Plant Species


Cumulative plant class count

class name count

Cumulative family count

class name count
Aspergillaceae 18
Thermoascaceae 1
Gymnoascaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00024000 External link 512 Mycoin
/ Patulin
/ Clavitin
/ Tercinin
/ Leucopin
/ Clavicin
/ Expansion
/ Penicidin
/ Claviformin
/ 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
CHEMBL294018
D010365
21 / 26 / 48 23 / 2

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00024000 7 / 37
Q16637 Survival motor neuron protein Unclassified protein C00024000 4 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00024000 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00024000 3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00024000 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00024000 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00024000 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00024000 0 / 0
P23528 Cofilin-1 Unclassified protein C00024000 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00024000 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00024000 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00024000 0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00024000 5 / 3
Q96RI1 Bile acid receptor NR1H4 C00024000 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00024000 0 / 0
P03372 Estrogen receptor NR3A1 C00024000 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00024000 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00024000 4 / 3
P05412 Transcription factor AP-1 Transcription Factor C00024000 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00024000 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00024000 0 / 0

23 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
467 ATF3 activating transcription factor 3 C00024000
10018 BCL2L11, BAM, BIM, BOD BCL2-like 11 (apoptosis facilitator) C00024000
637 BID, FP497 BH3 interacting domain death agonist C00024000
847 CAT catalase (EC:1.11.1.6) C00024000
9076 CLDN1, CLD1, ILVASC, SEMP1 claudin 1 C00024000
1365 CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 claudin 3 C00024000
1364 CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R claudin 4 C00024000
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00024000
3458 IFNG, IFG, IFI interferon, gamma C00024000
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00024000
3596 IL13, IL-13, P600 interleukin 13 C00024000
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00024000
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00024000
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00024000
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00024000
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00024000
100506658 OCLN, BLCPMG occludin (EC:2.1.1.67) C00024000
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00024000
23645 PPP1R15A, GADD34 protein phosphatase 1, regulatory subunit 15A C00024000
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00024000
7082 TJP1, ZO-1 tight junction protein 1 C00024000
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00024000
7494 XBP1, TREB5, XBP-1, XBP2 X-box binding protein 1 C00024000

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P04637
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (48)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007674 Kidney Diseases C00024000
D049188 Prenatal Injuries C00024000