 | Proteus syndrome |
P31749
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #243060 | Spermatogenic failure 5; spgf5 |
Q9UQB9
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601367 | Stroke, ischemic |
P24723
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (26)
| KEGG | disease name | UniProt |
|---|---|---|
| H00881 | Li-Fraumeni syndrome |
O96017
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q99700 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00027 | Ovarian cancer |
P31751
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P31751
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P51812
(related)
Q99714 (related) |
| H00574 | Coffin-Lowry syndrome (CLS) |
P51812
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H01282 | Spermatogenic failure |
Q9UQB9
(related)
|
Diseases related to CTD interactions
5 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D056486 | D006247 | Drug-Induced Liver Injury |
marker/mechanism
|
20833158
|
|
| D004409 | D006247 | Dyskinesia, Drug-Induced |
marker/mechanism
|
2581196
|
|
| D006212 | D006247 | Hallucinations |
marker/mechanism
|
20833158
|
|
| D010243 | D006247 | Paralysis |
marker/mechanism
|
6258692
|
|
| D014202 | D006247 | Tremor |
marker/mechanism
|
6258692
15485139 |