KCF-S cluster No. 8088 (1 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|
Cumulative family count
| class name | count |
|---|---|
| Dendrobatidae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00028244
|
CMI 488
/ Epibatidine |
CHEMBL6623
CHEMBL54902 CHEMBL298826 CHEMBL298517 CHEMBL306959 CHEMBL513692 |
C082748
|
22 / 19 / 16 | 6 / 3 |
|
Human Protein / Gene in interactions
22 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00028244 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00028244 | 2 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | C00028244 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00028244 | 0 / 1 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | C00028244 | 0 / 0 |
| Q07001 | Acetylcholine receptor subunit delta | CHRN delta | C00028244 | 3 / 2 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00028244 | 1 / 1 |
| P07510 | Acetylcholine receptor subunit gamma | CHRN gamma | C00028244 | 2 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00028244 | 1 / 1 |
| P02708 | Acetylcholine receptor subunit alpha | CHRN alpha | C00028244 | 3 / 2 |
| P11230 | Acetylcholine receptor subunit beta | CHRN beta | C00028244 | 2 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00028244 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00028244 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00028244 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00028244 | 2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00028244 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00028244 | 0 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00028244 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00028244 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00028244 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00028244 | 1 / 2 |
| Q15822 | Neuronal acetylcholine receptor subunit alpha-2 | CHRN alpha | C00028244 | 1 / 1 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1135 | CHRNA2 | cholinergic receptor, nicotinic, alpha 2 (neuronal) |
C00028244
|
| 1136 | CHRNA3, LNCR2, NACHRA3, PAOD2 | cholinergic receptor, nicotinic, alpha 3 (neuronal) |
C00028244
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00028244
|
| 1139 | CHRNA7, CHRNA7-2, NACHRA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
C00028244
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00028244
|
| 1143 | CHRNB4 | cholinergic receptor, nicotinic, beta 4 (neuronal) |
C00028244
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (19)
| OMIM | preferred title | UniProt |
|---|---|---|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #610353 | Epilepsy, nocturnal frontal lobe, 4; enfl4 |
Q15822
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #265000 | Multiple pterygium syndrome, escobar variant; evmps |
P07510
|
| #253290 | Multiple pterygium syndrome, lethal type; lmps |
P02708
P07510 Q07001 |
| #608931 | Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency |
P11230
|
| #608930 | Myasthenic syndrome, congenital, fast-channel |
P02708
Q07001 |
| #601462 | Myasthenic syndrome, congenital, slow-channel; sccms |
P02708
P11230 Q07001 |
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (16)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00770 | Congenital myasthenic syndrome |
P02708
(related)
P11230 (related) Q07001 (related) |
| H00986 | Multiple pterygium syndrome |
P02708
(related)
P07510 (related) Q07001 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) Q15822 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|