PCIDB

KNApSAcK Metabolite C00024000

Metabolite

KNApSAcK Entry

id C00024000
Name Mycoin / Patulin / Clavitin / Tercinin / Leucopin / Clavicin / Expansion / Penicidin / Claviformin / 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
CAS RN 149-29-1
Standard InChI InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
Standard InChI (Main Layer) InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2

Cluster

Phytochemical cluster
KCF-S cluster No. 7818

Link

ChEMBL

By standard InChI CHEMBL294018
By standard InChI Main Layer CHEMBL294018

KEGG

By LinkDB C16748

CTD

By CAS RN D010365

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL294018 CHEMBL1226577 (1) CHEMBL1613992 (1)
CHEMBL1613995 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL294018 CHEMBL1613842 (1)
4 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL294018 CHEMBL1794524 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL294018 CHEMBL1794399 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL294018 CHEMBL1794371 (1) CHEMBL1794471 (1)
0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL294018 CHEMBL1226575 (1) CHEMBL1226576 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL294018 CHEMBL1794311 (1) CHEMBL1794376 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL294018 CHEMBL1614458 (1)
0 / 0
P23528 Cofilin-1 Unclassified protein CHEMBL294018 CHEMBL1226579 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL294018 CHEMBL1963893 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL294018 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL294018 CHEMBL1794382 (1) CHEMBL1794456 (1)
0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL294018 CHEMBL1794510 (1)
5 / 3
Q96RI1 Bile acid receptor NR1H4 CHEMBL294018 CHEMBL1794437 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL294018 CHEMBL1614521 (1) CHEMBL1613808 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL294018 CHEMBL1794542 (1)
1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL294018 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL294018 CHEMBL1614250 (1) CHEMBL1614421 (1)
4 / 3
P05412 Transcription factor AP-1 Transcription Factor CHEMBL294018 CHEMBL1226578 (1)
0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor CHEMBL294018 CHEMBL2114849 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL294018 CHEMBL1794536 (1)
0 / 0

CTD interaction (31)

compound gene gene name gene description interaction interaction type form reference
pmid
D010365 467 ATF3
activating transcription factor 3 Patulin results in increased expression of ATF3 mRNA increases expression
mRNA 21844328
D010365 10018 BCL2L11
BAM
BIM
BOD
BCL2-like 11 (apoptosis facilitator) Patulin results in increased expression of BCL2L11 mRNA increases expression
mRNA 21844328
D010365 637 BID
FP497
BH3 interacting domain death agonist Patulin results in increased expression of BID mRNA increases expression
mRNA 21844328
D010365 847 CAT
catalase (EC:1.11.1.6) CAT protein results in decreased susceptibility to Patulin decreases response to substance
protein 17090621
D010365 9076 CLDN1
CLD1
ILVASC
SEMP1
claudin 1 Patulin affects the localization of CLDN1 protein affects localization
protein 19013514
D010365 1365 CLDN3
C7orf1
CPE-R2
CPETR2
HRVP1
RVP1
claudin 3 Patulin affects the localization of CLDN3 protein affects localization
protein 19013514
D010365 1364 CLDN4
CPE-R
CPER
CPETR
CPETR1
WBSCR8
hCPE-R
claudin 4 Patulin affects the localization of CLDN4 protein affects localization
protein 19013514
D010365 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Patulin results in increased expression of DDIT3 mRNA increases expression
mRNA 21844328
D010365 3458 IFNG
IFG
IFI
interferon, gamma [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein decreases abundance
/ decreases secretion
protein 18214930
D010365 3458 IFNG
IFG
IFI
interferon, gamma Patulin results in decreased expression of IFNG mRNA decreases expression
mRNA 12112629
D010365 3458 IFNG
IFG
IFI
interferon, gamma Patulin results in decreased secretion of IFNG protein decreases secretion
protein 12112629
D010365 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein decreases abundance
/ decreases secretion
protein 18214930
D010365 3596 IL13
IL-13
P600
interleukin 13 [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein decreases abundance
/ decreases secretion
protein 18214930
D010365 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Patulin inhibits the reaction [IL1B protein results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 18308354
D010365 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 Patulin affects the secretion of IL4 protein affects secretion
protein 12112629
D010365 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein decreases abundance
/ decreases secretion
protein 18214930
D010365 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 Patulin results in increased expression of IL4 mRNA increases expression
mRNA 12112629
D010365 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Patulin inhibits the reaction [IL1B protein results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 18308354
D010365 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17090621
D010365 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Patulin results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 17090621
D010365 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17090621
D010365 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Patulin results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 17090621
D010365 100506658 OCLN
BLCPMG
occludin (EC:2.1.1.67) 1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein] decreases reaction
/ increases degradation
protein 19013514
D010365 100506658 OCLN
BLCPMG
occludin (EC:2.1.1.67) Patulin results in increased degradation of OCLN protein increases degradation
protein 19013514
D010365 100506658 OCLN
BLCPMG
occludin (EC:2.1.1.67) Zinc Sulfate inhibits the reaction [Patulin results in increased degradation of OCLN protein] decreases reaction
/ increases degradation
protein 19013514
D010365 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Patulin results in increased expression of PMAIP1 mRNA increases expression
mRNA 21844328
D010365 23645 PPP1R15A
GADD34
protein phosphatase 1, regulatory subunit 15A Patulin results in increased expression of PPP1R15A mRNA increases expression
mRNA 21844328
D010365 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) SOD1 protein results in decreased susceptibility to Patulin decreases response to substance
protein 17090621
D010365 7082 TJP1
ZO-1
tight junction protein 1 Patulin results in decreased expression of TJP1 protein decreases expression
protein 19013514
D010365 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Patulin results in increased expression of TP53 protein increases expression
protein 19744505
D010365 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 Patulin results in increased splicing of XBP1 mRNA increases splicing
mRNA 21844328

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P04637
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (48)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007674 D010365 Kidney Diseases marker/mechanism
22847133
D049188 D010365 Prenatal Injuries marker/mechanism
22847133